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MPM Genes
Novel Interactors
Known Interactors
Novel Interactions
Known Interactions

SymbolEntrez IDKnown PPIsNovel PPIsGO terms
ATIC 471 5 5 11
ATP1B1 481 21 7 28
ATXN1 6310 287 5 4
BAP1 8314 27 2 13
CDKN2A 1029 168 5 16
CTLA4 1493 17 10 10
DHFR 1719 10 7 15
FGFR1 2260 67 7 57
FGFR2 2263 46 8 107
FGFR3 2261 43 6 27
FLT1 2321 25 8 22
FLT3 2322 17 8 24
FLT4 2324 16 4 24
FOXO3 2309 27 4 35
GART 2618 4 5 10
GIPR 2696 2 0 14
HLA-DQA1 3117 9 6 5
HSP90AA1 3320 158 6 28
HSP90AB1 3326 59 10 36
HSP90B1 7184 36 2 16
IL4R 3566 23 5 17
KAZN 23254 12 6 1
KDR 3791 60 8 35
KRT5 3852 25 10 5
KRT72 140807 19 8 3
LCK 3932 143 5 28
LY6E 4061 6 8 2
LYN 4067 125 12 86
NTRK2 4915 34 3 35
PDCD1 5133 2 3 8
PDGFRA 5156 64 4 50
PDGFRB 5159 76 8 65
PDPN 10630 2 5 15
POLE 5426 12 7 11
POLE2 5427 13 6 7
POLE3 54107 7 7 6
POLE4 56655 7 4 5
PRR5 55615 5 3 6
RRM1 6240 10 12 11
RRM2 6241 9 10 6
SP1 6667 146 5 11
SRC 6714 300 9 108
- 445347 1 4 0
TBCE 6905 2 3 9
TTF1 7270 6 3 8
TUBA1A 7846 63 3 6
TUBA1C 84790 6 8 4
TUBA3C 7278 12 3 2
TUBA3D 113457 1 6 2
TUBA4A 7277 51 14 5
TUBA8 51807 7 2 2
TUBB1 81027 1 2 1
TUBB2A 7280 27 0 2
TUBB3 10381 34 6 3
TUBB4A 10382 10 7 5
TUBB4B 10383 19 4 7
TUBD1 51174 1 6 5
TUBE1 51175 0 6 1
TUBG1 7283 28 6 6
TUBG2 27175 3 3 2
TYMS 7298 3 9 28
WT1 7490 64 8 46

 

Symbol Entrez ID Known PPIs Novel PPIs
ADAM3A 1587 0 0
ALK 238 16 12
AR 367 265 0
ARHGAP22 58504 7 5
ARID1A 8289 17 7
ARID1B 57492 7 8
ASXL1 171023 6 9
BAP1 8314 27 2
BIRC5 332 25 8
BRIP1 83990 10 4
CDH5 1003 21 7
CDK12 51755 9 9
CDKN2A 1029 168 5
CHEK2 11200 80 5
CTNNB1 1499 187 11
DAXX 1616 113 10
DDX3X 1654 92 4
DPYD 1806 3 8
EGFR 1956 409 4
EPHB1 2047 13 10
ESR1 2099 365 6
FGF6 2251 5 2
HRAS 3265 146 7
IGKC 3514 4 2
IRS2 8660 40 10
JAK1 3716 72 8
JUN 3725 180 9
KDM6A 7403 11 7
KDR 3791 60 8
KEAP1 9817 77 15
KMT2A 4297 31 13
MAPK8 5599 137 8
MET 4233 112 12
MRE11 4361 20 8
MTOR 2475 52 7
MUC1 4582 134 12
NF2 4771 74 4
NR2F2 7026 18 3
NSD1 64324 36 5
PBRM1 55193 11 11
PIK3CA 5290 70 8
PRDM1 639 10 6
PTEN 5728 356 9
RASSF1 11186 70 5
RB1 5925 190 9
RHEB 6009 29 6
RICTOR 253260 11 8
SDHB 6390 6 9
SETD2 29072 8 6
SMARCB1 6598 112 3
STK11 6794 134 5
SUZ12 23512 17 9
TERT 7015 80 9
TP53 7157 489 6
TRAF7 84231 12 6
TRIO 7204 13 5
TSC1 7248 99 11
VEGFB 7423 6 5
WT1 7490 64 8

 

Pathways P_values Mesothelioma Genes Known Interactors Novel Interactors
Glucocorticoid Receptor Signaling 6.31E-56 KRT72, HSP90B1, FGFR3, HSP90AB1, FGFR1, KRT5, FOXO3, FGFR2, HSP90AA1 POU2F1, NCOR2, KRT8, MAPK10, JAK3, NR3C2, IL13, SMARCA4, SMAD4, SMARCB1, ACTB, FRS2, TRAF6, SMAD2, PIK3C2B, SMARCE1, SMARCC2, AR, SGK1, PTGES3, BCL2L1, STAT5B, JUN, KRT17, IRS1, GAB1, PGR, SUMO1, FKBP4, FKBP5, KRT19, PTPN11, HSPA8, STAT5A, KRT31, CREBBP, NCOR1, CHUK, CDK7, EP300, MAP3K14, KRT40, IL4, BAG1, NFATC1, SOS1, HSPA9, HSPA4, CEBPB, PRKACA, HRAS, RAC1, ADRB2, KAT2B, KRT38, NFKBIA, IKBKG, STAT3, SMAD3, ESR1, CD3E, PIK3R3, KRT1, JAK2, IL1B, POLR2E, RAF1, JAK1, IKBKB, HLTF, ANXA1, TGFBR2, PIK3R2, NR3C1, ARID1A, KRT15, IKBKE, TRAF2, TBP, AKT1, PIK3R1, KRT14, SMARCC1, YWHAH, TAF4, PIK3CA, STAT1, TNF, CDKN1A, GRB2, MAPK8, MAPK3, NFKB1, IRS2, ATM, AKT2, RELA, PIK3CG, KRT18, NFATC3, NOS2, UBE2I, MAPK1, POLR2G, CD247, SHC1 KRT74, HMGB1, PRKAG1, IL6, KRT6B, KRT78, KRT80, KRT7, KRT4, TAF3, NPPA, MAP3K7, KRT6A
Molecular Mechanisms of Cancer 5.01E-53 CDKN2A, SRC, FGFR3, FGFR1, FGFR2 CAMK2B, GNA11, MAPK10, JAK3, SMAD4, E2F3, GNAQ, FRS2, ATR, LRP1, RBL1, PRKCE, CCND2, CTNNB1, CDKN2C, SMAD2, PIK3C2B, PTK2, NFKB2, PRKCD, BCL2L1, FAS, ITGA5, JUN, RASGRF1, E2F1, IRS1, GAB1, MAX, TP53, APC, FYN, SMAD7, ARHGEF7, PTPN11, ITGB1, CREBBP, CRK, PRKCI, RAPGEF1, CDK6, PRKCZ, FOXO1, FASLG, NOTCH1, CDK7, PAK1, EP300, SOS1, PRKCA, PRKD1, MDM2, PRKACA, HRAS, RAC1, CDK1, BIRC2, CDC42, ADCY6, PRKCQ, NFKBIA, IKBKG, SMAD3, PRKCH, PIK3R3, JAK2, RAF1, JAK1, NLK, CDK5, SYNGAP1, ABL1, BMPR2, MYC, TGFBR2, PIK3R2, CDKN1B, SMAD1, CCND1, CASP3, GSK3B, APAF1, AKT1, GNA12, PIK3R1, CTNND1, CBL, CDC25C, GNAI2, PIK3CA, E2F2, CDKN1A, GRB2, CDH1, MAPK8, PRKDC, CASP7, MAPK3, BRCA1, PAK2, NFKB1, CDK4, IRS2, ATM, CDK2, CASP9, TYK2, AKT2, RELA, CASP6, PIK3CG, GAB2, HIF1A, MAPK1, RASA1, PAK4, RB1, SHC1, CHEK1 CDK14, CDK20, CDKN2B, PRKAG1, WNT7B, RND2, WNT6, CDK8, RHOQ, RAPGEF3, MAP3K7, WNT3
14-3-3-mediated Signaling 7.94E-44 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, FGFR2, TUBA8, TUBB2A, FGFR3, TUBB4A TNFRSF1A, MAPK10, PRKCQ, YWHAE, SNCA, FRS2, PRKCH, PRKCE, PIK3R3, YWHAG, RAF1, PIK3C2B, PRKCD, PIK3R2, CDKN1B, TUBA1B, TP73, YWHAZ, JUN, GSK3B, TRAF2, YWHAQ, AKT1, IRS1, GAB1, PIK3R1, CBL, YWHAH, PIK3CA, PTPN11, TNF, GRB2, MAPT, MAPK8, PRKCI, PRKCZ, TSC1, YWHAB, FOXO1, MAPK3, IRS2, TUBB, ATM, AKT2, GFAP, PLCG2, PIK3CG, PRKCA, RPS6KA1, MAPK1, PLCG1, PRKD1, HRAS, PDCD6IP TUBA3E, PLCL1
PTEN Signaling 7.94E-43 FGFR1, FLT1, KDR, PDGFRA, FOXO3, FGFR2, NTRK2, FGFR3, PDGFRB, FLT4 CDC42, CSNK2A2, INPPL1, IKBKG, TNFRSF11A, RPS6KB1, EGFR, PIK3R3, RAF1, INSR, IKBKB, PTK2, NFKB2, IGF1R, FOXG1, BMPR2, TGFBR2, PIK3R2, CDKN1B, CCND1, BCAR1, CASP3, BCL2L1, ITGA5, IKBKE, GSK3B, AKT1, PIK3R1, CBL, YWHAH, INPP5D, PIK3CA, ITGB1, CDKN1A, GRB2, PRKCZ, FOXO1, MAPK3, RPS6KB2, NFKB1, FASLG, CHUK, CSNK2B, CASP9, SOS1, AKT2, IGF2R, RELA, PIK3CG, PDPK1, NGFR, MAPK1, HRAS, RAC1, CSNK2A1, SHC1 OCRL
PDGF Signaling 5.01E-42 FGFR1, SRC, PDGFRA, FGFR2, FGFR3, PDGFRB EIF2AK2, JAK3, CSNK2A2, SPHK1, INPPL1, STAT3, FRS2, CAV3, PIK3R3, JAK2, CRKL, RAF1, JAK1, PIK3C2B, PDGFC, ABL1, MYC, ACP1, PIK3R2, JUN, PDGFD, IRS1, PDGFB, GAB1, PIK3R1, INPP5D, PIK3CA, STAT1, PTPN11, SPHK2, GRB2, CRK, MAPK8, MAPK3, IRS2, CSNK2B, ATM, TYK2, SOS1, PLCG2, PIK3CG, CAV1, SRF, PRKCA, MAPK1, PLCG1, RASA1, PDGFA, HRAS, CSNK2A1, SHC1 OCRL
Pancreatic Adenocarcinoma Signaling 2.51E-41 FGFR1, CDKN2A, FGFR2, FGFR3 CDC42, MAPK10, JAK3, SMAD4, PLD1, E2F3, STAT3, FRS2, SMAD3, ERBB2, VEGFC, EGFR, PIK3R3, JAK2, VEGFA, SMAD2, RAF1, BIRC5, JAK1, PIK3C2B, PDGFC, NFKB2, ABL1, TGFBR2, PIK3R2, CDKN1B, CCND1, BCL2L1, AKT1, PGF, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, STAT1, PTPN11, E2F2, CDKN1A, GRB2, MAPK8, VEGFB, MAPK3, NFKB1, CDK4, IRS2, NOTCH1, ATM, CDK2, CASP9, TYK2, AKT2, RELA, PIK3CG, PLD2, MAPK1, MDM2, RB1, RAC1 CDKN2B
B Cell Receptor Signaling 1.58E-40 FGFR1, LYN, FGFR2, FGFR3 CAMK2B, CDC42, PRKCQ, CD22, INPPL1, NFKBIA, DAPP1, IKBKG, SYK, FRS2, CD79A, RPS6KB1, PAG1, PIK3R3, RAF1, IKBKB, PIK3C2B, PTK2, VAV1, FCGR2A, NFKB2, ABL1, BCL6, PIK3R2, PTK2B, BCL2L1, ETS1, IKBKE, JUN, GSK3B, AKT1, IRS1, GAB1, PIK3R1, INPP5D, CFL1, PIK3CA, PTPN11, GRB2, CD19, CREBBP, PTPN6, MAPK8, FOXO1, MAP3K3, MAPK3, RPS6KB2, NFKB1, IRS2, CHUK, ATM, CD79B, BTK, EP300, MAP3K14, EGR1, NFATC1, MEF2C, SOS1, AKT2, RELA, PLCG2, PIK3CG, NFATC3, PDPK1, FCGR2B, GAB2, CSK, MAPK1, PTPRC, HRAS, RAC1, SHC1 OCRL, CALML5, IGHD, MAP3K7
T Cell Receptor Signaling 3.98E-40 FGFR1, CTLA4, LCK, FGFR2, FGFR3 PRKCQ, NFKBIA, IKBKG, LCP2, CD8A, FRS2, CD4, LAT, ZAP70, CD3E, PAG1, PIK3R3, RAF1, IKBKB, PIK3C2B, VAV1, NFKB2, CD28, PIK3R2, BMX, IKBKE, JUN, IRS1, GAB1, PIK3R1, CBL, PTPRH, FYN, PIK3CA, PTPN11, ITK, GRB2, TEC, MAPK8, SHB, MAPK3, NFKB1, IRS2, CHUK, ATM, BTK, NFATC1, SOS1, TXK, RELA, PIK3CG, NFATC3, CSK, MAPK1, PLCG1, RASA1, PTPRC, HRAS, CD247, RAC1 CALML5
NF-_B Signaling 1.26E-39 FGFR1, LCK, FLT1, KDR, PDGFRA, FGFR2, NTRK2, FGFR3, PDGFRB, FLT4 EIF2AK2, TLR1, TNFRSF1A, PRKCQ, CSNK2A2, FCER1G, NFKBIA, TLR4, IKBKG, FRS2, TNFRSF11A, RIPK1, TLR2, HDAC1, ZAP70, TRAF6, EGFR, PIK3R3, IL1B, RAF1, INSR, IKBKB, PIK3C2B, TRAF3, NFKB2, IGF1R, BMPR2, TGFBR2, PIK3R2, GSK3B, TRAF2, TDP2, AKT1, IRS1, GAB1, PIK3R1, CD40, TBK1, PIK3CA, PTPN11, TNF, GRB2, CREBBP, MAPK8, PRKCZ, MAP3K3, IRAK1, NFKB1, HDAC2, IRS2, CHUK, CSNK2B, ATM, LTA, EP300, MAP3K14, UBE2N, BTRC, AKT2, IGF2R, RELA, PLCG2, PIK3CG, NGFR, ARAF, PRKACA, HRAS, CSNK2A1 MAP3K7
Tec Kinase Signaling 3.98E-39 FGFR1, LCK, SRC, LYN, FGFR2, FGFR3 GNA11, MAPK10, PRKCQ, JAK3, FGR, FCER1G, TLR4, GNAQ, WAS, STAT3, ACTG1, ACTB, FRS2, PRKCH, PRKCE, PIK3R3, JAK2, JAK1, PIK3C2B, PTK2, VAV1, NFKB2, PRKCD, PIK3R2, PTK2B, STAT6, GTF2I, BMX, FAS, STAT5B, YES1, ITGA5, GNA12, IRS1, GAB1, PIK3R1, MS4A2, GNAI2, FYN, PIK3CA, STAT1, PTPN11, TNF, ITGB1, STAT5A, ITK, GRB2, TEC, MAPK8, PRKCI, PRKCZ, PAK2, NFKB1, FASLG, IRS2, ATM, PAK1, BTK, TYK2, TXK, RELA, PLCG2, PIK3CG, PRKCA, PLCG1, PRKD1, PAK4 RHOQ, RND2
Chronic Myeloid Leukemia Signaling 1.00E-38 FGFR1, CDKN2A, FGFR2, FGFR3 SMAD4, E2F3, IKBKG, FRS2, SMAD3, RBL1, HDAC1, PIK3R3, CRKL, RAF1, IKBKB, PIK3C2B, HDAC3, NFKB2, ABL1, MYC, TGFBR2, PIK3R2, CDKN1B, CCND1, BCL2L1, STAT5B, IKBKE, AKT1, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, E2F2, STAT5A, CDKN1A, GRB2, CRK, CDK6, MAPK3, NFKB1, HDAC2, CDK4, IRS2, CHUK, ATM, SOS1, AKT2, RELA, PIK3CG, CBLC, HDAC6, GAB2, CTBP2, MAPK1, MDM2, RB1, HRAS
Glioma Signaling 1.58E-38 FGFR1, CDKN2A, PDGFRA, FGFR2, FGFR3, PDGFRB CAMK2B, PRKCQ, E2F3, FRS2, RBL1, PRKCH, PRKCE, EGFR, PIK3R3, CDKN2C, RAF1, PIK3C2B, PDGFC, IGF1R, ABL1, PRKCD, PIK3R2, CCND1, PDGFD, AKT1, E2F1, IRS1, PDGFB, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, E2F2, CDKN1A, GRB2, PRKCI, CDK6, PRKCZ, MAPK3, CDK4, IRS2, ATM, SOS1, AKT2, IGF2R, PLCG2, PIK3CG, PRKCA, MAPK1, PLCG1, PRKD1, MDM2, RB1, PDGFA, HRAS, SHC1 CAMK1D, CDKN2B, CALML5
IGF-1 Signaling 1.58E-37 FGFR1, FOXO3, FGFR2, FGFR3 GRB10, SOCS5, CSNK2A2, YWHAE, STAT3, FRS2, RPS6KB1, PIK3R3, YWHAG, JAK2, RAF1, JAK1, PIK3C2B, PTK2, IGF1R, PIK3R2, SOCS6, YWHAZ, JUN, YWHAQ, AKT1, IRS1, GAB1, PIK3R1, YWHAH, SOCS7, PIK3CA, PTPN11, GRB2, MAPK8, PRKCI, PRKCZ, YWHAB, FOXO1, MAPK3, RPS6KB2, IRS2, CSNK2B, ATM, PXN, CASP9, SOS1, AKT2, PIK3CG, NEDD4, PDPK1, SRF, MAPK1, SOCS1, RASA1, PRKACA, HRAS, CSNK2A1, SHC1 PRKAG1
Small Cell Lung Cancer Signaling 2.00E-37 FGFR1, FGFR2, FGFR3 BIRC2, NFKBIA, IKBKG, FRS2, RXRA, TRAF1, TRAF6, PIK3R3, IKBKB, PIK3C2B, PTK2, TRAF3, NFKB2, ABL1, MYC, PIK3R2, CDKN1B, CCND1, BCL2L1, CKS1B, IKBKE, TRAF2, FHIT, APAF1, AKT1, E2F1, IRS1, GAB1, PIK3R1, MAX, TP53, NOS1, PIK3CA, PTPN11, GRB2, CDK6, NFKB1, CDK4, IRS2, CHUK, ATM, CDK2, CASP9, RXRB, AKT2, RELA, PIK3CG, RB1, RARB CDKN2B
Axonal Guidance Signaling 2.51E-37 TUBB1, TUBA1A, TUBA4A, TUBA8, TUBB2A, NTRK2, FGFR3, FGFR1, TUBB3, TUBG1, TUBA1C, TUBB4B, FGFR2, TUBB4A GNA11, MMP2, EFNA5, GNAQ, WAS, FRS2, ADAM12, FES, NCK1, PRKCE, EFNB2, EFNB1, MME, PIK3C2B, WASL, PTK2, RTN4, PRKCD, NRP1, BCAR1, ITGA5, PDGFD, EPHA3, IRS1, GAB1, FYN, CFL1, ARHGEF7, PTPN11, ITGB1, GIT1, CRK, PRKCI, PRKCZ, VEGFB, KEL, PAK1, MYL12A, ROBO1, NTF3, NFATC1, EPHA4, SOS1, FARP2, PLCG2, PRKCA, PLCG1, PRKD1, PRKACA, PDGFA, HRAS, RAC1, SEMA4G, CDC42, PRKCQ, ERBB2, PRKCH, NTF4, BDNF, VEGFC, PIK3R3, CRKL, VEGFA, RAF1, ADAM15, CDK5, EPHB2, PDGFC, ABL1, PIK3R2, NCK2, TUBA1B, GSK3B, AKT1, NRP2, PGF, GNA12, MICAL1, PDGFB, PIK3R1, GNAI2, PIK3CA, GRB2, MET, MAPK3, PAK2, IRS2, TUBB, ATM, PXN, AKT2, PIK3CG, NFATC3, NGFR, MKNK1, MAPK1, RASA1, PAK4, SHC1 MYL6B, DPYSL2, PRKAG1, PLCL1, WNT7B, WNT6, PLXNA1, TUBA3E, WNT3
p53 Signaling 3.98E-37 FGFR1, CDKN2A, FGFR2, WT1, FGFR3 KAT2B, PML, CCNG1, THBS1, CSNK1D, FRS2, ATR, HDAC1, TP63, PIK3R3, CCND2, CTNNB1, BIRC5, PIK3C2B, ST13, RRM2B, CCNK, PIK3R2, CCND1, TP73, BCL2L1, FAS, JUN, GSK3B, APAF1, AKT1, E2F1, IRS1, GAB1, PIK3R1, PIAS1, TP53, PCNA, TOPBP1, PIK3CA, PTPN11, CDKN1A, GRB2, MAPK8, PRKDC, SIRT1, BRCA1, CDK4, IRS2, ATM, EP300, CDK2, AKT2, CASP6, PIK3CG, HIF1A, MDM2, RB1, CHEK1 GML
PI3K/AKT Signaling 1.58E-36 HSP90B1, FOXO3, HSP90AA1, HSP90AB1 JAK3, INPPL1, YWHAE, NFKBIA, IKBKG, PPP2R5A, NOS3, RPS6KB1, PIK3R3, YWHAG, JAK2, CTNNB1, RAF1, JAK1, IKBKB, NFKB2, PIK3R2, CDKN1B, CCND1, BCL2L1, YWHAZ, ITGA5, IKBKE, GSK3B, YWHAQ, AKT1, CDC37, GAB1, PIK3R1, TP53, YWHAH, INPP5D, PIK3CA, ITGB1, CDKN1A, GRB2, PRKCZ, TSC1, YWHAB, FOXO1, MAPK3, RPS6KB2, NFKB1, CHUK, TYK2, SOS1, AKT2, RELA, PIK3CG, PDPK1, GAB2, MAPK1, MDM2, HRAS, SHC1 OCRL, PPP2CB, MCL1, EIF4EBP1
VEGF Signaling 3.98E-36 FGFR1, FLT1, SRC, KDR, FOXO3, FGFR2, FGFR3, FLT4 VCL, YWHAE, ACTG1, ACTB, FRS2, ARNT, NOS3, ACTN4, VEGFC, PIK3R3, VEGFA, RAF1, PIK3C2B, ACTN1, PTK2, SH2D2A, PDGFC, EIF1AY, PIK3R2, PTK2B, BCL2L1, AKT1, PGF, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, GRB2, PTPN6, VEGFB, FOXO1, MAPK3, IRS2, ATM, PXN, SOS1, AKT2, PLCG2, PIK3CG, PRKCA, HIF1A, MAPK1, PLCG1, HRAS, SHC1 EIF2B1, EIF2B2
Role of Macrophages_ Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 6.31E-36 SRC, FGFR3, FGFR1, FGFR2 CAMK2B, TLR1, TNFRSF1A, GNAQ, FRS2, LRP1, TRAF1, TLR2, TRAF6, PRKCE, CTNNB1, PIK3C2B, TRAF3, PRKCD, HNF1A, JUN, PDGFD, IL6R, IRS1, GAB1, APC, FN1, PTPN11, CREBBP, PRKCI, PRKCZ, VEGFB, CHUK, LTA, EP300, MAP3K14, NFATC1, PLCG2, PRKCA, CEBPB, PLCG1, PRKD1, PDGFA, HRAS, RAC1, PRKCQ, NFKBIA, TLR4, IKBKG, STAT3, PRKCH, RIPK1, VEGFC, PIK3R3, JAK2, IL1B, VEGFA, RAF1, IKBKB, FGF2, NLK, PDGFC, MYC, PIK3R2, CCND1, IKBKE, GSK3B, TRAF2, AKT1, PGF, PDGFB, PIK3R1, PIK3CA, TNF, GRB2, MAPK3, IRAK1, NFKB1, IRS2, ATM, AKT2, RELA, PIK3CG, NFATC3, NOS2, NGFR, MAPK1, SOCS1 IL1RL1, IL6, PLCL1, WNT7B, IL7, WNT6, CALML5, MAP3K7, WNT3, APC2
Role of NFAT in Regulation of the Immune Response 7.94E-36 FGFR1, HLA-DQA1, LCK, LYN, FGFR2, FGFR3 GNA11, PRKCQ, FCER1G, NFKBIA, IKBKG, LCP2, CSNK1D, GNAQ, SYK, FRS2, CD80, CD4, ITPR1, LAT, CD79A, CD86, ZAP70, CD3E, PIK3R3, RAF1, IKBKB, PIK3C2B, FCGR2A, NFKB2, CD28, PIK3R2, HLA-B, IKBKE, JUN, GSK3B, AKT1, GNA12, IRS1, GAB1, PIK3R1, MS4A2, GNAI2, FYN, PIK3CA, PTPN11, ITK, GATA4, GRB2, MEF2D, MAPK3, NFKB1, IRS2, CHUK, ATM, CD79B, BTK, NFATC1, MEF2C, SOS1, AKT2, RELA, PLCG2, PIK3CG, NFATC3, FCGR2B, HLA-A, MAPK1, PLCG1, HRAS, CD247 HLA-DQB1, CALML5
CD28 Signaling in T Helper Cells 1.00E-35 FGFR1, HLA-DQA1, CTLA4, LCK, FGFR2, FGFR3 CDC42, MAPK10, PRKCQ, FCER1G, NFKBIA, IKBKG, LCP2, WAS, SYK, FRS2, CD80, CD4, ITPR1, LAT, CD86, ZAP70, CD3E, PIK3R3, IKBKB, PIK3C2B, VAV1, NFKB2, CD28, PIK3R2, HLA-B, IKBKE, JUN, AKT1, IRS1, GAB1, PIK3R1, FYN, PIK3CA, PTPN11, ITK, GRB2, PTPN6, MAPK8, NFKB1, IRS2, CHUK, ATM, PAK1, NFATC1, AKT2, RELA, PIK3CG, NFATC3, PDPK1, HLA-A, CSK, PLCG1, PTPRC, CD247, RAC1 HLA-DQB1, CALML5
Prolactin Signaling 1.58E-35 FGFR1, FGFR2, FGFR3, SP1 SOCS5, PRKCQ, STAT3, FRS2, PRKCH, PRKCE, PIK3R3, JAK2, RAF1, PIK3C2B, MYC, PRKCD, PIK3R2, NR3C1, SOCS6, STAT5B, NMI, JUN, IRS1, GAB1, PIK3R1, SOCS7, FYN, PIK3CA, STAT1, PTPN11, STAT5A, GRB2, CREBBP, PRKCI, PRKCZ, MAPK3, IRS2, ATM, EP300, SOS1, PLCG2, PIK3CG, PDPK1, PRKCA, CEBPB, MAPK1, PLCG1, SOCS1, PRKD1, HRAS, SHC1
Erythropoietin Signaling 5.01E-35 FGFR1, SRC, FGFR2, FGFR3 PRKCQ, NFKBIA, IKBKG, FRS2, PRKCH, RPS6KB1, PRKCE, PIK3R3, JAK2, RAF1, PIK3C2B, NFKB2, PRKCD, PIK3R2, STAT5B, JUN, AKT1, IRS1, GAB1, PIK3R1, CBL, PIK3CA, PTPN11, STAT5A, GRB2, PTPN6, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, ATM, SOS1, AKT2, EPOR, RELA, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, SOCS1, PRKD1, HRAS, SHC1
iCOS-iCOSL Signaling in T Helper Cells 7.94E-35 FGFR1, HLA-DQA1, LCK, FGFR2, FGFR3 CAMK2B, PRKCQ, FCER1G, NFKBIA, IL2RG, IKBKG, LCP2, FRS2, CD80, CD4, ITPR1, LAT, ZAP70, CD3E, PIK3R3, IKBKB, PIK3C2B, VAV1, NFKB2, CD28, PIK3R2, TRAT1, HLA-B, IKBKE, AKT1, IL2RB, IRS1, GAB1, PIK3R1, CD40, INPP5D, PIK3CA, PTPN11, ITK, GRB2, NFKB1, IRS2, CHUK, ATM, NFATC1, AKT2, RELA, PIK3CG, NFATC3, PDPK1, HLA-A, GAB2, CSK, PLCG1, PTPRC, CD247, RAC1, SHC1 HLA-DQB1, CALML5
Germ Cell-Sertoli Cell Junction Signaling 1.26E-34 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, FGFR2, TUBA8, TUBB2A, FGFR3, TUBB4A IQGAP1, CDC42, VCL, TNFRSF1A, MAPK10, ZYX, ACTG1, ACTB, FRS2, ACTN4, PIK3R3, CTNNB1, JUP, PIK3C2B, ACTN1, WASL, PTK2, RAB8B, TGFBR2, PIK3R2, SORBS1, BCAR1, TUBA1B, AKT1, TJP1, IRS1, GAB1, PIK3R1, CTNND1, CFL1, PIK3CA, PTPN11, TNF, ITGB1, GRB2, CDH1, MAPK8, MAP3K3, MAPK3, PAK2, IRS2, TUBB, ATM, PAK1, MAP3K14, PXN, PIK3CG, PDPK1, MAPK1, PAK4, HRAS, RAC1 GSN, RHOQ, TUBA3E, MAP3K7, RND2
IL-8 Signaling 1.26E-34 FGFR1, FLT1, SRC, KDR, FGFR2, FGFR3, FLT4 IQGAP1, ITGAV, MMP2, MAPK10, PRKCQ, PLD1, IKBKG, FRS2, PRKCH, VEGFC, RPS6KB1, TRAF6, PRKCE, EGFR, PIK3R3, CCND2, VEGFA, RAF1, IKBKB, PIK3C2B, PTK2, PDGFC, PRKCD, PIK3R2, PTK2B, CCND1, CXCR1, BCL2L1, IKBKE, JUN, AKT1, PGF, GNA12, IRS1, GAB1, LASP1, PIK3R1, GNAI2, PIK3CA, PTPN11, GRB2, ITGB3, CDH1, MAPK8, PRKCI, PRKCZ, VEGFB, MAPK3, IRAK1, PAK2, NFKB1, IRS2, CHUK, ATM, AKT2, RELA, PIK3CG, PRKCA, PLD2, MAPK1, PRKD1, ARAF, HRAS, RAC1 ITGAM, RHOQ, EIF4EBP1, RND2
HGF Signaling 1.00E-33 FGFR1, CDKN2A, FGFR2, FGFR3 CDC42, MAPK10, PRKCQ, ELF1, STAT3, FRS2, PRKCH, PRKCE, PIK3R3, CRKL, RAF1, PIK3C2B, PTK2, PRKCD, PIK3R2, CCND1, ETS1, ITGA5, JUN, AKT1, IRS1, GAB1, PIK3R1, ETS2, PIK3CA, PTPN11, ITGB1, CDKN1A, GRB2, MET, MAPK8, PRKCI, RAPGEF1, PRKCZ, MAP3K3, MAPK3, IRS2, ATM, PAK1, MAP3K14, CDK2, PXN, SOS1, AKT2, PLCG2, PIK3CG, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, RAC1 IL6, MAP3K7
Huntington's Disease Signaling 1.26E-33 FGFR1, FGFR2, FGFR3, SP1 NCOR2, GNA11, PRKCQ, DNM1, GNAQ, SNCA, FRS2, ITPR1, PRKCH, BDNF, HDAC1, PRKCE, EGFR, PIK3R3, CLTC, POLR2E, PIK3C2B, CDK5, PSME1, HDAC3, IGF1R, PRKCD, CDK5R1, SGK1, DNM2, PIK3R2, UBB, CASP3, BCL2L1, JUN, TBP, APAF1, AKT1, IRS1, GAB1, PIK3R1, TP53, DNM1L, TAF4, HTT, PIK3CA, PTPN11, HSPA8, GRB2, CREBBP, NCOR1, MAPK8, PRKCI, PRKCZ, UBC, CASP7, MAPK3, HDAC2, IRS2, ATM, EP300, CASP9, SOS1, AKT2, CASP6, PIK3CG, GRIN2B, HSPA9, HSPA4, PDPK1, ARFIP2, HDAC6, DLG4, PRKCA, NAPG, MAPK1, PRKD1, RASA1, POLR2G, HRAS, SHC1 GPAA1, PENK, DCTN1, CAPN2
p70S6K Signaling 1.26E-33 FGFR1, SRC, IL4R, LYN, FGFR2, FGFR3 PRKCQ, PLD1, YWHAE, EEF2, IL2RG, GNAQ, SYK, PPP2R5A, FRS2, PRKCH, CD79A, RPS6KB1, PRKCE, EGFR, PIK3R3, YWHAG, RAF1, JAK1, PIK3C2B, PRKCD, PIK3R2, YWHAZ, YWHAQ, AKT1, IRS1, GAB1, PIK3R1, YWHAH, GNAI2, PIK3CA, PTPN11, GRB2, CD19, MAPT, PRKCI, PRKCZ, YWHAB, MAPK3, IRS2, ATM, CD79B, BTK, IL4, SOS1, AKT2, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, SHC1 PPP2CB, PLCL1
IL-3 Signaling 5.01E-33 FGFR1, FGFR2, FGFR3 PRKCQ, STAT3, FRS2, PRKCH, PRKCE, PIK3R3, JAK2, CRKL, RAF1, JAK1, PIK3C2B, PRKCD, PIK3R2, STAT6, STAT5B, JUN, AKT1, IRS1, GAB1, PIK3R1, INPP5D, PIK3CA, STAT1, PTPN11, STAT5A, GRB2, PTPN6, PRKCI, RAPGEF1, PRKCZ, FOXO1, MAPK3, IRS2, CSF2RB, ATM, PAK1, SOS1, AKT2, PIK3CG, GAB2, PRKCA, MAPK1, PRKD1, HRAS, RAC1, SHC1
JAK/Stat Signaling 5.01E-33 FGFR1, FGFR2, FGFR3 SOCS5, JAK3, GNAQ, STAT3, FRS2, PIK3R3, JAK2, RAF1, JAK1, PIK3C2B, PTPN1, NFKB2, PIK3R2, STAT6, BCL2L1, SOCS6, STAT5B, JUN, AKT1, IRS1, GAB1, PIK3R1, PIAS1, SOCS7, PIK3CA, STAT1, PTPN11, STAT5A, CDKN1A, GRB2, PTPN6, MAPK3, NFKB1, IRS2, ATM, TYK2, SOS1, AKT2, RELA, PIK3CG, CEBPB, MAPK1, SOCS1, HRAS, SHC1 IL6
NF-_B Activation by Viruses 6.31E-33 FGFR1, LCK, FGFR2, FGFR3 EIF2AK2, ITGAV, PRKCQ, NFKBIA, IKBKG, FRS2, CD4, PRKCH, RIPK1, PRKCE, PIK3R3, RAF1, IKBKB, PIK3C2B, NFKB2, PRKCD, PIK3R2, ITGA5, IKBKE, TRAF2, TBP, AKT1, IRS1, GAB1, PIK3R1, CCR5, PIK3CA, PTPN11, ITGB1, GRB2, ITGB3, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, CHUK, ATM, MAP3K14, AKT2, RELA, PIK3CG, PRKCA, MAPK1, PRKD1, HRAS
Natural Killer Cell Signaling 6.31E-32 FGFR1, LCK, FGFR2, FGFR3 PRKCQ, INPPL1, FCER1G, LCP2, SYK, FRS2, PRKCH, LAT, NCK1, ZAP70, PRKCE, PIK3R3, RAF1, PIK3C2B, VAV1, FCGR2A, PRKCD, PIK3R2, AKT1, IRS1, GAB1, PIK3R1, FYN, INPP5D, PIK3CA, PTPN11, SH3BP2, GRB2, PTPN6, PRKCI, PRKCZ, MAPK3, PAK2, IRS2, ATM, PAK1, SOS1, AKT2, PLCG2, PIK3CG, PRKCA, MAPK1, PLCG1, PRKD1, PAK4, SH2D1A, HRAS, CD247, RAC1, SHC1 OCRL, CD244
Clathrin-mediated Endocytosis Signaling 1.26E-31 FGFR1, SRC, FGFR2, FGFR3 CDC42, CD2AP, FGF4, CSNK2A2, DNM1, ACTG1, ACTB, FRS2, VEGFC, PIK3R3, VEGFA, CLTC, FGF10, PIK3C2B, FGF2, WASL, EPHB2, PDGFC, APOB, DNM2, PIK3R2, UBB, ITGA5, ITGB4, FGF5, FGF6, FGF1, TF, PDGFD, PGF, IRS1, PDGFB, HGS, FGF18, GAB1, FGF23, PIK3R1, CBL, AP1B1, DNM1L, PIK3CA, PTPN11, HSPA8, ITGB1, GRB2, MET, ITGB3, VEGFB, UBC, SH3GL2, S100A8, IRS2, CTTN, CSNK2B, ATM, FGF7, FGF3, PIK3CG, FGF17, MDM2, FGF8, AP2M1, DAB2, PDGFA, RAC1, CSNK2A1, FGF9 AMPH, ALB
RAR Activation 2.00E-31 SRC NCOR2, KAT2B, PML, ADCY6, MAPK10, PRKCQ, CSNK2A2, SMARCA4, SMAD4, SMARCB1, ACTB, SMAD3, RXRA, PRKCH, REL, PRKCE, PIK3R3, JAK2, VEGFA, SMAD2, HLTF, SMARCE1, SMARCC2, NFKB2, PRKCD, PIK3R2, SMAD1, PSMC5, RARG, STAT5B, ARID1A, JUN, AKT1, RARA, ZBTB16, PIK3R1, SMARCC1, TAF4, SMAD7, PIK3CA, SNW1, STAT5A, CREBBP, NCOR1, MAPK8, PRKCI, PRKCZ, CARM1, NFKB1, CDK7, CSNK2B, CSF2RB, EP300, RXRB, AKT2, NR2F2, RELA, PIK3CG, PARP1, PDPK1, PRKCA, CSK, NR2F1, MAPK1, PRKD1, PRKACA, RAC1, CSNK2A1, RARB PRMT1, PRKAG1
HER-2 Signaling in Breast Cancer 2.51E-31 FGFR1, FGFR2, FGFR3 CDC42, MMP2, PRKCQ, FRS2, ERBB2, PRKCH, PRKCE, EGFR, PIK3R3, PIK3C2B, PRKCD, PIK3R2, CDKN1B, CCND1, ERBB3, ITGB4, GSK3B, AKT1, IRS1, GAB1, PIK3R1, TP53, AREG, PIK3CA, PTPN11, ITGB1, CDKN1A, GRB2, ITGB3, PRKCI, CDK6, PRKCZ, TSC1, FOXO1, IRS2, ATM, CASP9, SOS1, AKT2, PIK3CG, PRKCA, PLCG1, PRKD1, MDM2, HRAS NRG1
Neuregulin Signaling 2.51E-31 SRC, HSP90B1, HSP90AA1, HSP90AB1 PRKCQ, ERBB2, PRKCH, RPS6KB1, PRKCE, EGFR, PIK3R3, CRKL, RAF1, CDK5, GRB7, MYC, PRKCD, CDK5R1, PIK3R2, CDKN1B, ERBB3, STAT5B, ITGA5, AKT1, PIK3R1, AREG, PTPN11, ITGB1, STAT5A, GRB2, CRK, PRKCI, PRKCZ, MAPK3, RPS6KB2, MATK, SOS1, AKT2, PLCG2, PDPK1, DLG4, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, SHC1 NRG1
Renin-Angiotensin Signaling 6.31E-31 FGFR1, FGFR2, FGFR3 ADCY6, MAPK10, PRKCQ, GNAQ, STAT3, FRS2, ITPR1, PRKCH, PRKCE, PIK3R3, JAK2, RAF1, PIK3C2B, PTK2, NFKB2, PRKCD, PIK3R2, PTK2B, JUN, SHC2, IRS1, GAB1, PIK3R1, SHF, PIK3CA, STAT1, PTPN11, TNF, GRB2, PTPN6, MAPK8, PRKCI, PRKCZ, MAPK3, PAK2, NFKB1, IRS2, ATM, PAK1, SOS1, SHC3, RELA, PLCG2, PIK3CG, PRKCA, MAPK1, PLCG1, PRKD1, PAK4, PRKACA, HRAS, RAC1, SHC1 PRKAG1
PAK Signaling 6.31E-31 FGFR1, PDGFRA, FGFR2, FGFR3, PDGFRB CDC42, MAPK10, FRS2, NCK1, PIK3R3, RAF1, PIK3C2B, WASL, PTK2, PDGFC, PIK3R2, PTK2B, NCK2, MYLK, CASP3, ITGA5, PDGFD, EPHA3, IRS1, PDGFB, GAB1, PIK3R1, CFL1, ARHGEF7, PIK3CA, PTPN11, TNF, ITGB1, GRB2, GIT1, MAPK8, MAPK3, PAK2, IRS2, ATM, PAK1, MYL12A, PXN, SOS1, PIK3CG, MAPK1, PAK4, PDGFA, HRAS, RAC1, SHC1 MYL6B
ErbB Signaling 1.00E-30 FGFR1, FGFR2, FGFR3 CDC42, MAPK10, PRKCQ, FRS2, ERBB2, PRKCH, NCK1, RPS6KB1, PRKCE, EGFR, PIK3R3, RAF1, PIK3C2B, PRKCD, PIK3R2, NCK2, ERBB3, JUN, GSK3B, AKT1, IRS1, GAB1, PIK3R1, AREG, PIK3CA, PTPN11, GRB2, MAPK8, PRKCI, PRKCZ, FOXO1, MAPK3, PAK2, IRS2, ATM, PAK1, SOS1, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, PRKD1, PAK4, HRAS, SHC1 NRG1
Insulin Receptor Signaling 1.26E-30 FGFR1, FOXO3, FGFR2, FGFR3 GRB10, INPPL1, FRS2, PTPRF, SH2B2, NCK1, RPS6KB1, PIK3R3, JAK2, CRKL, RAF1, INSR, JAK1, PIK3C2B, PTPN1, SGK1, PIK3R2, GSK3B, PPP1CC, AKT1, IRS1, GAB1, PIK3R1, CBL, FYN, INPP5D, PIK3CA, PTPN11, GRB2, CRK, MAPK8, PRKCI, RAPGEF1, PRKCZ, TSC1, FOXO1, MAPK3, RPS6KB2, IRS2, ATM, TRIP10, SOS1, AKT2, PIK3CG, PDPK1, SLC2A4, ACLY, MAPK1, PRKACA, HRAS, SHC1 OCRL, PRKAG1, RHOQ, EIF2B1, EIF2B2, EIF4EBP1
IL-15 Signaling 1.58E-30 FGFR2, FGFR1, LCK, FGFR3 AKT1, JAK3, IL2RB, IRS1, GAB1, PIK3R1, IL2RG, STAT3, SYK, PIK3CA, PTPN11, TNF, FRS2, STAT5A, GRB2, MAPK3, NFKB1, FASLG, PIK3R3, IRS2, JAK2, ATM, RAF1, IL4, JAK1, PIK3C2B, TYK2, PTK2, AKT2, RELA, PIK3CG, NFKB2, PIK3R2, STAT6, MAPK1, PLCG1, BCL2L1, STAT5B, HRAS, SHC1 IL6
Actin Cytoskeleton Signaling 1.58E-30 FGFR1, FGFR2, FGFR3 IQGAP1, CDC42, VCL, FGF4, WAS, ACTG1, ACTB, FRS2, ACTN4, PIK3R3, TLN1, FLNA, CRKL, RAF1, EZR, FGF10, TIAM1, PIK3C2B, ACTN1, FGF2, WASL, PTK2, VAV1, PDGFC, PIK3R2, MYLK, BCAR1, ITGA5, FGF5, FGF6, FGF1, PDGFD, GNA12, IRS1, PDGFB, FGF18, GAB1, FGF23, PIK3R1, APC, FN1, CFL1, ARHGEF7, PIK3CA, PTPN11, ITGB1, GRB2, GIT1, CRK, MAPK3, PAK2, IRS2, ATM, PAK1, MYL12A, ARHGAP35, PXN, FGF7, FGF3, MATK, SOS1, PIK3CG, FGF17, CSK, MAPK1, FGF8, PAK4, PDGFA, HRAS, RAC1, SHC1, FGF9 MYL6B, GSN, APC2
eNOS Signaling 3.16E-30 FGFR1, FLT1, KDR, HSP90B1, FGFR2, HSP90AA1, FGFR3, FLT4, HSP90AB1 ADCY6, GUCY1B3, PRKCQ, GNAQ, FRS2, ITPR1, STUB1, ESR2, NOS3, PRKCH, VEGFC, ESR1, PRKCE, CCNA1, PIK3R3, VEGFA, CHRNA7, PIK3C2B, PDGFC, PRKCD, DNM2, PIK3R2, CASP3, AKT1, PGF, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, HSPA8, GRB2, PRKCI, PRKCZ, VEGFB, IRS2, LPAR2, ATM, CASP9, AKT2, PLCG2, PIK3CG, HSPA9, HSPA4, CAV1, PDPK1, PRKCA, PLCG1, PRKD1, CCNA2, PRKACA PRKAG1, CALML5, AQP5, CHRM3
Glioblastoma Multiforme Signaling 3.16E-30 FGFR1, CDKN2A, SRC, PDGFRA, FGFR2, FGFR3, PDGFRB CDC42, E2F3, FRS2, ITPR1, RPS6KB1, EGFR, PIK3R3, CTNNB1, RAF1, PIK3C2B, PDGFC, IGF1R, MYC, PRKCD, PIK3R2, CDKN1B, CCND1, GSK3B, PDGFD, AKT1, E2F1, IRS1, PDGFB, GAB1, PIK3R1, TP53, APC, PIK3CA, PTPN11, E2F2, CDKN1A, GRB2, CDK6, TSC1, FOXO1, MAPK3, CDK4, IRS2, ATM, CDK2, SOS1, AKT2, PLCG2, PIK3CG, MAPK1, PLCG1, MDM2, RB1, PDGFA, HRAS, RAC1, SHC1 WNT6, RHOQ, PLCL1, WNT3, WNT7B, RND2
Neuroinflammation Signaling Pathway 3.98E-30 FGFR1, HLA-DQA1, FGFR2, FGFR3 BIRC2, GJB1, TLR1, TNFRSF1A, MAPK10, JAK3, SLC6A13, TLR4, IKBKG, SNCA, SYK, FRS2, CD80, RIPK1, BDNF, BACE1, TLR2, CD86, TRAF6, PIK3R3, JAK2, IL1B, CTNNB1, CALB2, IRF3, BIRC5, JAK1, IKBKB, PIK3C2B, APP, IL34, TRAF3, MAPK6, NFKB2, BMPR2, TGFBR2, GRIN2A, PIK3R2, CASP3, HLA-B, FAS, IKBKE, JUN, GSK3B, AKT1, IL6R, IRS1, GAB1, PIK3R1, CD40, CSF1R, TBK1, MAPK15, PIK3CA, STAT1, PTPN11, TNF, GRB2, CREBBP, MAPT, MAPK8, MAPK3, IRAK1, NFKB1, FASLG, IRS2, CHUK, ATM, EP300, IL4, NFATC1, TYK2, AKT2, RELA, PLCG2, PIK3CG, GRIN2B, NFATC3, NOS2, HLA-A, MAPK1, PLCG1 HMGB1, HLA-DQB1, ACVR1B, IL6, GRIN1, GRIA1
Lymphotoxin _ Receptor Signaling 5.01E-30 FGFR2, FGFR1, FGFR3 BIRC2, TRAF2, APAF1, AKT1, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, PIK3CA, PTPN11, FRS2, GRB2, CREBBP, TRAF1, MAPK3, TRAF6, NFKB1, PIK3R3, IRS2, CHUK, ATM, LTA, EP300, MAP3K14, CASP9, IKBKB, PIK3C2B, TRAF3, AKT2, RELA, PIK3CG, NFKB2, PDPK1, PIK3R2, MAPK1, CASP3, BCL2L1, IKBKE
Colorectal Cancer Metastasis Signaling 6.31E-30 FGFR1, SRC, FGFR2, FGFR3 MMP2, TLR1, ADCY6, TNFRSF1A, MAPK10, JAK3, SMAD4, TLR4, STAT3, FRS2, SMAD3, LRP1, VEGFC, TLR2, EGFR, PIK3R3, JAK2, CTNNB1, VEGFA, SMAD2, BIRC5, JAK1, PIK3C2B, PDGFC, NFKB2, MYC, TGFBR2, PIK3R2, CCND1, HNF1A, CASP3, BCL2L1, JUN, GSK3B, AKT1, PGF, IL6R, IRS1, GAB1, PIK3R1, TP53, APC, PIK3CA, STAT1, PTPN11, TNF, GRB2, CDH1, MAPK8, VEGFB, MAPK3, NFKB1, IRS2, ATM, CASP9, TYK2, SOS1, AKT2, SIAH1, RELA, PIK3CG, NOS2, MAPK1, PRKACA, HRAS, RAC1 WNT6, PRKAG1, RHOQ, IL6, WNT3, WNT7B, MMP17, RND2
ERK/MAPK Signaling 7.94E-30 FGFR1, SRC, FGFR2, FGFR3 MYCN, ELF1, STAT3, PPP2R5A, FRS2, ESR1, PRKCE, PIK3R3, YWHAG, TLN1, CRKL, RAF1, PIK3C2B, PTK2, MYC, PRKCD, PIK3R2, PTK2B, BCAR1, ETS1, YWHAZ, ITGA5, PPP1CC, YWHAQ, IRS1, GAB1, PIK3R1, YWHAH, ETS2, FYN, PIK3CA, STAT1, PTPN11, ITGB1, GRB2, CREBBP, CRK, PRKCI, RAPGEF1, YWHAB, MAPK3, PAK2, IRS2, RAPGEF4, ATM, PAK1, EP300, PXN, NFATC1, SOS1, PLCG2, PIK3CG, SRF, PRKCA, MKNK1, RPS6KA1, MAPK1, PLCG1, ARAF, PAK4, PRKACA, HRAS, RAC1, SHC1 PPP2CB, PRKAG1, RAPGEF3, EIF4EBP1
Prostate Cancer Signaling 7.94E-30 FGFR1, HSP90B1, FGFR2, HSP90AA1, FGFR3, HSP90AB1 NKX3-1, NFKBIA, IKBKG, FRS2, PIK3R3, CTNNB1, RAF1, PIK3C2B, NFKB2, AR, ABL1, PIK3R2, CDKN1B, CCND1, GSK3B, AKT1, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, CDKN1A, GRB2, CREBBP, FOXO1, MAPK3, NFKB1, IRS2, CHUK, ATM, EP300, CDK2, CASP9, SOS1, AKT2, RELA, PIK3CG, PDPK1, MAPK1, MDM2, RB1, HRAS
Acute Myeloid Leukemia Signaling 7.94E-30 FGFR1, FGFR2, FLT3, FGFR3 PML, CSF3R, STAT3, FRS2, RPS6KB1, CCNA1, PIK3R3, RAF1, JUP, KIT, PIK3C2B, NFKB2, MYC, PIK3R2, CCND1, HNF1A, STAT5B, FLT3LG, AKT1, RARA, CSF2RA, IRS1, GAB1, PIK3R1, CSF1R, PIK3CA, PTPN11, STAT5A, GRB2, MAPK3, RPS6KB2, NFKB1, IRS2, CSF2RB, ATM, PIM2, SOS1, AKT2, RELA, PIK3CG, PIM1, MAPK1, ARAF, HRAS EIF4EBP1
Gap Junction Signaling 1.00E-29 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, FGFR2, TUBA8, TUBB2A, FGFR3, SP1, TUBB4A GJB1, ADCY6, GUCY1B3, PRKCQ, CSNK1D, GNAQ, ACTG1, ACTB, FRS2, ITPR1, PRKCH, PRKCE, EGFR, PIK3R3, CTNNB1, RAF1, PIK3C2B, PRKCD, PIK3R2, TUBA1B, GJA1, AKT1, TJP1, IRS1, GAB1, PIK3R1, GRIA3, GNAI2, PIK3CA, PTPN11, GRB2, PRKCI, PRKCZ, MAPK3, IRS2, TUBB, ATM, SOS1, AKT2, PLCG2, PIK3CG, CAV1, PRKCA, SP3, MAPK1, PLCG1, PRKD1, GUCY2C, PRKACA, HRAS GJB3, PRKAG1, TUBA3E, PLCL1, GRIA1
Type II Diabetes Mellitus Signaling 1.58E-29 FGFR1, FGFR2, FGFR3 SOCS5, TNFRSF1A, MAPK10, PRKCQ, PKM, NFKBIA, IKBKG, FRS2, PRKCH, SH2B2, PRKCE, PIK3R3, INSR, IKBKB, PIK3C2B, NFKB2, CD36, PRKCD, PIK3R2, SOCS6, IKBKE, TRAF2, AKT1, IRS1, GAB1, PIK3R1, SOCS7, PIK3CA, PTPN11, TNF, GRB2, MAPK8, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, CHUK, ATM, MAP3K14, AKT2, RELA, PIK3CG, PDPK1, PRKCA, NGFR, SLC2A4, CEBPB, MAPK1, SOCS1, PRKD1 PRKAG1, MAP3K7, ENPP7
PKC_ Signaling in T Lymphocytes 2.00E-29 FGFR1, HLA-DQA1, LCK, FGFR2, FGFR3 POU2F1, CAMK2B, PRKCQ, FCER1G, NFKBIA, IKBKG, LCP2, FRS2, CD80, CD4, LAT, CD86, ZAP70, CD3E, PIK3R3, IKBKB, PIK3C2B, VAV1, NFKB2, CD28, PIK3R2, HLA-B, IKBKE, JUN, IRS1, GAB1, PIK3R1, FYN, PIK3CA, PTPN11, GRB2, MAPK8, MAP3K3, MAPK3, NFKB1, IRS2, CHUK, ATM, MAP3K14, NFATC1, SOS1, RELA, PLCG2, PIK3CG, NFATC3, HLA-A, MAPK1, PLCG1, HRAS, CD247, RAC1 HLA-DQB1, MAP3K7
FGF Signaling 2.51E-29 FGFR2, FGFR1, FGFR3 FGF5, FGF6, FGF1, AKT1, FGF4, IRS1, FGF18, GAB1, FGF23, PIK3R1, STAT3, PIK3CA, PTPN11, FRS2, GRB2, MET, CREBBP, ITPR1, PTPN6, CRK, MAPK8, MAPK3, PIK3R3, IRS2, CRKL, ATM, RAF1, EP300, FGF10, FGF7, PIK3C2B, FGF2, FGF3, SOS1, AKT2, PIK3CG, FGF17, PRKCA, PIK3R2, MAPK1, PLCG1, FGF8, HRAS, RAC1, FGF9
IL-7 Signaling Pathway 2.51E-29 FGFR2, FGFR1, FGFR3, FOXO3, LYN JUN, GSK3B, AKT1, JAK3, IRS1, GAB1, PIK3R1, IL2RG, FYN, PIK3CA, STAT1, PTPN11, FRS2, IL7R, STAT5A, GRB2, MET, FOXO1, MAPK3, PIK3R3, IRS2, ATM, CDK2, JAK1, PIK3C2B, NFATC1, PTK2, SOS1, AKT2, PIK3CG, FOXG1, BCL6, MYC, PDPK1, PIK3R2, CDKN1B, CCND1, MAPK1, SOCS1, STAT5B, SHC1 MCL1, IL7
Nitric Oxide Signaling in the Cardiovascular System 6.31E-29 FGFR1, FLT1, KDR, HSP90B1, FGFR2, HSP90AA1, FGFR3, FLT4, HSP90AB1 GUCY1B3, PRKCQ, FRS2, ITPR1, NOS3, PRKCH, VEGFC, PRKCE, PIK3R3, VEGFA, PIK3C2B, PDGFC, PRKCD, PIK3R2, AKT1, PGF, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, GRB2, PRKCI, PRKCZ, VEGFB, CACNA1D, MAPK3, IRS2, ADRB3, ATM, AKT2, PIK3CG, CAV1, PRKCA, MAPK1, PRKD1, GUCY2C, PRKACA PRKAG1, CALML5, CACNA1S, PLN
Non-Small Cell Lung Cancer Signaling 6.31E-29 FGFR2, FGFR1, CDKN2A, FGFR3, FOXO3 FHIT, AKT1, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, ERBB2, GRB2, RXRA, ITPR1, CDK6, MAPK3, EGFR, PIK3R3, CDK4, IRS2, ATM, RAF1, CASP9, RXRB, PIK3C2B, SOS1, AKT2, PIK3CG, ABL1, PDPK1, PRKCA, PIK3R2, RASSF1, CCND1, MAPK1, PLCG1, RB1, HRAS, RARB
Ephrin Receptor Signaling 7.94E-29 SRC SH2D3C, CDC42, GNA11, EFNA5, GNAQ, WAS, STAT3, NCK1, VEGFC, DOK1, EFNB2, EFNB1, JAK2, CRKL, VEGFA, RAF1, WASL, EPHB2, PTK2, PDGFC, ABL1, ACP1, GRIN2A, SORBS1, NCK2, BCAR1, ITGA5, FGF1, PDGFD, AKT1, PGF, EPHA3, GNA12, PDGFB, GNAI2, FYN, CFL1, PTPN11, ITGB1, GRB2, CREBBP, CRK, RAPGEF1, VEGFB, MAPK3, PAK2, PAK1, EP300, MAP3K14, PXN, EPHA4, SOS1, AKT2, PIK3CG, GRIN2B, MAPK1, RASA1, PAK4, PDGFA, HRAS, RAC1, SHC1 GRIN1
Growth Hormone Signaling 7.94E-29 FGFR2, FGFR1, FGFR3 SOCS5, PRKCQ, IRS1, GAB1, PIK3R1, SOCS7, STAT3, PIK3CA, STAT1, PTPN11, FRS2, STAT5A, GRB2, PTPN6, PRKCH, PRKCI, PRKCZ, RPS6KB1, MAPK3, PRKCE, RPS6KB2, PIK3R3, IRS2, JAK2, RPS6KA3, ATM, PIK3C2B, PLCG2, PIK3CG, IGF1R, PRKCD, PDPK1, SRF, PRKCA, SLC2A4, PIK3R2, RPS6KA1, MAPK1, PLCG1, SOCS1, PRKD1, SOCS6, STAT5B
Fc_ Receptor-mediated Phagocytosis in Macrophages and Monocytes 1.00E-28 SRC, LYN CDC42, AKT1, PRKCQ, FGR, PIK3R1, PLD1, CBL, LCP2, WAS, SYK, FYN, INPP5D, ACTG1, ACTB, CRK, PRKCH, PRKCI, PRKCZ, NCK1, RPS6KB1, MAPK3, PRKCE, RPS6KB2, PIK3R3, TLN1, PAK1, EZR, PXN, FYB, VAV1, AKT2, FCGR2A, PIK3CG, PRKCD, GAB2, PRKCA, PIK3R2, PTK2B, NCK2, PLD2, MAPK1, PLCG1, PRKD1, YES1, RAC1
ILK Signaling 1.26E-28 FGFR1, FGFR2, FGFR3 CDC42, VCL, TNFRSF1A, MAPK10, MUC1, PPP2R5A, ACTG1, ACTB, FRS2, ACTN4, SH2B2, VEGFC, PIK3R3, CTNNB1, FLNA, VEGFA, PIK3C2B, ACTN1, PTK2, PDGFC, NFKB2, MYC, PIK3R2, CCND1, NCK2, CASP3, ITGB4, JUN, GSK3B, AKT1, DSP, PGF, IRS1, GAB1, PIK3R1, FN1, CFL1, PIK3CA, PTPN11, TNF, ITGB1, GRB2, CREBBP, ITGB3, CDH1, MAPK8, VEGFB, MAPK3, NFKB1, IRS2, ATM, EP300, PXN, AKT2, RELA, PIK3CG, KRT18, PDPK1, NOS2, HIF1A, MAPK1 PPP2CB, MYL6B, RHOQ, FBLIM1, RND2
Angiopoietin Signaling 1.26E-28 FGFR2, FGFR1, FGFR3 AKT1, DOK2, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, PIK3CA, PTPN11, FRS2, STAT5A, GRB2, NOS3, CRK, NCK1, FOXO1, PAK2, NFKB1, PIK3R3, IRS2, CHUK, ATM, PAK1, BIRC5, CASP9, IKBKB, PIK3C2B, PTK2, SOS1, AKT2, GRB7, RELA, PIK3CG, NFKB2, PIK3R2, RASA1, PAK4, STAT5B, HRAS, IKBKE, GRB14
Role of Tissue Factor in Cancer 1.26E-28 FGFR1, LCK, SRC, LYN, FGFR2, FGFR3 CDC42, GNA11, ITGAV, FGR, GNAQ, FRS2, VEGFC, RPS6KB1, EGFR, PIK3R3, JAK2, IL1B, VEGFA, PIK3C2B, PIK3R2, PTK2B, CASP3, BCL2L1, STAT5B, YES1, FGF5, AKT1, GNA12, IRS1, GAB1, PIK3R1, TP53, FYN, CFL1, PIK3CA, PTPN11, ITGB1, STAT5A, GRB2, ITGB3, MAPK3, IRS2, RPS6KA3, ATM, PAK1, EGR1, AKT2, PIK3CG, PRKCA, RPS6KA1, MAPK1, HRAS, RAC1 PLAUR
Integrin Signaling 1.58E-28 FGFR1, SRC, FGFR2, FGFR3 CDC42, ITGAV, VCL, NEDD9, ZYX, WAS, ACTG1, ACTB, FRS2, ACTN4, NCK1, PIK3R3, TLN1, CRKL, RAF1, PIK3C2B, ACTN1, WASL, PTK2, GRB7, ABL1, PIK3R2, NCK2, MYLK, BCAR1, ITGA5, TNK2, ITGB4, GSK3B, ASAP1, AKT1, IRS1, PDGFB, GAB1, PIK3R1, FYN, ARHGEF7, PIK3CA, PTPN11, ITGB1, GRB2, GIT1, ITGB3, CRK, MAPK8, RAPGEF1, MAPK3, PAK2, IRS2, CTTN, ATM, PAK1, MYL12A, PXN, SOS1, AKT2, PLCG2, PIK3CG, CAV1, MAPK1, PLCG1, PAK4, HRAS, RAC1, SHC1 GSN, ITGAM, RHOQ, CAPN2, RND2
IL-6 Signaling 1.58E-28 FGFR1, FGFR2, FGFR3 TNFRSF1A, MAPK10, CSNK2A2, NFKBIA, IKBKG, STAT3, FRS2, TRAF6, PIK3R3, JAK2, IL1B, VEGFA, RAF1, IKBKB, PIK3C2B, NFKB2, PIK3R2, IKBKE, JUN, TRAF2, AKT1, IL6R, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, TNF, GRB2, MAPK8, MAPK3, NFKB1, IRS2, CHUK, CSNK2B, ATM, MAP3K14, SOS1, AKT2, RELA, PIK3CG, SRF, NGFR, CEBPB, MAPK1, SOCS1, HRAS, CSNK2A1, SHC1 IL1RL1, MCL1, IL6, MAP3K7
Telomerase Signaling 2.00E-28 FGFR1, HSP90B1, FGFR2, HSP90AA1, FGFR3, SP1, HSP90AB1 IL2RG, ELF1, PPP2R5A, FRS2, HDAC1, POT1, EGFR, PIK3R3, RAF1, PIK3C2B, HDAC3, ABL1, MYC, PIK3R2, PTGES3, ETS1, AKT1, E2F1, IL2RB, IRS1, GAB1, PIK3R1, TP53, ETS2, TERF1, PIK3CA, PTPN11, CDKN1A, GRB2, MAPK3, HDAC2, IRS2, ATM, SOS1, AKT2, TERT, PIK3CG, PDPK1, HDAC6, TINF2, MAPK1, RB1, HRAS, SHC1 PPP2CB
PPAR Signaling 3.16E-28 HSP90AA1, PDGFRB, PDGFRA, HSP90B1, HSP90AB1 JUN, NCOR2, TRAF2, PDGFD, TNFRSF1A, PPARA, PDGFB, NFKBIA, IKBKG, SNW1, TNF, STAT5A, NR1H3, GRB2, RXRA, CREBBP, NCOR1, MAPK3, TRAF6, NFKB1, AIP, CHUK, IL1B, RAF1, EP300, MAP3K14, INSR, IKBKB, SOS1, PDGFC, RELA, NFKB2, PPARD, NGFR, NR2F1, MAPK1, STAT5B, PDGFA, HRAS, SHC1, IKBKE IL1RL1, MAP3K7
LPS-stimulated MAPK Signaling 3.16E-28 FGFR2, FGFR1, FGFR3 JUN, CDC42, MAPK10, PRKCQ, IRS1, GAB1, PIK3R1, NFKBIA, TLR4, IKBKG, PIK3CA, PTPN11, FRS2, GRB2, PRKCH, MAPK8, PRKCI, PRKCZ, MAPK3, PRKCE, NFKB1, PIK3R3, IRS2, CHUK, ATM, PAK1, RAF1, MAP3K14, IKBKB, PIK3C2B, RELA, PIK3CG, NFKB2, PRKCD, SRF, PRKCA, PIK3R2, MAPK1, PRKD1, HRAS, RAC1, IKBKE MAP3K7
Thrombopoietin Signaling 3.16E-28 FGFR2, FGFR1, FGFR3 JUN, PRKCQ, IRS1, GAB1, PIK3R1, STAT3, PIK3CA, STAT1, PTPN11, FRS2, STAT5A, GRB2, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, PIK3R3, IRS2, JAK2, ATM, RAF1, PIK3C2B, SOS1, PLCG2, PIK3CG, MYC, PRKCD, GAB2, PRKCA, PIK3R2, MAPK1, PLCG1, PRKD1, STAT5B, HRAS, SHC1
FAK Signaling 3.16E-28 FGFR1, SRC, FGFR2, FGFR3 VCL, WAS, ACTG1, ACTB, FRS2, HMMR, EGFR, PIK3R3, TLN1, RAF1, PIK3C2B, PTK2, PIK3R2, BCAR1, ITGA5, ASAP1, AKT1, IRS1, GAB1, PIK3R1, FYN, ARHGEF7, PIK3CA, PTPN11, ITGB1, GRB2, CRK, MAPK3, PAK2, IRS2, ATM, PAK1, PXN, SOS1, AKT2, PLCG2, PIK3CG, PDPK1, CSK, MAPK1, PLCG1, PAK4, HRAS, RAC1 CAPN2
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 3.16E-28 FGFR1, FGFR2, FGFR3 TNFRSF1A, MAPK10, PRKCQ, JAK3, PPARA, NFKBIA, TLR4, IKBKG, PPP2R5A, FRS2, PRKCH, TLR2, PRKCE, PIK3R3, JAK2, JAK1, IKBKB, PIK3C2B, NFKB2, PRKCD, APOB, PIK3R2, IKBKE, JUN, PPP1CC, AKT1, IRS1, GAB1, PIK3R1, PIK3CA, STAT1, PTPN11, TNF, GRB2, CREBBP, PTPN6, MAPK8, PRKCI, PRKCZ, MAP3K3, MAPK3, NFKB1, S100A8, IRS2, CHUK, ATM, MAP3K14, IL4, TYK2, AKT2, RELA, PLCG2, PIK3CG, NOS2, PRKCA, NGFR, MAPK1, PLCG1, PRKD1, RAC1 PPP2CB, RHOQ, SIRPA, ALB, MAP3K7, RND2
Leukocyte Extravasation Signaling 3.98E-28 FGFR1, SRC, FGFR2, FGFR3 CDC42, MMP2, VCL, MAPK10, PRKCQ, WAS, ACTG1, ACTB, FRS2, PRKCH, ACTN4, PRKCE, PIK3R3, CTNNB1, CRKL, EZR, ARHGAP1, PIK3C2B, ACTN1, WASL, PTK2, VAV1, CDH5, ABL1, PRKCD, PIK3R2, PTK2B, BMX, BCAR1, ITGA5, PECAM1, IRS1, GAB1, THY1, PIK3R1, CTNND1, GNAI2, PIK3CA, PTPN11, ITGB1, ITK, GRB2, TEC, ITGB3, CRK, MAPK8, PRKCI, PRKCZ, IRS2, CTTN, RAPGEF4, ATM, BTK, ARHGAP35, PXN, CD44, TXK, PLCG2, PIK3CG, PRKCA, TIMP3, MAPK1, PLCG1, PRKD1, RAC1 ITGAM, RAPGEF3, MMP17
PI3K Signaling in B Lymphocytes 3.98E-28 IL4R, FOXO3, LYN CAMK2B, NFKBIA, DAPP1, ATF3, TLR4, IKBKG, SYK, ITPR1, SH2B2, ATF5, CD79A, RAF1, IKBKB, VAV1, NFKB2, ABL1, PIK3R2, IKBKE, JUN, AKT1, IRS1, PIK3R1, CD40, CBL, FYN, INPP5D, PIK3CA, CD19, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, CHUK, CD79B, BTK, IL4, NFATC1, AKT2, RELA, PLCG2, PIK3CG, NFATC3, PDPK1, FCGR2B, MAPK1, PLCG1, PTPRC, HRAS, RAC1 CALML5, PLCL1
IL-4 Signaling 1.26E-27 FGFR2, FGFR1, HLA-DQA1, FGFR3, IL4R AKT1, JAK3, IL13RA1, NR3C2, IRS1, INPPL1, GAB1, PIK3R1, IL2RG, INPP5D, PIK3CA, PTPN11, FRS2, GRB2, PTPN6, RPS6KB1, RPS6KB2, HMGA1, PIK3R3, IRS2, JAK2, ATM, IL4, JAK1, PIK3C2B, NFATC1, TYK2, SOS1, AKT2, PIK3CG, NFATC3, HLA-A, PIK3R2, NR3C1, STAT6, SOCS1, HLA-B, HRAS, SHC1 OCRL, HLA-DQB1
Virus Entry via Endocytic Pathways 2.00E-27 FGFR1, SRC, FGFR2, FGFR3 CDC42, PRKCQ, DNM1, ACTG1, ACTB, FRS2, PRKCH, PRKCE, PIK3R3, FLNA, CLTC, PIK3C2B, ABL1, PRKCD, DNM2, PIK3R2, CD55, HLA-B, ITGA5, ITGB4, FOLR1, IRS1, GAB1, PIK3R1, AP1B1, FYN, PIK3CA, PTPN11, ITGB1, GRB2, ITGB3, PRKCI, PRKCZ, IRS2, ATM, PLCG2, PIK3CG, CAV1, HLA-A, PRKCA, PLCG1, PRKD1, AP2M1, HRAS, RAC1
IL-2 Signaling 2.51E-27 FGFR2, FGFR1, LCK, FGFR3 JUN, AKT1, JAK3, CSNK2A2, IL2RB, IRS1, GAB1, PIK3R1, IL2RG, SYK, PIK3CA, PTPN11, FRS2, STAT5A, GRB2, MAPK8, MAPK3, PIK3R3, IRS2, CSNK2B, ATM, RAF1, JAK1, PIK3C2B, SOS1, AKT2, PIK3CG, PIK3R2, PTK2B, MAPK1, SOCS1, STAT5B, HRAS, CSNK2A1, SHC1
Regulation of the Epithelial-Mesenchymal Transition Pathway 2.51E-27 FGFR1, FGFR2, FGFR3, PDGFRB MMP2, JAK3, FGF4, SMAD4, STAT3, FRS2, SMAD3, DVL3, EGFR, PIK3R3, JAK2, CTNNB1, SMAD2, RAF1, FGF10, JAK1, PIK3C2B, FGF2, NFKB2, TGFBR2, PIK3R2, HNF1A, ETS1, GSK3B, FGF5, FGF6, FGF1, PDGFD, AKT1, IRS1, FGF18, GAB1, FGF23, PIK3R1, APC, PIK3CA, PTPN11, GRB2, MET, CDH1, MAPK3, NFKB1, IRS2, NOTCH1, ATM, FGF7, EGR1, FGF3, TYK2, SOS1, AKT2, RELA, PIK3CG, FGF17, HIF1A, MAPK1, FGF8, ARAF, HRAS, FGF9 WNT6, WNT3, WNT7B
Breast Cancer Regulation by Stathmin1 2.51E-27 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, TUBB4B, TUBA4A, FGFR2, TUBA8, TUBB2A, FGFR3, TUBB4A CAMK2B, CDC42, ADCY6, PRKCQ, E2F3, GNAQ, PPP2R5A, FRS2, ITPR1, PRKCH, PRKCE, PIK3R3, RAF1, PIK3C2B, PRKCD, PIK3R2, CDKN1B, TUBA1B, PPP1CC, E2F1, IRS1, GAB1, PIK3R1, TP53, GNAI2, ARHGEF7, PIK3CA, PTPN11, E2F2, CDKN1A, GRB2, PRKCI, PRKCZ, MAPK3, IRS2, TUBB, ATM, PAK1, CDK2, SOS1, PIK3CG, PRKCA, MAPK1, PRKD1, PRKACA, HRAS, RAC1, SHC1, CDK1 PPP2CB, CAMK1D, PRKAG1, CALML5, TUBA3E
NGF Signaling 3.98E-27 FGFR1, FGFR2, FGFR3 CDC42, MAPK10, IKBKG, FRS2, RPS6KB1, TRAF6, PIK3R3, RAF1, IKBKB, PIK3C2B, NFKB2, PRKCD, PIK3R2, IKBKE, AKT1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, GRB2, CREBBP, CRK, MAPK8, PRKCZ, MAP3K3, MAPK3, RPS6KB2, NFKB1, IRS2, CHUK, RPS6KA3, ATM, EP300, MAP3K14, SOS1, AKT2, RELA, PLCG2, PIK3CG, PDPK1, NGFR, RPS6KA1, MAPK1, PLCG1, HRAS, RAC1, SHC1 MAP3K7
EGF Signaling 3.98E-27 FGFR2, FGFR1, FGFR3, SRC JUN, AKT1, CSNK2A2, IRS1, GAB1, PIK3R1, STAT3, PIK3CA, STAT1, PTPN11, FRS2, GRB2, ITPR1, MAPK8, RPS6KB1, MAPK3, EGFR, PIK3R3, IRS2, CSNK2B, ATM, RAF1, JAK1, PIK3C2B, SOS1, AKT2, PIK3CG, SRF, PRKCA, PIK3R2, MAPK1, PLCG1, RASA1, HRAS, CSNK2A1, SHC1
ErbB2-ErbB3 Signaling 7.94E-27 FGFR2, FGFR1, FGFR3, SP1 JUN, GSK3B, AKT1, JAK3, IRS1, GAB1, PIK3R1, STAT3, ETV4, PIK3CA, PTPN11, FRS2, STAT5A, ERBB2, GRB2, FOXO1, MAPK3, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, TYK2, SOS1, PIK3CG, MYC, PDPK1, PIK3R2, CDKN1B, CCND1, MAPK1, ERBB3, STAT5B, HRAS, SHC1 NRG1
VEGF Family Ligand-Receptor Interactions 7.94E-27 FGFR2, FGFR1, FLT1, FGFR3, FLT4, KDR AKT1, NRP2, PRKCQ, PGF, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, NOS3, PRKCH, PRKCI, PRKCZ, VEGFB, VEGFC, MAPK3, PRKCE, PIK3R3, IRS2, VEGFA, ATM, RAF1, PIK3C2B, SOS1, AKT2, PLCG2, PIK3CG, PRKCD, PRKCA, PIK3R2, NRP1, MAPK1, PLCG1, PRKD1, HRAS, SHC1
Aryl Hydrocarbon Receptor Signaling 7.94E-27 CDKN2A, SRC, HSP90B1, DHFR, HSP90AA1, SP1, HSP90AB1 NCOR2, POLA1, SMARCA4, ATR, RXRA, ARNT, ESR2, RBL1, ESR1, CCNA1, CCND2, IL1B, NFKB2, MYC, AHR, CDKN1B, PTGES3, CCND1, TP73, RARG, FAS, JUN, APAF1, RARA, E2F1, TP53, TNF, CDKN1A, MAPK8, CDK6, MAPK3, NFKB1, FASLG, AIP, CDK4, ATM, EP300, CDK2, RXRB, RELA, NR2F1, MAPK1, MDM2, CCNA2, RB1, RARB, CHEK1 NFIB, GSTA2, IL6
Fc Epsilon RI Signaling 1.58E-26 FGFR1, LYN, FGFR2, FGFR3 MAPK10, PRKCQ, IL13, INPPL1, FCER1G, LCP2, SYK, FRS2, PRKCH, LAT, PRKCE, PIK3R3, RAF1, PIK3C2B, VAV1, PRKCD, PIK3R2, AKT1, IRS1, GAB1, PIK3R1, MS4A2, FYN, INPP5D, PIK3CA, PTPN11, TNF, GRB2, MAPK8, PRKCI, PRKCZ, MAPK3, IRS2, ATM, BTK, IL4, SOS1, AKT2, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, RAC1 OCRL
Endothelin-1 Signaling 2.51E-26 FGFR1, SRC, FGFR2, FGFR3 PAFAH1B1, GNA11, ADCY6, GUCY1B3, MAPK10, PRKCQ, PLA2G7, PLD1, GNAQ, FRS2, ITPR1, NOS3, PRKCH, PRKCE, PIK3R3, RAF1, PIK3C2B, MAPK6, MYC, PRKCD, PIK3R2, CASP3, JUN, GNA12, SHC2, IRS1, GAB1, PIK3R1, SHF, MAPK15, GNAI2, NOS1, PIK3CA, PTPN11, GRB2, MAPK8, PRKCI, PAFAH1B3, PRKCZ, CASP7, MAPK3, IRS2, ATM, CASP9, SOS1, SHC3, PLCG2, CASP6, PIK3CG, NOS2, PRKCA, PLD2, MAPK1, PLCG1, PRKD1, ARAF, GUCY2C, HRAS, SHC1 PNPLA3, PNPLA8, PLCL1
Paxillin Signaling 6.31E-26 FGFR1, SRC, FGFR2, FGFR3 CDC42, ITGAV, VCL, MAPK10, ACTG1, ACTB, FRS2, ACTN4, NCK1, PIK3R3, TLN1, PIK3C2B, ACTN1, PTK2, PTPN12, PIK3R2, PTK2B, NCK2, BCAR1, ITGA5, ITGB4, IRS1, GAB1, PIK3R1, ARHGEF7, PIK3CA, PTPN11, ITGB1, GRB2, ITGB3, CRK, MAPK8, PAK2, IRS2, ATM, PAK1, PXN, SOS1, PIK3CG, ARFIP2, CSK, MAPK1, PAK4, HRAS, RAC1 ITGAM
Th1 and Th2 Activation Pathway 1.58E-25 FGFR1, HLA-DQA1, IL4R, FGFR2, FGFR3 PRKCQ, JAK3, IL13, IFNAR1, CD274, IL2RG, GATA3, STAT3, CD8A, FRS2, CD80, CD4, CD86, S1PR1, CD3E, PIK3R3, JAK2, JAK1, PIK3C2B, VAV1, BMPR2, TGFBR2, CD28, PIK3R2, STAT6, HLA-B, STAT5B, JUN, IL6R, IL2RB, IRS1, GAB1, PIK3R1, CD40, CCR5, PIK3CA, STAT1, PTPN11, STAT5A, GRB2, NFKB1, IRS2, NOTCH1, ATM, LTA, IL4, NFATC1, TYK2, PIK3CG, NFATC3, HLA-A, SOCS1, CD247 IL1RL1, HLA-DQA2, HLA-DPB1, HLA-DQB1, ACVR1B, IL6
RANK Signaling in Osteoclasts 2.00E-25 FGFR2, FGFR1, FGFR3, SRC JUN, BIRC2, TRAF2, AKT1, MAPK10, IRS1, GAB1, PIK3R1, NFKBIA, CBL, IKBKG, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, TNFRSF11A, MAP3K3, MAPK3, TRAF6, NFKB1, PIK3R3, IRS2, CHUK, ATM, RAF1, MAP3K14, IKBKB, PIK3C2B, NFATC1, AKT2, RELA, PIK3CG, NFKB2, PIK3R2, PTK2B, MAPK1, IKBKE CALML5, MITF, MAP3K7, GSN
Macropinocytosis Signaling 2.00E-25 FGFR2, FGFR1, FGFR3, SRC CDC42, PDGFD, PRKCQ, IRS1, PDGFB, GAB1, PIK3R1, CSF1R, PIK3CA, PTPN11, ITGB1, FRS2, GRB2, MET, ITGB3, PRKCH, PRKCI, ACTN4, PRKCZ, PRKCE, PIK3R3, IRS2, ATM, PAK1, PIK3C2B, PDGFC, PLCG2, PIK3CG, PRKCD, PRKCA, PIK3R2, PLCG1, PRKD1, PDGFA, HRAS, ITGA5, RAC1, ITGB4
Myc Mediated Apoptosis Signaling 3.16E-25 FGFR2, FGFR1, CDKN2A, FGFR3 YWHAQ, APAF1, AKT1, MAPK10, IRS1, GAB1, PIK3R1, YWHAE, TP53, YWHAH, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, PRKCZ, YWHAB, FASLG, PIK3R3, IRS2, YWHAG, ATM, CASP9, PIK3C2B, SOS1, AKT2, PIK3CG, IGF1R, MYC, PIK3R2, CASP3, FAS, YWHAZ, HRAS, SHC1
Role of Osteoblasts_ Osteoclasts and Chondrocytes in Rheumatoid Arthritis 3.98E-25 FGFR1, SRC, FGFR2, FGFR3 BIRC2, CTSK, TNFRSF1A, MAPK10, SMAD4, NFKBIA, IKBKG, FRS2, LRP1, TNFRSF11A, TRAF6, PIK3R3, IL1B, CTNNB1, IKBKB, PIK3C2B, BMPR2, PIK3R2, PTK2B, SMAD1, HNF1A, ITGA5, IKBKE, JUN, GSK3B, TRAF2, AKT1, IRS1, GAB1, PIK3R1, CBL, CSF1R, APC, PIK3CA, PTPN11, TNF, ITGB1, GRB2, ITGB3, MAPK8, FOXO1, MAPK3, NFKB1, IRS2, CHUK, ATM, MAP3K14, IL4, CASP9, NFATC1, AKT2, RELA, PIK3CG, NFATC3, NGFR, MAPK1 IL1RL1, WNT6, GSN, SP7, CALML5, IL6, MAP3K7, WNT3, WNT7B, IL7, APC2
G_q Signaling 3.98E-25 FGFR1, FGFR2, FGFR3 GNA11, PRKCQ, PLD1, NFKBIA, IKBKG, GNAQ, FRS2, ITPR1, PRKCH, PRKCE, PIK3R3, RAF1, IKBKB, PIK3C2B, NFKB2, PRKCD, PIK3R2, PTK2B, IKBKE, GSK3B, AKT1, IRS1, GAB1, PIK3R1, RGS16, PIK3CA, PTPN11, GRB2, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, CHUK, ATM, BTK, NFATC1, AKT2, RELA, PLCG2, PIK3CG, NFATC3, PRKCA, CSK, PLD2, MAPK1, PLCG1, PRKD1 CALML5, RHOQ, CHRM3, RGS4, RND2
IL-12 Signaling and Production in Macrophages 5.01E-25 FGFR1, FGFR2, FGFR3 MAPK10, PRKCQ, MST1R, TLR4, IKBKG, FRS2, RXRA, PRKCH, TLR2, TRAF6, REL, PRKCE, PIK3R3, IKBKB, PIK3C2B, NFKB2, PRKCD, APOB, PIK3R2, STAT6, IKBKE, JUN, ALOX12, AKT1, IRS1, GAB1, PIK3R1, CD40, PIK3CA, STAT1, PTPN11, TNF, GRB2, MAPK8, PRKCI, PRKCZ, MAPK3, NFKB1, S100A8, IRS2, CHUK, ATM, EP300, IL4, AKT2, RELA, PIK3CG, NOS2, PRKCA, CEBPB, MAPK1, PRKD1 ALB
Role of JAK1 and JAK3 in _c Cytokine Signaling 6.31E-25 FGFR2, FGFR1, FGFR3, IL4R JAK3, IL2RB, IRS1, GAB1, PIK3R1, IL2RG, STAT3, SYK, PIK3CA, STAT1, PTPN11, FRS2, IL7R, STAT5A, GRB2, SH2B2, FES, MAPK3, PIK3R3, IRS2, JAK2, ATM, IL4, JAK1, PIK3C2B, PIK3CG, PIK3R2, PTK2B, STAT6, MAPK1, SOCS1, STAT5B, HRAS, SHC1 IL7
Renal Cell Carcinoma Signaling 7.94E-25 FGFR2, FGFR1, FGFR3 JUN, CDC42, AKT1, IRS1, PDGFB, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, MET, CREBBP, ARNT, CRK, RAPGEF1, UBC, MAPK3, PAK2, PIK3R3, IRS2, VEGFA, ATM, PAK1, RAF1, EP300, PIK3C2B, SOS1, AKT2, PIK3CG, VHL, PIK3R2, HIF1A, UBB, MAPK1, PAK4, ETS1, HRAS, RAC1
Type I Diabetes Mellitus Signaling 2.00E-24 HLA-DQA1 TRAF2, SOCS5, APAF1, TNFRSF1A, MAPK10, HSPD1, FCER1G, PIAS1, NFKBIA, IKBKG, SOCS7, STAT1, TNF, CD80, MAPK8, RIPK1, CD86, TRAF6, IRAK1, CD3E, NFKB1, FASLG, CHUK, JAK2, IL1B, LTA, MAP3K14, CASP9, JAK1, IKBKB, RELA, GZMB, NFKB2, NOS2, CD28, HLA-A, NGFR, MAPK1, CASP3, SOCS1, HLA-B, SOCS6, FAS, CD247, IKBKE MAP3K7, HLA-DQB1
CTLA4 Signaling in Cytotoxic T Lymphocytes 5.01E-24 FGFR2, FGFR1, CTLA4, LCK, FGFR3 AKT1, PTPN22, IRS1, FCER1G, GAB1, PIK3R1, AP1B1, LCP2, SYK, FYN, CD8A, PPP2R5A, PIK3CA, PTPN11, FRS2, GRB2, CD80, PTPN6, LAT, CD86, ZAP70, CD3E, PIK3R3, IRS2, JAK2, CLTC, ATM, PIK3C2B, AP1M1, AKT2, PIK3CG, CD28, HLA-A, PIK3R2, TRAT1, PLCG1, HLA-B, AP2M1, CD247 PPP2CB
Role of NFAT in Cardiac Hypertrophy 1.58E-23 FGFR1, SRC, FGFR2, FGFR3 CAMK2B, ADCY6, MAPK10, PRKCQ, GNAQ, FRS2, ITPR1, PRKCH, HDAC1, PRKCE, PIK3R3, RAF1, PIK3C2B, HDAC3, IGF1R, TGFBR2, PRKCD, PIK3R2, GSK3B, AKT1, IRS1, GAB1, PIK3R1, GNAI2, PIK3CA, PTPN11, GATA4, GRB2, MAPK8, PRKCI, MEF2D, PRKCZ, MAPK3, HDAC2, IRS2, ATM, EP300, MEF2C, SOS1, AKT2, PLCG2, PIK3CG, HDAC6, PRKCA, MAPK1, PLCG1, PRKD1, PRKACA, HRAS, SHC1 NKX2-5, CAMK1D, PRKAG1, CALML5, IL6, PLCL1, MAP3K7
mTOR Signaling 3.16E-23 FGFR1, FGFR2, PRR5, FGFR3 PRKCQ, PLD1, PPP2R5A, FRS2, MLST8, PRKCH, VEGFC, RPS6KB1, PRKCE, PIK3R3, VEGFA, RPS7, INSR, PIK3C2B, PDGFC, PRKCD, PIK3R2, EIF3F, AKT1, PGF, FKBP1A, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, GRB2, DGKZ, PRKCI, RPS3A, PRKCZ, TSC1, VEGFB, MAPK3, RPS6KB2, IRS2, RPS6KA3, ATM, AKT2, RPS3, PIK3CG, PDPK1, PRKCA, HIF1A, PLD2, RPS6KA1, MAPK1, PRKD1, HRAS, RAC1 PPP2CB, EIF4G2, EIF3H, PRKAG1, RHOQ, RPS20, ULK1, EIF4EBP1, RND2
FLT3 Signaling in Hematopoietic Progenitor Cells 5.01E-23 FGFR2, FGFR1, FLT3, FGFR3 FLT3LG, AKT1, IRS1, GAB1, PIK3R1, CBL, STAT3, INPP5D, PIK3CA, STAT1, PTPN11, FRS2, STAT5A, GRB2, CREBBP, RPS6KB1, MAPK3, PIK3R3, IRS2, RPS6KA3, ATM, RAF1, EP300, PIK3C2B, SOS1, AKT2, PIK3CG, PDPK1, GAB2, PIK3R2, STAT6, RPS6KA1, MAPK1, STAT5B, HRAS, SHC1 EIF4EBP1
IL-17A Signaling in Airway Cells 6.31E-23 FGFR2, FGFR1, FGFR3 GSK3B, AKT1, MAPK10, JAK3, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, STAT3, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, MAPK3, TRAF6, NFKB1, PIK3R3, IRS2, CHUK, JAK2, ATM, JAK1, IKBKB, PIK3C2B, TYK2, AKT2, RELA, PIK3CG, NFKB2, PIK3R2, MAPK1, IKBKE IL6, MAP3K7
Dendritic Cell Maturation 7.94E-23 FGFR1, HLA-DQA1, FGFR2, FGFR3 TNFRSF1A, MAPK10, FCER1G, NFKBIA, IFNAR1, TLR4, IKBKG, FRS2, CD80, TLR2, CD86, TRAF6, PIK3R3, JAK2, IL1B, IKBKB, PIK3C2B, FCGR2A, NFKB2, PIK3R2, HLA-B, IKBKE, AKT1, IRS1, GAB1, PIK3R1, CD40, PIK3CA, STAT1, PTPN11, TNF, GRB2, CREBBP, MAPK8, MAPK3, NFKB1, IRS2, CHUK, ATM, LTA, EP300, MAP3K14, AKT2, COL18A1, RELA, PLCG2, PIK3CG, FCGR2B, HLA-A, NGFR, MAPK1, PLCG1, DDR2 CCR7, HLA-DQB1, IL6, PLCL1
Hereditary Breast Cancer Signaling 7.94E-23 FGFR1, TUBG1, FGFR2, FGFR3 FANCC, SMARCA4, BARD1, SMARCB1, ACTB, FRS2, ATR, HDAC1, PIK3R3, POLR2E, PIK3C2B, HLTF, SMARCE1, SMARCC2, HDAC3, PIK3R2, CCND1, UBB, FANCA, ARID1A, AKT1, E2F1, IRS1, GAB1, PIK3R1, SMARCC1, TP53, CDC25C, PIK3CA, PTPN11, CDKN1A, GRB2, CREBBP, CDK6, UBC, BRCA1, HDAC2, CDK4, IRS2, ATM, EP300, AKT2, PIK3CG, HDAC6, POLR2G, RB1, HRAS, CDK1, CHEK1
Ovarian Cancer Signaling 7.94E-23 FGFR1, CDKN2A, SRC, FGFR2, FGFR3 MMP2, FRS2, VEGFC, RPS6KB1, EGFR, PIK3R3, CTNNB1, VEGFA, RAF1, PIK3C2B, PDGFC, ABL1, PIK3R2, CCND1, HNF1A, GJA1, GSK3B, AKT1, PGF, E2F1, IRS1, GAB1, PIK3R1, TP53, APC, PIK3CA, PTPN11, GRB2, VEGFB, MAPK3, RPS6KB2, BRCA1, CDK4, IRS2, ATM, AKT2, CD44, PIK3CG, MAPK1, RB1, PRKACA, HRAS, FGF9 WNT6, PRKAG1, WNT3, WNT7B
CD40 Signaling 1.00E-22 FGFR2, FGFR1, FGFR3 JUN, TRAF2, MAPK10, JAK3, IRS1, GAB1, PIK3R1, CD40, NFKBIA, IKBKG, STAT3, PIK3CA, PTPN11, FRS2, GRB2, TRAF1, MAPK8, MAPK3, TRAF6, NFKB1, PIK3R3, IRS2, CHUK, ATM, LTA, MAP3K14, IKBKB, PIK3C2B, TRAF3, RELA, PIK3CG, NFKB2, PIK3R2, MAPK1, IKBKE MAP3K7
G_12/13 Signaling 1.26E-22 FGFR1, SRC, FGFR2, FGFR3 CDC42, MAPK10, NFKBIA, IKBKG, FRS2, PIK3R3, CTNNB1, RAF1, IKBKB, PIK3C2B, PTK2, VAV1, CDH5, NFKB2, PIK3R2, PTK2B, IKBKE, JUN, AKT1, GNA12, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, GRB2, TEC, CDH1, MAPK8, MEF2D, MAPK3, NFKB1, IRS2, CHUK, LPAR2, ATM, MYL12A, BTK, PXN, MEF2C, AKT2, RELA, PIK3CG, MAPK1, RASA1, HRAS MYL6B
Th1 Pathway 1.26E-22 FGFR1, HLA-DQA1, FGFR2, FGFR3 PRKCQ, JAK3, IFNAR1, CD274, GATA3, STAT3, CD8A, FRS2, CD80, CD4, CD86, CD3E, PIK3R3, JAK2, JAK1, PIK3C2B, VAV1, CD28, PIK3R2, HLA-B, IL6R, IRS1, GAB1, PIK3R1, CD40, CCR5, PIK3CA, STAT1, PTPN11, GRB2, NFKB1, IRS2, NOTCH1, ATM, LTA, IL4, NFATC1, TYK2, PIK3CG, NFATC3, HLA-A, SOCS1, CD247 HLA-DQA2, HLA-DPB1, HLA-DQB1, IL6
Bladder Cancer Signaling 1.58E-22 CDKN2A, FGFR3 FGF5, FGF6, FGF1, MMP2, PGF, FGF4, E2F1, FGF18, THBS1, FGF23, TP53, ERBB2, CDKN1A, CDH1, VEGFB, VEGFC, MAPK3, EGFR, CDK4, VEGFA, RAF1, FGF10, FGF7, FGF2, FGF3, PDGFC, ABL1, MYC, FGF17, RASSF1, CCND1, MAPK1, MDM2, FGF8, RB1, HRAS, FGF9 MMP17
GDNF Family Ligand-Receptor Interactions 2.00E-22 FGFR2, FGFR1, FGFR3 JUN, CDC42, DOK2, MAPK10, RET, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, DOK3, ITPR1, MAPK8, NCK1, MAPK3, DOK4, DOK1, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, SOS1, DOK5, PLCG2, PIK3CG, PIK3R2, MAPK1, PLCG1, RASA1, HRAS, RAC1, SHC1
Fc_RIIB Signaling in B Lymphocytes 2.00E-22 FGFR2, FGFR1, FGFR3, LYN AKT1, MAPK10, IRS1, GAB1, PIK3R1, SYK, INPP5D, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, CD79A, DOK1, PIK3R3, IRS2, ATM, CD79B, BTK, PIK3C2B, SOS1, PLCG2, PIK3CG, PDPK1, FCGR2B, PIK3R2, HRAS, SHC1
GM-CSF Signaling 3.98E-22 FGFR2, FGFR1, FGFR3, LYN CAMK2B, AKT1, CSF2RA, IRS1, GAB1, PIK3R1, STAT3, PIK3CA, STAT1, PTPN11, FRS2, GRB2, MAPK3, PIK3R3, IRS2, JAK2, CSF2RB, ATM, RAF1, PIK3C2B, SOS1, AKT2, PIK3CG, PIK3R2, CCND1, PIM1, MAPK1, BCL2L1, ETS1, STAT5B, HRAS, SHC1
CXCR4 Signaling 5.01E-22 FGFR1, SRC, LYN, FGFR2, FGFR3 GNA11, ADCY6, MAPK10, PRKCQ, GNAQ, FRS2, CD4, ITPR1, PRKCH, PRKCE, PIK3R3, RAF1, PIK3C2B, PTK2, PRKCD, PIK3R2, BCAR1, JUN, AKT1, GNA12, IRS1, GAB1, PIK3R1, GNAI2, PIK3CA, PTPN11, GRB2, CRK, MAPK8, PRKCI, PRKCZ, MAPK3, PAK2, IRS2, ATM, PAK1, MYL12A, PXN, EGR1, AKT2, PIK3CG, PRKCA, MAPK1, PRKD1, PAK4, HRAS, RAC1 MYL6B, RHOQ, RND2
HIF1_ Signaling 5.01E-22 FGFR2, FGFR1, HSP90AA1, FGFR3 JUN, MMP2, AKT1, MAPK10, PGF, IRS1, GAB1, PIK3R1, TP53, MAPK15, NOS1, PIK3CA, PTPN11, FRS2, EGLN1, GRB2, CREBBP, ARNT, NOS3, MAPK8, VEGFB, VEGFC, MAPK3, PIK3R3, IRS2, VEGFA, ATM, EP300, PIK3C2B, AKT2, MAPK6, PDGFC, PIK3CG, VHL, NOS2, SLC2A4, PIK3R2, HIF1A, MAPK1, MDM2, HRAS MMP17
Th2 Pathway 7.94E-22 FGFR1, HLA-DQA1, IL4R, FGFR2, FGFR3 PRKCQ, JAK3, IL13, IL2RG, GATA3, FRS2, CD80, CD4, CD86, S1PR1, CD3E, PIK3R3, JAK2, JAK1, PIK3C2B, VAV1, BMPR2, TGFBR2, CD28, PIK3R2, STAT6, HLA-B, STAT5B, JUN, IL2RB, IRS1, GAB1, PIK3R1, CD40, CCR5, PIK3CA, PTPN11, STAT5A, GRB2, NFKB1, IRS2, NOTCH1, ATM, IL4, TYK2, PIK3CG, HLA-A, CD247 IL1RL1, HLA-DQA2, HLA-DPB1, HLA-DQB1, ACVR1B
STAT3 Pathway 7.94E-22 FGFR2, FGFR1, FLT1, NTRK2, FGFR3, PDGFRB, SRC, FLT4, KDR, PDGFRA SOCS5, MAPK10, SOCS7, STAT3, CDKN1A, PTPN6, MAPK8, TNFRSF11A, MAPK3, EGFR, JAK2, RAF1, PTPN2, INSR, TYK2, IGF2R, IGF1R, BMPR2, MYC, TGFBR2, NGFR, PIM1, MAPK1, SOCS1, SOCS6, HRAS, RAC1
UVB-Induced MAPK Signaling 7.94E-22 FGFR2, FGFR1, FGFR3 JUN, AKT1, MAPK10, PRKCQ, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, GRB2, PRKCH, MAPK8, PRKCI, PRKCZ, RPS6KB1, MAPK3, PRKCE, EGFR, PIK3R3, IRS2, RPS6KA3, ATM, PIK3C2B, PIK3CG, PRKCD, PRKCA, PIK3R2, MAPK1, PRKD1 EIF4EBP1
Melanoma Signaling 1.00E-21 FGFR2, FGFR1, CDKN2A, FGFR3 AKT1, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, CDKN1A, GRB2, CDH1, MAPK3, PIK3R3, CDK4, IRS2, ATM, RAF1, PIK3C2B, AKT2, PIK3CG, PIK3R2, CCND1, MAPK1, MDM2, RB1, HRAS MITF
Cell Cycle: G2/M DNA Damage Checkpoint Regulation 2.00E-21 CDKN2A KAT2B, YWHAQ, TRIP12, YWHAE, TP53, YWHAH, BORA, CDC25C, SKP1, ATR, CDKN1A, CKS2, PRKCZ, PRKDC, YWHAB, BRCA1, YWHAG, CDK7, ATM, EP300, BTRC, ABL1, RPS6KA1, MDM2, CKS1B, YWHAZ, CDK1, PLK1, CHEK1
CREB Signaling in Neurons 2.00E-21 FGFR1, FGFR2, FGFR3 CAMK2B, GNA11, ADCY6, PRKCQ, GNAQ, FRS2, ITPR1, PRKCH, PRKCE, PIK3R3, POLR2E, RAF1, PIK3C2B, PRKCD, GRIN2A, PIK3R2, TBP, AKT1, GNA12, IRS1, GAB1, PIK3R1, GRIA3, GNAI2, PIK3CA, PTPN11, GRB2, GRM7, CREBBP, PRKCI, PRKCZ, MAPK3, IRS2, ATM, EP300, SOS1, AKT2, PLCG2, PIK3CG, GRIN2B, PRKCA, RPS6KA1, MAPK1, PLCG1, PRKD1, POLR2G, PRKACA, HRAS, SHC1 PRKAG1, CALML5, GRIN1, PLCL1, GRIA1
PPAR_/RXR_ Activation 2.00E-21 HSP90B1, HSP90AA1, HSP90AB1 NCOR2, GNA11, ADCY6, PPARA, SMAD4, NFKBIA, IKBKG, GNAQ, NCOA6, SMAD3, RXRA, TRAF6, JAK2, IL1B, SMAD2, RAF1, INSR, IKBKB, NFKB2, BMPR2, CD36, TGFBR2, STAT5B, IKBKE, JUN, IRS1, NR2C2, GRB2, CREBBP, NCOR1, MAPK8, MAPK3, NFKB1, AIP, CHUK, EP300, MAP3K14, MEF2C, SOS1, RELA, PLCG2, PRKCA, NR2F1, MAPK1, PLCG1, PRKACA, HRAS, SHC1 IL1RL1, GPD1, ACVR1B, PRKAG1, IL6, PLCL1, MAP3K7
Endometrial Cancer Signaling 2.51E-21 FGFR2, FGFR1, FGFR3, FOXO3 GSK3B, AKT1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, ERBB2, GRB2, CDH1, MAPK3, PIK3R3, IRS2, CTNNB1, ATM, RAF1, CASP9, PIK3C2B, SOS1, AKT2, PIK3CG, MYC, PDPK1, PIK3R2, CCND1, MAPK1, HRAS APC2
Rac Signaling 2.51E-21 FGFR2, FGFR1, FGFR3 JUN, IQGAP1, CDC42, IRS1, GAB1, PIK3R1, PLD1, CFL1, PIK3CA, PTPN11, ITGB1, FRS2, GRB2, MAPK8, PRKCI, PRKCZ, RPS6KB1, MAPK3, PAK2, NFKB1, PIK3R3, IRS2, ATM, PAK1, RAF1, TIAM1, PIK3C2B, PTK2, CD44, PI4KA, RELA, PIK3CG, NFKB2, ARFIP2, CDK5R1, PIK3R2, PTK2B, MAPK1, PAK4, HRAS, ITGA5, RAC1 ELK4
Thrombin Signaling 2.51E-21 FGFR1, SRC, FGFR2, FGFR3 CAMK2B, GNA11, ADCY6, PRKCQ, GATA3, GNAQ, FRS2, ITPR1, PRKCH, RPS6KB1, PRKCE, EGFR, PIK3R3, RAF1, IKBKB, PIK3C2B, PTK2, NFKB2, PRKCD, PIK3R2, MYLK, TBP, AKT1, GNA12, IRS1, GAB1, PIK3R1, GNAI2, PIK3CA, PTPN11, GATA4, GRB2, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, ATM, MYL12A, GATA1, SOS1, AKT2, RELA, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, SHC1 MYL6B, CAMK1D, RHOQ, PLCL1, RND2
Osteoarthritis Pathway 3.16E-21 FGFR1, FOXO3, FGFR3, SP1 TNFRSF1A, SPHK1, SMAD4, TLR4, SMAD3, LRP1, VEGFC, TLR2, IL1B, CTNNB1, VEGFA, SMAD2, ANXA2, FGF2, HDAC3, PDGFC, NFKB2, PPARD, BMPR2, TGFBR2, SMAD1, HNF1A, CASP3, ITGA5, PGF, FGF18, FN1, SMAD7, TNF, ITGB1, CREBBP, VEGFB, SIRT1, CASP7, NFKB1, S100A8, CHUK, NOTCH1, EP300, ANXA5, CASP9, MEF2C, RELA, CASP6, NOS2, HIF1A, CEBPB, TIMP3, EPAS1, FGF8, RAC1, DDR2 IL1RL1, ALPP, OCRL, HMGB1, PRKAG1, SP7
Cell Cycle: G1/S Checkpoint Regulation 1.00E-20 CDKN2A GSK3B, E2F1, SMAD4, MAX, E2F3, TP53, SMAD3, E2F2, SKP1, ATR, CDKN1A, RBL1, CDK6, FOXO1, HDAC1, HDAC2, CDK4, CCND2, CDKN2C, ATM, CDK2, BTRC, HDAC3, ABL1, MYC, HDAC6, CDKN1B, CCND1, BMI1, MDM2, RB1 NRG1, CDKN2B
PEDF Signaling 1.00E-20 FGFR2, FGFR1, FGFR3 AKT1, IRS1, GAB1, PIK3R1, NFKBIA, TP53, IKBKG, PIK3CA, PTPN11, FRS2, GRB2, BDNF, CASP7, MAPK3, NFKB1, FASLG, PIK3R3, IRS2, CHUK, ATM, RAF1, IKBKB, PIK3C2B, AKT2, RELA, PIK3CG, NFKB2, SRF, PIK3R2, HNF1A, MAPK1, BCL2L1, FAS, HRAS, RAC1, IKBKE
Reelin Signaling in Neurons 1.26E-20 FGFR2, FGFR1, LCK, FGFR3, SRC, LYN GSK3B, DAB1, PAFAH1B1, AKT1, MAPK10, FGR, IRS1, GAB1, PIK3R1, FYN, PIK3CA, PTPN11, ITGB1, FRS2, GRB2, ITGB3, MAPT, MAPK8, PAFAH1B3, APBB1, PIK3R3, IRS2, CRKL, ATM, MAP4K1, PIK3C2B, APP, MAPK8IP3, CDK5, PIK3CG, CDK5R1, PIK3R2, YES1, ITGA5
GNRH Signaling 2.51E-20 SRC CAMK2B, CDC42, GNA11, MMP2, ADCY6, MAPK10, PRKCQ, DNM1, GNAQ, ITPR1, PRKCH, PRKCE, EGFR, RAF1, PTK2, NFKB2, PRKCD, DNM2, PTK2B, JUN, DNM1L, GNAI2, GRB2, CREBBP, MAPK8, PRKCI, PRKCZ, MAP3K3, MAPK3, PAK2, NFKB1, PAK1, EP300, MAP3K14, PXN, EGR1, SOS1, RELA, PRKCA, MAPK1, PRKD1, PAK4, PRKACA, HRAS, RAC1 PRKAG1, CALML5, MAP3K7
P2Y Purigenic Receptor Signaling Pathway 3.16E-20 FGFR2, FGFR1, FGFR3 JUN, AKT1, ADCY6, PRKCQ, IRS1, GAB1, PIK3R1, GNAQ, GNAI2, PIK3CA, PTPN11, FRS2, GRB2, P2RY2, CREBBP, ITGB3, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, NFKB1, PIK3R3, IRS2, ATM, RAF1, EP300, PIK3C2B, AKT2, RELA, PLCG2, PIK3CG, NFKB2, MYC, PRKCD, PRKCA, PIK3R2, MAPK1, PLCG1, PRKD1, PRKACA, HRAS PLCL1, PRKAG1
ErbB4 Signaling 3.16E-20 FGFR2, FGFR1, FGFR3 AKT1, PRKCQ, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, SOS1, PLCG2, PIK3CG, PRKCD, PDPK1, PRKCA, PIK3R2, MAPK1, PLCG1, PRKD1, HRAS, SHC1 NRG1
Sertoli Cell-Sertoli Cell Junction Signaling 3.16E-20 TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, TUBA8, TUBB2A, TUBB4A CDC42, VCL, TNFRSF1A, GUCY1B3, MAPK10, WAS, ACTG1, ACTB, NOS3, ACTN4, DLG1, CTNNB1, RAF1, JUP, ACTN1, RAB8B, SORBS1, BCAR1, TUBA1B, ITGA5, SPTAN1, JUN, GSK3B, AKT1, TJP1, EPB41, NOS1, TNF, ITGB1, CDH1, MAPK8, MAP3K3, MAPK3, TUBB, MAP3K14, AKT2, NOS2, MAPK1, PRKACA, HRAS, RAC1 PRKAG1, TUBA3E, MAP3K7
Epithelial Adherens Junction Signaling 5.01E-20 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, TUBA8, TUBB2A, TUBB4A IQGAP1, CDC42, VCL, ZYX, WAS, ACTG1, ACTB, ACTN4, EGFR, CTNNB1, JUP, ACTN1, WASL, BMPR2, TGFBR2, SORBS1, HNF1A, TUBA1B, YES1, FGF1, AKT1, CTNND1, APC, CLIP1, MET, CRK, CDH1, RAPGEF1, NOTCH1, TUBB, AKT2, FARP2, HRAS, RAC1 MYL6B, ACVR1B, TUBA3E
Neurotrophin/TRK Signaling 5.01E-20 FGFR2, FGFR1, NTRK2, FGFR3 JUN, CDC42, AKT1, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, CREBBP, MAPK8, NTF4, BDNF, MAPK3, PIK3R3, IRS2, ATM, RAF1, EP300, NTF3, PIK3C2B, SOS1, PIK3CG, PDPK1, NGFR, PIK3R2, RPS6KA1, MAPK1, PLCG1, HRAS, SHC1
Phospholipase C Signaling 6.31E-20 LCK, SRC, LYN ADCY6, PRKCQ, FCER1G, PLD1, LCP2, GNAQ, SYK, ITPR1, PRKCH, LAT, CD79A, HDAC1, ZAP70, PRKCE, CD3E, RAF1, HDAC3, FCGR2A, NFKB2, PRKCD, ITGA5, FYN, ARHGEF7, ITGB1, ITK, GRB2, CREBBP, PRKCI, MEF2D, PRKCZ, MAPK3, NFKB1, HDAC2, RPS6KA3, CD79B, MYL12A, BTK, EP300, NFATC1, MEF2C, SOS1, RELA, PLCG2, NFATC3, FCGR2B, HDAC6, PRKCA, PLD2, MAPK1, PLCG1, PRKD1, HRAS, CD247, RAC1, SHC1, AHNAK MYL6B, CALML5, RHOQ, RAPGEF3, RND2
AMPK Signaling 6.31E-20 FGFR1, SRC, FOXO3, FGFR2, FGFR3 ADRB2, KAT2B, PPM1A, SMARCA4, EEF2, SMARCB1, PPP2R5A, ACTB, FRS2, MLST8, NOS3, RPS6KB1, PIK3R3, CHRNA7, INSR, PIK3C2B, HLTF, SMARCE1, SMARCC2, FOXG1, PIK3R2, CCND1, HNF4A, CFTR, ACACA, ARID1A, AKT1, IRS1, GAB1, PIK3R1, SMARCC1, PIK3CA, PTPN11, CDKN1A, GRB2, CREBBP, TSC1, FOXO1, SIRT1, IRS2, ADRB3, PPAT, ATM, EP300, AKT2, PIK3CG, PDPK1, SLC2A4, MAPK1, CCNA2, PRKACA PPP2CB, PRKAG1, ULK1, EIF4EBP1, MAP3K7, CHRM3
Estrogen-Dependent Breast Cancer Signaling 7.94E-20 FGFR2, FGFR1, FGFR3, SRC, SP1 JUN, AKT1, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, STAT5A, GRB2, CREBBP, ESR1, MAPK3, NFKB1, EGFR, PIK3R3, IRS2, ATM, EP300, PIK3C2B, AKT2, TERT, RELA, PIK3CG, NFKB2, IGF1R, PIK3R2, CCND1, MAPK1, STAT5B, HRAS
Cardiac Hypertrophy Signaling 7.94E-20 FGFR1, FGFR2, FGFR3 ADRB2, GNA11, ADCY6, MAPK10, GNAQ, FRS2, RPS6KB1, PIK3R3, RAF1, PIK3C2B, IGF1R, TGFBR2, PIK3R2, JUN, GSK3B, AKT1, IL6R, GNA12, IRS1, GAB1, PIK3R1, GNAI2, PIK3CA, PTPN11, GATA4, GRB2, CREBBP, MAPK8, MEF2D, MAP3K3, CACNA1D, MAPK3, IRS2, ADRB3, ATM, MYL12A, EP300, MAP3K14, MEF2C, SOS1, PLCG2, PIK3CG, SRF, RPS6KA1, MAPK1, PLCG1, PRKACA, HRAS NKX2-5, MYL6B, PRKAG1, CALML5, CACNA1S, RHOQ, IL6, EIF2B1, EIF2B2, PLCL1, MAP3K7, RND2
Systemic Lupus Erythematosus Signaling 1.26E-19 FGFR1, LCK, LYN, FGFR2, FGFR3 CD72, HNRNPC, CD22, FCER1G, FRS2, CD80, SNRPA, LAT, CD79A, CD86, CD3E, PIK3R3, IL1B, PIK3C2B, LSM1, FCGR2A, CD28, PIK3R2, HLA-B, JUN, AKT1, IL6R, IRS1, GAB1, PIK3R1, CD40, CBL, CREM, INPP5D, PIK3CA, PTPN11, TNF, GRB2, PTPN6, MAPK3, IRS2, ATM, CD79B, PIM2, NFATC1, SOS1, AKT2, PLCG2, PIK3CG, NFATC3, FCGR2B, HLA-A, MAPK1, PLCG1, PTPRC, HNRNPA2B1, HRAS, CD247, SNRPB C7, IL6, SNRPA1
Melanocyte Development and Pigmentation Signaling 2.00E-19 FGFR2, FGFR1, FGFR3, SRC ADCY6, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, CREBBP, PTPN6, CRK, SH2B2, RPS6KB1, MAPK3, RPS6KB2, PIK3R3, IRS2, RPS6KA3, ATM, RAF1, EP300, KIT, PIK3C2B, SOS1, PLCG2, PIK3CG, SOX10, PIK3R2, RPS6KA1, MAPK1, PLCG1, PRKACA, HRAS, SHC1 MITF, PRKAG1
Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 2.51E-19 JUN, MAPK10, SMAD4, NFKBIA, IKBKG, FYN, SMAD3, GRB2, CD80, MAPK8, LAT, ZAP70, MAPK3, CD3E, NFKB1, CHUK, SMAD2, RAF1, IKBKB, NFATC1, VAV1, SOS1, RELA, PLCG2, NFKB2, NFATC3, TGFBR2, CD28, MAPK1, PLCG1, HRAS, CD247, RAC1, IKBKE CALML5
Apoptosis Signaling 3.98E-19 BIRC2, APAF1, TNFRSF1A, PRKCQ, NFKBIA, TP53, IKBKG, TNF, MAPK8, CASP7, MAPK3, PRKCE, NFKB1, FASLG, CHUK, HTRA2, RAF1, MAP3K14, CASP9, IKBKB, RELA, PLCG2, CASP6, NFKB2, PARP1, PRKCA, RPS6KA1, MAPK1, PLCG1, CASP3, BCL2L1, FAS, HRAS, CDK1, IKBKE, SPTAN1 MCL1, CAPN2
Neuropathic Pain Signaling In Dorsal Horn Neurons 5.01E-19 FGFR2, FGFR1, NTRK2, FGFR3, SRC CAMK2B, PRKCQ, IRS1, GAB1, PIK3R1, GRIA3, PIK3CA, PTPN11, FRS2, GRB2, GRM7, ITPR1, PRKCH, PRKCI, PRKCZ, BDNF, MAPK3, PRKCE, PIK3R3, IRS2, ATM, PIK3C2B, PLCG2, PIK3CG, GRIN2B, PRKCD, GRIN2A, PRKCA, PIK3R2, MAPK1, PLCG1, PRKD1, PRKACA GRIN1, PLCL1, GRIA1, CAMK1D, PRKAG1
IL-9 Signaling 5.01E-19 FGFR2, FGFR1, FGFR3 JAK3, IRS1, GAB1, PIK3R1, IL2RG, STAT3, PIK3CA, STAT1, PTPN11, TNF, FRS2, STAT5A, GRB2, NFKB1, PIK3R3, IRS2, ATM, JAK1, PIK3C2B, RELA, PIK3CG, NFKB2, PIK3R2, STAT5B
Hepatic Cholestasis 7.94E-19 ADCY6, TNFRSF1A, MAPK10, PRKCQ, PPARA, IL13, NR5A2, NFKBIA, TLR4, IKBKG, RXRA, PRKCH, ESR1, TRAF6, PRKCE, IL1B, INSR, IKBKB, NFKB2, PRKCD, HNF1A, HNF4A, IKBKE, JUN, TRAF2, RARA, TNF, NR1H3, MAPK8, PRKCI, PRKCZ, SLC4A2, IRAK1, NFKB1, CHUK, SREBF1, NR1H4, LTA, MAP3K14, IL4, RELA, PRKCA, NGFR, PRKD1, PRKACA, NR1I2 IL1RL1, PRKAG1, IL6, MAP3K7, GCG
Human Embryonic Stem Cell Pluripotency 7.94E-19 FGFR2, FGFR1, NTRK2, FGFR3, PDGFRB, PDGFRA GSK3B, PDGFD, AKT1, FGF4, IRS1, PDGFB, SPHK1, GAB1, SMAD4, PIK3R1, APC, SMAD7, PIK3CA, PTPN11, FRS2, SMAD3, GRB2, NTF4, BDNF, FOXO1, S1PR1, PIK3R3, IRS2, CTNNB1, SMAD2, ATM, NTF3, PIK3C2B, FGF2, AKT2, PDGFC, PIK3CG, BMPR2, TGFBR2, PDPK1, PIK3R2, SMAD1, HNF1A, PDGFA WNT6, WNT3, WNT7B
Remodeling of Epithelial Adherens Junctions 7.94E-19 TUBA8, TUBB3, TUBG1, TUBB1, TUBA1C, TUBB2A, TUBA1A, SRC, TUBB4B, TUBB4A, TUBA4A IQGAP1, VCL, MAPRE1, HGS, DNM1, CTNND1, APC, ZYX, DNM1L, CLIP1, ACTG1, ACTB, MET, CDH1, ACTN4, CTNNB1, TUBB, ACTN1, DNM2, TUBA1B TUBA3E
G Beta Gamma Signaling 1.26E-18 SRC CDC42, GNA11, AKT1, PRKCQ, GNA12, GNAQ, GNAI2, GRB2, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, CAV3, EGFR, PAK1, RAF1, BTK, SOS1, AKT2, PLCG2, PIK3CG, PRKCD, CAV1, PDPK1, CAV2, PRKCA, DNM2, MAPK1, PLCG1, PRKD1, PRKACA, HRAS, SHC1 PRKAG1
GP6 Signaling Pathway 1.58E-18 FGFR2, FGFR1, FGFR3, LYN GSK3B, AKT1, PRKCQ, IRS1, FCER1G, GAB1, PIK3R1, LCP2, SYK, FYN, PIK3CA, PTPN11, FRS2, GRB2, ITPR1, ITGB3, PRKCH, LAT, PRKCI, PRKCZ, LAMA4, PRKCE, PIK3R3, IRS2, TLN1, ATM, BTK, PIK3C2B, PTK2, AKT2, COL18A1, PLCG2, PIK3CG, PRKCD, PDPK1, GP6, PRKCA, PIK3R2, PRKD1, RAC1 CALML5
Acute Phase Response Signaling 2.51E-18 SOCS5, TNFRSF1A, NFKBIA, IKBKG, STAT3, RIPK1, TRAF6, PIK3R3, JAK2, IL1B, HNRNPK, RAF1, IKBKB, NFKB2, PIK3R2, NR3C1, HNF1A, SOCS6, TTR, IKBKE, JUN, TRAF2, TF, AKT1, IL6R, PIK3R1, SOCS7, FN1, PIK3CA, PTPN11, TNF, GRB2, MAPK8, MAPK3, IRAK1, NFKB1, CHUK, MAP3K14, SOS1, AKT2, RELA, PIK3CG, PDPK1, NGFR, CEBPB, MAPK1, SOCS1, HRAS, SHC1 IL6, ALB, MAP3K7
Sphingosine-1-phosphate Signaling 2.51E-18 FGFR2, FGFR1, FGFR3, PDGFRB, PDGFRA PDGFD, AKT1, ADCY6, GNA12, IRS1, PDGFB, SPHK1, GAB1, PIK3R1, GNAQ, GNAI2, PIK3CA, PTPN11, FRS2, GRB2, CASP7, MAPK3, S1PR1, PIK3R3, IRS2, ATM, CASP9, PIK3C2B, PTK2, AKT2, PDGFC, PLCG2, CASP6, PIK3CG, PIK3R2, PTK2B, MAPK1, PLCG1, CASP3, PDGFA, RAC1 RHOQ, PLCL1, RND2
Sirtuin Signaling Pathway 2.51E-18 TUBA1C, TUBA1A, TUBA4A, FOXO3, TUBA8, SP1 MYCN, PPARA, ESRRA, STAT3, TOMM20, NOS3, APP, MAP1LC3A, MAPK6, BECN1, NFKB2, MYC, TUBA1B, TP73, NDUFS6, JUN, GSK3B, VDAC1, AKT1, TIMM17A, NDRG1, E2F1, SMARCA5, SF3A1, TP53, GABPA, MAPK15, ARNTL, TNF, XRCC5, NR1H3, PPID, CDH1, PRKDC, FOXO1, SIRT1, MAPK3, NFKB1, SREBF1, NR1H4, TOMM34, GABARAP, NR1H2, SIRT2, WRN, RELA, SLC25A6, PARP1, TRIM28, NEDD4, NOS2, HIF1A, ACLY, MAPK1, EPAS1, RARB, TOMM40 HSF1, TOMM7, CPS1, TUBA3E, NDUFV2
SAPK/JNK Signaling 2.51E-18 FGFR2, FGFR1, LCK, FGFR3 JUN, TRAF2, CDC42, MAPK10, GNA12, IRS1, FCER1G, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, GRB2, CRK, MAPK8, RIPK1, MAP3K3, PIK3R3, IRS2, CRKL, HNRNPK, ATM, MAP4K1, PIK3C2B, MAPK8IP3, NFATC1, SOS1, SH2D2A, PIK3CG, NFATC3, PIK3R2, HRAS, RAC1, SHC1 MAP3K7
CNTF Signaling 3.16E-18 FGFR2, FGFR1, FGFR3 AKT1, IRS1, GAB1, PIK3R1, STAT3, PIK3CA, STAT1, PTPN11, FRS2, GRB2, RPS6KB1, MAPK3, RPS6KB2, PIK3R3, IRS2, JAK2, RPS6KA3, ATM, RAF1, JAK1, PIK3C2B, TYK2, SOS1, PIK3CG, PIK3R2, RPS6KA1, MAPK1, HRAS
Role of JAK2 in Hormone-like Cytokine Signaling 3.98E-18 IRS2, SOCS5, JAK2, JAK1, IRS1, HLTF, TYK2, SH2B1, EPOR, PTPN1, SOCS7, SH2B3, STAT3, STAT1, PTPN11, STAT5A, SOCS1, PTPN6, SOCS6, STAT5B, SH2B2, SHC1 SIRPA
Mouse Embryonic Stem Cell Pluripotency 5.01E-18 FGFR2, FGFR1, FGFR3 GSK3B, AKT1, JAK3, IRS1, GAB1, SMAD4, PIK3R1, TP53, APC, STAT3, PIK3CA, PTPN11, FRS2, GRB2, CREBBP, DVL3, MAPK3, PIK3R3, IRS2, JAK2, CTNNB1, ATM, RAF1, JAK1, PIK3C2B, TYK2, SOS1, AKT2, PIK3CG, BMPR2, MYC, PIK3R2, SMAD1, HNF1A, MAPK1, HRAS MAP3K7
Sumoylation Pathway 5.01E-18 SP1 JUN, RNF4, PML, MAPK10, SMAD4, PIAS1, NFKBIA, SUMO1, TP53, PCNA, SUMO4, SNCA, CREBBP, STUB1, CDH1, MAPK8, SUMO2, HDAC1, SIRT1, NFKB1, HDAC2, FASLG, RCC1, EP300, SENP6, NFKB2, AR, UBE2I, NR3C1, CTBP2, SP3, MDM2, ETS1, FAS RHOQ, RAN, RND2
Amyotrophic Lateral Sclerosis Signaling 5.01E-18 FGFR2, FGFR1, FGFR3 BIRC2, RNF19A, APAF1, PGF, IRS1, GAB1, PIK3R1, TP53, GRIA3, NOS1, PIK3CA, PTPN11, FRS2, GRB2, VEGFB, VEGFC, CACNA1D, CASP7, PIK3R3, IRS2, VEGFA, ATM, PAK1, CASP9, PIK3C2B, PDGFC, PIK3CG, GRIN2B, GRIN2A, PIK3R2, CASP3, BCL2L1, RAC1 CACNA1S, GRIN1, CAPN2, GRIA1
G-Protein Coupled Receptor Signaling 7.94E-18 FGFR1, SRC, FGFR2, FGFR3 CAMK2B, ADRB2, GNA11, ADCY6, PDE6G, NFKBIA, IKBKG, GNAQ, STAT3, FRS2, S1PR1, PRKCE, PIK3R3, RAF1, IKBKB, PIK3C2B, SYNGAP1, NFKB2, PIK3R2, PTK2B, IKBKE, TDP2, AKT1, PDE4A, IRS1, GAB1, PIK3R1, RGS16, GNAI2, FYN, PIK3CA, PTPN11, PDE4D, GRB2, GRM7, CREBBP, MAPK3, NFKB1, IRS2, CHUK, RAPGEF4, ADRB3, ATM, EP300, SOS1, AKT2, RELA, PIK3CG, PDPK1, PRKCA, RPS6KA1, MAPK1, RASA1, PRKACA, HRAS, SHC1 GLP1R, DRD3, PRKAG1, RAPGEF3, GRK4, CHRM3, RGS4
fMLP Signaling in Neutrophils 1.00E-17 FGFR2, FGFR1, FGFR3 CDC42, PRKCQ, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, WAS, GNAI2, PIK3CA, PTPN11, FRS2, GRB2, ITPR1, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, NFKB1, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, NFATC1, RELA, PIK3CG, NFKB2, NFATC3, PRKCD, PRKCA, PIK3R2, MAPK1, PRKD1, HRAS, RAC1 CALML5
3-phosphoinositide Biosynthesis 1.26E-17 FGFR1, LCK, PDGFRA, FGFR2, FGFR3, PDGFRB, PDCD1 PPP1R8, PPP2R5A, FRS2, ERBB2, CD80, PTPRF, CD86, EGFR, PIK3R3, KIT, PIK3C2B, PAWR, VAV1, PI4KA, PTPN1, CD28, ACP1, PTPN12, PIK3R2, TRAT1, ERBB3, PPP1CC, NUDT3, PTPN22, IRS1, GAB1, PIK3R1, CDC25C, TPTE, PTPRH, WBP11, FYN, DUSP23, PIK3CA, PTPN11, GRB2, CD19, MET, PTPN6, IRS2, ATM, PTPN2, PTPRJ, PIK3CG, CA3, RASA1, PTPRC OCRL, SIRPA
Protein Kinase A Signaling 1.26E-17 CAMK2B, ADCY6, PRKCQ, PDE6G, SMAD4, YWHAE, NFKBIA, IKBKG, PTPN18, GNAQ, SMAD3, PTPN21, ITPR1, PTPRF, PTPRA, NOS3, PRKCH, PTPRS, PRKCE, YWHAG, CTNNB1, FLNA, RAF1, PTK2, ADD3, PTPN1, NFKB2, TGFBR2, PRKCD, ACP1, PTPN12, PTK2B, MYLK, HNF1A, YWHAZ, GSK3B, PPP1CC, TDP2, YWHAQ, PDE4A, PTPN22, YWHAH, CDC25C, PTPRH, GNAI2, CREM, PTPN11, PDE4D, CREBBP, PTPN6, PRKCI, PRKCZ, YWHAB, MAPK3, NFKB1, CHUK, MYL12A, EP300, PTPN2, PXN, NFATC1, PTPRJ, RELA, PLCG2, NFATC3, PRKCA, NGFR, PTPRE, MAPK1, PLCG1, PRKD1, PTPRC, PRKACA ADD1, PTPRT, MYL6B, CDC26, PRKAG1, CALML5, SIRPA, PLCL1, PYGL, PLN
ERK5 Signaling 1.58E-17 SRC, FOXO3 YWHAQ, AKT1, GNA12, GAB1, YWHAE, YWHAH, GNAQ, PTPN11, CREBBP, MEF2D, PRKCZ, YWHAB, MAP3K3, RPS6KB1, RPS6KB2, EGFR, YWHAG, RPS6KA3, EP300, WNK1, MEF2C, SH2D2A, MYC, SGK1, RPS6KA1, YWHAZ, HRAS, FOSL1 ELK4
Phagosome Formation 1.58E-17 FGFR2, FGFR1, FGFR3 TLR1, PRKCQ, IRS1, INPPL1, FCER1G, GAB1, PIK3R1, TLR4, SYK, FN1, INPP5D, PIK3CA, PTPN11, ITGB1, FRS2, GRB2, PRKCH, PRKCI, PRKCZ, TLR2, PRKCE, PIK3R3, IRS2, ATM, PIK3C2B, FCGR2A, PLCG2, PIK3CG, FCAR, PRKCD, FCGR2B, PRKCA, PIK3R2, PLCG1, PRKD1, ITGA5 ITGAM, RHOQ, PLCL1, RND2
Role of p14/p19ARF in Tumor Suppression 2.51E-17 FGFR2, FGFR1, CDKN2A, TTF1, FGFR3 E2F1, IRS1, GAB1, PIK3R1, SF3A1, TP53, PIK3CA, PTPN11, FRS2, NPM3, GRB2, PIK3R3, IRS2, ATM, PIK3C2B, PIK3CG, PIK3R2, MDM2, RB1, RAC1
Superpathway of Inositol Phosphate Compounds 2.51E-17 FGFR1, LCK, PDGFRA, FGFR2, FGFR3, PDGFRB, PDCD1 PPP1R8, IP6K2, INPPL1, PPP2R5A, FRS2, ERBB2, CD80, PTPRF, CD86, EGFR, PIK3R3, KIT, PIK3C2B, PAWR, VAV1, PI4KA, PTPN1, CD28, ACP1, PTPN12, PIK3R2, TRAT1, ERBB3, PPP1CC, NUDT3, PTPN22, IRS1, GAB1, PIK3R1, CDC25C, TPTE, PTPRH, WBP11, FYN, INPP5D, DUSP23, PIK3CA, PTPN11, GRB2, CD19, MET, PTPN6, IRS2, ATM, PTPN2, PTPRJ, PLCG2, PIK3CG, CA3, PLCG1, RASA1, PTPRC OCRL, SIRPA
Wnt/_-catenin Signaling 2.51E-17 CDKN2A, SRC SOX8, CSNK2A2, TLE1, NR5A2, CSNK1D, GNAQ, PPP2R5A, LRP1, DVL3, HDAC1, CTNNB1, NLK, CDH5, PPARD, SOX10, BMPR2, MYC, TGFBR2, CCND1, UBB, HNF1A, RARG, GJA1, JUN, GSK3B, AKT1, RARA, TP53, APC, CREBBP, CDH1, UBC, CSNK2B, MAP4K1, EP300, BTRC, AKT2, CD44, RUVBL2, MDM2, CSNK2A1, RARB PPP2CB, WNT6, ACVR1B, MAP3K7, WNT3, WNT7B, APC2
IL-17 Signaling 2.51E-17 FGFR2, FGFR1, FGFR3 JUN, GSK3B, AKT1, MAPK10, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, MAPK3, TRAF6, NFKB1, PIK3R3, IRS2, JAK2, ATM, MAP3K14, JAK1, PIK3C2B, AKT2, RELA, PIK3CG, NOS2, PIK3R2, CEBPB, MAPK1, HRAS IL6, MAP3K7
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 2.51E-17 FGFR2, FGFR1, FGFR3 EIF2AK2, TLR1, MAPK10, PRKCQ, IRS1, IL13, GAB1, PIK3R1, TLR4, SYK, PIK3CA, PTPN11, TNF, FRS2, GRB2, PRKCH, MAPK8, PRKCI, PRKCZ, TLR2, MAPK3, TRAF6, PRKCE, NFKB1, PIK3R3, IRS2, IL1B, IRF3, ATM, LTA, IL4, PIK3C2B, RELA, PLCG2, PIK3CG, NFKB2, PRKCD, PRKCA, PIK3R2, MAPK1, PRKD1 IL6
HMGB1 Signaling 3.98E-17 FGFR2, FGFR1, FGFR3, SP1 JUN, KAT2B, CDC42, AKT1, TNFRSF1A, MAPK10, IRS1, IL13, GAB1, PIK3R1, TLR4, PIK3CA, PTPN11, TNF, FRS2, GRB2, MAPK8, MAPK3, NFKB1, PIK3R3, IRS2, IL1B, ATM, LTA, IL4, PIK3C2B, AKT2, RELA, PIK3CG, KAT6A, NFKB2, NGFR, PIK3R2, MAPK1, HRAS, RAC1 RHOQ, IL6, HMGB1, RND2
UVA-Induced MAPK Signaling 3.98E-17 FGFR2, FGFR1, FGFR3 JUN, MAPK10, IRS1, GAB1, PIK3R1, TP53, PIK3CA, STAT1, PTPN11, FRS2, GRB2, MAPK8, RPS6KB1, MAPK3, RPS6KB2, EGFR, PIK3R3, IRS2, RPS6KA3, ATM, CASP9, PIK3C2B, PLCG2, PIK3CG, PARP1, PRKCA, PIK3R2, RPS6KA1, MAPK1, PLCG1, CASP3, BCL2L1, HRAS PLCL1, PARP4, PARP3
Signaling by Rho Family GTPases 6.31E-17 FGFR1, FGFR2, FGFR3 IQGAP1, CDC42, GNA11, MAPK10, PLD1, GNAQ, WAS, ACTG1, ACTB, FRS2, PIK3R3, RAF1, EZR, PIK3C2B, WASL, PTK2, CDH5, PI4KA, NFKB2, PIK3R2, PTK2B, MYLK, ITGA5, JUN, GNA12, IRS1, GAB1, PIK3R1, GNAI2, CFL1, CLIP1, ARHGEF7, PIK3CA, PTPN11, ITGB1, GRB2, CDH1, MAPK8, PRKCI, PRKCZ, MAPK3, PAK2, NFKB1, IRS2, ATM, PAK1, MYL12A, GFAP, RELA, PIK3CG, NEDD4, ARFIP2, MAPK1, PAK4, RAC1 DES, MYL6B, RHOQ, RND2
Docosahexaenoic Acid (DHA) Signaling 7.94E-17 FGFR2, FGFR1, FGFR3 GSK3B, APAF1, AKT1, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, FOXO1, PIK3R3, IRS2, IL1B, ATM, CASP9, PIK3C2B, APP, AKT2, PIK3CG, PDPK1, PIK3R2, CASP3, BCL2L1
Ceramide Signaling 1.00E-16 FGFR2, FGFR1, FGFR3 JUN, AKT1, TNFRSF1A, IRS1, SPHK1, GAB1, PIK3R1, PPP2R5A, PIK3CA, PTPN11, TNF, FRS2, SPHK2, GRB2, MAPK8, PRKCZ, MAPK3, S1PR1, NFKB1, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, AKT2, RELA, PIK3CG, NFKB2, NGFR, PIK3R2, HRAS PPP2CB, ENPP7
Role of PI3K/AKT Signaling in the Pathogenesis of Influenza 1.26E-16 FGFR2, FGFR1, FGFR3 GSK3B, AKT1, IRS1, GAB1, PIK3R1, NFKBIA, IFNAR1, IKBKG, CCR5, GNAI2, PIK3CA, PTPN11, FRS2, GRB2, CRK, MAPK3, NFKB1, PIK3R3, IRS2, CRKL, IRF3, ATM, CASP9, PIK3C2B, AKT2, RELA, PIK3CG, NFKB2, PIK3R2, MAPK1
Ephrin A Signaling 7.94E-16 FGFR2, FGFR1, FGFR3 CDC42, EPHA3, IRS1, EFNA5, GAB1, PIK3R1, FYN, CFL1, PIK3CA, PTPN11, FRS2, GRB2, PIK3R3, IRS2, ATM, PAK1, PIK3C2B, PTK2, VAV1, EPHA4, PIK3CG, NGFR, PIK3R2, BCAR1, RAC1
NRF2-mediated Oxidative Stress Response 1.00E-15 FGFR1, FGFR2, FGFR3 SQSTM1, PRKCQ, UBE2E3, ACTG1, ACTB, FRS2, PRKCH, PRKCE, PIK3R3, RAF1, PIK3C2B, PRKCD, DNAJA3, PIK3R2, UBB, VCP, JUN, GSK3B, AKT1, IRS1, GAB1, PIK3R1, STIP1, FKBP5, PIK3CA, PTPN11, GRB2, CREBBP, MAPK8, PRKCI, PRKCZ, MAPK3, IRS2, ATM, EP300, PIK3CG, PRKCA, MAPK1, PRKD1, HRAS, EIF2AK3, FOSL1, DNAJC7 SCARB1, AOX1, FMO1, GSTA2, MAP3K7
Hepatic Fibrosis / Hepatic Stellate Cell Activation 1.26E-15 FGFR1, FLT1, KDR, PDGFRA, IL4R, FGFR2, PDGFRB, FLT4 MMP2, TNFRSF1A, SMAD4, IFNAR1, TLR4, SMAD3, VEGFC, EGFR, IL1B, VEGFA, SMAD2, FGF2, PDGFC, NFKB2, IGF1R, TGFBR2, FAS, FGF1, PDGFD, PGF, IL6R, PDGFB, CD40, CCR5, FN1, SMAD7, STAT1, TNF, MET, VEGFB, NFKB1, FASLG, KLF6, IL4, COL18A1, RELA, NGFR, PDGFA CCR7, IL1RL1, MYL6B, IL6
Aldosterone Signaling in Epithelial Cells 1.26E-15 FGFR2, FGFR1, HSP90AA1, FGFR3, HSP90B1, HSP90AB1 HSPA13, PRKCQ, HSPD1, NR3C2, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, HSPA8, FRS2, GRB2, ITPR1, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, SOS1, PI4KA, PLCG2, PIK3CG, HSPA9, PRKCD, HSPA4, NEDD4, PDPK1, PRKCA, SGK1, PIK3R2, MAPK1, PLCG1, PRKD1, HSPH1, DNAJC7 PLCL1
EIF2 Signaling 1.58E-15 FGFR1, FGFR2, FGFR3 EIF2AK2, MYCN, RPLP1, ATF3, RPL8, ACTB, FRS2, ATF5, PIK3R3, VEGFA, RAF1, RPS7, INSR, PIK3C2B, IGF1R, EIF1AY, MYC, PIK3R2, CCND1, PPP1R15A, EIF3F, GSK3B, PPP1CC, AKT1, IRS1, GAB1, PIK3R1, EIF2AK1, PIK3CA, PTPN11, GRB2, RPS3A, MAPK3, IRS2, SREBF1, ATM, SOS1, AKT2, RPS3, PIK3CG, PDPK1, MAPK1, HRAS, EIF2AK3, SHC1, RPL10 RPL19, EIF4G2, HNRNPA1, EIF3H, RPS20, EIF2B1, EIF2B2
Cyclins and Cell Cycle Regulation 1.58E-15 CDKN2A GSK3B, E2F1, E2F3, TP53, PPP2R5A, E2F2, SKP1, ATR, CDKN1A, CDK6, HDAC1, CCNA1, HDAC2, CDK4, CCND2, CDK7, CDKN2C, ATM, RAF1, CDK2, BTRC, HDAC3, ABL1, HDAC6, CDKN1B, CCND1, CCNA2, RB1, CDK1 PPP2CB, CDKN2B
Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency 1.58E-15 FGFR2, FGFR1, FGFR3 GSK3B, AKT1, JAK3, IRS1, GAB1, SMAD4, PIK3R1, TP53, APC, STAT3, PIK3CA, PTPN11, FRS2, GATA4, GRB2, MAPK3, PIK3R3, IRS2, JAK2, CTNNB1, ATM, RAF1, JAK1, PIK3C2B, TYK2, SOS1, AKT2, PIK3CG, BMPR2, PIK3R2, SMAD1, MAPK1, HRAS, SHC1 WNT6, WNT3, WNT7B
Cholecystokinin/Gastrin-mediated Signaling 2.00E-15 SRC JUN, MAPK10, PRKCQ, GNA12, GNAQ, CREM, TNF, GRB2, ITPR1, PRKCH, MAPK8, PRKCI, MEF2D, PRKCZ, MAPK3, PRKCE, EGFR, IL1B, RAF1, PXN, PTK2, EPHA4, MEF2C, SOS1, PRKCD, SRF, PRKCA, PTK2B, BCAR1, MAPK1, PRKD1, HRAS, SHC1 RHOQ, RND2
Adipogenesis pathway 2.00E-15 FGFR2, FGFR1, FGFR3 KAT2B, FGF1, PAXIP1, AKT1, TNFRSF1A, RUNX1T1, KMT2B, TP53, ARNTL, TNF, SMAD3, RBBP4, FOXO1, HDAC1, SIRT1, RPS6KB1, HDAC2, SREBF1, CDK7, CTNNB1, SAP18, FGF2, CDK5, SIRT2, HDAC3, NR2F2, KAT6A, BMPR2, EZH2, HDAC6, SLC2A4, CTBP2, SMAD1, HIF1A, CEBPB, RPS6KA1, STAT5B, RB1 LPIN1
TNFR1 Signaling 3.16E-15 JUN, BIRC2, TRAF2, CDC42, APAF1, TNFRSF1A, NFKBIA, IKBKG, TNF, MAPK8, RIPK1, CASP7, PAK2, NFKB1, CHUK, PAK1, MAP3K14, CASP9, IKBKB, RELA, CASP6, NFKB2, CASP3, PAK4, IKBKE
Glioma Invasiveness Signaling 1.00E-14 FGFR2, FGFR1, FGFR3 ITGAV, MMP2, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, ITGB3, MAPK3, HMMR, PIK3R3, IRS2, ATM, PIK3C2B, PTK2, CD44, PIK3CG, PIK3R2, TIMP3, MAPK1, HRAS RHOQ, PLAUR, RND2
Androgen Signaling 1.00E-14 HSP90AA1, SRC JUN, KAT2B, TBP, GNA11, PRKCQ, GNA12, GNAQ, GNAI2, SMAD3, CREBBP, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, NFKB1, CDK7, POLR2E, EP300, RELA, NFKB2, AR, PRKCD, HSPA4, PRKCA, CCND1, MAPK1, PRKD1, POLR2G, PRKACA, SHC1 CALML5, PRKAG1
Pyridoxal 5'-phosphate Salvage Pathway 1.00E-14 EIF2AK2, DMPK, TTK, PRKCQ, CSNK1D, PRKCH, MAPK8, CDK6, MAPK3, PRKCE, IRAK1, PAK2, CDK4, CDK7, PAK1, CDK2, CDK5, AKT2, MAPK6, PRKCD, SGK1, PIM1, MAPK1, ARAF, CDK1, PLK1 GRK4, CDK8
Induction of Apoptosis by HIV1 1.26E-14 BIRC2, TRAF2, APAF1, TNFRSF1A, MAPK10, NFKBIA, TP53, IKBKG, TNF, TRAF1, MAPK8, RIPK1, NFKB1, FASLG, CHUK, HTRA2, MAP3K14, CASP9, IKBKB, RELA, NFKB2, SLC25A6, NGFR, CASP3, BCL2L1, FAS, IKBKE
Calcium-induced T Lymphocyte Apoptosis 1.58E-14 HLA-DQA1, LCK PRKCQ, FCER1G, CD4, ITPR1, PRKCH, PRKCI, MEF2D, PRKCZ, HDAC1, ZAP70, PRKCE, CD3E, HDAC2, NR4A1, EP300, PRKCD, HLA-A, PRKCA, PLCG1, PRKD1, HLA-B, CD247 CALML5, CAPN2, HLA-DQB1
Xenobiotic Metabolism Signaling 2.00E-14 FGFR1, HSP90B1, FGFR2, HSP90AA1, FGFR3, HSP90AB1 NCOR2, CAMK2B, PRKCQ, PPP2R5A, FRS2, RXRA, ARNT, PRKCH, PRKCE, PIK3R3, IL1B, RAF1, PIK3C2B, NFKB2, NR1I3, PRKCD, AHR, PIK3R2, PTGES3, IRS1, GAB1, PIK3R1, SUMO1, PIK3CA, SNW1, PTPN11, TNF, GRB2, CREBBP, MAPK8, PRKCI, PRKCZ, MAP3K3, MAPK3, NFKB1, AIP, IRS2, ATM, EP300, MAP3K14, RELA, PIK3CG, NOS2, PRKCA, MAPK1, PRKD1, HRAS, EIF2AK3, DNAJC7, CHST15, NR1I2 PPP2CB, CAMK1D, FMO1, GSTA2, IL6, MGMT, MAP3K7
Corticotropin Releasing Hormone Signaling 2.00E-14 JUN, ADCY6, GUCY1B3, PRKCQ, GNAQ, GNAI2, NOS1, CREBBP, ITPR1, NOS3, PRKCH, PRKCI, MEF2D, PRKCZ, BDNF, MAPK3, PRKCE, FASLG, KRT1, VEGFA, NR4A1, RAF1, EP300, MEF2C, PLCG2, PRKCD, NOS2, PRKCA, MAPK1, PLCG1, PRKD1, GUCY2C, PRKACA CRH, CALML5, PRKAG1
iNOS Signaling 2.51E-14 JUN, HMGA1, IRAK1, NFKB1, CHUK, JAK2, JAK3, JAK1, IKBKB, TYK2, NFKBIA, RELA, TLR4, IKBKG, NFKB2, NOS2, STAT1, MAPK1, CREBBP, TRAF6, IKBKE CALML5
TR/RXR Activation 3.16E-14 FGFR2, FGFR1, FGFR3 NCOR2, AKT1, THRA, IRS1, GAB1, PIK3R1, SREBF2, PIK3CA, PTPN11, NCOA6, FRS2, GRB2, RXRA, NCOR1, ENO1, PIK3R3, IRS2, SREBF1, ATM, EP300, RXRB, PIK3C2B, HDAC3, AKT2, PIK3CG, PIK3R2, HIF1A, MDM2, ACACA, THRB SCARB1
Relaxin Signaling 3.98E-14 FGFR2, FGFR1, FGFR3 JUN, TDP2, GNA11, AKT1, PDE4A, ADCY6, GUCY1B3, PDE6G, GNA12, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, GNAQ, GNAI2, PIK3CA, PTPN11, FRS2, PDE4D, GRB2, NOS3, PRKCZ, MAPK3, NFKB1, PIK3R3, IRS2, VEGFA, ATM, PIK3C2B, AKT2, RELA, PIK3CG, NFKB2, NOS2, PIK3R2, MAPK1, GUCY2C, PRKACA PRKAG1
CCR3 Signaling in Eosinophils 1.00E-13 FGFR2, FGFR1, FGFR3 PRKCQ, IRS1, GAB1, PIK3R1, GNAI2, CFL1, PIK3CA, PTPN11, FRS2, GRB2, ITPR1, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, PAK2, PIK3R3, IRS2, ATM, PAK1, RAF1, PIK3C2B, PIK3CG, PRKCD, PRKCA, PIK3R2, MYLK, MAPK1, PRKD1, PAK4, HRAS, RAC1 CALML5
Regulation of eIF4 and p70S6K Signaling 1.58E-13 FGFR2, FGFR1, FGFR3 AKT1, IRS1, GAB1, PIK3R1, PPP2R5A, PIK3CA, PTPN11, ITGB1, FRS2, GRB2, RPS3A, PRKCZ, RPS6KB1, MAPK3, PIK3R3, IRS2, ATM, RAF1, RPS7, PIK3C2B, SOS1, AKT2, RPS3, PIK3CG, EIF1AY, PDPK1, PIK3R2, MKNK1, MAPK1, HRAS, EIF3F, ITGA5, SHC1 RPS20, PPP2CB, EIF2B1, EIF2B2, EIF4EBP1, EIF4G2, EIF3H
Regulation of Cellular Mechanics by Calpain Protease 1.58E-13 SRC VCL, ITGB1, GRB2, CDK6, ACTN4, MAPK3, CCNA1, EGFR, CDK4, TLN1, EZR, CDK2, PXN, ACTN1, PTK2, CDKN1B, CCND1, MAPK1, CCNA2, RB1, HRAS, ITGA5, CDK1 CAPN2
Protein Ubiquitination Pathway 1.58E-13 HSP90B1, HSP90AA1, HSP90AB1, BAP1 BIRC2, HSPA13, UBE2E3, USP28, USP7, USP21, UCHL5, STUB1, UBE2A, TRAF6, AMFR, PSME1, VHL, USP15, UBB, PSMC5, SUGT1, HLA-B, HSPH1, USP19, UBE4B, USP54, HSPD1, CBL, PSMD11, USP8, HSPA8, SKP1, USP26, USP4, UBC, BRCA1, UBE2O, UCHL1, PSMC3, BAG1, UBE2N, BTRC, USP50, UBE2D3, UBE3A, HSPA9, USP39, HSPA4, NEDD4, HLA-A, UBE2L6, UBE2I, USP2, MDM2, DNAJC7 USP13, PSMD13
Role of PKR in Interferon Induction and Antiviral Response 3.16E-13 EIF2AK2, TRAF2, NFKB1, CHUK, APAF1, AKT1, TNFRSF1A, CASP9, IKBKB, NFKBIA, TRAF3, TP53, RELA, IKBKG, NFKB2, STAT1, TNF, CASP3, TRAF6, IKBKE MAP3K7
Agrin Interactions at Neuromuscular Junction 5.01E-13 SRC JUN, CDC42, MAPK10, GABPA, ARHGEF7, ACTG1, ACTB, ITGB1, ERBB2, ITGB3, MAPK8, MAPK3, PAK2, EGFR, CTTN, PAK1, PXN, PTK2, MAPK1, PAK4, ERBB3, DAG1, HRAS, ITGA5, RAC1 NRG1
Role of IL-17A in Arthritis 5.01E-13 FGFR2, FGFR1, FGFR3 MAPK10, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, MAPK3, NFKB1, PIK3R3, IRS2, ATM, PIK3C2B, RELA, PIK3CG, NFKB2, NOS2, PIK3R2, RPS6KA1, MAPK1
TWEAK Signaling 1.00E-12 BIRC2, TRAF2, NFKB1, CHUK, APAF1, MAP3K14, CASP9, IKBKB, NFKBIA, TRAF3, RELA, CASP6, IKBKG, NFKB2, CASP3, TRAF1, RIPK1, CASP7, IKBKE
IL-15 Production 1.26E-12 NFKB1, JAK2, PTK6, IRF3, JAK3, MST1R, JAK1, TYK2, PTK2, TXK, RELA, NFKB2, STAT1, PTK2B, PRKCI, PRKCZ IL6
MSP-RON Signaling Pathway 1.58E-12 FGFR2, FGFR1, FGFR3 MST1R, IRS1, GAB1, PIK3R1, TLR4, ACTG1, PIK3CA, PTPN11, TNF, ACTB, FRS2, GRB2, PRKCZ, TLR2, PIK3R3, IRS2, JAK2, CSF2RB, ATM, PIK3C2B, PIK3CG, NOS2, PIK3R2 ITGAM
CCR5 Signaling in Macrophages 3.98E-12 JUN, MAPK10, PRKCQ, FCER1G, CCR5, GNAI2, CD4, PRKCH, MAPK8, PRKCI, PRKCZ, PRKCE, CD3E, FASLG, PLCG2, PRKCD, PRKCA, PTK2B, MAPK1, PLCG1, PRKD1, FAS, CD247 CALML5
IL-10 Signaling 3.98E-12 SP1, IL4R JUN, NFKBIA, IKBKG, CCR5, STAT3, TNF, MAPK8, TRAF6, NFKB1, CHUK, IL1B, MAP3K14, JAK1, IKBKB, TYK2, FCGR2A, RELA, NFKB2, FCGR2B, MAPK1, IKBKE IL1RL1, IL6, MAP3K7
Leptin Signaling in Obesity 5.01E-12 FGFR2, FGFR1, FGFR3 AKT1, ADCY6, IRS1, GAB1, PIK3R1, STAT3, PIK3CA, PTPN11, FRS2, GRB2, FOXO1, MAPK3, PIK3R3, IRS2, JAK2, ATM, PIK3C2B, AKT2, PLCG2, PIK3CG, PIK3R2, MAPK1, PLCG1, PRKACA PLCL1, PRKAG1
Hypoxia Signaling in the Cardiovascular System 5.01E-12 HSP90AA1, HSP90B1, HSP90AB1 JUN, AKT1, UBE2E3, NFKBIA, SUMO1, TP53, IKBKG, CSNK1D, CREBBP, ARNT, NOS3, UBE2A, UBE2O, VEGFA, ATM, EP300, UBE2N, UBE2D3, VHL, UBE2L6, SLC2A4, UBE2I, HIF1A, MDM2
TREM1 Signaling 5.01E-12 AKT1, TLR1, CD40, TLR4, STAT3, TNF, ITGB1, STAT5A, GRB2, TLR2, CD86, MAPK3, IRAK1, NFKB1, JAK2, IL1B, AKT2, RELA, PLCG2, NFKB2, FCGR2B, MAPK1, PLCG1, STAT5B, ITGA5 IL1RL1, IL6
Estrogen-mediated S-phase Entry 5.01E-12 CCNA1, CDK4, CDK2, E2F1, E2F3, MYC, CDKN1B, CCND1, E2F2, CDKN1A, ESR2, RBL1, CCNA2, RB1, ESR1, CDK1
TNFR2 Signaling 6.31E-12 JUN, BIRC2, TRAF2, NFKB1, CHUK, LTA, MAP3K14, IKBKB, NFKBIA, TBK1, RELA, IKBKG, NFKB2, TNF, TRAF1, MAPK8, IKBKE
Death Receptor Signaling 7.94E-12 BIRC2, TRAF2, APAF1, TNFRSF1A, NFKBIA, TBK1, IKBKG, ACTG1, TNF, ACTB, MAPK8, RIPK1, CASP7, NFKB1, FASLG, CHUK, HTRA2, MAP3K14, CASP9, IKBKB, RELA, CASP6, NFKB2, PARP1, CASP3, FAS, IKBKE, SPTAN1 PARP4, PARP3
Caveolar-mediated Endocytosis Signaling 7.94E-12 SRC ITGAV, CD48, FYN, ACTG1, ACTB, ITGB1, ITGB3, EGFR, FLNA, INSR, PTPN1, ABL1, CAV1, HLA-A, PRKCA, COPA, DNM2, COPB1, CD55, HLA-B, ITGA5, ITGB4 ITGAM, ALB
Cell Cycle Control of Chromosomal Replication 7.94E-12 POLE POLA1, RPA2, CDK4, CDK7, CDK2, MCM2, LIG1, CDK5, PCNA, ORC4, CDC7, POLA2, CDC45, CDT1, MCM6, CDK6, CDC6, MCM5, CDK1 CDK14, CDK20, CDK8
Antiproliferative Role of Somatostatin Receptor 2 7.94E-12 FGFR2, FGFR1, FGFR3, SRC GUCY1B3, IRS1, GAB1, PIK3R1, NOS1, PIK3CA, PTPN11, FRS2, CDKN1A, GRB2, PTPN6, MAPK3, PIK3R3, IRS2, ATM, PIK3C2B, PIK3CG, PIK3R2, CDKN1B, MAPK1, GUCY2C, HRAS
UVC-Induced MAPK Signaling 1.00E-11 SRC JUN, PRKCE, EGFR, MAPK10, PRKCQ, RAF1, TP53, PRKCD, PRKCA, ATR, MAPK1, PRKD1, ARAF, PRKCH, MAPK8, PRKCI, PRKCZ, HRAS, MAPK3
April Mediated Signaling 1.26E-11 JUN, TRAF2, NFKB1, CHUK, MAPK10, MAP3K14, IKBKB, NFATC1, NFKBIA, TRAF3, RELA, IKBKG, NFKB2, NFATC3, MAPK1, TRAF1, MAPK8, TRAF6, IKBKE
VDR/RXR Activation 1.58E-11 WT1, SP1 NCOR2, PRKCQ, KLF4, CDKN1A, RXRA, NCOR1, PRKCH, PRKCI, PRKCZ, FOXO1, PRKCE, EP300, RXRB, PPARD, PRKCD, PRKCA, CDKN1B, CEBPB, PSMC5, YY1, PRKD1, VDR, PDGFA, CSNK2A1 IL1RL1
Nur77 Signaling in T Lymphocytes 2.51E-11 HLA-DQA1 CD3E, HDAC2, APAF1, NR4A1, EP300, CASP9, FCER1G, NFATC1, CD28, HLA-A, CD80, RXRA, CASP3, HLA-B, MEF2D, CD247, HDAC1, CD86, MAP3K3 HLA-DQB1, CALML5
Synaptic Long Term Potentiation 3.16E-11 CAMK2B, PPP1CC, GNA11, PRKCQ, GNAQ, GRIA3, GRM7, CREBBP, ITPR1, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, RAF1, EP300, PLCG2, GRIN2B, PRKCD, GRIN2A, PRKCA, RPS6KA1, MAPK1, PLCG1, PRKD1, PRKACA, HRAS CALML5, GRIN1, RAPGEF3, PLCL1, GRIA1, PRKAG1
B Cell Activating Factor Signaling 3.98E-11 JUN, TRAF2, NFKB1, CHUK, MAPK10, MAP3K14, IKBKB, NFATC1, NFKBIA, TRAF3, RELA, IKBKG, NFKB2, NFATC3, MAPK1, TRAF1, MAPK8, TRAF6, IKBKE
Synaptic Long Term Depression 3.98E-11 LYN PAFAH1B1, GNA11, GUCY1B3, PRKCQ, GNA12, PLA2G7, GNAQ, GRIA3, GNAI2, PPP2R5A, NOS1, GRM7, ITPR1, NOS3, PRKCH, PRKCI, PAFAH1B3, PRKCZ, MAPK3, PRKCE, RAF1, PLCG2, IGF1R, PRKCD, NOS2, PRKCA, MAPK1, PLCG1, PRKD1, GUCY2C, HRAS CRH, PNPLA3, PPP2CB, PNPLA8, PLCL1, GRIA1
Role of JAK family kinases in IL-6-type Cytokine Signaling 3.98E-11 JAK2, MAPK10, IL6R, JAK1, TYK2, STAT3, STAT1, PTPN11, STAT5A, MAPK1, SOCS1, MAPK8, STAT5B, MAPK3 IL6
Toll-like Receptor Signaling 5.01E-11 JUN, EIF2AK2, TLR1, PPARA, NFKBIA, TLR4, IKBKG, TNF, TOLLIP, TRAF1, MAPK8, TLR2, UBC, TRAF6, IRAK1, NFKB1, CHUK, IL1B, MAP3K14, IKBKB, RELA, NFKB2, UBB, MAPK1 IL1RL1, MAP3K7
Oncostatin M Signaling 1.00E-10 JAK2, RAF1, JAK3, JAK1, TYK2, SOS1, STAT3, STAT1, STAT5A, TIMP3, GRB2, MAPK1, EPAS1, STAT5B, HRAS, SHC1, MAPK3
Activation of IRF by Cytosolic Pattern Recognition Receptors 1.35E-10 JUN, NFKB1, CHUK, IRF3, MAPK10, LTA, IKBKB, CD40, NFKBIA, TRAF3, IFNAR1, TBK1, RELA, IKBKG, NFKB2, STAT1, TNF, CREBBP, MAPK8, RIPK1, TRAF6, IKBKE IL6
Estrogen Receptor Signaling 1.45E-10 SRC NCOR2, KAT2B, TBP, PELP1, SMARCA4, PGR, RBFOX2, TAF4, GRB2, CREBBP, ESR2, NCOR1, DDX5, CARM1, PRKDC, ESR1, MAPK3, CDK7, POLR2E, RAF1, EP300, HDAC3, SOS1, SPEN, NR3C1, CTBP2, MAPK1, POLR2G, HRAS, SHC1, MED15 TAF3, CDK8
Role of BRCA1 in DNA Damage Response 1.70E-10 POU2F1, FANCC, E2F1, SMARCA4, BARD1, E2F3, SMARCC1, TP53, SMARCB1, TOPBP1, STAT1, ACTB, E2F2, ATR, CDKN1A, RBL1, BRCA1, ATM, HLTF, SMARCE1, SMARCC2, FANCA, RB1, ARID1A, PLK1, CHEK1
TGF-_ Signaling 2.51E-10 JUN, CDC42, SMAD4, SMAD7, SMAD3, GRB2, CREBBP, MAPK8, HDAC1, MAPK3, TRAF6, SMAD2, RAF1, MAP4K1, EP300, SOS1, BMPR2, TGFBR2, SMAD1, MAPK1, VDR, HNF4A, HRAS NKX2-5, AMHR2, MAP3K7, ACVR1B
4-1BB Signaling in T Lymphocytes 3.31E-10 JUN, TRAF2, NFKB1, CHUK, MAPK10, MAP3K14, IKBKB, NFKBIA, RELA, IKBKG, NFKB2, MAPK1, TRAF1, MAPK8, MAPK3, IKBKE
Cdc42 Signaling 4.37E-10 HLA-DQA1, SRC JUN, GSK3B, IQGAP1, CDC42, MAPK10, FCER1G, APC, WAS, CFL1, CLIP1, ITGB1, ITK, MAPK8, PRKCI, PRKCZ, CD3E, PAK2, PAK1, RAF1, MYL12A, WASL, VAV1, HLA-A, MYLK, MAPK1, RASA1, HLA-B, PAK4, CD247, ITGA5, TNK2 EXOC4, HLA-DQA2, HLA-DPB1, HLA-DQB1, MYL6B, APC2
Salvage Pathways of Pyrimidine Ribonucleotides 4.47E-10 EIF2AK2, DMPK, TTK, PRKCQ, CSNK1D, PRKCH, MAPK8, CDK6, MAPK3, PRKCE, IRAK1, PAK2, CDK4, CDK7, PAK1, CDK2, CDK5, AKT2, MAPK6, PRKCD, SGK1, PIM1, MAPK1, ARAF, CDK1, PLK1 GRK4, CDK8
Melatonin Signaling 4.79E-10 PRKCE, CAMK2B, PRKCQ, RAF1, PLCG2, GNAQ, GNAI2, PRKCD, PRKCA, SLC2A4, MAPK1, PLCG1, PRKD1, ARAF, PRKCH, PRKCI, PRKACA, PRKCZ, RORB, MAPK3 CALML5, PRKAG1, PLCL1
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 5.89E-10 HLA-DQA1 TLR1, FCER1G, CD40, TLR4, TNF, CD80, CD79A, TLR2, CD86, NFKB1, FASLG, CHUK, IL1B, CD79B, LTA, MAP3K14, IL4, TRAF3, RELA, NFKB2, CD28, HLA-A, HLA-B, FAS IL6, HLA-DQB1
Ephrin B Signaling 6.61E-10 EFNB2, CDC42, EFNB1, GNA11, CTNNB1, HNRNPK, PAK1, GNA12, PXN, EPHB2, PTK2, CBL, VAV1, GNAQ, GNAI2, CFL1, ACP1, NCK2, MAPK1, HRAS, RAC1, MAPK3 ITSN2
T Helper Cell Differentiation 6.61E-10 HLA-DQA1, IL4R TNFRSF1A, IL6R, IL4, IL13, FCER1G, CD40, IL2RG, GATA3, BCL6, STAT3, TGFBR2, CD28, HLA-A, NGFR, STAT1, TNF, STAT6, CD80, HLA-B, CD86 HLA-DQB1, IL6
Factors Promoting Cardiogenesis in Vertebrates 1.02E-09 GSK3B, PRKCQ, SMAD4, APC, GATA4, LRP1, PRKCH, PRKCI, PRKCZ, CDC6, PRKCE, CTNNB1, SMAD2, CDK2, MEF2C, BMPR2, TGFBR2, PRKCD, PRKCA, SMAD1, HNF1A, PRKD1 NKX2-5, NPPA, MAP3K7, WNT3, ACVR1B
Inhibition of Angiogenesis by TSP1 1.05E-09 KDR JUN, AKT1, VEGFA, GUCY1B3, MAPK10, THBS1, TP53, AKT2, CD36, TGFBR2, FYN, MAPK1, CASP3, NOS3, MAPK8
CD27 Signaling in Lymphocytes 1.10E-09 JUN, TRAF2, NFKB1, SIVA1, CHUK, APAF1, MAPK10, MAP3K14, CASP9, IKBKB, NFKBIA, RELA, IKBKG, NFKB2, CASP3, BCL2L1, MAPK8, MAP3K3, IKBKE MAP3K7
Semaphorin Signaling in Neurons 1.10E-09 PAK2, PAK1, ARHGAP1, CRMP1, CDK5, PTK2, FYN, CFL1, ITGB1, NRP1, MET, MAPK1, PAK4, FES, RAC1, MAPK3 RHOQ, DPYSL2, PLXNA1, RND2
Cancer Drug Resistance By Drug Efflux 1.66E-09 FOXO3 NFKB1, PIK3R3, AKT1, RAF1, PIK3R1, TP53, AKT2, PIK3CG, FOXG1, PIK3CA, PIK3R2, MAPK1, MDM2, ARAF, HRAS, FOXO1, MAPK3 YBX1
IL-17A Signaling in Fibroblasts 1.78E-09 JUN, GSK3B, NFKB1, CHUK, IKBKB, NFKBIA, RELA, IKBKG, NFKB2, CEBPB, MAPK1, MAPK3, TRAF6, IKBKE MAP3K7, IL6
Thyroid Cancer Signaling 2.24E-09 NTRK2 CTNNB1, RET, NTF3, RXRB, TP53, MYC, CCND1, HNF1A, RXRA, MAPK1, CDH1, NTF4, HRAS, BDNF, SHC1, MAPK3
Antioxidant Action of Vitamin C 2.45E-09 PAFAH1B1, CSF2RA, MAPK10, PLA2G7, PLD1, NFKBIA, IKBKG, TNF, STAT5A, MAPK8, PAFAH1B3, MAPK3, NFKB1, CHUK, JAK2, CSF2RB, IKBKB, RELA, PLCG2, NFKB2, SLC2A4, PLD2, MAPK1, PLCG1, STAT5B, IKBKE PNPLA3, PNPLA8, PLCL1
Role of JAK1_ JAK2 and TYK2 in Interferon Signaling 4.37E-09 NFKB1, JAK2, RAF1, PTPN2, JAK1, TYK2, IFNAR1, RELA, NFKB2, STAT3, STAT1, SOCS1, PTPN6
ATM Signaling 4.68E-09 JUN, PPP1CC, CBX5, MAPK10, USP7, NFKBIA, TP53, CDC25C, TOPBP1, PPP2R5A, ATR, CDKN1A, CREBBP, MAPK8, BRCA1, ATM, EP300, KAT5, CDK2, ABL1, TRIM28, TP73, RAD17, MDM2, CDK1, CHEK1 PPP2CB
HIPPO signaling 6.76E-09 PPP1CC, YWHAQ, SMAD4, YWHAE, AJUBA, YWHAH, CSNK1D, PPP2R5A, SMAD3, SKP1, PRKCZ, YWHAB, YWHAG, DLG1, SMAD2, BTRC, CD44, DLG4, FAT4, RASSF1, SMAD1, YWHAZ PPP2CB, LATS2, SAV1
Crosstalk between Dendritic Cells and Natural Killer Cells 1.12E-08 CAMK2B, IL2RB, CD40, IL2RG, TLR4, ACTG1, TNF, ACTB, CD80, CD86, NFKB1, FASLG, TLN1, CSF2RB, LTA, IL4, RELA, NFKB2, CD28, HLA-A, HLA-B, FAS CCR7, IL6
Dopamine-DARPP32 Feedback in cAMP Signaling 1.17E-08 PPP1CC, ADCY6, GUCY1B3, PRKCQ, CSNK1D, GNAQ, GNAI2, CREM, PPP2R5A, NOS1, CREBBP, ITPR1, PRKCH, PRKCI, PRKCZ, CACNA1D, PRKCE, EP300, CDK5, PAWR, PLCG2, GRIN2B, PRKCD, GRIN2A, PRKCA, PLCG1, PRKD1, PRKACA CALML5, CACNA1S, GRIN1, PPP2CB, PLCL1, DRD3, PRKAG1
IL-1 Signaling 2.34E-08 JUN, GNA11, ADCY6, MAPK10, GNA12, NFKBIA, IKBKG, GNAQ, GNAI2, TOLLIP, MAPK8, TRAF6, IRAK1, NFKB1, CHUK, MAP3K14, IKBKB, RELA, NFKB2, MAPK1, PRKACA, IKBKE MAP3K7, PRKAG1
Amyloid Processing 2.51E-08 PRKCE, GSK3B, AKT1, CSNK2B, CSNK2A2, APP, CDK5, AKT2, CSNK1D, CDK5R1, MAPK1, MAPT, PRKACA, BACE1, CSNK2A1, MAPK3 PRKAG1, CAPN2
Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency 2.75E-08 BRCA1, PPP1R8, RARA, FGF4, RXRB, TDRD7, NR5A2, TP53, NR2F2, ETS2, CASP6, PARP1, NR2F1, BMI1, RB1, NR5A1 PHB
GADD45 Signaling 2.75E-08 BRCA1, CDK4, CCND2, CCND1, ATM, ATR, CDK2, CDKN1A, TP53, PCNA, CDK1
_-Adrenergic Signaling 3.24E-08 PRKCE, ADCY6, PRKCQ, RAF1, PLCG2, GNAQ, GNAI2, PRKCD, PRKCA, MAPK1, PLCG1, ITPR1, PRKD1, PRKCH, PRKCI, PRKACA, PRKCZ, HRAS, MAPK3 PYGL, CALML5, PRKAG1
Sperm Motility 3.31E-08 PAFAH1B1, PDE4A, GUCY1B3, PRKCQ, MST1R, PLA2G7, PDE4D, ITPR1, PRKCH, PRKCI, PAFAH1B3, PRKCZ, PRKCE, PTK6, PTK2, TXK, PLCG2, PRKCD, PRKCA, PTK2B, PLCG1, PRKD1, PRKACA CALML5, PNPLA3, PNPLA8, PLCL1, NPPA, PRKAG1
BMP signaling pathway 4.68E-08 JUN, NFKB1, MAPK10, RAF1, MAGED1, SMAD4, SOS1, RELA, NFKB2, BMPR2, SMAD7, SMAD1, GRB2, MAPK1, CREBBP, MAPK8, PRKACA, HRAS, MAPK3 MAP3K7, NKX2-5, PRKAG1
IL-22 Signaling 5.62E-08 STAT3, AKT1, STAT1, MAPK10, STAT5A, MAPK1, JAK1, MAPK8, STAT5B, TYK2, AKT2, MAPK3
Chemokine Signaling 6.17E-08 SRC JUN, CAMK2B, RAF1, PTK2, PLCG2, PIK3CG, CCR5, GNAQ, GNAI2, CFL1, PRKCA, PTK2B, MAPK1, PLCG1, MAPK8, HRAS, MAPK3 CALML5, CAMK1D
Role of RIG1-like Receptors in Antiviral Innate Immunity 9.33E-08 TRAF2, NFKB1, CHUK, IRF3, EP300, IKBKB, NFKBIA, TRAF3, TBK1, RELA, IKBKG, NFKB2, CREBBP, RIPK1, TRAF6, IKBKE
B Cell Development 1.48E-07 HLA-DQA1 CD79B, CD40, HLA-A, IL7R, CD19, CD80, HLA-B, PTPRC, CD79A, CD86 HLA-DQB1, IGHD, IL7
LXR/RXR Activation 1.51E-07 NCOR2, TF, TNFRSF1A, TLR4, TNF, NR1H3, RXRA, NCOR1, NFKB1, S100A8, SREBF1, IL1B, IRF3, NR1H4, RXRB, NR1H2, RELA, NFKB2, CD36, APOB, NOS2, NGFR, ACACA, TTR IL1RL1, IL6, ALB, PLTP
Antiproliferative Role of TOB in T Cell Signaling 1.74E-07 CCNA1, TGFBR2, CDKN1B, SMAD2, SMAD3, SKP1, CDK2, RPS6KA1, MAPK1, CCNA2, SMAD4, RB1
nNOS Signaling in Neurons 2.69E-07 PRKCE, PRKCQ, GRIN2B, PRKCD, DLG4, NOS1, GRIN2A, PRKCA, PRKD1, PRKCH, PRKCI, PRKCZ CALML5, GRIN1, CAPN2
RhoGDI Signaling 2.88E-07 SRC CDC42, GNA11, GNA12, GNAQ, GNAI2, CFL1, ARHGEF7, ACTG1, ACTB, ITGB1, CREBBP, ESR2, DGKZ, CDH1, ESR1, PAK2, PAK1, EZR, MYL12A, EP300, ARHGAP35, ARHGAP1, WASL, CD44, CDH5, PI4KA, PRKCA, PAK4, ITGA5, RAC1 RHOQ, MYL6B, RND2
Cytotoxic T Lymphocyte-mediated Apoptosis of Target Cells 3.31E-07 CD3E, FASLG, APAF1, CASP9, FCER1G, CASP6, GZMB, HLA-A, CASP3, HLA-B, FAS, CD247, CASP7
Primary Immunodeficiency Signaling 3.72E-07 LCK CD3E, JAK3, BTK, CD40, IL2RG, IKBKG, CD8A, IL7R, CD19, CD4, PTPRC, CD79A, ZAP70 IGHD, RFX5
p38 MAPK Signaling 4.57E-07 TRAF2, TNFRSF1A, MAX, TP53, STAT1, TNF, CREBBP, MAPT, MEF2D, RPS6KB1, TRAF6, RPS6KB2, IRAK1, FASLG, IL1B, RPS6KA3, MAP4K1, EP300, MEF2C, MYC, TGFBR2, SRF, MKNK1, RPS6KA1, FAS IL1RL1, MAP3K7
Tight Junction Signaling 6.31E-07 JUN, CDC42, VCL, AKT1, TJP1, TNFRSF1A, EPB41, PPP2R5A, ACTG1, TNF, ACTB, PRKCI, PRKCZ, NUDT21, NFKB1, CDK4, CTNNB1, TIAM1, AKT2, RELA, NFKB2, TGFBR2, NGFR, MYLK, NAPG, PRKACA, RAC1, SPTAN1 PPP2CB, HSF1, MYL6B, GPAA1, PRKAG1
Role of CHK Proteins in Cell Cycle Checkpoint Control 9.77E-07 BRCA1, ATM, CDK2, E2F1, E2F3, TP53, PCNA, CDC25C, PPP2R5A, E2F2, ATR, CDKN1A, RAD17, CDK1, PLK1, CHEK1 PPP2CB
FXR/RXR Activation 1.26E-06 TF, AKT1, RARA, MAPK10, PPARA, NR5A2, TNF, NR1H3, RXRA, CREBBP, MAPK8, FOXO1, SLC4A2, SREBF1, IL1B, NR1H4, AKT2, APOB, HNF1A, HNF4A, SLC51A, MTTP, TTR, NR1I2 SCARB1, ALB, PLTP
CDK5 Signaling 1.74E-06 NTRK2 PPP1CC, ADCY6, MAPK10, RAF1, EGR1, CDK5, MAPK6, MAPK15, ABL1, CDK5R1, PPP2R5A, NGFR, ITGB1, MAPK1, MAPT, MAPK8, PRKACA, HRAS, BDNF, MAPK3 PPP2CB, PRKAG1
GPCR-Mediated Nutrient Sensing in Enteroendocrine Cells 2.09E-06 PRKCE, GNA11, RAPGEF4, ADCY6, PRKCQ, PLCG2, GNAQ, GNAI2, PRKCD, PRKCA, GIP, PLCG1, ITPR1, PRKD1, PRKCH, PRKCI, PRKACA, PRKCZ GCG, PRKAG1, PLCL1
Graft-versus-Host Disease Signaling 2.19E-06 HLA-DQA1 FASLG, IL1B, FCER1G, GZMB, CD28, HLA-A, TNF, CD80, HLA-B, FAS, CD86 HLA-DQB1, IL6
MIF Regulation of Innate Immunity 2.75E-06 JUN, NFKB1, CD74, MAPK10, NFKBIA, TP53, RELA, TLR4, IKBKG, NFKB2, NOS2, MAPK1, MAPK8, MAPK3
Unfolded protein response 2.88E-06 HSP90B1 TRAF2, SREBF1, AMFR, SREBF2, HSPA9, HSPA4, HSPA8, CEBPB, PPP1R15A, HSPH1, MAPK8, VCP, ERN1, EIF2AK3
DNA damage-induced 14-3-3_ Signaling 4.79E-06 BRCA1, AKT1, ATM, ATR, CDK2, RAD17, TP53, AKT2, CDK1
OX40 Signaling Pathway 5.50E-06 HLA-DQA1 JUN, CD3E, TRAF2, NFKB1, MAPK10, FCER1G, NFKBIA, TRAF3, RELA, IKBKG, NFKB2, HLA-A, CD4, HLA-B, BCL2L1, MAPK8, CD247 HLA-DPB1, HLA-DQA2, HLA-DQB1
PXR/RXR Activation 7.08E-06 FOXO3 AKT1, INSR, PPARA, AKT2, RELA, NR1I3, TNF, NR3C1, RXRA, HNF4A, PRKACA, FOXO1, NR1I2 GSTA2, IL6, PRKAG1
Mechanisms of Viral Exit from Host Cells 8.71E-06 PRKCE, SH3GL2, PRKCQ, PRKCD, NEDD4, ACTG1, PRKCA, ACTB, PRKD1, PRKCH, PRKCI, PRKCZ, PDCD6IP
Autoimmune Thyroid Disease Signaling 8.91E-06 HLA-DQA1 FASLG, IL4, FCER1G, CD40, GZMB, CD28, HLA-A, CD80, HLA-B, FAS, TG, CD86 HLA-DQB1
Parkinson's Signaling 0.00001 SNCA, UCHL1, CASP9, MAPK1, CASP3, MAPK8 PARK7
Phagosome Maturation 1.02E-05 TUBA8, TUBB3, TUBG2, TUBG1, TUBB1, TUBE1, TUBA1C, TUBB2A, TUBA1A, TUBB4B, TUBB4A, TUBA4A, TUBD1 CTSK, ATP6V0D1, NOS1, PRDX2, TUBB, HLA-A, DYNLT1, TUBA1B, NAPG, HLA-B, DYNLL1 TCIRG1, TUBA3E, GPAA1
Role of IL-17F in Allergic Inflammatory Airway Diseases 2.69E-05 NFKB1, IL1B, RPS6KA3, RAF1, EP300, RELA, NFKB2, RPS6KA1, MAPK1, CREBBP, MAPK3, TRAF6 IL6
Communication between Innate and Adaptive Immune Cells 3.24E-05 IL1B, TLR1, CD79B, IL4, FCER1G, CD40, TLR4, CD8A, CD28, HLA-A, TNF, CD80, CD4, HLA-B, CD79A, TLR2, CD86 CCR7, IGHD, IL6
Atherosclerosis Signaling 4.37E-05 ALOX12, NFKB1, S100A8, PDGFD, PAFAH1B1, IL1B, PDGFB, PLA2G7, CD40, COL18A1, PDGFC, RELA, NFKB2, CD36, APOB, TNF, ALOX12B, PAFAH1B3, PDGFA IL6, PNPLA3, PNPLA8, ALB
Tumoricidal Function of Hepatic Natural Killer Cells 4.79E-05 FASLG, APAF1, SERPINB9, CASP9, CASP3, FAS, CASP7, CASP6, GZMB
Calcium Signaling 6.46E-05 CAMK2B, GRIA3, CREBBP, ITPR1, MEF2D, TNNT1, HDAC1, MAPK3, TP63, HDAC2, ATP2B4, EP300, CHRNA7, TRPC6, HDAC3, NFATC1, MEF2C, GRIN2B, NFATC3, HDAC6, GRIN2A, MAPK1, PRKACA CALML5, GRIN1, GRIA1, MYL6B, CAMK1D, PRKAG1
IL-17A Signaling in Gastric Cells 6.92E-05 JUN, NFKB1, EGFR, TNF, MAPK10, MAPK1, MAPK8, MAPK3, RELA
Actin Nucleation by ARP-WASP Complex 7.76E-05 CDC42, GNA12, WASL, SOS1, WAS, ITGB1, NCK2, GRB2, HRAS, NCK1, ITGA5, RAC1 RHOQ, RND2
Cell Cycle Regulation by BTG Family Proteins 8.32E-05 BTG1, CDK4, PPP2R5A, CCND1, E2F2, CDK2, E2F1, RB1, E2F3 PPP2CB, PRMT1
3-phosphoinositide Degradation 9.33E-05 PDCD1 PPP1CC, NUDT3, PPP1R8, PTPN22, INPPL1, CDC25C, TPTE, PTPRH, WBP11, INPP5D, DUSP23, PPP2R5A, PTPN11, PTPRF, PTPN6, PTPN2, PAWR, PTPRJ, PTPN1, ACP1, PTPN12, CA3, RASA1, PTPRC OCRL, SIRPA
Role of MAPK Signaling in the Pathogenesis of Influenza 0.000112 PAFAH1B1, AKT1, MAPK10, RAF1, PLA2G7, AKT2, PRKCA, TNF, MAPK1, CASP3, MAPK8, PAFAH1B3, HRAS, MAPK3 PNPLA3, PNPLA8
Endoplasmic Reticulum Stress Pathway 0.000112 HSP90B1 TRAF2, CASP9, CASP3, MAPK8, ERN1, EIF2AK3, CASP7
D-myo-inositol (1_4_5_6)-Tetrakisphosphate Biosynthesis 0.000129 PDCD1 PPP1CC, NUDT3, PPP1R8, PTPN22, CDC25C, TPTE, PTPRH, WBP11, DUSP23, PPP2R5A, PTPN11, PTPRF, PTPN6, PTPN2, PAWR, PTPRJ, PTPN1, ACP1, PTPN12, CA3, RASA1, PTPRC OCRL, SIRPA
D-myo-inositol (3_4_5_6)-tetrakisphosphate Biosynthesis 0.000129 PDCD1 PPP1CC, NUDT3, PPP1R8, PTPN22, CDC25C, TPTE, PTPRH, WBP11, DUSP23, PPP2R5A, PTPN11, PTPRF, PTPN6, PTPN2, PAWR, PTPRJ, PTPN1, ACP1, PTPN12, CA3, RASA1, PTPRC OCRL, SIRPA
GPCR-Mediated Integration of Enteroendocrine Signaling Exemplified by an L Cell 0.000135 GIPR ADRB2, GNA11, ADCY6, ADRB3, PLCG2, GNAQ, GNAI2, GIP, PLCG1, ITPR1, PRKACA GCG, GLP1R, PRKAG1, PLCL1
D-myo-inositol-5-phosphate Metabolism 0.000145 PDCD1 PPP1CC, NUDT3, PPP1R8, PTPN22, CDC25C, TPTE, PTPRH, WBP11, DUSP23, PPP2R5A, PTPN11, PTPRF, PTPN6, PTPN2, PAWR, PTPRJ, PTPN1, PLCG2, ACP1, PTPN12, CA3, PLCG1, RASA1, PTPRC OCRL, SIRPA
Regulation of Actin-based Motility by Rho 0.000182 PAK2, CDC42, PAK1, MYL12A, WASL, PI4KA, WAS, CFL1, ACTB, ITGB1, MYLK, PAK4, ITGA5, RAC1 MYL6B, RHOQ, GSN, RND2
MIF-mediated Glucocorticoid Regulation 0.000251 TLR4, IKBKG, NFKB2, NFKB1, CD74, NR3C1, MAPK1, NFKBIA, MAPK3, RELA
Wnt/Ca+ pathway 0.000295 GSK3B, NFKB1, PDE6G, EP300, NFATC1, RELA, PLCG2, NFKB2, NFATC3, PRKCA, CREBBP, PLCG1, DVL3 PLCL1
Cellular Effects of Sildenafil (Viagra) 0.000513 PDE4A, ADCY6, GUCY1B3, MYL12A, PLCG2, ACTG1, ACTB, PDE4D, MYLK, PLCG1, ITPR1, NOS3, GUCY2C, PRKACA, CACNA1D CALML5, CACNA1S, MYL6B, PRKAG1, PLCL1, NPPA
Cardiomyocyte Differentiation via BMP Receptors 0.00055 BMPR2, GATA4, SMAD4, MEF2C MAP3K7, NKX2-5, NPPA
G Protein Signaling Mediated by Tubby 0.000575 LCK ABL1, GNAQ, JAK2, TUB, INSR, PLCG1, PLCG2
Telomere Extension by Telomerase 0.000617 POT1, TERF1, TINF2, XRCC5, HNRNPA2B1 HNRNPA1
Allograft Rejection Signaling 0.000724 HLA-DQA1 FASLG, IL4, FCER1G, CD40, GZMB, CD28, HLA-A, TNF, CD80, HLA-B, FAS, CD86 HLA-DPB1, HLA-DQA2, HLA-DQB1
cAMP-mediated signaling 0.000851 SRC CAMK2B, ADRB2, TDP2, PDE4A, ADCY6, PDE6G, GNAI2, STAT3, CREM, PDE4D, GRM7, CREBBP, MAPK3, S1PR1, RAPGEF4, ADRB3, RAF1, EP300, RPS6KA1, MAPK1, PRKACA CALML5, GLP1R, RAPGEF3, DRD3, GRK4, CHRM3, CAMK1D, RGS4
Retinoic acid Mediated Apoptosis Signaling 0.000871 APAF1, RARA, CASP9, RXRB, IFNAR1, DAP3, PARP1, RXRA, CASP3, RARG, RARB PARP4, PARP3
Granzyme B Signaling 0.000912 PARP1, APAF1, CASP9, CASP3, PRKDC, GZMB
Circadian Rhythm Signaling 0.000933 CSNK1D, ARNTL, CRY2, GRIN2A, PER3, EP300, CREBBP, GRIN2B GRIN1
Polyamine Regulation in Colon Cancer 0.001047 MYC, OAZ1, CTNNB1, SAT1, PSME1, MAX, APC
Interferon Signaling 0.001445 JAK2, STAT1, PTPN2, JAK1, SOCS1, PIAS1, TYK2, IFNAR1, RELA
Airway Inflammation in Asthma 0.00182 TNF, IL4, IL13
G_i Signaling 0.002455 SRC ADCY6, RAF1, SOS1, GNAI2, STAT3, CAV1, GRB2, GRM7, MAPK1, PRKACA, HRAS, SHC1, MAPK3, S1PR1 PRKAG1, RGS4, DRD3
DNA Double-Strand Break Repair by Homologous Recombination 0.003236 ABL1, BRCA1, POLA1, ATM, LIG1
DNA Double-Strand Break Repair by Non-Homologous End Joining 0.003236 PARP1, ATM, XRCC5, PRKDC, WRN
RhoA Signaling 0.003548 LPAR2, NRP2, EZR, MYL12A, ARHGAP35, GNA12, ARHGAP1, PLD1, PTK2, PI4KA, IGF1R, NEDD4, CFL1, ACTG1, ACTB, PTK2B, MYLK MYL6B, PLXNA1
Citrulline-Nitric Oxide Cycle 0.004266 NOS2, NOS1, NOS3
dTMP De Novo Biosynthesis 0.004266 DHFR, TYMS SHMT2
Superpathway of Citrulline Metabolism 0.004467 NOS2, NOS1, NOS3 OAT, CPS1
LPS/IL-1 Mediated Inhibition of RXR Function 0.004467 JUN, TRAF2, RARA, TNFRSF1A, PPARA, NR5A2, TLR4, PPARGC1B, TNF, NR1H3, RXRA, MAPK8, TRAF6, IRAK1, SREBF1, IL1B, NR1H4, NR1H2, NR1I3, NGFR, CHST15, NR1I2 IL1RL1, FMO1, GSTA2, SCARB1, MGMT, MAP3K7, PLTP
Maturity Onset Diabetes of Young (MODY) Signaling 0.004467 INSR, HNF1A, GAPDH, HNF4A, CACNA1D CACNA1S
G_s Signaling 0.005129 SRC ADRB2, RAPGEF4, ADCY6, ADRB3, EP300, ADD3, MAPK1, CREBBP, PRKACA, MAPK3 ADD1, CHRM3, GLP1R, RAPGEF3, PRKAG1
Purine Nucleotides De Novo Biosynthesis II 0.007943 GART, ATIC PPAT GMPS
Hematopoiesis from Pluripotent Stem Cells 0.009772 CD3E, CD8A, IL4, CD4, FCER1G, CD247 IGHD, IL6, IL7
Neuroprotective Role of THOP1 in Alzheimer's Disease 0.01122 MME, NFYA, HTRA2, APP, YWHAE, GZMB, GZMK, HLA-A, GZMA, HLA-B, MAPT, PRKACA TMPRSS15, ENDOU, CTRL, PRKAG1
BER pathway 0.01122 POLE PARP1, LIG1, PCNA
NAD Biosynthesis from 2-amino-3-carboxymuconate Semialdehyde 0.013183 ABL1, NMNAT1 NADSYN1
Role of Wnt/GSK-3_ Signaling in the Pathogenesis of Influenza 0.016218 GSK3B, CSNK1D, CTNNB1, HNF1A, IFNAR1, DVL3, SIAH1, APC WNT3, WNT7B, WNT6, APC2
Inflammasome pathway 0.016596 TLR4, NFKB2, NFKB1, IL1B NEK7
5-aminoimidazole Ribonucleotide Biosynthesis I 0.017378 GART PPAT
Airway Pathology in Chronic Obstructive Pulmonary Disease 0.019953 MMP2, TNF CELA2A
Phospholipases 0.02138 PAFAH1B1, PLD2, PLCG1, PLA2G7, PAFAH1B3, PLD1, PLCG2 PNPLA3, PNPLA8, PLCL1
nNOS Signaling in Skeletal Muscle Cells 0.025119 NOS1, DAG1 CALML5
Antigen Presentation Pathway 0.026303 HLA-DQA1 HLA-A, CD74, HLA-B HLA-DPB1, HLA-DQA2, HLA-DQB1
Netrin Signaling 0.029512 NFATC3, NCK2, PRKACA, NFATC1, NCK1, RAC1 PRKAG1
Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I 0.0302 RRM2, RRM1, TYMS RRM2B DTYMK
Glutamate Receptor Signaling 0.031623 GRIA3, DLG4, GRIN2A, GRM7, GRIN2B GRIA1, CALML5, GRIN1
Mitotic Roles of Polo-Like Kinase 0.031623 HSP90B1, HSP90AB1, HSP90AA1 CDC7, PPP2R5A, CDC25C, CDK1, PLK1 CDC26, PPP2CB
Thymine Degradation 0.033113 DPYD, DPYSL2
Uracil Degradation II (Reductive) 0.033113 DPYD, DPYSL2
Embryonic Stem Cell Differentiation into Cardiac Lineages 0.038019 SP4, GATA4 NKX2-5
RAN Signaling 0.038905 RCC1, KPNA2, KPNB1 RAN
Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F 0.046774 IL1B, TNF, IL13 IL6
PCP pathway 0.046774 JUN, EFNB1, MAPK10, MAPK8, DVL3, RAC1 WNT3, WNT7B, WNT6
Glycolysis I 0.047863 TPI1, ENO2, PKM, GAPDH, ENO1
Basal Cell Carcinoma Signaling 0.052481 GSK3B, CTNNB1, HNF1A, TP53, DVL3, APC WNT3, WNT7B, WNT6, APC2
Granzyme A Signaling 0.066069 ANP32A, GZMA, EP300, CREBBP
Eicosanoid Signaling 0.075858 ALOX12, PTGDS, PAFAH1B1, PLA2G7, ALOX12B, PAFAH1B3 PNPLA3, ALOX5AP, PNPLA8
Assembly of RNA Polymerase III Complex 0.075858 GTF3C1, TBP, SF3A1
Acetyl-CoA Biosynthesis III (from Citrate) 0.077625 ACLY
Asparagine Biosynthesis I 0.077625 ASNS
Sorbitol Degradation I 0.077625 SORD
Sonic Hedgehog Signaling 0.081283 GSK3B, PRKACA, CDK1 PRKAG1
GABA Receptor Signaling 0.089125 ADCY6, UBB, GABARAP, SLC6A13, AP2M1, DNM1, UBC, GPHN, AP1B1
Assembly of RNA Polymerase II Complex 0.093325 TAF4, TBP, DR1, CDK7, POLR2E, POLR2G TAF3
Superpathway of Serine and Glycine Biosynthesis I 0.097724 PSPH SHMT2
NAD biosynthesis II (from tryptophan) 0.107399 ABL1, NMNAT1 NADSYN1
Sphingomyelin Metabolism 0.125026 SGMS1 ENPP7
Cardiac _-adrenergic Signaling 0.133045 PPP1CC, TDP2, PDE4A, ADCY6, PDE6G, PPP2R5A, PDE4D, PRKACA, CACNA1D CACNA1S, PLN, PPP2CB, PRKAG1
Lipid Antigen Presentation by CD1 0.141579 CD3E, FCER1G, AP2M1, AP1B1
Glycine Biosynthesis I 0.150314 SHMT2
Glycine Biosynthesis III 0.150314 AGXT
Spliceosomal Cycle 0.150314 U2AF2
Folate Transformations I 0.152757 MTR SHMT2
Prostanoid Biosynthesis 0.152757 PTGDS, PTGES3
Complement System 0.159588 CD59, CD46, CD55 ITGAM, C7
D-myo-inositol (1_4_5)-trisphosphate Degradation 0.162181 INPP5D, INPPL1 OCRL
Granulocyte Adhesion and Diapedesis 0.163305 MMP2, IL1B, TNFRSF1A, EZR, CSF3R, THY1, CDH5, GNAI2, NGFR, TNF, ITGB1, ITGB3, ITGA5, PECAM1, SDC3 ITGAM, IL1RL1, MMP17
Calcium Transport I 0.181552 ATP2B4, ANXA5
1D-myo-inositol Hexakisphosphate Biosynthesis II (Mammalian) 0.18239 INPP5D, INPPL1 OCRL
D-myo-inositol (1_3_4)-trisphosphate Biosynthesis 0.18239 INPP5D, INPPL1 OCRL
Mitochondrial Dysfunction 0.183654 VDAC1, MAPK10, HTRA2, CASP9, APP, SNCA, CASP3, NDUFS6, MAPK8, LRRK2, BACE1 PARK7, UQCR11, NDUFV2, ATP5G3
Inhibition of Matrix Metalloproteases 0.186638 MMP2, TIMP3, LRP1, ADAM12 MMP17
Assembly of RNA Polymerase I Complex 0.210863 TBP TAF1B
Biotin-carboxyl Carrier Protein Assembly 0.21677 ACACA
Diphthamide Biosynthesis 0.21677 EEF2
Inosine-5'-phosphate Biosynthesis II 0.21677 ATIC
Methionine Salvage II (Mammalian) 0.21677 MTR
N-acetylglucosamine Degradation I 0.21677 GNPDA1
NADH Repair 0.21677 GAPDH
Oxidized GTP and dGTP Detoxification 0.21677 RUVBL2
Tetrahydrobiopterin Biosynthesis I 0.21677 GCH1
Tetrahydrobiopterin Biosynthesis II 0.21677 GCH1
Phototransduction Pathway 0.232274 GUCY1B3, PDE6G, GUCY2C, PRKACA, ARR3 PRKAG1
Acyl-CoA Hydrolysis 0.240436 HNF4A, ACOT7
Hematopoiesis from Multipotent Stem Cells 0.240436 IL4 IL7
Methionine Degradation I (to Homocysteine) 0.244906 EHMT1 MGMT, PRMT1
Dopamine Receptor Signaling 0.253513 PPP1CC, GCH1, PPP2R5A, ADCY6, PRKACA PPP2CB, PRKAG1, DRD3
Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F 0.266686 IL1B, TNF, IL13
Choline Biosynthesis III 0.270396 PLD2, PLD1
DNA Methylation and Transcriptional Repression Signaling 0.274157 HDAC2, RBBP4, SAP18, HDAC1
Arginine Degradation I (Arginase Pathway) 0.277971 OAT
Geranylgeranyldiphosphate Biosynthesis 0.277971 FDPS
Glycerol-3-phosphate Shuttle 0.277971 GPD1
Molybdenum Cofactor Biosynthesis 0.277971 GPHN
N-acetylglucosamine Degradation II 0.277971 GNPDA1
Spermine and Spermidine Degradation I 0.277971 SAT1
Cysteine Biosynthesis III (mammalia) 0.289068 EHMT1 MGMT, PRMT1
Superpathway of D-myo-inositol (1_4_5)-trisphosphate Metabolism 0.289068 INPP5D, INPPL1 OCRL
Nucleotide Excision Repair Pathway 0.291743 RPA2, CDK7, POLR2E, POLR2G
Superpathway of Methionine Degradation 0.328095 MTR, EHMT1 MGMT, PRMT1
Gluconeogenesis I 0.33266 ENO2, GAPDH, ENO1
2-ketoglutarate Dehydrogenase Complex 0.334965 DLST
Folate Polyglutamylation 0.334965 SHMT2
Serine Biosynthesis 0.334965 PSPH
Tetrahydrofolate Salvage from 5_10-methenyltetrahydrofolate 0.334965 GART
Tetrapyrrole Biosynthesis II 0.334965 ALAD
Trans_ trans-farnesyl Diphosphate Biosynthesis 0.334965 FDPS
D-myo-inositol (1_4_5)-Trisphosphate Biosynthesis 0.354813 PLCG1, PI4KA, PLCG2
Extrinsic Prothrombin Activation Pathway 0.359749 PROS1, SERPINC1
Superpathway of Cholesterol Biosynthesis 0.376704 FDPS, MSMO1 MVD
Arginine Biosynthesis IV 0.386367 OAT
Arginine Degradation VI (Arginase 2 Pathway) 0.386367 OAT
Glycerol Degradation I 0.386367 GPD1
NAD Biosynthesis III 0.386367 NMNAT1
Proline Biosynthesis II (from Arginine) 0.386367 OAT
Urea Cycle 0.386367 CPS1
Zymosterol Biosynthesis 0.386367 MSMO1
Dermatan Sulfate Degradation (Metazoa) 0.38815 HEXDC IDUA
Superpathway of Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate) 0.38815 FDPS MVD
tRNA Splicing 0.400867 TDP2, PDE4A, PDE4D, PDE6G
Role of Cytokines in Mediating Communication between Immune Cells 0.416869 IL1B, TNF, IL4, IL13 IL6
Transcriptional Regulatory Network in Embryonic Stem Cells 0.416869 KAT6A, STAT3, GATA4, HNF4A PAX6
Agranulocyte Adhesion and Diapedesis 0.425598 MMP2, IL1B, TNFRSF1A, EZR, CDH5, GNAI2, FN1, ACTG1, TNF, ACTB, ITGB1, CXCR1, ITGA5, PECAM1 MYL6B, MMP17
Ceramide Biosynthesis 0.43451 SPTSSA
NAD Salvage Pathway III 0.43451 NMNAT1
Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza 0.437522 CCR5, IL1B, TNF IL6
Pyrimidine Ribonucleotides Interconversion 0.472063 CTPS2, ENTPD6, ANXA1 HNRNPA1
Inositol Pyrophosphates Biosynthesis 0.47863 IP6K2
Salvage Pathways of Pyrimidine Deoxyribonucleotides 0.47863 TK1
Pyrimidine Ribonucleotides De Novo Biosynthesis 0.506991 CTPS2, ENTPD6, ANXA1 HNRNPA1
Citrulline Biosynthesis 0.519996 OAT
Heme Biosynthesis II 0.519996 ALAD
Pathogenesis of Multiple Sclerosis 0.519996 CCR5
Sucrose Degradation V (Mammalian) 0.519996 TPI1
Coagulation System 0.5236 PROS1, PLAUR, SERPINC1
autophagy 0.539511 SQSTM1, CTSK, MAP1LC3A, BECN1 ULK1
Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza 0.547016 FDPS, IFNAR1
Glycine Betaine Degradation 0.557186 SHMT2
Notch Signaling 0.579429 NOTCH1, HEY2, NUMBL
Dolichyl-diphosphooligosaccharide Biosynthesis 0.591562 DPAGT1
UDP-N-acetyl-D-galactosamine Biosynthesis II 0.591562 GNPDA1
Cleavage and Polyadenylation of Pre-mRNA 0.623735 NUDT21
Glucocorticoid Biosynthesis 0.623735 CYP17A1
Pregnenolone Biosynthesis 0.623735 MICAL1
Androgen Biosynthesis 1 CYP17A1
Cholesterol Biosynthesis I 1 MSMO1
Cholesterol Biosynthesis II (via 24_25-dihydrolanosterol) 1 MSMO1
Cholesterol Biosynthesis III (via Desmosterol) 1 MSMO1
Chondroitin Sulfate Biosynthesis 1 CHST15
Chondroitin Sulfate Biosynthesis (Late Stages) 1 CHST15
Chondroitin Sulfate Degradation (Metazoa) 1 HEXDC
Dermatan Sulfate Biosynthesis 1 CHST15
Dermatan Sulfate Biosynthesis (Late Stages) 1 CHST15
Fatty Acid _-oxidation 1 ALOX12B
Glutaryl-CoA Degradation 1 PARK7
Glutathione-mediated Detoxification 1 GSTA2
Glycogen Degradation II 1 PYGL
Glycogen Degradation III 1 PYGL
Gustation Pathway 1 TDP2, PDE4A, ADCY6, PDE4D, PDE6G, P2RY2, ITPR1, PRKACA PRKAG1
Heparan Sulfate Biosynthesis 1 CHST15
Heparan Sulfate Biosynthesis (Late Stages) 1 CHST15
Histidine Degradation VI 1 MICAL1
Intrinsic Prothrombin Activation Pathway 1 COL18A1 PROS1, SERPINC1
Methylglyoxal Degradation III 1 AKR1B1
Mevalonate Pathway I 1 MVD
Mismatch Repair in Eukaryotes 1 PCNA
NAD Phosphorylation and Dephosphorylation 1 ACP1
NAD Salvage Pathway II 1 ACP1, NMNAT1
Nicotine Degradation II 1 FMO1, AOX1
Nicotine Degradation III 1 AOX1
Oleate Biosynthesis II (Animals) 1 PTPRT
Oxidative Phosphorylation 1 NDUFS6 UQCR11, NDUFV2, ATP5G3
Putrescine Degradation III 1 SAT1
Retinol Biosynthesis 1 PNPLA3
Role of IL-17A in Psoriasis 1 S100A8
Serotonin Receptor Signaling 1 GCH1, ADCY6
Stearate Biosynthesis I (Animals) 1 HNF4A, ACOT7
TCA Cycle II (Eukaryotic) 1 DLST
Triacylglycerol Biosynthesis 1 LPIN1
Triacylglycerol Degradation 1 PNPLA3
Tryptophan Degradation III (Eukaryotic) 1 PARK7
Ubiquinol-10 Biosynthesis (Eukaryotic) 1 MICAL1
Vitamin-C Transport 1 SLC2A4
tRNA Charging 1 NARS, EPRS
_-glutamyl Cycle 1 GGCT

 

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