IL6

Description		interleukin 6
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Interleukin-6 Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-6 Receptor Binding Protein Binding Growth Factor Activity
	Biological Process	Neutrophil Apoptotic Process Germinal Center B Cell Differentiation Immunoglobulin Production Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Immunoglobulin Production Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Inflammatory Response Humoral Immune Response Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Lipid Storage Response To Activity Cytokine-mediated Signaling Pathway Platelet Activation Endocrine Pancreas Development Neuron Projection Development Response To Peptidoglycan Interleukin-21 Production Negative Regulation Of Chemokine Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Collagen Biosynthetic Process Positive Regulation Of Peptidyl-serine Phosphorylation Maintenance Of Blood-brain Barrier Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Post-translational Protein Modification Cellular Protein Metabolic Process Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Translation Regulation Of Angiogenesis Negative Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Glucocorticoid Defense Response To Virus Positive Regulation Of Glial Cell Proliferation T Follicular Helper Cell Differentiation Regulation Of Astrocyte Activation Neuron Cellular Homeostasis Glucagon Secretion Regulation Of Glucagon Secretion Interleukin-6-mediated Signaling Pathway Cellular Response To Hydrogen Peroxide Cellular Response To Lipopolysaccharide T-helper 17 Cell Lineage Commitment Hepatocyte Proliferation Positive Regulation Of Extracellular Matrix Disassembly Liver Regeneration Cellular Response To Virus Regulation Of Neuroinflammatory Response Positive Regulation Of Neuroinflammatory Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Apoptotic DNA Fragmentation Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Microglial Cell Activation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of T-helper 2 Cell Cytokine Production Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Interleukin-1-mediated Signaling Pathway Positive Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Senescence-Associated Secretory Phenotype (SASP) Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Transcriptional Regulation by VENTX Post-translational protein phosphorylation ADORA2B mediated anti-inflammatory cytokines production CD163 mediating an anti-inflammatory response
Drugs		Ginseng YSIL6 VX-702 Atiprimod CRx-139 Andrographolide Tapinarof Siltuximab Polaprezinc Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Binimetinib Dilmapimod
Diseases		Graft-versus-host disease
GWAS		Asthma ( 31959851 30929738 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Birth weight ( 31043758) Blond vs. brown/black hair color ( 30531825) C-reactive protein ( 21196492) C-reactive protein levels ( 30388399) Calcific aortic valve stenosis ( 32141789) Cerebrospinal fluid clusterin levels in APOEe4- carriers ( 26545630) Dialysis-related mortality ( 21546767) Fibrinogen ( 23969696) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Longevity ( 26912274) Longevity (age >90th survival percentile) ( 31413261) Longevity (age >99th survival percentile) ( 31413261) Multiple sclerosis ( 31604244) Offspring birth weight ( 31043758) Peripheral artery disease ( 31285632) Pulse pressure ( 30224653 30578418) Takayasu arteritis ( 25604533)
Novel Interacting Genes		2 novel interacting genes: - DNAH11
Interacting Genes		6 interacting genes: IL6R IL6ST PTHLH SH3GL2 ZBTB16 ZC3H12A
Entrez ID		3569
HPRD ID		00970
Ensembl ID		ENSG00000136244
Uniprot IDs		B4DNQ5 B4DVM1 B5MC21 P05231 Q75MH2
PDB IDs		1ALU 1IL6 1N2Q 1P9M 2IL6 4CNI 4J4L 4NI7 4NI9 4O9H 4ZS7 5FUC
Enriched GO Terms of Interacting Partners?
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