IDUA

Description		alpha-L-iduronidase
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GO Annotations	Cellular Component	Coated Vesicle Lysosomal Lumen Extracellular Exosome
	Molecular Function	L-iduronidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Signaling Receptor Binding
	Biological Process	Disaccharide Metabolic Process Glycosaminoglycan Catabolic Process Chondroitin Sulfate Catabolic Process Dermatan Sulfate Catabolic Process Heparin Catabolic Process
Pathways		HS-GAG degradation CS/DS degradation MPS I - Hurler syndrome
Drugs
Diseases		Mucopolysaccharidosis type I (MPS1); Hurler-Scheie syndrome (MPS1HS); Hurler syndrome (MPS1H); Scheie syndrome (MPS1S)
GWAS		Blood protein levels ( 30072576 29875488) Heel bone mineral density ( 30598549) Limited cutaneous systemic scleroderma ( 29293537) Lumbar spine bone mineral density ( 22504420) Mean reticulocyte volume ( 32888494) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269)
Novel Interacting Genes		1 novel interacting genes: FGFR3
Interacting Genes		1 interacting genes: MPP3
Entrez ID		3425
HPRD ID		02016
Ensembl ID		ENSG00000127415
Uniprot IDs		P35475
PDB IDs		1Y24 3W81 3W82 4KGJ 4KGL 4KH2 4MJ2 4MJ4 4OBR 4OBS 6I6R 6I6X
Enriched GO Terms of Interacting Partners?
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