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GZMB

Description granzyme B
Image
GO Annotations Cellular Component
  • Immunological Synapse
  • Extracellular Region
  • Nucleus
  • Cytoplasm
  • Mitochondrion
  • Cytosol
  • Membrane
  • Intracellular Membrane-bounded Organelle
Molecular Function
  • Serine-type Endopeptidase Activity
  • Protein Binding
  • Serine-type Peptidase Activity
Biological Process
  • Apoptotic Process
  • Negative Regulation Of Translation
  • Cytolysis
  • Natural Killer Cell Mediated Cytotoxicity
  • Proteolysis Involved In Cellular Protein Catabolic Process
  • Pyroptosis
  • Granzyme-mediated Programmed Cell Death Signaling Pathway
  • Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways
  • NOTCH2 intracellular domain regulates transcription
  • Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases
GWAS
  • Blood protein levels ( 30072576 29875488)
  • Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189)
  • Vitiligo ( 20410501 27723757)
Novel Interacting Genes 1 novel interacting genes: NEK9
Interacting Genes 26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID 3002
HPRD ID 00476
Ensembl ID ENSG00000100453
Uniprot IDs J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs 1FQ3 1IAU
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025