TUBB1

Description		tubulin beta 1 class VI
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Extracellular Exosome
	Molecular Function	GTPase Activity Structural Constituent Of Cytoskeleton GTP Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Spindle Assembly
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		Vindesine Paclitaxel Docetaxel Epothilone D Patupilone CYT997 ZEN-012 Cabazitaxel Eribulin Milataxel Phenethyl Isothiocyanate
Diseases
GWAS		Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Mean platelet volume ( 22139419 32888494 27863252) Platelet count ( 29403010 32888494 22423221 27863252 24777453) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Novel Interacting Genes		2 novel interacting genes: C20orf85 PRELID3B
Interacting Genes		1 interacting genes: TTK
Entrez ID		81027
HPRD ID		18243
Ensembl ID		ENSG00000101162
Uniprot IDs		Q9H4B7
PDB IDs
Enriched GO Terms of Interacting Partners?
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