PARP3

Description		poly(ADP-ribose) polymerase family member 3
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Centriole Nuclear Body Site Of Double-strand Break Intercellular Bridge
	Molecular Function	Catalytic Activity NAD+ ADP-ribosyltransferase Activity Protein Binding NAD DNA ADP-ribosyltransferase Activity Protein ADP-ribosylase Activity
	Biological Process	Telomere Maintenance DNA Repair Double-strand Break Repair Protein ADP-ribosylation DNA ADP-ribosylation Negative Regulation Of Isotype Switching Positive Regulation Of DNA Ligation Regulation Of Mitotic Spindle Organization Protein Poly-ADP-ribosylation Protein Auto-ADP-ribosylation Protein Mono-ADP-ribosylation Negative Regulation Of Telomerase RNA Reverse Transcriptase Activity Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways
Drugs		2-methyl-3,5,7,8-tetrahydro-4H-thiopyrano[4,3-d]pyrimidin-4-one -ylcarbonyl)-4-fluorobenzyl]phthalazin-1(2H)-one N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Olaparib Rucaparib
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: BAP1
Interacting Genes		4 interacting genes: APP H1-1 MEOX2 PARP1
Entrez ID		10039
HPRD ID		06370
Ensembl ID		ENSG00000041880
Uniprot IDs		A0A024R318 Q9Y6F1
PDB IDs		2EOC 3C49 3C4H 3CE0 3FHB 4GV0 4GV2 4GV4 4L6Z 4L70 4L7L 4L7N 4L7O 4L7P 4L7R 4L7U
Enriched GO Terms of Interacting Partners?
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