MGMT

Description		O-6-methylguanine-DNA methyltransferase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane
	Molecular Function	DNA Binding Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Methyltransferase Activity DNA-methyltransferase Activity Metal Ion Binding
	Biological Process	DNA Ligation DNA Repair DNA Methylation DNA Dealkylation Involved In DNA Repair Negative Regulation Of Apoptotic Process Positive Regulation Of Double-strand Break Repair
Pathways		MGMT-mediated DNA damage reversal
Drugs		Cysteine Zinc S-Methylcysteine S-Benzylcysteine Dinitrochlorobenzene Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Adult body size ( 32376654) Alzheimer's disease in APOE e4- carriers ( 25778476) Anorexia nervosa ( 31308545) Chronotype ( 30696823) Drug experimentation measurement ( 30718321) Gut microbiota (functional units) ( 27694959) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Lead levels ( 26025379) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) MGMT methylation in smokers ( 26183928) Modic changes ( 30808802) Response to temozolomide ( 23047291) Tea consumption ( 31046077) Waist-to-hip circumference ratio (ever vs never smoking interaction) ( 23192594)
Novel Interacting Genes		1 novel interacting genes: FGFR2
Interacting Genes		9 interacting genes: CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 PCNA PRKACA PRKCA UBA1
Entrez ID		4255
HPRD ID		01135
Ensembl ID		ENSG00000170430
Uniprot IDs		B4DEE8 P16455
PDB IDs		1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH
Enriched GO Terms of Interacting Partners?
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