Search Results for: KAZN

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel CELA2A chymotrypsin like elastase 2A
  • Formation of the cornified envelope
Novel CELA2B chymotrypsin like elastase 2B
Novel CTRC chymotrypsin C
  • Cobalamin (Cbl, vitamin B12) transport and metabolism
  • Tropical calcific pancreatitis
  • Hereditary pancreatitis; Hereditary chronic pancreatitis
Novel FBLIM1 filamin binding LIM protein 1
  • Cell-extracellular matrix interactions
Novel KIF1B kinesin family member 1B
  • COPI-dependent Golgi-to-ER retrograde traffic
  • Kinesins
  • Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
Novel NPPA natriuretic peptide A
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression
  • Physiological factors
  • Amyloid fiber formation
  • Atrial fibrillation
ARID5A AT-rich interaction domain 5A
CLVS2 clavesin 2
  • Lysosome Vesicle Biogenesis
COIL coilin
DVL3 dishevelled segment polarity protein 3
  • TCF dependent signaling in response to WNT
  • WNT mediated activation of DVL
  • PCP/CE pathway
  • PCP/CE pathway
  • Degradation of DVL
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Negative regulation of TCF-dependent signaling by DVL-interacting proteins
  • RHO GTPases Activate Formins
  • WNT5:FZD7-mediated leishmania damping
  • WNT5:FZD7-mediated leishmania damping
LMO2 LIM domain only 2
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
LZTS1 leucine zipper tumor suppressor 1
LZTS2 leucine zipper tumor suppressor 2
PPL periplakin
  • Formation of the cornified envelope
  • Butyrophilin (BTN) family interactions
PSMA1 proteasome 20S subunit alpha 1
  • Activation of NF-kappaB in B cells
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • ER-Phagosome pathway
  • Cross-presentation of soluble exogenous antigens (endosomes)
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • SCF-beta-TrCP mediated degradation of Emi1
  • APC/C:Cdc20 mediated degradation of Securin
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • Vpu mediated degradation of CD4
  • Vif-mediated degradation of APOBEC3G
  • SCF(Skp2)-mediated degradation of p27/p21
  • Degradation of beta-catenin by the destruction complex
  • Downstream TCR signaling
  • Regulation of activated PAK-2p34 by proteasome mediated degradation
  • Separation of Sister Chromatids
  • FCERI mediated NF-kB activation
  • Autodegradation of the E3 ubiquitin ligase COP1
  • Regulation of ornithine decarboxylase (ODC)
  • ABC-family proteins mediated transport
  • AUF1 (hnRNP D0) binds and destabilizes mRNA
  • Asymmetric localization of PCP proteins
  • Degradation of AXIN
  • Degradation of DVL
  • Hedgehog ligand biogenesis
  • Hh mutants are degraded by ERAD
  • Dectin-1 mediated noncanonical NF-kB signaling
  • CLEC7A (Dectin-1) signaling
  • Degradation of GLI1 by the proteasome
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • Hedgehog 'on' state
  • Regulation of RAS by GAPs
  • TNFR2 non-canonical NF-kB pathway
  • NIK-->noncanonical NF-kB signaling
  • Defective CFTR causes cystic fibrosis
  • MAPK6/MAPK4 signaling
  • UCH proteinases
  • Ub-specific processing proteases
  • CDT1 association with the CDC6:ORC:origin complex
  • Orc1 removal from chromatin
  • CDK-mediated phosphorylation and removal of Cdc6
  • G2/M Checkpoints
  • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
  • Ubiquitin-dependent degradation of Cyclin D
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX3 expression and activity
  • Regulation of PTEN stability and activity
  • Neddylation
  • Regulation of expression of SLITs and ROBOs
  • Interleukin-1 signaling
  • Negative regulation of NOTCH4 signaling
  • Antigen processing: Ubiquitination & Proteasome degradation
TNS4 tensin 4
  • MET interacts with TNS proteins
TXN2 thioredoxin 2
  • Degradation of cysteine and homocysteine
  • Detoxification of Reactive Oxygen Species
USP2 ubiquitin specific peptidase 2
  • TNFR1-induced proapoptotic signaling
  • Regulation of TNFR1 signaling
  • TNFR1-induced NFkappaB signaling pathway
  • Ub-specific processing proteases
  • Regulation of TP53 Degradation

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