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CD22

Description CD22 molecule
Image
GO Annotations Cellular Component
  • Cytoplasm
  • Early Endosome
  • Plasma Membrane
  • Integral Component Of Plasma Membrane
  • External Side Of Plasma Membrane
  • Cell Surface
  • Integral Component Of Membrane
  • Neuronal Cell Body Membrane
  • Recycling Endosome
  • Extracellular Exosome
Molecular Function
  • IgM Binding
  • Signaling Receptor Binding
  • Protein Binding
  • Protein Phosphatase Binding
  • Carbohydrate Binding
  • Sialic Acid Binding
  • CD4 Receptor Binding
Biological Process
  • Negative Regulation Of Immunoglobulin Production
  • Cell Adhesion
  • Regulation Of Endocytosis
  • Regulation Of B Cell Proliferation
  • B Cell Activation
  • Regulation Of Immune Response
  • Negative Regulation Of Calcium-mediated Signaling
  • Negative Regulation Of B Cell Receptor Signaling Pathway
Pathways
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
  • CD22 mediated BCR regulation
  • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
  • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
  • Epratuzumab
  • Inotuzumab ozogamicin
  • Moxetumomab Pasudotox
Diseases
GWAS
  • Red cell distribution width ( 32888494)
Interacting Genes 20 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140
Entrez ID 933
HPRD ID 00114
Ensembl ID ENSG00000012124
Uniprot IDs P20273 Q0EAF5
PDB IDs 5VKJ 5VKM 5VL3
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025