SPHK2

Description		sphingosine kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Inner Membrane Lysosomal Membrane Endoplasmic Reticulum Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Lipid Kinase Activity NAD+ Kinase Activity Protein Binding ATP Binding Sphinganine Kinase Activity D-erythro-sphingosine Kinase Activity Small GTPase Binding Nucleosomal Histone Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Cytokine Production Involved In Immune Response Sphingosine-1-phosphate Receptor Signaling Pathway Sphingolipid Metabolic Process Sphinganine-1-phosphate Biosynthetic Process Sphingosine Metabolic Process Phosphorylation Sphingolipid Biosynthetic Process Negative Regulation Of Cell Growth Negative Regulation Of Histone Deacetylation Interleukin-13 Production Interleukin-6 Production Tumor Necrosis Factor Production Positive Regulation Of Mast Cell Activation Involved In Immune Response Positive Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Mast Cell Degranulation Histone H2A-K5 Acetylation Histone H2B-K12 Acetylation Positive Regulation Of Gene Expression, Epigenetic Sphingosine Biosynthetic Process Lipid Phosphorylation Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Calcium Ion Import Negative Regulation Of Histone Deacetylase Activity Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Phorbol 13-acetate 12-myristate Regulation Of Cytochrome-c Oxidase Activity Positive Regulation Of Ceramide Biosynthetic Process Positive Regulation Of Histone H3-K9 Acetylation Regulation Of ATP Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs		Opaganib
Diseases
GWAS		Bipolar disorder ( 21926972) Crohn's disease ( 23128233) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Monocyte count ( 32888494) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Non-oily fish consumption ( 32066663) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: BCL2 FYN LYN
Entrez ID		56848
HPRD ID		06157
Ensembl ID		ENSG00000063176
Uniprot IDs		A0A024QZH5 B3KV83 E9PCV4 Q9NRA0
PDB IDs
Enriched GO Terms of Interacting Partners?
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