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PDGFRA
Description
platelet derived growth factor receptor alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Microvillus
Cilium
External Side Of Plasma Membrane
Membrane
Cell Junction
Intrinsic Component Of Plasma Membrane
Protein-containing Complex
Receptor Complex
Molecular Function
Protein Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet-derived Growth Factor Alpha-receptor Activity
Vascular Endothelial Growth Factor-activated Receptor Activity
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Growth Factor Binding
Vascular Endothelial Growth Factor Binding
Protein Homodimerization Activity
Protein-containing Complex Binding
Platelet-derived Growth Factor Binding
Biological Process
MAPK Cascade
Luteinization
In Utero Embryonic Development
Cell Activation
Hematopoietic Progenitor Cell Differentiation
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Multicellular Organism Development
Estrogen Metabolic Process
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Platelet Activation
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Peptidyl-tyrosine Phosphorylation
Signal Transduction Involved In Regulation Of Gene Expression
Extracellular Matrix Organization
Lung Development
Adrenal Gland Development
Positive Regulation Of Cell Migration
Male Genitalia Development
Leydig Cell Differentiation
Positive Regulation Of Kinase Activity
Cellular Response To Reactive Oxygen Species
Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Odontogenesis Of Dentin-containing Tooth
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Embryonic Digestive Tract Morphogenesis
Embryonic Cranial Skeleton Morphogenesis
Embryonic Skeletal System Morphogenesis
White Fat Cell Differentiation
Regulation Of Chemotaxis
Positive Regulation Of Protein Kinase B Signaling
Cardiac Myofibril Assembly
Roof Of Mouth Development
Face Morphogenesis
Cell Chemotaxis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Amino Acid Stimulus
Metanephric Glomerular Capillary Formation
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of Mesenchymal Stem Cell Differentiation
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Imatinib-resistant PDGFR mutants
Sunitinib-resistant PDGFR mutants
Regorafenib-resistant PDGFR mutants
Sorafenib-resistant PDGFR mutants
PDGFR mutants bind TKIs
Drugs
Becaplermin
Imatinib
Sunitinib
XL820
Olaratumab
Pazopanib
Midostaurin
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Foreskin keratinocyte (neonatal)
Fostamatinib
Erdafitinib
Amuvatinib
Ripretinib
Diseases
Glioma
GWAS
Adult asthma (
27611488
)
Asthma (
27611488
)
Blood protein levels (
30072576
)
Cadmium levels (
26025379
)
Core binding factor acute myeloid leukemia (
27903959
)
Corneal astigmatism (
22144915
29422769
)
Corneal curvature (
24963161
23401653
21665993
)
Height (
18193045
)
Hematocrit (
29403010
)
Hemoglobin (
29403010
)
Lupus nephritis in systemic lupus erythematosus (
24925725
)
Macular thickness (
30535121
)
Mean corpuscular hemoglobin (
29403010
20139978
)
Mean corpuscular volume (
29403010
20139978
)
Platelet count (
29403010
)
Post bronchodilator FEV1/FVC ratio (
26634245
)
Pulse pressure (
30578418
)
Red blood cell count (
29403010
28453575
20139978
)
Serum VEGFR2 concentration (
25411163
)
Systolic blood pressure (
30578418
)
Uterine fibroids (
30194396
31649266
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Novel Interacting Genes
4 novel interacting genes:
ALB
CD244
RAPGEF1
SPOCK1
Interacting Genes
64 interacting genes:
AKT1
ARNT
AURKA
BECN1
CAV1
CAV3
CBL
CCND2
CD44
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CRK
CRKL
EGFR
EPHA2
ERBB2
ERBB3
FBXO25
FGFR4
FZR1
GRB14
GRM1
HGF
ITGAV
ITGB3
JAK1
KASH5
KDELR2
LATS2
MAP2K5
MYC
NF2
PDGFA
PDGFB
PDGFC
PDGFRB
PIK3CA
PIK3R1
PLCG1
PLPP6
PRMT5
PTPN11
RAF1
SHB
SHF
SLC9A3R1
SMURF1
SNX2
SNX4
SNX6
SRPK1
STAT1
STAT3
STAT5A
STAT5B
STK11
TERT
TGFBR2
TP53
TTYH2
ULBP2
Entrez ID
5156
HPRD ID
01429
Ensembl ID
ENSG00000134853
Uniprot IDs
P16234
PDB IDs
1GQ5
5GRN
5K5X
6A32
6JOI
6JOJ
6JOK
6JOL
Enriched GO Terms of Interacting Partners
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