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CDK8
Description
cyclin dependent kinase 8
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Mediator Complex
Protein-containing Complex
Molecular Function
Protein Kinase Activity
Cyclin-dependent Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity
Biological Process
Transcription Initiation From RNA Polymerase II Promoter
Protein Phosphorylation
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Cell Cycle
Pathways
PPARA activates gene expression
NOTCH1 Intracellular Domain Regulates Transcription
Generic Transcription Pathway
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Transcriptional regulation of white adipocyte differentiation
Transcriptional regulation of white adipocyte differentiation
Drugs
Alvocidib
Diseases
GWAS
Immune response to measles-mumps-rubella vaccine (
24811271
)
Sporadic pituitary adenoma (
26029870
)
Novel Interacting Genes
2 novel interacting genes:
FLT1
FLT3
Interacting Genes
38 interacting genes:
AURKA
BCL6
BMPR1A
BUB1
CCNC
CCND1
CCNH
CDH1
CDKN2B
CTDP1
ERBB2
ERCC3
ESR1
ESR2
H3C14
KRAS
MAML1
MBP
MCC
MED12
MED21
MED25
MED26
MED8
MED9
MLH3
MYC
NRIP1
POLR2A
PRMT5
SMAD2
SMAD3
SMARCA4
SREBF1
SUZ12
TOP1
TP53
WDR77
Entrez ID
1024
HPRD ID
04422
Ensembl ID
ENSG00000132964
Uniprot IDs
P49336
PDB IDs
3RGF
4CRL
4F6S
4F6U
4F6W
4F70
4F7J
4F7L
4F7N
4F7S
4G6L
5BNJ
5CEI
5FGK
5HBE
5HBH
5HBJ
5HNB
5HVY
5I5Z
5ICP
5IDN
5IDP
5XQX
5XS2
6QTG
6QTJ
6R3S
6T41
Enriched GO Terms of Interacting Partners
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