KDR - Wiki-MPM

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	ALB	albumin	Platelet degranulation Recycling of bile acids and salts Heme biosynthesis Heme degradation Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transport of organic anions Post-translational protein phosphorylation HDL remodeling	Amsacrine Cefotaxime Pyridostigmine Phenol Norelgestromin Aniline Guaiacol Artenimol Silver Patent Blue
Novel	CACNA1S	calcium voltage-gated channel subunit alpha1 S	NCAM1 interactions	Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Cinnarizine Magnesium sulfate Levomenthol Ethanol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Clevidipine Nilvadipine Trimebutine Pinaverium Aranidipine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil	Hypokalemic periodic paralysis (HypoPP)
Novel	CHIC2	cysteine rich hydrophobic domain 2
Novel	GSTA2	glutathione S-transferase alpha 2	Glutathione conjugation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Glutathione Chloroquine Glutathione disulfide
Novel	KIT	KIT proto-oncogene, receptor tyrosine kinase	PIP3 activates AKT signaling Signaling by SCF-KIT Signaling by SCF-KIT Regulation of KIT signaling Regulation of KIT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Dasatinib-resistant KIT mutants Imatinib-resistant KIT mutants KIT mutants bind TKIs Masitinib-resistant KIT mutants Nilotinib-resistant KIT mutants Regorafenib-resistant KIT mutants Signaling by kinase domain mutants of KIT Sunitinib-resistant KIT mutants Signaling by juxtamembrane domain KIT mutants Sorafenib-resistant KIT mutants Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by extracellular domain mutants of KIT	Sorafenib Imatinib Dasatinib Sunitinib Phosphonotyrosine Nilotinib XL820 OSI-930 ABT-869 Pazopanib Midostaurin Regorafenib Ponatinib Lenvatinib Ancestim Fostamatinib Erdafitinib Amuvatinib Pexidartinib Ripretinib Avapritinib	Piebaldism Acute myeloid leukemia (AML)
Novel	SHOX2	short stature homeobox 2
Novel	SRP72	signal recognition particle 72	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Novel	UTP3	UTP3 small subunit processome component	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
	ACP1	acid phosphatase 1		Adenine 4-Nitrophenyl Phosphate
	AIMP2	aminoacyl tRNA synthetase complex interacting multifunctional protein 2	Selenoamino acid metabolism Cytosolic tRNA aminoacylation
	ANXA5	annexin A5	Platelet degranulation	Fluocinolone acetonide L-Alpha-Glycerophosphorylserine L-thioproline K201 free base sn-glycero-3-phosphoethanolamine 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid Copper
	ATR	ATR serine/threonine kinase	Meiotic synapsis Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint		Alveolar rhabdomyosarcoma Seckel syndrome
	BMX	BMX non-receptor tyrosine kinase	Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane	Fostamatinib Zanubrutinib
	BTRC	beta-transducin repeat containing E3 ubiquitin protein ligase	Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Deactivation of the beta-catenin transactivating complex Circadian Clock Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation
	CAV1	caveolin 1	Triglyceride catabolism eNOS activation NOSTRIN mediated eNOS trafficking Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling FOXO-mediated transcription of cell cycle genes		Congenital generalized lipodystrophy (CGL)
	CBL	Cbl proto-oncogene	Interleukin-6 signaling Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Spry regulation of FGF signaling Regulation of KIT signaling EGFR downregulation TGF-beta receptor signaling activates SMADs Constitutive Signaling by EGFRvIII Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Negative regulation of MET activity PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell InlB-mediated entry of Listeria monocytogenes into host cell Regulation of signaling by CBL Regulation of signaling by CBL Negative regulation of FLT3 FLT3 signaling by CBL mutants		Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
	CCDC88A	coiled-coil domain containing 88A
	CDH5	cadherin 5	Adherens junctions interactions VEGFR2 mediated vascular permeability	Lenalidomide FX06
	COL18A1	collagen type XVIII alpha 1 chain	Collagen degradation Activation of Matrix Metalloproteinases Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Laminin interactions Collagen chain trimerization		Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
	CRK	CRK proto-oncogene, adaptor protein	ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis

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