KRT5 - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	DCTN1	dynactin subunit 1	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Perry syndrome Distal hereditary motor neuropathies (dHMN)
Novel	GPD1	glycerol-3-phosphate dehydrogenase 1	Synthesis of PA	NADH Metformin
Novel	KRT4	keratin 4	Keratinization Formation of the cornified envelope		White sponge nevus
Novel	KRT6A	keratin 6A	Keratinization Formation of the cornified envelope	Zinc Zinc acetate	Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
Novel	KRT6B	keratin 6B	Keratinization Formation of the cornified envelope		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
Novel	KRT7	keratin 7	Keratinization Formation of the cornified envelope	Primaquine Verpasep caltespen
Novel	NADSYN1	NAD synthetase 1	Nicotinate metabolism	Glutamic acid
Novel	SAP18	Sin3A associated protein 18	HDACs deacetylate histones NoRC negatively regulates rRNA expression Potential therapeutics for SARS
Novel	SORD	sorbitol dehydrogenase	Fructose biosynthesis Formation of xylulose-5-phosphate	NADH Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine
Novel	TARBP2	TARBP2 subunit of RISC loading complex	MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
	ALOX12	arachidonate 12-lipoxygenase, 12S type	Synthesis of Hepoxilins (HX) and Trioxilins (TrX) Synthesis of Lipoxins (LX) Synthesis of 12-eicosatetraenoic acid derivatives Biosynthesis of DHA-derived SPMs Biosynthesis of DPAn-6 SPMs Biosynthesis of DPAn-3-derived maresins
	ALOX12B	arachidonate 12-lipoxygenase, 12R type	Synthesis of 12-eicosatetraenoic acid derivatives		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
	APC	APC regulator of WNT signaling pathway	Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases		Familial adenomatous polyposis Esophageal cancer Gastric cancer Cancer of the anal canal Gallbladder cancer
	DSP	desmoplakin	Apoptotic cleavage of cell adhesion proteins Neutrophil degranulation Keratinization Formation of the cornified envelope	Zinc Artenimol Zinc acetate	Arrhythmogenic right ventricular cardiomyopathy (ARVC) Naxos disease and Carvajal syndrome Striate palmoplantar keratoderma Skin fragility-woolly hair syndrome Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic
	DST	dystonin	Type I hemidesmosome assembly
	EVPL	envoplakin	Formation of the cornified envelope
	INCA1	inhibitor of CDK, cyclin A1 interacting protein 1
	KIFC3	kinesin family member C3
	KRT1	keratin 1	Neutrophil degranulation Keratinization Formation of the cornified envelope	Zinc Copper Zinc acetate	Epidermolytic palmoplantar keratoderma (EPPK) Ichthyosis hystrix, Curth-Macklin type Epidermolytic hyperkeratosis (EHK); Bullous congenital ichthyosiform erythroderma (BCIE) Striate palmoplantar keratoderma
	KRT14	keratin 14	Type I hemidesmosome assembly Keratinization Formation of the cornified envelope	Zinc Zinc acetate	Naegeli-Franceschetti-Jadassohn syndrome Dermatopathia pigmentosa reticularis Epidermolysis bullosa simplex, including: Epidermolysis bullosa simplex, Dowling-Meara type (EBS-DM); Epidermolysis bullosa simplex, Koebner type (EBS-K); Epidermolysis bullosa simplex, Weber-Cockayne type (EBS-WC); Epidermolysis bullosa simplex with mottled pigmentation (EBS-MP); Epidermolysis bullosa simplex with migratory circinate erythema; Epidermolysis bullosa simplex, recessive; Epidermolysis bullosa, lethal acantholytic

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