PENK

Description		proenkephalin
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GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Lumen Plasma Membrane Dendrite Symmetric Synapse Chromaffin Granule Lumen Synaptic Vesicle Lumen Neuronal Cell Body Perikaryon Axon Terminus Cell Body Fiber Neuronal Dense Core Vesicle Lumen
	Molecular Function	Opioid Peptide Activity Neuropeptide Hormone Activity Opioid Receptor Binding
	Biological Process	Osteoblast Differentiation Behavioral Fear Response Response To Hypoxia Startle Response Aggressive Behavior Signal Transduction G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Aging Sensory Perception Response To Radiation Response To Toxic Substance Glial Cell Proliferation Sensory Perception Of Pain Response To Estradiol Response To Lipopolysaccharide Cellular Response To Oxidative Stress Response To Nicotine Locomotory Exploration Behavior Response To Morphine Post-translational Protein Modification Cellular Protein Metabolic Process Response To Ethanol Response To Calcium Ion General Adaptation Syndrome, Behavioral Process Cellular Response To Vitamin D Cellular Response To CAMP Cellular Response To Transforming Growth Factor Beta Stimulus Response To Epinephrine Cellular Response To Virus Synaptic Signaling Via Neuropeptide Positive Regulation Of Behavioral Fear Response
Pathways		Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (i) signalling events Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Height ( 18391951) Problematic alcohol use ( 32451486) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Suicide in bipolar disorder ( 25917933)
Novel Interacting Genes		2 novel interacting genes: ADD3 HSP90AB1
Interacting Genes
Entrez ID		5179
HPRD ID		08837
Ensembl ID		ENSG00000181195
Uniprot IDs		A0A024R7V4 P01210
PDB IDs		1PLW 1PLX 2LWC 5E33 5E3A
Enriched GO Terms of Interacting Partners?
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