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MPM Genes
Novel Interactors
Known Interactors
Novel Interactions
Known Interactions

SymbolEntrez IDKnown PPIsNovel PPIsGO terms
ATIC 471 1 5 11
ATP1B1 481 18 7 28
ATXN1 6310 251 5 4
BAP1 8314 25 2 13
CDKN2A 1029 100 6 16
CTLA4 1493 14 10 10
DHFR 1719 9 7 15
FGFR1 2260 53 7 57
FGFR2 2263 41 9 107
FGFR3 2261 40 6 27
FLT1 2321 24 8 22
FLT3 2322 14 8 24
FLT4 2324 14 4 24
FOXO3 2309 25 4 35
GART 2618 2 5 10
GIPR 2696 2 0 14
HLA-DQA1 3117 8 7 5
HSP90AA1 3320 142 6 28
HSP90AB1 3326 52 10 36
HSP90B1 7184 24 2 16
IL4R 3566 22 5 17
KAZN 23254 3 6 1
KDR 3791 55 8 35
KRT5 3852 17 10 5
KRT72 140807 4 8 3
LCK 3932 123 5 28
LY6E 4061 2 8 2
LYN 4067 115 12 86
NTRK2 4915 30 3 35
PDCD1 5133 2 3 8
PDGFRA 5156 33 4 50
PDGFRB 5159 62 8 65
PDPN 10630 1 5 15
POLE 5426 11 7 11
POLE2 5427 13 6 7
POLE3 54107 7 7 6
POLE4 56655 6 4 5
PRR5 55615 0 3 6
RRM1 6240 7 12 11
RRM2 6241 7 10 6
SP1 6667 141 5 11
SRC 6714 266 9 108
- 445347 1 4 0
TBCE 6905 2 3 9
TTF1 7270 6 3 8
TUBA1A 7846 59 3 6
TUBA1C 84790 4 8 4
TUBA3C 7278 12 3 2
TUBA3D 113457 1 6 2
TUBA4A 7277 49 14 5
TUBA8 51807 5 2 2
TUBB1 81027 1 2 1
TUBB2A 7280 25 0 2
TUBB3 10381 29 6 3
TUBB4A 10382 6 7 5
TUBB4B 10383 15 4 7
TUBD1 51174 1 6 5
TUBE1 51175 0 6 1
TUBG1 7283 26 6 6
TUBG2 27175 3 3 2
TYMS 7298 2 9 28
WT1 7490 29 8 46

Pathways P_values Mesothelioma Genes Known Interactors Novel Interactors
Glucocorticoid Receptor Signaling 6.31E-56 KRT72, HSP90B1, FGFR3, HSP90AB1, FGFR1, KRT5, FOXO3, FGFR2, HSP90AA1 POU2F1, NCOR2, KRT8, MAPK10, JAK3, NR3C2, IL13, SMARCA4, SMAD4, SMARCB1, ACTB, FRS2, TRAF6, SMAD2, PIK3C2B, SMARCE1, SMARCC2, AR, SGK1, PTGES3, BCL2L1, STAT5B, JUN, KRT17, IRS1, GAB1, PGR, SUMO1, FKBP4, FKBP5, KRT19, PTPN11, HSPA8, STAT5A, KRT31, CREBBP, NCOR1, CHUK, CDK7, EP300, MAP3K14, KRT40, IL4, BAG1, NFATC1, SOS1, HSPA9, HSPA4, CEBPB, PRKACA, HRAS, RAC1, ADRB2, KAT2B, KRT38, NFKBIA, IKBKG, STAT3, SMAD3, ESR1, CD3E, PIK3R3, KRT1, JAK2, IL1B, POLR2E, RAF1, JAK1, IKBKB, HLTF, ANXA1, TGFBR2, PIK3R2, NR3C1, ARID1A, KRT15, IKBKE, TRAF2, TBP, AKT1, PIK3R1, KRT14, SMARCC1, YWHAH, TAF4, PIK3CA, STAT1, TNF, CDKN1A, GRB2, MAPK8, MAPK3, NFKB1, IRS2, ATM, AKT2, RELA, PIK3CG, KRT18, NFATC3, NOS2, UBE2I, MAPK1, POLR2G, CD247, SHC1 KRT74, HMGB1, PRKAG1, IL6, KRT6B, KRT78, KRT80, KRT7, KRT4, TAF3, NPPA, MAP3K7, KRT6A
Molecular Mechanisms of Cancer 5.01E-53 CDKN2A, SRC, FGFR3, FGFR1, FGFR2 CAMK2B, GNA11, MAPK10, JAK3, SMAD4, E2F3, GNAQ, FRS2, ATR, LRP1, RBL1, PRKCE, CCND2, CTNNB1, CDKN2C, SMAD2, PIK3C2B, PTK2, NFKB2, PRKCD, BCL2L1, FAS, ITGA5, JUN, RASGRF1, E2F1, IRS1, GAB1, MAX, TP53, APC, FYN, SMAD7, ARHGEF7, PTPN11, ITGB1, CREBBP, CRK, PRKCI, RAPGEF1, CDK6, PRKCZ, FOXO1, FASLG, NOTCH1, CDK7, PAK1, EP300, SOS1, PRKCA, PRKD1, MDM2, PRKACA, HRAS, RAC1, CDK1, BIRC2, CDC42, ADCY6, PRKCQ, NFKBIA, IKBKG, SMAD3, PRKCH, PIK3R3, JAK2, RAF1, JAK1, NLK, CDK5, SYNGAP1, ABL1, BMPR2, MYC, TGFBR2, PIK3R2, CDKN1B, SMAD1, CCND1, CASP3, GSK3B, APAF1, AKT1, GNA12, PIK3R1, CTNND1, CBL, CDC25C, GNAI2, PIK3CA, E2F2, CDKN1A, GRB2, CDH1, MAPK8, PRKDC, CASP7, MAPK3, BRCA1, PAK2, NFKB1, CDK4, IRS2, ATM, CDK2, CASP9, TYK2, AKT2, RELA, CASP6, PIK3CG, GAB2, HIF1A, MAPK1, RASA1, PAK4, RB1, SHC1, CHEK1 CDK14, CDK20, CDKN2B, PRKAG1, WNT7B, RND2, WNT6, CDK8, RHOQ, RAPGEF3, MAP3K7, WNT3
14-3-3-mediated Signaling 7.94E-44 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, FGFR2, TUBA8, TUBB2A, FGFR3, TUBB4A TNFRSF1A, MAPK10, PRKCQ, YWHAE, SNCA, FRS2, PRKCH, PRKCE, PIK3R3, YWHAG, RAF1, PIK3C2B, PRKCD, PIK3R2, CDKN1B, TUBA1B, TP73, YWHAZ, JUN, GSK3B, TRAF2, YWHAQ, AKT1, IRS1, GAB1, PIK3R1, CBL, YWHAH, PIK3CA, PTPN11, TNF, GRB2, MAPT, MAPK8, PRKCI, PRKCZ, TSC1, YWHAB, FOXO1, MAPK3, IRS2, TUBB, ATM, AKT2, GFAP, PLCG2, PIK3CG, PRKCA, RPS6KA1, MAPK1, PLCG1, PRKD1, HRAS, PDCD6IP TUBA3E, PLCL1
PTEN Signaling 7.94E-43 FGFR1, FLT1, KDR, PDGFRA, FOXO3, FGFR2, NTRK2, FGFR3, PDGFRB, FLT4 CDC42, CSNK2A2, INPPL1, IKBKG, TNFRSF11A, RPS6KB1, EGFR, PIK3R3, RAF1, INSR, IKBKB, PTK2, NFKB2, IGF1R, FOXG1, BMPR2, TGFBR2, PIK3R2, CDKN1B, CCND1, BCAR1, CASP3, BCL2L1, ITGA5, IKBKE, GSK3B, AKT1, PIK3R1, CBL, YWHAH, INPP5D, PIK3CA, ITGB1, CDKN1A, GRB2, PRKCZ, FOXO1, MAPK3, RPS6KB2, NFKB1, FASLG, CHUK, CSNK2B, CASP9, SOS1, AKT2, IGF2R, RELA, PIK3CG, PDPK1, NGFR, MAPK1, HRAS, RAC1, CSNK2A1, SHC1 OCRL
PDGF Signaling 5.01E-42 FGFR1, SRC, PDGFRA, FGFR2, FGFR3, PDGFRB EIF2AK2, JAK3, CSNK2A2, SPHK1, INPPL1, STAT3, FRS2, CAV3, PIK3R3, JAK2, CRKL, RAF1, JAK1, PIK3C2B, PDGFC, ABL1, MYC, ACP1, PIK3R2, JUN, PDGFD, IRS1, PDGFB, GAB1, PIK3R1, INPP5D, PIK3CA, STAT1, PTPN11, SPHK2, GRB2, CRK, MAPK8, MAPK3, IRS2, CSNK2B, ATM, TYK2, SOS1, PLCG2, PIK3CG, CAV1, SRF, PRKCA, MAPK1, PLCG1, RASA1, PDGFA, HRAS, CSNK2A1, SHC1 OCRL
Pancreatic Adenocarcinoma Signaling 2.51E-41 FGFR1, CDKN2A, FGFR2, FGFR3 CDC42, MAPK10, JAK3, SMAD4, PLD1, E2F3, STAT3, FRS2, SMAD3, ERBB2, VEGFC, EGFR, PIK3R3, JAK2, VEGFA, SMAD2, RAF1, BIRC5, JAK1, PIK3C2B, PDGFC, NFKB2, ABL1, TGFBR2, PIK3R2, CDKN1B, CCND1, BCL2L1, AKT1, PGF, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, STAT1, PTPN11, E2F2, CDKN1A, GRB2, MAPK8, VEGFB, MAPK3, NFKB1, CDK4, IRS2, NOTCH1, ATM, CDK2, CASP9, TYK2, AKT2, RELA, PIK3CG, PLD2, MAPK1, MDM2, RB1, RAC1 CDKN2B
B Cell Receptor Signaling 1.58E-40 FGFR1, LYN, FGFR2, FGFR3 CAMK2B, CDC42, PRKCQ, CD22, INPPL1, NFKBIA, DAPP1, IKBKG, SYK, FRS2, CD79A, RPS6KB1, PAG1, PIK3R3, RAF1, IKBKB, PIK3C2B, PTK2, VAV1, FCGR2A, NFKB2, ABL1, BCL6, PIK3R2, PTK2B, BCL2L1, ETS1, IKBKE, JUN, GSK3B, AKT1, IRS1, GAB1, PIK3R1, INPP5D, CFL1, PIK3CA, PTPN11, GRB2, CD19, CREBBP, PTPN6, MAPK8, FOXO1, MAP3K3, MAPK3, RPS6KB2, NFKB1, IRS2, CHUK, ATM, CD79B, BTK, EP300, MAP3K14, EGR1, NFATC1, MEF2C, SOS1, AKT2, RELA, PLCG2, PIK3CG, NFATC3, PDPK1, FCGR2B, GAB2, CSK, MAPK1, PTPRC, HRAS, RAC1, SHC1 OCRL, CALML5, IGHD, MAP3K7
T Cell Receptor Signaling 3.98E-40 FGFR1, CTLA4, LCK, FGFR2, FGFR3 PRKCQ, NFKBIA, IKBKG, LCP2, CD8A, FRS2, CD4, LAT, ZAP70, CD3E, PAG1, PIK3R3, RAF1, IKBKB, PIK3C2B, VAV1, NFKB2, CD28, PIK3R2, BMX, IKBKE, JUN, IRS1, GAB1, PIK3R1, CBL, PTPRH, FYN, PIK3CA, PTPN11, ITK, GRB2, TEC, MAPK8, SHB, MAPK3, NFKB1, IRS2, CHUK, ATM, BTK, NFATC1, SOS1, TXK, RELA, PIK3CG, NFATC3, CSK, MAPK1, PLCG1, RASA1, PTPRC, HRAS, CD247, RAC1 CALML5
NF-_B Signaling 1.26E-39 FGFR1, LCK, FLT1, KDR, PDGFRA, FGFR2, NTRK2, FGFR3, PDGFRB, FLT4 EIF2AK2, TLR1, TNFRSF1A, PRKCQ, CSNK2A2, FCER1G, NFKBIA, TLR4, IKBKG, FRS2, TNFRSF11A, RIPK1, TLR2, HDAC1, ZAP70, TRAF6, EGFR, PIK3R3, IL1B, RAF1, INSR, IKBKB, PIK3C2B, TRAF3, NFKB2, IGF1R, BMPR2, TGFBR2, PIK3R2, GSK3B, TRAF2, TDP2, AKT1, IRS1, GAB1, PIK3R1, CD40, TBK1, PIK3CA, PTPN11, TNF, GRB2, CREBBP, MAPK8, PRKCZ, MAP3K3, IRAK1, NFKB1, HDAC2, IRS2, CHUK, CSNK2B, ATM, LTA, EP300, MAP3K14, UBE2N, BTRC, AKT2, IGF2R, RELA, PLCG2, PIK3CG, NGFR, ARAF, PRKACA, HRAS, CSNK2A1 MAP3K7
Tec Kinase Signaling 3.98E-39 FGFR1, LCK, SRC, LYN, FGFR2, FGFR3 GNA11, MAPK10, PRKCQ, JAK3, FGR, FCER1G, TLR4, GNAQ, WAS, STAT3, ACTG1, ACTB, FRS2, PRKCH, PRKCE, PIK3R3, JAK2, JAK1, PIK3C2B, PTK2, VAV1, NFKB2, PRKCD, PIK3R2, PTK2B, STAT6, GTF2I, BMX, FAS, STAT5B, YES1, ITGA5, GNA12, IRS1, GAB1, PIK3R1, MS4A2, GNAI2, FYN, PIK3CA, STAT1, PTPN11, TNF, ITGB1, STAT5A, ITK, GRB2, TEC, MAPK8, PRKCI, PRKCZ, PAK2, NFKB1, FASLG, IRS2, ATM, PAK1, BTK, TYK2, TXK, RELA, PLCG2, PIK3CG, PRKCA, PLCG1, PRKD1, PAK4 RHOQ, RND2
Chronic Myeloid Leukemia Signaling 1.00E-38 FGFR1, CDKN2A, FGFR2, FGFR3 SMAD4, E2F3, IKBKG, FRS2, SMAD3, RBL1, HDAC1, PIK3R3, CRKL, RAF1, IKBKB, PIK3C2B, HDAC3, NFKB2, ABL1, MYC, TGFBR2, PIK3R2, CDKN1B, CCND1, BCL2L1, STAT5B, IKBKE, AKT1, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, E2F2, STAT5A, CDKN1A, GRB2, CRK, CDK6, MAPK3, NFKB1, HDAC2, CDK4, IRS2, CHUK, ATM, SOS1, AKT2, RELA, PIK3CG, CBLC, HDAC6, GAB2, CTBP2, MAPK1, MDM2, RB1, HRAS
Glioma Signaling 1.58E-38 FGFR1, CDKN2A, PDGFRA, FGFR2, FGFR3, PDGFRB CAMK2B, PRKCQ, E2F3, FRS2, RBL1, PRKCH, PRKCE, EGFR, PIK3R3, CDKN2C, RAF1, PIK3C2B, PDGFC, IGF1R, ABL1, PRKCD, PIK3R2, CCND1, PDGFD, AKT1, E2F1, IRS1, PDGFB, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, E2F2, CDKN1A, GRB2, PRKCI, CDK6, PRKCZ, MAPK3, CDK4, IRS2, ATM, SOS1, AKT2, IGF2R, PLCG2, PIK3CG, PRKCA, MAPK1, PLCG1, PRKD1, MDM2, RB1, PDGFA, HRAS, SHC1 CAMK1D, CDKN2B, CALML5
IGF-1 Signaling 1.58E-37 FGFR1, FOXO3, FGFR2, FGFR3 GRB10, SOCS5, CSNK2A2, YWHAE, STAT3, FRS2, RPS6KB1, PIK3R3, YWHAG, JAK2, RAF1, JAK1, PIK3C2B, PTK2, IGF1R, PIK3R2, SOCS6, YWHAZ, JUN, YWHAQ, AKT1, IRS1, GAB1, PIK3R1, YWHAH, SOCS7, PIK3CA, PTPN11, GRB2, MAPK8, PRKCI, PRKCZ, YWHAB, FOXO1, MAPK3, RPS6KB2, IRS2, CSNK2B, ATM, PXN, CASP9, SOS1, AKT2, PIK3CG, NEDD4, PDPK1, SRF, MAPK1, SOCS1, RASA1, PRKACA, HRAS, CSNK2A1, SHC1 PRKAG1
Small Cell Lung Cancer Signaling 2.00E-37 FGFR1, FGFR2, FGFR3 BIRC2, NFKBIA, IKBKG, FRS2, RXRA, TRAF1, TRAF6, PIK3R3, IKBKB, PIK3C2B, PTK2, TRAF3, NFKB2, ABL1, MYC, PIK3R2, CDKN1B, CCND1, BCL2L1, CKS1B, IKBKE, TRAF2, FHIT, APAF1, AKT1, E2F1, IRS1, GAB1, PIK3R1, MAX, TP53, NOS1, PIK3CA, PTPN11, GRB2, CDK6, NFKB1, CDK4, IRS2, CHUK, ATM, CDK2, CASP9, RXRB, AKT2, RELA, PIK3CG, RB1, RARB CDKN2B
Axonal Guidance Signaling 2.51E-37 TUBB1, TUBA1A, TUBA4A, TUBA8, TUBB2A, NTRK2, FGFR3, FGFR1, TUBB3, TUBG1, TUBA1C, TUBB4B, FGFR2, TUBB4A GNA11, MMP2, EFNA5, GNAQ, WAS, FRS2, ADAM12, FES, NCK1, PRKCE, EFNB2, EFNB1, MME, PIK3C2B, WASL, PTK2, RTN4, PRKCD, NRP1, BCAR1, ITGA5, PDGFD, EPHA3, IRS1, GAB1, FYN, CFL1, ARHGEF7, PTPN11, ITGB1, GIT1, CRK, PRKCI, PRKCZ, VEGFB, KEL, PAK1, MYL12A, ROBO1, NTF3, NFATC1, EPHA4, SOS1, FARP2, PLCG2, PRKCA, PLCG1, PRKD1, PRKACA, PDGFA, HRAS, RAC1, SEMA4G, CDC42, PRKCQ, ERBB2, PRKCH, NTF4, BDNF, VEGFC, PIK3R3, CRKL, VEGFA, RAF1, ADAM15, CDK5, EPHB2, PDGFC, ABL1, PIK3R2, NCK2, TUBA1B, GSK3B, AKT1, NRP2, PGF, GNA12, MICAL1, PDGFB, PIK3R1, GNAI2, PIK3CA, GRB2, MET, MAPK3, PAK2, IRS2, TUBB, ATM, PXN, AKT2, PIK3CG, NFATC3, NGFR, MKNK1, MAPK1, RASA1, PAK4, SHC1 MYL6B, DPYSL2, PRKAG1, PLCL1, WNT7B, WNT6, PLXNA1, TUBA3E, WNT3
p53 Signaling 3.98E-37 FGFR1, CDKN2A, FGFR2, WT1, FGFR3 KAT2B, PML, CCNG1, THBS1, CSNK1D, FRS2, ATR, HDAC1, TP63, PIK3R3, CCND2, CTNNB1, BIRC5, PIK3C2B, ST13, RRM2B, CCNK, PIK3R2, CCND1, TP73, BCL2L1, FAS, JUN, GSK3B, APAF1, AKT1, E2F1, IRS1, GAB1, PIK3R1, PIAS1, TP53, PCNA, TOPBP1, PIK3CA, PTPN11, CDKN1A, GRB2, MAPK8, PRKDC, SIRT1, BRCA1, CDK4, IRS2, ATM, EP300, CDK2, AKT2, CASP6, PIK3CG, HIF1A, MDM2, RB1, CHEK1 GML
PI3K/AKT Signaling 1.58E-36 HSP90B1, FOXO3, HSP90AA1, HSP90AB1 JAK3, INPPL1, YWHAE, NFKBIA, IKBKG, PPP2R5A, NOS3, RPS6KB1, PIK3R3, YWHAG, JAK2, CTNNB1, RAF1, JAK1, IKBKB, NFKB2, PIK3R2, CDKN1B, CCND1, BCL2L1, YWHAZ, ITGA5, IKBKE, GSK3B, YWHAQ, AKT1, CDC37, GAB1, PIK3R1, TP53, YWHAH, INPP5D, PIK3CA, ITGB1, CDKN1A, GRB2, PRKCZ, TSC1, YWHAB, FOXO1, MAPK3, RPS6KB2, NFKB1, CHUK, TYK2, SOS1, AKT2, RELA, PIK3CG, PDPK1, GAB2, MAPK1, MDM2, HRAS, SHC1 OCRL, PPP2CB, MCL1, EIF4EBP1
VEGF Signaling 3.98E-36 FGFR1, FLT1, SRC, KDR, FOXO3, FGFR2, FGFR3, FLT4 VCL, YWHAE, ACTG1, ACTB, FRS2, ARNT, NOS3, ACTN4, VEGFC, PIK3R3, VEGFA, RAF1, PIK3C2B, ACTN1, PTK2, SH2D2A, PDGFC, EIF1AY, PIK3R2, PTK2B, BCL2L1, AKT1, PGF, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, GRB2, PTPN6, VEGFB, FOXO1, MAPK3, IRS2, ATM, PXN, SOS1, AKT2, PLCG2, PIK3CG, PRKCA, HIF1A, MAPK1, PLCG1, HRAS, SHC1 EIF2B1, EIF2B2
Role of Macrophages_ Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 6.31E-36 SRC, FGFR3, FGFR1, FGFR2 CAMK2B, TLR1, TNFRSF1A, GNAQ, FRS2, LRP1, TRAF1, TLR2, TRAF6, PRKCE, CTNNB1, PIK3C2B, TRAF3, PRKCD, HNF1A, JUN, PDGFD, IL6R, IRS1, GAB1, APC, FN1, PTPN11, CREBBP, PRKCI, PRKCZ, VEGFB, CHUK, LTA, EP300, MAP3K14, NFATC1, PLCG2, PRKCA, CEBPB, PLCG1, PRKD1, PDGFA, HRAS, RAC1, PRKCQ, NFKBIA, TLR4, IKBKG, STAT3, PRKCH, RIPK1, VEGFC, PIK3R3, JAK2, IL1B, VEGFA, RAF1, IKBKB, FGF2, NLK, PDGFC, MYC, PIK3R2, CCND1, IKBKE, GSK3B, TRAF2, AKT1, PGF, PDGFB, PIK3R1, PIK3CA, TNF, GRB2, MAPK3, IRAK1, NFKB1, IRS2, ATM, AKT2, RELA, PIK3CG, NFATC3, NOS2, NGFR, MAPK1, SOCS1 IL1RL1, IL6, PLCL1, WNT7B, IL7, WNT6, CALML5, MAP3K7, WNT3, APC2
Role of NFAT in Regulation of the Immune Response 7.94E-36 FGFR1, HLA-DQA1, LCK, LYN, FGFR2, FGFR3 GNA11, PRKCQ, FCER1G, NFKBIA, IKBKG, LCP2, CSNK1D, GNAQ, SYK, FRS2, CD80, CD4, ITPR1, LAT, CD79A, CD86, ZAP70, CD3E, PIK3R3, RAF1, IKBKB, PIK3C2B, FCGR2A, NFKB2, CD28, PIK3R2, HLA-B, IKBKE, JUN, GSK3B, AKT1, GNA12, IRS1, GAB1, PIK3R1, MS4A2, GNAI2, FYN, PIK3CA, PTPN11, ITK, GATA4, GRB2, MEF2D, MAPK3, NFKB1, IRS2, CHUK, ATM, CD79B, BTK, NFATC1, MEF2C, SOS1, AKT2, RELA, PLCG2, PIK3CG, NFATC3, FCGR2B, HLA-A, MAPK1, PLCG1, HRAS, CD247 HLA-DQB1, CALML5
CD28 Signaling in T Helper Cells 1.00E-35 FGFR1, HLA-DQA1, CTLA4, LCK, FGFR2, FGFR3 CDC42, MAPK10, PRKCQ, FCER1G, NFKBIA, IKBKG, LCP2, WAS, SYK, FRS2, CD80, CD4, ITPR1, LAT, CD86, ZAP70, CD3E, PIK3R3, IKBKB, PIK3C2B, VAV1, NFKB2, CD28, PIK3R2, HLA-B, IKBKE, JUN, AKT1, IRS1, GAB1, PIK3R1, FYN, PIK3CA, PTPN11, ITK, GRB2, PTPN6, MAPK8, NFKB1, IRS2, CHUK, ATM, PAK1, NFATC1, AKT2, RELA, PIK3CG, NFATC3, PDPK1, HLA-A, CSK, PLCG1, PTPRC, CD247, RAC1 HLA-DQB1, CALML5
Prolactin Signaling 1.58E-35 FGFR1, FGFR2, FGFR3, SP1 SOCS5, PRKCQ, STAT3, FRS2, PRKCH, PRKCE, PIK3R3, JAK2, RAF1, PIK3C2B, MYC, PRKCD, PIK3R2, NR3C1, SOCS6, STAT5B, NMI, JUN, IRS1, GAB1, PIK3R1, SOCS7, FYN, PIK3CA, STAT1, PTPN11, STAT5A, GRB2, CREBBP, PRKCI, PRKCZ, MAPK3, IRS2, ATM, EP300, SOS1, PLCG2, PIK3CG, PDPK1, PRKCA, CEBPB, MAPK1, PLCG1, SOCS1, PRKD1, HRAS, SHC1
Erythropoietin Signaling 5.01E-35 FGFR1, SRC, FGFR2, FGFR3 PRKCQ, NFKBIA, IKBKG, FRS2, PRKCH, RPS6KB1, PRKCE, PIK3R3, JAK2, RAF1, PIK3C2B, NFKB2, PRKCD, PIK3R2, STAT5B, JUN, AKT1, IRS1, GAB1, PIK3R1, CBL, PIK3CA, PTPN11, STAT5A, GRB2, PTPN6, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, ATM, SOS1, AKT2, EPOR, RELA, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, SOCS1, PRKD1, HRAS, SHC1
iCOS-iCOSL Signaling in T Helper Cells 7.94E-35 FGFR1, HLA-DQA1, LCK, FGFR2, FGFR3 CAMK2B, PRKCQ, FCER1G, NFKBIA, IL2RG, IKBKG, LCP2, FRS2, CD80, CD4, ITPR1, LAT, ZAP70, CD3E, PIK3R3, IKBKB, PIK3C2B, VAV1, NFKB2, CD28, PIK3R2, TRAT1, HLA-B, IKBKE, AKT1, IL2RB, IRS1, GAB1, PIK3R1, CD40, INPP5D, PIK3CA, PTPN11, ITK, GRB2, NFKB1, IRS2, CHUK, ATM, NFATC1, AKT2, RELA, PIK3CG, NFATC3, PDPK1, HLA-A, GAB2, CSK, PLCG1, PTPRC, CD247, RAC1, SHC1 HLA-DQB1, CALML5
Germ Cell-Sertoli Cell Junction Signaling 1.26E-34 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, FGFR2, TUBA8, TUBB2A, FGFR3, TUBB4A IQGAP1, CDC42, VCL, TNFRSF1A, MAPK10, ZYX, ACTG1, ACTB, FRS2, ACTN4, PIK3R3, CTNNB1, JUP, PIK3C2B, ACTN1, WASL, PTK2, RAB8B, TGFBR2, PIK3R2, SORBS1, BCAR1, TUBA1B, AKT1, TJP1, IRS1, GAB1, PIK3R1, CTNND1, CFL1, PIK3CA, PTPN11, TNF, ITGB1, GRB2, CDH1, MAPK8, MAP3K3, MAPK3, PAK2, IRS2, TUBB, ATM, PAK1, MAP3K14, PXN, PIK3CG, PDPK1, MAPK1, PAK4, HRAS, RAC1 GSN, RHOQ, TUBA3E, MAP3K7, RND2
IL-8 Signaling 1.26E-34 FGFR1, FLT1, SRC, KDR, FGFR2, FGFR3, FLT4 IQGAP1, ITGAV, MMP2, MAPK10, PRKCQ, PLD1, IKBKG, FRS2, PRKCH, VEGFC, RPS6KB1, TRAF6, PRKCE, EGFR, PIK3R3, CCND2, VEGFA, RAF1, IKBKB, PIK3C2B, PTK2, PDGFC, PRKCD, PIK3R2, PTK2B, CCND1, CXCR1, BCL2L1, IKBKE, JUN, AKT1, PGF, GNA12, IRS1, GAB1, LASP1, PIK3R1, GNAI2, PIK3CA, PTPN11, GRB2, ITGB3, CDH1, MAPK8, PRKCI, PRKCZ, VEGFB, MAPK3, IRAK1, PAK2, NFKB1, IRS2, CHUK, ATM, AKT2, RELA, PIK3CG, PRKCA, PLD2, MAPK1, PRKD1, ARAF, HRAS, RAC1 ITGAM, RHOQ, EIF4EBP1, RND2
HGF Signaling 1.00E-33 FGFR1, CDKN2A, FGFR2, FGFR3 CDC42, MAPK10, PRKCQ, ELF1, STAT3, FRS2, PRKCH, PRKCE, PIK3R3, CRKL, RAF1, PIK3C2B, PTK2, PRKCD, PIK3R2, CCND1, ETS1, ITGA5, JUN, AKT1, IRS1, GAB1, PIK3R1, ETS2, PIK3CA, PTPN11, ITGB1, CDKN1A, GRB2, MET, MAPK8, PRKCI, RAPGEF1, PRKCZ, MAP3K3, MAPK3, IRS2, ATM, PAK1, MAP3K14, CDK2, PXN, SOS1, AKT2, PLCG2, PIK3CG, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, RAC1 IL6, MAP3K7
Huntington's Disease Signaling 1.26E-33 FGFR1, FGFR2, FGFR3, SP1 NCOR2, GNA11, PRKCQ, DNM1, GNAQ, SNCA, FRS2, ITPR1, PRKCH, BDNF, HDAC1, PRKCE, EGFR, PIK3R3, CLTC, POLR2E, PIK3C2B, CDK5, PSME1, HDAC3, IGF1R, PRKCD, CDK5R1, SGK1, DNM2, PIK3R2, UBB, CASP3, BCL2L1, JUN, TBP, APAF1, AKT1, IRS1, GAB1, PIK3R1, TP53, DNM1L, TAF4, HTT, PIK3CA, PTPN11, HSPA8, GRB2, CREBBP, NCOR1, MAPK8, PRKCI, PRKCZ, UBC, CASP7, MAPK3, HDAC2, IRS2, ATM, EP300, CASP9, SOS1, AKT2, CASP6, PIK3CG, GRIN2B, HSPA9, HSPA4, PDPK1, ARFIP2, HDAC6, DLG4, PRKCA, NAPG, MAPK1, PRKD1, RASA1, POLR2G, HRAS, SHC1 GPAA1, PENK, DCTN1, CAPN2
p70S6K Signaling 1.26E-33 FGFR1, SRC, IL4R, LYN, FGFR2, FGFR3 PRKCQ, PLD1, YWHAE, EEF2, IL2RG, GNAQ, SYK, PPP2R5A, FRS2, PRKCH, CD79A, RPS6KB1, PRKCE, EGFR, PIK3R3, YWHAG, RAF1, JAK1, PIK3C2B, PRKCD, PIK3R2, YWHAZ, YWHAQ, AKT1, IRS1, GAB1, PIK3R1, YWHAH, GNAI2, PIK3CA, PTPN11, GRB2, CD19, MAPT, PRKCI, PRKCZ, YWHAB, MAPK3, IRS2, ATM, CD79B, BTK, IL4, SOS1, AKT2, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, SHC1 PPP2CB, PLCL1
IL-3 Signaling 5.01E-33 FGFR1, FGFR2, FGFR3 PRKCQ, STAT3, FRS2, PRKCH, PRKCE, PIK3R3, JAK2, CRKL, RAF1, JAK1, PIK3C2B, PRKCD, PIK3R2, STAT6, STAT5B, JUN, AKT1, IRS1, GAB1, PIK3R1, INPP5D, PIK3CA, STAT1, PTPN11, STAT5A, GRB2, PTPN6, PRKCI, RAPGEF1, PRKCZ, FOXO1, MAPK3, IRS2, CSF2RB, ATM, PAK1, SOS1, AKT2, PIK3CG, GAB2, PRKCA, MAPK1, PRKD1, HRAS, RAC1, SHC1
JAK/Stat Signaling 5.01E-33 FGFR1, FGFR2, FGFR3 SOCS5, JAK3, GNAQ, STAT3, FRS2, PIK3R3, JAK2, RAF1, JAK1, PIK3C2B, PTPN1, NFKB2, PIK3R2, STAT6, BCL2L1, SOCS6, STAT5B, JUN, AKT1, IRS1, GAB1, PIK3R1, PIAS1, SOCS7, PIK3CA, STAT1, PTPN11, STAT5A, CDKN1A, GRB2, PTPN6, MAPK3, NFKB1, IRS2, ATM, TYK2, SOS1, AKT2, RELA, PIK3CG, CEBPB, MAPK1, SOCS1, HRAS, SHC1 IL6
NF-_B Activation by Viruses 6.31E-33 FGFR1, LCK, FGFR2, FGFR3 EIF2AK2, ITGAV, PRKCQ, NFKBIA, IKBKG, FRS2, CD4, PRKCH, RIPK1, PRKCE, PIK3R3, RAF1, IKBKB, PIK3C2B, NFKB2, PRKCD, PIK3R2, ITGA5, IKBKE, TRAF2, TBP, AKT1, IRS1, GAB1, PIK3R1, CCR5, PIK3CA, PTPN11, ITGB1, GRB2, ITGB3, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, CHUK, ATM, MAP3K14, AKT2, RELA, PIK3CG, PRKCA, MAPK1, PRKD1, HRAS
Natural Killer Cell Signaling 6.31E-32 FGFR1, LCK, FGFR2, FGFR3 PRKCQ, INPPL1, FCER1G, LCP2, SYK, FRS2, PRKCH, LAT, NCK1, ZAP70, PRKCE, PIK3R3, RAF1, PIK3C2B, VAV1, FCGR2A, PRKCD, PIK3R2, AKT1, IRS1, GAB1, PIK3R1, FYN, INPP5D, PIK3CA, PTPN11, SH3BP2, GRB2, PTPN6, PRKCI, PRKCZ, MAPK3, PAK2, IRS2, ATM, PAK1, SOS1, AKT2, PLCG2, PIK3CG, PRKCA, MAPK1, PLCG1, PRKD1, PAK4, SH2D1A, HRAS, CD247, RAC1, SHC1 OCRL, CD244
Clathrin-mediated Endocytosis Signaling 1.26E-31 FGFR1, SRC, FGFR2, FGFR3 CDC42, CD2AP, FGF4, CSNK2A2, DNM1, ACTG1, ACTB, FRS2, VEGFC, PIK3R3, VEGFA, CLTC, FGF10, PIK3C2B, FGF2, WASL, EPHB2, PDGFC, APOB, DNM2, PIK3R2, UBB, ITGA5, ITGB4, FGF5, FGF6, FGF1, TF, PDGFD, PGF, IRS1, PDGFB, HGS, FGF18, GAB1, FGF23, PIK3R1, CBL, AP1B1, DNM1L, PIK3CA, PTPN11, HSPA8, ITGB1, GRB2, MET, ITGB3, VEGFB, UBC, SH3GL2, S100A8, IRS2, CTTN, CSNK2B, ATM, FGF7, FGF3, PIK3CG, FGF17, MDM2, FGF8, AP2M1, DAB2, PDGFA, RAC1, CSNK2A1, FGF9 AMPH, ALB
RAR Activation 2.00E-31 SRC NCOR2, KAT2B, PML, ADCY6, MAPK10, PRKCQ, CSNK2A2, SMARCA4, SMAD4, SMARCB1, ACTB, SMAD3, RXRA, PRKCH, REL, PRKCE, PIK3R3, JAK2, VEGFA, SMAD2, HLTF, SMARCE1, SMARCC2, NFKB2, PRKCD, PIK3R2, SMAD1, PSMC5, RARG, STAT5B, ARID1A, JUN, AKT1, RARA, ZBTB16, PIK3R1, SMARCC1, TAF4, SMAD7, PIK3CA, SNW1, STAT5A, CREBBP, NCOR1, MAPK8, PRKCI, PRKCZ, CARM1, NFKB1, CDK7, CSNK2B, CSF2RB, EP300, RXRB, AKT2, NR2F2, RELA, PIK3CG, PARP1, PDPK1, PRKCA, CSK, NR2F1, MAPK1, PRKD1, PRKACA, RAC1, CSNK2A1, RARB PRMT1, PRKAG1
HER-2 Signaling in Breast Cancer 2.51E-31 FGFR1, FGFR2, FGFR3 CDC42, MMP2, PRKCQ, FRS2, ERBB2, PRKCH, PRKCE, EGFR, PIK3R3, PIK3C2B, PRKCD, PIK3R2, CDKN1B, CCND1, ERBB3, ITGB4, GSK3B, AKT1, IRS1, GAB1, PIK3R1, TP53, AREG, PIK3CA, PTPN11, ITGB1, CDKN1A, GRB2, ITGB3, PRKCI, CDK6, PRKCZ, TSC1, FOXO1, IRS2, ATM, CASP9, SOS1, AKT2, PIK3CG, PRKCA, PLCG1, PRKD1, MDM2, HRAS NRG1
Neuregulin Signaling 2.51E-31 SRC, HSP90B1, HSP90AA1, HSP90AB1 PRKCQ, ERBB2, PRKCH, RPS6KB1, PRKCE, EGFR, PIK3R3, CRKL, RAF1, CDK5, GRB7, MYC, PRKCD, CDK5R1, PIK3R2, CDKN1B, ERBB3, STAT5B, ITGA5, AKT1, PIK3R1, AREG, PTPN11, ITGB1, STAT5A, GRB2, CRK, PRKCI, PRKCZ, MAPK3, RPS6KB2, MATK, SOS1, AKT2, PLCG2, PDPK1, DLG4, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, SHC1 NRG1
Renin-Angiotensin Signaling 6.31E-31 FGFR1, FGFR2, FGFR3 ADCY6, MAPK10, PRKCQ, GNAQ, STAT3, FRS2, ITPR1, PRKCH, PRKCE, PIK3R3, JAK2, RAF1, PIK3C2B, PTK2, NFKB2, PRKCD, PIK3R2, PTK2B, JUN, SHC2, IRS1, GAB1, PIK3R1, SHF, PIK3CA, STAT1, PTPN11, TNF, GRB2, PTPN6, MAPK8, PRKCI, PRKCZ, MAPK3, PAK2, NFKB1, IRS2, ATM, PAK1, SOS1, SHC3, RELA, PLCG2, PIK3CG, PRKCA, MAPK1, PLCG1, PRKD1, PAK4, PRKACA, HRAS, RAC1, SHC1 PRKAG1
PAK Signaling 6.31E-31 FGFR1, PDGFRA, FGFR2, FGFR3, PDGFRB CDC42, MAPK10, FRS2, NCK1, PIK3R3, RAF1, PIK3C2B, WASL, PTK2, PDGFC, PIK3R2, PTK2B, NCK2, MYLK, CASP3, ITGA5, PDGFD, EPHA3, IRS1, PDGFB, GAB1, PIK3R1, CFL1, ARHGEF7, PIK3CA, PTPN11, TNF, ITGB1, GRB2, GIT1, MAPK8, MAPK3, PAK2, IRS2, ATM, PAK1, MYL12A, PXN, SOS1, PIK3CG, MAPK1, PAK4, PDGFA, HRAS, RAC1, SHC1 MYL6B
ErbB Signaling 1.00E-30 FGFR1, FGFR2, FGFR3 CDC42, MAPK10, PRKCQ, FRS2, ERBB2, PRKCH, NCK1, RPS6KB1, PRKCE, EGFR, PIK3R3, RAF1, PIK3C2B, PRKCD, PIK3R2, NCK2, ERBB3, JUN, GSK3B, AKT1, IRS1, GAB1, PIK3R1, AREG, PIK3CA, PTPN11, GRB2, MAPK8, PRKCI, PRKCZ, FOXO1, MAPK3, PAK2, IRS2, ATM, PAK1, SOS1, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, PRKD1, PAK4, HRAS, SHC1 NRG1
Insulin Receptor Signaling 1.26E-30 FGFR1, FOXO3, FGFR2, FGFR3 GRB10, INPPL1, FRS2, PTPRF, SH2B2, NCK1, RPS6KB1, PIK3R3, JAK2, CRKL, RAF1, INSR, JAK1, PIK3C2B, PTPN1, SGK1, PIK3R2, GSK3B, PPP1CC, AKT1, IRS1, GAB1, PIK3R1, CBL, FYN, INPP5D, PIK3CA, PTPN11, GRB2, CRK, MAPK8, PRKCI, RAPGEF1, PRKCZ, TSC1, FOXO1, MAPK3, RPS6KB2, IRS2, ATM, TRIP10, SOS1, AKT2, PIK3CG, PDPK1, SLC2A4, ACLY, MAPK1, PRKACA, HRAS, SHC1 OCRL, PRKAG1, RHOQ, EIF2B1, EIF2B2, EIF4EBP1
IL-15 Signaling 1.58E-30 FGFR2, FGFR1, LCK, FGFR3 AKT1, JAK3, IL2RB, IRS1, GAB1, PIK3R1, IL2RG, STAT3, SYK, PIK3CA, PTPN11, TNF, FRS2, STAT5A, GRB2, MAPK3, NFKB1, FASLG, PIK3R3, IRS2, JAK2, ATM, RAF1, IL4, JAK1, PIK3C2B, TYK2, PTK2, AKT2, RELA, PIK3CG, NFKB2, PIK3R2, STAT6, MAPK1, PLCG1, BCL2L1, STAT5B, HRAS, SHC1 IL6
Actin Cytoskeleton Signaling 1.58E-30 FGFR1, FGFR2, FGFR3 IQGAP1, CDC42, VCL, FGF4, WAS, ACTG1, ACTB, FRS2, ACTN4, PIK3R3, TLN1, FLNA, CRKL, RAF1, EZR, FGF10, TIAM1, PIK3C2B, ACTN1, FGF2, WASL, PTK2, VAV1, PDGFC, PIK3R2, MYLK, BCAR1, ITGA5, FGF5, FGF6, FGF1, PDGFD, GNA12, IRS1, PDGFB, FGF18, GAB1, FGF23, PIK3R1, APC, FN1, CFL1, ARHGEF7, PIK3CA, PTPN11, ITGB1, GRB2, GIT1, CRK, MAPK3, PAK2, IRS2, ATM, PAK1, MYL12A, ARHGAP35, PXN, FGF7, FGF3, MATK, SOS1, PIK3CG, FGF17, CSK, MAPK1, FGF8, PAK4, PDGFA, HRAS, RAC1, SHC1, FGF9 MYL6B, GSN, APC2
eNOS Signaling 3.16E-30 FGFR1, FLT1, KDR, HSP90B1, FGFR2, HSP90AA1, FGFR3, FLT4, HSP90AB1 ADCY6, GUCY1B3, PRKCQ, GNAQ, FRS2, ITPR1, STUB1, ESR2, NOS3, PRKCH, VEGFC, ESR1, PRKCE, CCNA1, PIK3R3, VEGFA, CHRNA7, PIK3C2B, PDGFC, PRKCD, DNM2, PIK3R2, CASP3, AKT1, PGF, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, HSPA8, GRB2, PRKCI, PRKCZ, VEGFB, IRS2, LPAR2, ATM, CASP9, AKT2, PLCG2, PIK3CG, HSPA9, HSPA4, CAV1, PDPK1, PRKCA, PLCG1, PRKD1, CCNA2, PRKACA PRKAG1, CALML5, AQP5, CHRM3
Glioblastoma Multiforme Signaling 3.16E-30 FGFR1, CDKN2A, SRC, PDGFRA, FGFR2, FGFR3, PDGFRB CDC42, E2F3, FRS2, ITPR1, RPS6KB1, EGFR, PIK3R3, CTNNB1, RAF1, PIK3C2B, PDGFC, IGF1R, MYC, PRKCD, PIK3R2, CDKN1B, CCND1, GSK3B, PDGFD, AKT1, E2F1, IRS1, PDGFB, GAB1, PIK3R1, TP53, APC, PIK3CA, PTPN11, E2F2, CDKN1A, GRB2, CDK6, TSC1, FOXO1, MAPK3, CDK4, IRS2, ATM, CDK2, SOS1, AKT2, PLCG2, PIK3CG, MAPK1, PLCG1, MDM2, RB1, PDGFA, HRAS, RAC1, SHC1 WNT6, RHOQ, PLCL1, WNT3, WNT7B, RND2
Neuroinflammation Signaling Pathway 3.98E-30 FGFR1, HLA-DQA1, FGFR2, FGFR3 BIRC2, GJB1, TLR1, TNFRSF1A, MAPK10, JAK3, SLC6A13, TLR4, IKBKG, SNCA, SYK, FRS2, CD80, RIPK1, BDNF, BACE1, TLR2, CD86, TRAF6, PIK3R3, JAK2, IL1B, CTNNB1, CALB2, IRF3, BIRC5, JAK1, IKBKB, PIK3C2B, APP, IL34, TRAF3, MAPK6, NFKB2, BMPR2, TGFBR2, GRIN2A, PIK3R2, CASP3, HLA-B, FAS, IKBKE, JUN, GSK3B, AKT1, IL6R, IRS1, GAB1, PIK3R1, CD40, CSF1R, TBK1, MAPK15, PIK3CA, STAT1, PTPN11, TNF, GRB2, CREBBP, MAPT, MAPK8, MAPK3, IRAK1, NFKB1, FASLG, IRS2, CHUK, ATM, EP300, IL4, NFATC1, TYK2, AKT2, RELA, PLCG2, PIK3CG, GRIN2B, NFATC3, NOS2, HLA-A, MAPK1, PLCG1 HMGB1, HLA-DQB1, ACVR1B, IL6, GRIN1, GRIA1
Lymphotoxin _ Receptor Signaling 5.01E-30 FGFR2, FGFR1, FGFR3 BIRC2, TRAF2, APAF1, AKT1, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, PIK3CA, PTPN11, FRS2, GRB2, CREBBP, TRAF1, MAPK3, TRAF6, NFKB1, PIK3R3, IRS2, CHUK, ATM, LTA, EP300, MAP3K14, CASP9, IKBKB, PIK3C2B, TRAF3, AKT2, RELA, PIK3CG, NFKB2, PDPK1, PIK3R2, MAPK1, CASP3, BCL2L1, IKBKE
Colorectal Cancer Metastasis Signaling 6.31E-30 FGFR1, SRC, FGFR2, FGFR3 MMP2, TLR1, ADCY6, TNFRSF1A, MAPK10, JAK3, SMAD4, TLR4, STAT3, FRS2, SMAD3, LRP1, VEGFC, TLR2, EGFR, PIK3R3, JAK2, CTNNB1, VEGFA, SMAD2, BIRC5, JAK1, PIK3C2B, PDGFC, NFKB2, MYC, TGFBR2, PIK3R2, CCND1, HNF1A, CASP3, BCL2L1, JUN, GSK3B, AKT1, PGF, IL6R, IRS1, GAB1, PIK3R1, TP53, APC, PIK3CA, STAT1, PTPN11, TNF, GRB2, CDH1, MAPK8, VEGFB, MAPK3, NFKB1, IRS2, ATM, CASP9, TYK2, SOS1, AKT2, SIAH1, RELA, PIK3CG, NOS2, MAPK1, PRKACA, HRAS, RAC1 WNT6, PRKAG1, RHOQ, IL6, WNT3, WNT7B, MMP17, RND2
ERK/MAPK Signaling 7.94E-30 FGFR1, SRC, FGFR2, FGFR3 MYCN, ELF1, STAT3, PPP2R5A, FRS2, ESR1, PRKCE, PIK3R3, YWHAG, TLN1, CRKL, RAF1, PIK3C2B, PTK2, MYC, PRKCD, PIK3R2, PTK2B, BCAR1, ETS1, YWHAZ, ITGA5, PPP1CC, YWHAQ, IRS1, GAB1, PIK3R1, YWHAH, ETS2, FYN, PIK3CA, STAT1, PTPN11, ITGB1, GRB2, CREBBP, CRK, PRKCI, RAPGEF1, YWHAB, MAPK3, PAK2, IRS2, RAPGEF4, ATM, PAK1, EP300, PXN, NFATC1, SOS1, PLCG2, PIK3CG, SRF, PRKCA, MKNK1, RPS6KA1, MAPK1, PLCG1, ARAF, PAK4, PRKACA, HRAS, RAC1, SHC1 PPP2CB, PRKAG1, RAPGEF3, EIF4EBP1
Prostate Cancer Signaling 7.94E-30 FGFR1, HSP90B1, FGFR2, HSP90AA1, FGFR3, HSP90AB1 NKX3-1, NFKBIA, IKBKG, FRS2, PIK3R3, CTNNB1, RAF1, PIK3C2B, NFKB2, AR, ABL1, PIK3R2, CDKN1B, CCND1, GSK3B, AKT1, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, CDKN1A, GRB2, CREBBP, FOXO1, MAPK3, NFKB1, IRS2, CHUK, ATM, EP300, CDK2, CASP9, SOS1, AKT2, RELA, PIK3CG, PDPK1, MAPK1, MDM2, RB1, HRAS
Acute Myeloid Leukemia Signaling 7.94E-30 FGFR1, FGFR2, FLT3, FGFR3 PML, CSF3R, STAT3, FRS2, RPS6KB1, CCNA1, PIK3R3, RAF1, JUP, KIT, PIK3C2B, NFKB2, MYC, PIK3R2, CCND1, HNF1A, STAT5B, FLT3LG, AKT1, RARA, CSF2RA, IRS1, GAB1, PIK3R1, CSF1R, PIK3CA, PTPN11, STAT5A, GRB2, MAPK3, RPS6KB2, NFKB1, IRS2, CSF2RB, ATM, PIM2, SOS1, AKT2, RELA, PIK3CG, PIM1, MAPK1, ARAF, HRAS EIF4EBP1
Gap Junction Signaling 1.00E-29 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, FGFR2, TUBA8, TUBB2A, FGFR3, SP1, TUBB4A GJB1, ADCY6, GUCY1B3, PRKCQ, CSNK1D, GNAQ, ACTG1, ACTB, FRS2, ITPR1, PRKCH, PRKCE, EGFR, PIK3R3, CTNNB1, RAF1, PIK3C2B, PRKCD, PIK3R2, TUBA1B, GJA1, AKT1, TJP1, IRS1, GAB1, PIK3R1, GRIA3, GNAI2, PIK3CA, PTPN11, GRB2, PRKCI, PRKCZ, MAPK3, IRS2, TUBB, ATM, SOS1, AKT2, PLCG2, PIK3CG, CAV1, PRKCA, SP3, MAPK1, PLCG1, PRKD1, GUCY2C, PRKACA, HRAS GJB3, PRKAG1, TUBA3E, PLCL1, GRIA1
Type II Diabetes Mellitus Signaling 1.58E-29 FGFR1, FGFR2, FGFR3 SOCS5, TNFRSF1A, MAPK10, PRKCQ, PKM, NFKBIA, IKBKG, FRS2, PRKCH, SH2B2, PRKCE, PIK3R3, INSR, IKBKB, PIK3C2B, NFKB2, CD36, PRKCD, PIK3R2, SOCS6, IKBKE, TRAF2, AKT1, IRS1, GAB1, PIK3R1, SOCS7, PIK3CA, PTPN11, TNF, GRB2, MAPK8, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, CHUK, ATM, MAP3K14, AKT2, RELA, PIK3CG, PDPK1, PRKCA, NGFR, SLC2A4, CEBPB, MAPK1, SOCS1, PRKD1 PRKAG1, MAP3K7, ENPP7
PKC_ Signaling in T Lymphocytes 2.00E-29 FGFR1, HLA-DQA1, LCK, FGFR2, FGFR3 POU2F1, CAMK2B, PRKCQ, FCER1G, NFKBIA, IKBKG, LCP2, FRS2, CD80, CD4, LAT, CD86, ZAP70, CD3E, PIK3R3, IKBKB, PIK3C2B, VAV1, NFKB2, CD28, PIK3R2, HLA-B, IKBKE, JUN, IRS1, GAB1, PIK3R1, FYN, PIK3CA, PTPN11, GRB2, MAPK8, MAP3K3, MAPK3, NFKB1, IRS2, CHUK, ATM, MAP3K14, NFATC1, SOS1, RELA, PLCG2, PIK3CG, NFATC3, HLA-A, MAPK1, PLCG1, HRAS, CD247, RAC1 HLA-DQB1, MAP3K7
FGF Signaling 2.51E-29 FGFR2, FGFR1, FGFR3 FGF5, FGF6, FGF1, AKT1, FGF4, IRS1, FGF18, GAB1, FGF23, PIK3R1, STAT3, PIK3CA, PTPN11, FRS2, GRB2, MET, CREBBP, ITPR1, PTPN6, CRK, MAPK8, MAPK3, PIK3R3, IRS2, CRKL, ATM, RAF1, EP300, FGF10, FGF7, PIK3C2B, FGF2, FGF3, SOS1, AKT2, PIK3CG, FGF17, PRKCA, PIK3R2, MAPK1, PLCG1, FGF8, HRAS, RAC1, FGF9
IL-7 Signaling Pathway 2.51E-29 FGFR2, FGFR1, FGFR3, FOXO3, LYN JUN, GSK3B, AKT1, JAK3, IRS1, GAB1, PIK3R1, IL2RG, FYN, PIK3CA, STAT1, PTPN11, FRS2, IL7R, STAT5A, GRB2, MET, FOXO1, MAPK3, PIK3R3, IRS2, ATM, CDK2, JAK1, PIK3C2B, NFATC1, PTK2, SOS1, AKT2, PIK3CG, FOXG1, BCL6, MYC, PDPK1, PIK3R2, CDKN1B, CCND1, MAPK1, SOCS1, STAT5B, SHC1 MCL1, IL7
Nitric Oxide Signaling in the Cardiovascular System 6.31E-29 FGFR1, FLT1, KDR, HSP90B1, FGFR2, HSP90AA1, FGFR3, FLT4, HSP90AB1 GUCY1B3, PRKCQ, FRS2, ITPR1, NOS3, PRKCH, VEGFC, PRKCE, PIK3R3, VEGFA, PIK3C2B, PDGFC, PRKCD, PIK3R2, AKT1, PGF, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, GRB2, PRKCI, PRKCZ, VEGFB, CACNA1D, MAPK3, IRS2, ADRB3, ATM, AKT2, PIK3CG, CAV1, PRKCA, MAPK1, PRKD1, GUCY2C, PRKACA PRKAG1, CALML5, CACNA1S, PLN
Non-Small Cell Lung Cancer Signaling 6.31E-29 FGFR2, FGFR1, CDKN2A, FGFR3, FOXO3 FHIT, AKT1, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, ERBB2, GRB2, RXRA, ITPR1, CDK6, MAPK3, EGFR, PIK3R3, CDK4, IRS2, ATM, RAF1, CASP9, RXRB, PIK3C2B, SOS1, AKT2, PIK3CG, ABL1, PDPK1, PRKCA, PIK3R2, RASSF1, CCND1, MAPK1, PLCG1, RB1, HRAS, RARB
Ephrin Receptor Signaling 7.94E-29 SRC SH2D3C, CDC42, GNA11, EFNA5, GNAQ, WAS, STAT3, NCK1, VEGFC, DOK1, EFNB2, EFNB1, JAK2, CRKL, VEGFA, RAF1, WASL, EPHB2, PTK2, PDGFC, ABL1, ACP1, GRIN2A, SORBS1, NCK2, BCAR1, ITGA5, FGF1, PDGFD, AKT1, PGF, EPHA3, GNA12, PDGFB, GNAI2, FYN, CFL1, PTPN11, ITGB1, GRB2, CREBBP, CRK, RAPGEF1, VEGFB, MAPK3, PAK2, PAK1, EP300, MAP3K14, PXN, EPHA4, SOS1, AKT2, PIK3CG, GRIN2B, MAPK1, RASA1, PAK4, PDGFA, HRAS, RAC1, SHC1 GRIN1
Growth Hormone Signaling 7.94E-29 FGFR2, FGFR1, FGFR3 SOCS5, PRKCQ, IRS1, GAB1, PIK3R1, SOCS7, STAT3, PIK3CA, STAT1, PTPN11, FRS2, STAT5A, GRB2, PTPN6, PRKCH, PRKCI, PRKCZ, RPS6KB1, MAPK3, PRKCE, RPS6KB2, PIK3R3, IRS2, JAK2, RPS6KA3, ATM, PIK3C2B, PLCG2, PIK3CG, IGF1R, PRKCD, PDPK1, SRF, PRKCA, SLC2A4, PIK3R2, RPS6KA1, MAPK1, PLCG1, SOCS1, PRKD1, SOCS6, STAT5B
Fc_ Receptor-mediated Phagocytosis in Macrophages and Monocytes 1.00E-28 SRC, LYN CDC42, AKT1, PRKCQ, FGR, PIK3R1, PLD1, CBL, LCP2, WAS, SYK, FYN, INPP5D, ACTG1, ACTB, CRK, PRKCH, PRKCI, PRKCZ, NCK1, RPS6KB1, MAPK3, PRKCE, RPS6KB2, PIK3R3, TLN1, PAK1, EZR, PXN, FYB, VAV1, AKT2, FCGR2A, PIK3CG, PRKCD, GAB2, PRKCA, PIK3R2, PTK2B, NCK2, PLD2, MAPK1, PLCG1, PRKD1, YES1, RAC1
ILK Signaling 1.26E-28 FGFR1, FGFR2, FGFR3 CDC42, VCL, TNFRSF1A, MAPK10, MUC1, PPP2R5A, ACTG1, ACTB, FRS2, ACTN4, SH2B2, VEGFC, PIK3R3, CTNNB1, FLNA, VEGFA, PIK3C2B, ACTN1, PTK2, PDGFC, NFKB2, MYC, PIK3R2, CCND1, NCK2, CASP3, ITGB4, JUN, GSK3B, AKT1, DSP, PGF, IRS1, GAB1, PIK3R1, FN1, CFL1, PIK3CA, PTPN11, TNF, ITGB1, GRB2, CREBBP, ITGB3, CDH1, MAPK8, VEGFB, MAPK3, NFKB1, IRS2, ATM, EP300, PXN, AKT2, RELA, PIK3CG, KRT18, PDPK1, NOS2, HIF1A, MAPK1 PPP2CB, MYL6B, RHOQ, FBLIM1, RND2
Angiopoietin Signaling 1.26E-28 FGFR2, FGFR1, FGFR3 AKT1, DOK2, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, PIK3CA, PTPN11, FRS2, STAT5A, GRB2, NOS3, CRK, NCK1, FOXO1, PAK2, NFKB1, PIK3R3, IRS2, CHUK, ATM, PAK1, BIRC5, CASP9, IKBKB, PIK3C2B, PTK2, SOS1, AKT2, GRB7, RELA, PIK3CG, NFKB2, PIK3R2, RASA1, PAK4, STAT5B, HRAS, IKBKE, GRB14
Role of Tissue Factor in Cancer 1.26E-28 FGFR1, LCK, SRC, LYN, FGFR2, FGFR3 CDC42, GNA11, ITGAV, FGR, GNAQ, FRS2, VEGFC, RPS6KB1, EGFR, PIK3R3, JAK2, IL1B, VEGFA, PIK3C2B, PIK3R2, PTK2B, CASP3, BCL2L1, STAT5B, YES1, FGF5, AKT1, GNA12, IRS1, GAB1, PIK3R1, TP53, FYN, CFL1, PIK3CA, PTPN11, ITGB1, STAT5A, GRB2, ITGB3, MAPK3, IRS2, RPS6KA3, ATM, PAK1, EGR1, AKT2, PIK3CG, PRKCA, RPS6KA1, MAPK1, HRAS, RAC1 PLAUR
Integrin Signaling 1.58E-28 FGFR1, SRC, FGFR2, FGFR3 CDC42, ITGAV, VCL, NEDD9, ZYX, WAS, ACTG1, ACTB, FRS2, ACTN4, NCK1, PIK3R3, TLN1, CRKL, RAF1, PIK3C2B, ACTN1, WASL, PTK2, GRB7, ABL1, PIK3R2, NCK2, MYLK, BCAR1, ITGA5, TNK2, ITGB4, GSK3B, ASAP1, AKT1, IRS1, PDGFB, GAB1, PIK3R1, FYN, ARHGEF7, PIK3CA, PTPN11, ITGB1, GRB2, GIT1, ITGB3, CRK, MAPK8, RAPGEF1, MAPK3, PAK2, IRS2, CTTN, ATM, PAK1, MYL12A, PXN, SOS1, AKT2, PLCG2, PIK3CG, CAV1, MAPK1, PLCG1, PAK4, HRAS, RAC1, SHC1 GSN, ITGAM, RHOQ, CAPN2, RND2
IL-6 Signaling 1.58E-28 FGFR1, FGFR2, FGFR3 TNFRSF1A, MAPK10, CSNK2A2, NFKBIA, IKBKG, STAT3, FRS2, TRAF6, PIK3R3, JAK2, IL1B, VEGFA, RAF1, IKBKB, PIK3C2B, NFKB2, PIK3R2, IKBKE, JUN, TRAF2, AKT1, IL6R, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, TNF, GRB2, MAPK8, MAPK3, NFKB1, IRS2, CHUK, CSNK2B, ATM, MAP3K14, SOS1, AKT2, RELA, PIK3CG, SRF, NGFR, CEBPB, MAPK1, SOCS1, HRAS, CSNK2A1, SHC1 IL1RL1, MCL1, IL6, MAP3K7
Telomerase Signaling 2.00E-28 FGFR1, HSP90B1, FGFR2, HSP90AA1, FGFR3, SP1, HSP90AB1 IL2RG, ELF1, PPP2R5A, FRS2, HDAC1, POT1, EGFR, PIK3R3, RAF1, PIK3C2B, HDAC3, ABL1, MYC, PIK3R2, PTGES3, ETS1, AKT1, E2F1, IL2RB, IRS1, GAB1, PIK3R1, TP53, ETS2, TERF1, PIK3CA, PTPN11, CDKN1A, GRB2, MAPK3, HDAC2, IRS2, ATM, SOS1, AKT2, TERT, PIK3CG, PDPK1, HDAC6, TINF2, MAPK1, RB1, HRAS, SHC1 PPP2CB
PPAR Signaling 3.16E-28 HSP90AA1, PDGFRB, PDGFRA, HSP90B1, HSP90AB1 JUN, NCOR2, TRAF2, PDGFD, TNFRSF1A, PPARA, PDGFB, NFKBIA, IKBKG, SNW1, TNF, STAT5A, NR1H3, GRB2, RXRA, CREBBP, NCOR1, MAPK3, TRAF6, NFKB1, AIP, CHUK, IL1B, RAF1, EP300, MAP3K14, INSR, IKBKB, SOS1, PDGFC, RELA, NFKB2, PPARD, NGFR, NR2F1, MAPK1, STAT5B, PDGFA, HRAS, SHC1, IKBKE IL1RL1, MAP3K7
LPS-stimulated MAPK Signaling 3.16E-28 FGFR2, FGFR1, FGFR3 JUN, CDC42, MAPK10, PRKCQ, IRS1, GAB1, PIK3R1, NFKBIA, TLR4, IKBKG, PIK3CA, PTPN11, FRS2, GRB2, PRKCH, MAPK8, PRKCI, PRKCZ, MAPK3, PRKCE, NFKB1, PIK3R3, IRS2, CHUK, ATM, PAK1, RAF1, MAP3K14, IKBKB, PIK3C2B, RELA, PIK3CG, NFKB2, PRKCD, SRF, PRKCA, PIK3R2, MAPK1, PRKD1, HRAS, RAC1, IKBKE MAP3K7
Thrombopoietin Signaling 3.16E-28 FGFR2, FGFR1, FGFR3 JUN, PRKCQ, IRS1, GAB1, PIK3R1, STAT3, PIK3CA, STAT1, PTPN11, FRS2, STAT5A, GRB2, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, PIK3R3, IRS2, JAK2, ATM, RAF1, PIK3C2B, SOS1, PLCG2, PIK3CG, MYC, PRKCD, GAB2, PRKCA, PIK3R2, MAPK1, PLCG1, PRKD1, STAT5B, HRAS, SHC1
FAK Signaling 3.16E-28 FGFR1, SRC, FGFR2, FGFR3 VCL, WAS, ACTG1, ACTB, FRS2, HMMR, EGFR, PIK3R3, TLN1, RAF1, PIK3C2B, PTK2, PIK3R2, BCAR1, ITGA5, ASAP1, AKT1, IRS1, GAB1, PIK3R1, FYN, ARHGEF7, PIK3CA, PTPN11, ITGB1, GRB2, CRK, MAPK3, PAK2, IRS2, ATM, PAK1, PXN, SOS1, AKT2, PLCG2, PIK3CG, PDPK1, CSK, MAPK1, PLCG1, PAK4, HRAS, RAC1 CAPN2
Production of Nitric Oxide and Reactive Oxygen Species in Macrophages 3.16E-28 FGFR1, FGFR2, FGFR3 TNFRSF1A, MAPK10, PRKCQ, JAK3, PPARA, NFKBIA, TLR4, IKBKG, PPP2R5A, FRS2, PRKCH, TLR2, PRKCE, PIK3R3, JAK2, JAK1, IKBKB, PIK3C2B, NFKB2, PRKCD, APOB, PIK3R2, IKBKE, JUN, PPP1CC, AKT1, IRS1, GAB1, PIK3R1, PIK3CA, STAT1, PTPN11, TNF, GRB2, CREBBP, PTPN6, MAPK8, PRKCI, PRKCZ, MAP3K3, MAPK3, NFKB1, S100A8, IRS2, CHUK, ATM, MAP3K14, IL4, TYK2, AKT2, RELA, PLCG2, PIK3CG, NOS2, PRKCA, NGFR, MAPK1, PLCG1, PRKD1, RAC1 PPP2CB, RHOQ, SIRPA, ALB, MAP3K7, RND2
Leukocyte Extravasation Signaling 3.98E-28 FGFR1, SRC, FGFR2, FGFR3 CDC42, MMP2, VCL, MAPK10, PRKCQ, WAS, ACTG1, ACTB, FRS2, PRKCH, ACTN4, PRKCE, PIK3R3, CTNNB1, CRKL, EZR, ARHGAP1, PIK3C2B, ACTN1, WASL, PTK2, VAV1, CDH5, ABL1, PRKCD, PIK3R2, PTK2B, BMX, BCAR1, ITGA5, PECAM1, IRS1, GAB1, THY1, PIK3R1, CTNND1, GNAI2, PIK3CA, PTPN11, ITGB1, ITK, GRB2, TEC, ITGB3, CRK, MAPK8, PRKCI, PRKCZ, IRS2, CTTN, RAPGEF4, ATM, BTK, ARHGAP35, PXN, CD44, TXK, PLCG2, PIK3CG, PRKCA, TIMP3, MAPK1, PLCG1, PRKD1, RAC1 ITGAM, RAPGEF3, MMP17
PI3K Signaling in B Lymphocytes 3.98E-28 IL4R, FOXO3, LYN CAMK2B, NFKBIA, DAPP1, ATF3, TLR4, IKBKG, SYK, ITPR1, SH2B2, ATF5, CD79A, RAF1, IKBKB, VAV1, NFKB2, ABL1, PIK3R2, IKBKE, JUN, AKT1, IRS1, PIK3R1, CD40, CBL, FYN, INPP5D, PIK3CA, CD19, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, CHUK, CD79B, BTK, IL4, NFATC1, AKT2, RELA, PLCG2, PIK3CG, NFATC3, PDPK1, FCGR2B, MAPK1, PLCG1, PTPRC, HRAS, RAC1 CALML5, PLCL1
IL-4 Signaling 1.26E-27 FGFR2, FGFR1, HLA-DQA1, FGFR3, IL4R AKT1, JAK3, IL13RA1, NR3C2, IRS1, INPPL1, GAB1, PIK3R1, IL2RG, INPP5D, PIK3CA, PTPN11, FRS2, GRB2, PTPN6, RPS6KB1, RPS6KB2, HMGA1, PIK3R3, IRS2, JAK2, ATM, IL4, JAK1, PIK3C2B, NFATC1, TYK2, SOS1, AKT2, PIK3CG, NFATC3, HLA-A, PIK3R2, NR3C1, STAT6, SOCS1, HLA-B, HRAS, SHC1 OCRL, HLA-DQB1
Virus Entry via Endocytic Pathways 2.00E-27 FGFR1, SRC, FGFR2, FGFR3 CDC42, PRKCQ, DNM1, ACTG1, ACTB, FRS2, PRKCH, PRKCE, PIK3R3, FLNA, CLTC, PIK3C2B, ABL1, PRKCD, DNM2, PIK3R2, CD55, HLA-B, ITGA5, ITGB4, FOLR1, IRS1, GAB1, PIK3R1, AP1B1, FYN, PIK3CA, PTPN11, ITGB1, GRB2, ITGB3, PRKCI, PRKCZ, IRS2, ATM, PLCG2, PIK3CG, CAV1, HLA-A, PRKCA, PLCG1, PRKD1, AP2M1, HRAS, RAC1
IL-2 Signaling 2.51E-27 FGFR2, FGFR1, LCK, FGFR3 JUN, AKT1, JAK3, CSNK2A2, IL2RB, IRS1, GAB1, PIK3R1, IL2RG, SYK, PIK3CA, PTPN11, FRS2, STAT5A, GRB2, MAPK8, MAPK3, PIK3R3, IRS2, CSNK2B, ATM, RAF1, JAK1, PIK3C2B, SOS1, AKT2, PIK3CG, PIK3R2, PTK2B, MAPK1, SOCS1, STAT5B, HRAS, CSNK2A1, SHC1
Regulation of the Epithelial-Mesenchymal Transition Pathway 2.51E-27 FGFR1, FGFR2, FGFR3, PDGFRB MMP2, JAK3, FGF4, SMAD4, STAT3, FRS2, SMAD3, DVL3, EGFR, PIK3R3, JAK2, CTNNB1, SMAD2, RAF1, FGF10, JAK1, PIK3C2B, FGF2, NFKB2, TGFBR2, PIK3R2, HNF1A, ETS1, GSK3B, FGF5, FGF6, FGF1, PDGFD, AKT1, IRS1, FGF18, GAB1, FGF23, PIK3R1, APC, PIK3CA, PTPN11, GRB2, MET, CDH1, MAPK3, NFKB1, IRS2, NOTCH1, ATM, FGF7, EGR1, FGF3, TYK2, SOS1, AKT2, RELA, PIK3CG, FGF17, HIF1A, MAPK1, FGF8, ARAF, HRAS, FGF9 WNT6, WNT3, WNT7B
Breast Cancer Regulation by Stathmin1 2.51E-27 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, TUBB4B, TUBA4A, FGFR2, TUBA8, TUBB2A, FGFR3, TUBB4A CAMK2B, CDC42, ADCY6, PRKCQ, E2F3, GNAQ, PPP2R5A, FRS2, ITPR1, PRKCH, PRKCE, PIK3R3, RAF1, PIK3C2B, PRKCD, PIK3R2, CDKN1B, TUBA1B, PPP1CC, E2F1, IRS1, GAB1, PIK3R1, TP53, GNAI2, ARHGEF7, PIK3CA, PTPN11, E2F2, CDKN1A, GRB2, PRKCI, PRKCZ, MAPK3, IRS2, TUBB, ATM, PAK1, CDK2, SOS1, PIK3CG, PRKCA, MAPK1, PRKD1, PRKACA, HRAS, RAC1, SHC1, CDK1 PPP2CB, CAMK1D, PRKAG1, CALML5, TUBA3E
NGF Signaling 3.98E-27 FGFR1, FGFR2, FGFR3 CDC42, MAPK10, IKBKG, FRS2, RPS6KB1, TRAF6, PIK3R3, RAF1, IKBKB, PIK3C2B, NFKB2, PRKCD, PIK3R2, IKBKE, AKT1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, GRB2, CREBBP, CRK, MAPK8, PRKCZ, MAP3K3, MAPK3, RPS6KB2, NFKB1, IRS2, CHUK, RPS6KA3, ATM, EP300, MAP3K14, SOS1, AKT2, RELA, PLCG2, PIK3CG, PDPK1, NGFR, RPS6KA1, MAPK1, PLCG1, HRAS, RAC1, SHC1 MAP3K7
EGF Signaling 3.98E-27 FGFR2, FGFR1, FGFR3, SRC JUN, AKT1, CSNK2A2, IRS1, GAB1, PIK3R1, STAT3, PIK3CA, STAT1, PTPN11, FRS2, GRB2, ITPR1, MAPK8, RPS6KB1, MAPK3, EGFR, PIK3R3, IRS2, CSNK2B, ATM, RAF1, JAK1, PIK3C2B, SOS1, AKT2, PIK3CG, SRF, PRKCA, PIK3R2, MAPK1, PLCG1, RASA1, HRAS, CSNK2A1, SHC1
ErbB2-ErbB3 Signaling 7.94E-27 FGFR2, FGFR1, FGFR3, SP1 JUN, GSK3B, AKT1, JAK3, IRS1, GAB1, PIK3R1, STAT3, ETV4, PIK3CA, PTPN11, FRS2, STAT5A, ERBB2, GRB2, FOXO1, MAPK3, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, TYK2, SOS1, PIK3CG, MYC, PDPK1, PIK3R2, CDKN1B, CCND1, MAPK1, ERBB3, STAT5B, HRAS, SHC1 NRG1
VEGF Family Ligand-Receptor Interactions 7.94E-27 FGFR2, FGFR1, FLT1, FGFR3, FLT4, KDR AKT1, NRP2, PRKCQ, PGF, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, NOS3, PRKCH, PRKCI, PRKCZ, VEGFB, VEGFC, MAPK3, PRKCE, PIK3R3, IRS2, VEGFA, ATM, RAF1, PIK3C2B, SOS1, AKT2, PLCG2, PIK3CG, PRKCD, PRKCA, PIK3R2, NRP1, MAPK1, PLCG1, PRKD1, HRAS, SHC1
Aryl Hydrocarbon Receptor Signaling 7.94E-27 CDKN2A, SRC, HSP90B1, DHFR, HSP90AA1, SP1, HSP90AB1 NCOR2, POLA1, SMARCA4, ATR, RXRA, ARNT, ESR2, RBL1, ESR1, CCNA1, CCND2, IL1B, NFKB2, MYC, AHR, CDKN1B, PTGES3, CCND1, TP73, RARG, FAS, JUN, APAF1, RARA, E2F1, TP53, TNF, CDKN1A, MAPK8, CDK6, MAPK3, NFKB1, FASLG, AIP, CDK4, ATM, EP300, CDK2, RXRB, RELA, NR2F1, MAPK1, MDM2, CCNA2, RB1, RARB, CHEK1 NFIB, GSTA2, IL6
Fc Epsilon RI Signaling 1.58E-26 FGFR1, LYN, FGFR2, FGFR3 MAPK10, PRKCQ, IL13, INPPL1, FCER1G, LCP2, SYK, FRS2, PRKCH, LAT, PRKCE, PIK3R3, RAF1, PIK3C2B, VAV1, PRKCD, PIK3R2, AKT1, IRS1, GAB1, PIK3R1, MS4A2, FYN, INPP5D, PIK3CA, PTPN11, TNF, GRB2, MAPK8, PRKCI, PRKCZ, MAPK3, IRS2, ATM, BTK, IL4, SOS1, AKT2, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, RAC1 OCRL
Endothelin-1 Signaling 2.51E-26 FGFR1, SRC, FGFR2, FGFR3 PAFAH1B1, GNA11, ADCY6, GUCY1B3, MAPK10, PRKCQ, PLA2G7, PLD1, GNAQ, FRS2, ITPR1, NOS3, PRKCH, PRKCE, PIK3R3, RAF1, PIK3C2B, MAPK6, MYC, PRKCD, PIK3R2, CASP3, JUN, GNA12, SHC2, IRS1, GAB1, PIK3R1, SHF, MAPK15, GNAI2, NOS1, PIK3CA, PTPN11, GRB2, MAPK8, PRKCI, PAFAH1B3, PRKCZ, CASP7, MAPK3, IRS2, ATM, CASP9, SOS1, SHC3, PLCG2, CASP6, PIK3CG, NOS2, PRKCA, PLD2, MAPK1, PLCG1, PRKD1, ARAF, GUCY2C, HRAS, SHC1 PNPLA3, PNPLA8, PLCL1
Paxillin Signaling 6.31E-26 FGFR1, SRC, FGFR2, FGFR3 CDC42, ITGAV, VCL, MAPK10, ACTG1, ACTB, FRS2, ACTN4, NCK1, PIK3R3, TLN1, PIK3C2B, ACTN1, PTK2, PTPN12, PIK3R2, PTK2B, NCK2, BCAR1, ITGA5, ITGB4, IRS1, GAB1, PIK3R1, ARHGEF7, PIK3CA, PTPN11, ITGB1, GRB2, ITGB3, CRK, MAPK8, PAK2, IRS2, ATM, PAK1, PXN, SOS1, PIK3CG, ARFIP2, CSK, MAPK1, PAK4, HRAS, RAC1 ITGAM
Th1 and Th2 Activation Pathway 1.58E-25 FGFR1, HLA-DQA1, IL4R, FGFR2, FGFR3 PRKCQ, JAK3, IL13, IFNAR1, CD274, IL2RG, GATA3, STAT3, CD8A, FRS2, CD80, CD4, CD86, S1PR1, CD3E, PIK3R3, JAK2, JAK1, PIK3C2B, VAV1, BMPR2, TGFBR2, CD28, PIK3R2, STAT6, HLA-B, STAT5B, JUN, IL6R, IL2RB, IRS1, GAB1, PIK3R1, CD40, CCR5, PIK3CA, STAT1, PTPN11, STAT5A, GRB2, NFKB1, IRS2, NOTCH1, ATM, LTA, IL4, NFATC1, TYK2, PIK3CG, NFATC3, HLA-A, SOCS1, CD247 IL1RL1, HLA-DQA2, HLA-DPB1, HLA-DQB1, ACVR1B, IL6
RANK Signaling in Osteoclasts 2.00E-25 FGFR2, FGFR1, FGFR3, SRC JUN, BIRC2, TRAF2, AKT1, MAPK10, IRS1, GAB1, PIK3R1, NFKBIA, CBL, IKBKG, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, TNFRSF11A, MAP3K3, MAPK3, TRAF6, NFKB1, PIK3R3, IRS2, CHUK, ATM, RAF1, MAP3K14, IKBKB, PIK3C2B, NFATC1, AKT2, RELA, PIK3CG, NFKB2, PIK3R2, PTK2B, MAPK1, IKBKE CALML5, MITF, MAP3K7, GSN
Macropinocytosis Signaling 2.00E-25 FGFR2, FGFR1, FGFR3, SRC CDC42, PDGFD, PRKCQ, IRS1, PDGFB, GAB1, PIK3R1, CSF1R, PIK3CA, PTPN11, ITGB1, FRS2, GRB2, MET, ITGB3, PRKCH, PRKCI, ACTN4, PRKCZ, PRKCE, PIK3R3, IRS2, ATM, PAK1, PIK3C2B, PDGFC, PLCG2, PIK3CG, PRKCD, PRKCA, PIK3R2, PLCG1, PRKD1, PDGFA, HRAS, ITGA5, RAC1, ITGB4
Myc Mediated Apoptosis Signaling 3.16E-25 FGFR2, FGFR1, CDKN2A, FGFR3 YWHAQ, APAF1, AKT1, MAPK10, IRS1, GAB1, PIK3R1, YWHAE, TP53, YWHAH, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, PRKCZ, YWHAB, FASLG, PIK3R3, IRS2, YWHAG, ATM, CASP9, PIK3C2B, SOS1, AKT2, PIK3CG, IGF1R, MYC, PIK3R2, CASP3, FAS, YWHAZ, HRAS, SHC1
Role of Osteoblasts_ Osteoclasts and Chondrocytes in Rheumatoid Arthritis 3.98E-25 FGFR1, SRC, FGFR2, FGFR3 BIRC2, CTSK, TNFRSF1A, MAPK10, SMAD4, NFKBIA, IKBKG, FRS2, LRP1, TNFRSF11A, TRAF6, PIK3R3, IL1B, CTNNB1, IKBKB, PIK3C2B, BMPR2, PIK3R2, PTK2B, SMAD1, HNF1A, ITGA5, IKBKE, JUN, GSK3B, TRAF2, AKT1, IRS1, GAB1, PIK3R1, CBL, CSF1R, APC, PIK3CA, PTPN11, TNF, ITGB1, GRB2, ITGB3, MAPK8, FOXO1, MAPK3, NFKB1, IRS2, CHUK, ATM, MAP3K14, IL4, CASP9, NFATC1, AKT2, RELA, PIK3CG, NFATC3, NGFR, MAPK1 IL1RL1, WNT6, GSN, SP7, CALML5, IL6, MAP3K7, WNT3, WNT7B, IL7, APC2
G_q Signaling 3.98E-25 FGFR1, FGFR2, FGFR3 GNA11, PRKCQ, PLD1, NFKBIA, IKBKG, GNAQ, FRS2, ITPR1, PRKCH, PRKCE, PIK3R3, RAF1, IKBKB, PIK3C2B, NFKB2, PRKCD, PIK3R2, PTK2B, IKBKE, GSK3B, AKT1, IRS1, GAB1, PIK3R1, RGS16, PIK3CA, PTPN11, GRB2, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, CHUK, ATM, BTK, NFATC1, AKT2, RELA, PLCG2, PIK3CG, NFATC3, PRKCA, CSK, PLD2, MAPK1, PLCG1, PRKD1 CALML5, RHOQ, CHRM3, RGS4, RND2
IL-12 Signaling and Production in Macrophages 5.01E-25 FGFR1, FGFR2, FGFR3 MAPK10, PRKCQ, MST1R, TLR4, IKBKG, FRS2, RXRA, PRKCH, TLR2, TRAF6, REL, PRKCE, PIK3R3, IKBKB, PIK3C2B, NFKB2, PRKCD, APOB, PIK3R2, STAT6, IKBKE, JUN, ALOX12, AKT1, IRS1, GAB1, PIK3R1, CD40, PIK3CA, STAT1, PTPN11, TNF, GRB2, MAPK8, PRKCI, PRKCZ, MAPK3, NFKB1, S100A8, IRS2, CHUK, ATM, EP300, IL4, AKT2, RELA, PIK3CG, NOS2, PRKCA, CEBPB, MAPK1, PRKD1 ALB
Role of JAK1 and JAK3 in _c Cytokine Signaling 6.31E-25 FGFR2, FGFR1, FGFR3, IL4R JAK3, IL2RB, IRS1, GAB1, PIK3R1, IL2RG, STAT3, SYK, PIK3CA, STAT1, PTPN11, FRS2, IL7R, STAT5A, GRB2, SH2B2, FES, MAPK3, PIK3R3, IRS2, JAK2, ATM, IL4, JAK1, PIK3C2B, PIK3CG, PIK3R2, PTK2B, STAT6, MAPK1, SOCS1, STAT5B, HRAS, SHC1 IL7
Renal Cell Carcinoma Signaling 7.94E-25 FGFR2, FGFR1, FGFR3 JUN, CDC42, AKT1, IRS1, PDGFB, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, MET, CREBBP, ARNT, CRK, RAPGEF1, UBC, MAPK3, PAK2, PIK3R3, IRS2, VEGFA, ATM, PAK1, RAF1, EP300, PIK3C2B, SOS1, AKT2, PIK3CG, VHL, PIK3R2, HIF1A, UBB, MAPK1, PAK4, ETS1, HRAS, RAC1
Type I Diabetes Mellitus Signaling 2.00E-24 HLA-DQA1 TRAF2, SOCS5, APAF1, TNFRSF1A, MAPK10, HSPD1, FCER1G, PIAS1, NFKBIA, IKBKG, SOCS7, STAT1, TNF, CD80, MAPK8, RIPK1, CD86, TRAF6, IRAK1, CD3E, NFKB1, FASLG, CHUK, JAK2, IL1B, LTA, MAP3K14, CASP9, JAK1, IKBKB, RELA, GZMB, NFKB2, NOS2, CD28, HLA-A, NGFR, MAPK1, CASP3, SOCS1, HLA-B, SOCS6, FAS, CD247, IKBKE MAP3K7, HLA-DQB1
CTLA4 Signaling in Cytotoxic T Lymphocytes 5.01E-24 FGFR2, FGFR1, CTLA4, LCK, FGFR3 AKT1, PTPN22, IRS1, FCER1G, GAB1, PIK3R1, AP1B1, LCP2, SYK, FYN, CD8A, PPP2R5A, PIK3CA, PTPN11, FRS2, GRB2, CD80, PTPN6, LAT, CD86, ZAP70, CD3E, PIK3R3, IRS2, JAK2, CLTC, ATM, PIK3C2B, AP1M1, AKT2, PIK3CG, CD28, HLA-A, PIK3R2, TRAT1, PLCG1, HLA-B, AP2M1, CD247 PPP2CB
Role of NFAT in Cardiac Hypertrophy 1.58E-23 FGFR1, SRC, FGFR2, FGFR3 CAMK2B, ADCY6, MAPK10, PRKCQ, GNAQ, FRS2, ITPR1, PRKCH, HDAC1, PRKCE, PIK3R3, RAF1, PIK3C2B, HDAC3, IGF1R, TGFBR2, PRKCD, PIK3R2, GSK3B, AKT1, IRS1, GAB1, PIK3R1, GNAI2, PIK3CA, PTPN11, GATA4, GRB2, MAPK8, PRKCI, MEF2D, PRKCZ, MAPK3, HDAC2, IRS2, ATM, EP300, MEF2C, SOS1, AKT2, PLCG2, PIK3CG, HDAC6, PRKCA, MAPK1, PLCG1, PRKD1, PRKACA, HRAS, SHC1 NKX2-5, CAMK1D, PRKAG1, CALML5, IL6, PLCL1, MAP3K7
mTOR Signaling 3.16E-23 FGFR1, FGFR2, PRR5, FGFR3 PRKCQ, PLD1, PPP2R5A, FRS2, MLST8, PRKCH, VEGFC, RPS6KB1, PRKCE, PIK3R3, VEGFA, RPS7, INSR, PIK3C2B, PDGFC, PRKCD, PIK3R2, EIF3F, AKT1, PGF, FKBP1A, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, GRB2, DGKZ, PRKCI, RPS3A, PRKCZ, TSC1, VEGFB, MAPK3, RPS6KB2, IRS2, RPS6KA3, ATM, AKT2, RPS3, PIK3CG, PDPK1, PRKCA, HIF1A, PLD2, RPS6KA1, MAPK1, PRKD1, HRAS, RAC1 PPP2CB, EIF4G2, EIF3H, PRKAG1, RHOQ, RPS20, ULK1, EIF4EBP1, RND2
FLT3 Signaling in Hematopoietic Progenitor Cells 5.01E-23 FGFR2, FGFR1, FLT3, FGFR3 FLT3LG, AKT1, IRS1, GAB1, PIK3R1, CBL, STAT3, INPP5D, PIK3CA, STAT1, PTPN11, FRS2, STAT5A, GRB2, CREBBP, RPS6KB1, MAPK3, PIK3R3, IRS2, RPS6KA3, ATM, RAF1, EP300, PIK3C2B, SOS1, AKT2, PIK3CG, PDPK1, GAB2, PIK3R2, STAT6, RPS6KA1, MAPK1, STAT5B, HRAS, SHC1 EIF4EBP1
IL-17A Signaling in Airway Cells 6.31E-23 FGFR2, FGFR1, FGFR3 GSK3B, AKT1, MAPK10, JAK3, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, STAT3, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, MAPK3, TRAF6, NFKB1, PIK3R3, IRS2, CHUK, JAK2, ATM, JAK1, IKBKB, PIK3C2B, TYK2, AKT2, RELA, PIK3CG, NFKB2, PIK3R2, MAPK1, IKBKE IL6, MAP3K7
Dendritic Cell Maturation 7.94E-23 FGFR1, HLA-DQA1, FGFR2, FGFR3 TNFRSF1A, MAPK10, FCER1G, NFKBIA, IFNAR1, TLR4, IKBKG, FRS2, CD80, TLR2, CD86, TRAF6, PIK3R3, JAK2, IL1B, IKBKB, PIK3C2B, FCGR2A, NFKB2, PIK3R2, HLA-B, IKBKE, AKT1, IRS1, GAB1, PIK3R1, CD40, PIK3CA, STAT1, PTPN11, TNF, GRB2, CREBBP, MAPK8, MAPK3, NFKB1, IRS2, CHUK, ATM, LTA, EP300, MAP3K14, AKT2, COL18A1, RELA, PLCG2, PIK3CG, FCGR2B, HLA-A, NGFR, MAPK1, PLCG1, DDR2 CCR7, HLA-DQB1, IL6, PLCL1
Hereditary Breast Cancer Signaling 7.94E-23 FGFR1, TUBG1, FGFR2, FGFR3 FANCC, SMARCA4, BARD1, SMARCB1, ACTB, FRS2, ATR, HDAC1, PIK3R3, POLR2E, PIK3C2B, HLTF, SMARCE1, SMARCC2, HDAC3, PIK3R2, CCND1, UBB, FANCA, ARID1A, AKT1, E2F1, IRS1, GAB1, PIK3R1, SMARCC1, TP53, CDC25C, PIK3CA, PTPN11, CDKN1A, GRB2, CREBBP, CDK6, UBC, BRCA1, HDAC2, CDK4, IRS2, ATM, EP300, AKT2, PIK3CG, HDAC6, POLR2G, RB1, HRAS, CDK1, CHEK1
Ovarian Cancer Signaling 7.94E-23 FGFR1, CDKN2A, SRC, FGFR2, FGFR3 MMP2, FRS2, VEGFC, RPS6KB1, EGFR, PIK3R3, CTNNB1, VEGFA, RAF1, PIK3C2B, PDGFC, ABL1, PIK3R2, CCND1, HNF1A, GJA1, GSK3B, AKT1, PGF, E2F1, IRS1, GAB1, PIK3R1, TP53, APC, PIK3CA, PTPN11, GRB2, VEGFB, MAPK3, RPS6KB2, BRCA1, CDK4, IRS2, ATM, AKT2, CD44, PIK3CG, MAPK1, RB1, PRKACA, HRAS, FGF9 WNT6, PRKAG1, WNT3, WNT7B
CD40 Signaling 1.00E-22 FGFR2, FGFR1, FGFR3 JUN, TRAF2, MAPK10, JAK3, IRS1, GAB1, PIK3R1, CD40, NFKBIA, IKBKG, STAT3, PIK3CA, PTPN11, FRS2, GRB2, TRAF1, MAPK8, MAPK3, TRAF6, NFKB1, PIK3R3, IRS2, CHUK, ATM, LTA, MAP3K14, IKBKB, PIK3C2B, TRAF3, RELA, PIK3CG, NFKB2, PIK3R2, MAPK1, IKBKE MAP3K7
G_12/13 Signaling 1.26E-22 FGFR1, SRC, FGFR2, FGFR3 CDC42, MAPK10, NFKBIA, IKBKG, FRS2, PIK3R3, CTNNB1, RAF1, IKBKB, PIK3C2B, PTK2, VAV1, CDH5, NFKB2, PIK3R2, PTK2B, IKBKE, JUN, AKT1, GNA12, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, GRB2, TEC, CDH1, MAPK8, MEF2D, MAPK3, NFKB1, IRS2, CHUK, LPAR2, ATM, MYL12A, BTK, PXN, MEF2C, AKT2, RELA, PIK3CG, MAPK1, RASA1, HRAS MYL6B
Th1 Pathway 1.26E-22 FGFR1, HLA-DQA1, FGFR2, FGFR3 PRKCQ, JAK3, IFNAR1, CD274, GATA3, STAT3, CD8A, FRS2, CD80, CD4, CD86, CD3E, PIK3R3, JAK2, JAK1, PIK3C2B, VAV1, CD28, PIK3R2, HLA-B, IL6R, IRS1, GAB1, PIK3R1, CD40, CCR5, PIK3CA, STAT1, PTPN11, GRB2, NFKB1, IRS2, NOTCH1, ATM, LTA, IL4, NFATC1, TYK2, PIK3CG, NFATC3, HLA-A, SOCS1, CD247 HLA-DQA2, HLA-DPB1, HLA-DQB1, IL6
Bladder Cancer Signaling 1.58E-22 CDKN2A, FGFR3 FGF5, FGF6, FGF1, MMP2, PGF, FGF4, E2F1, FGF18, THBS1, FGF23, TP53, ERBB2, CDKN1A, CDH1, VEGFB, VEGFC, MAPK3, EGFR, CDK4, VEGFA, RAF1, FGF10, FGF7, FGF2, FGF3, PDGFC, ABL1, MYC, FGF17, RASSF1, CCND1, MAPK1, MDM2, FGF8, RB1, HRAS, FGF9 MMP17
GDNF Family Ligand-Receptor Interactions 2.00E-22 FGFR2, FGFR1, FGFR3 JUN, CDC42, DOK2, MAPK10, RET, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, DOK3, ITPR1, MAPK8, NCK1, MAPK3, DOK4, DOK1, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, SOS1, DOK5, PLCG2, PIK3CG, PIK3R2, MAPK1, PLCG1, RASA1, HRAS, RAC1, SHC1
Fc_RIIB Signaling in B Lymphocytes 2.00E-22 FGFR2, FGFR1, FGFR3, LYN AKT1, MAPK10, IRS1, GAB1, PIK3R1, SYK, INPP5D, PIK3CA, PTPN11, FRS2, GRB2, MAPK8, CD79A, DOK1, PIK3R3, IRS2, ATM, CD79B, BTK, PIK3C2B, SOS1, PLCG2, PIK3CG, PDPK1, FCGR2B, PIK3R2, HRAS, SHC1
GM-CSF Signaling 3.98E-22 FGFR2, FGFR1, FGFR3, LYN CAMK2B, AKT1, CSF2RA, IRS1, GAB1, PIK3R1, STAT3, PIK3CA, STAT1, PTPN11, FRS2, GRB2, MAPK3, PIK3R3, IRS2, JAK2, CSF2RB, ATM, RAF1, PIK3C2B, SOS1, AKT2, PIK3CG, PIK3R2, CCND1, PIM1, MAPK1, BCL2L1, ETS1, STAT5B, HRAS, SHC1
CXCR4 Signaling 5.01E-22 FGFR1, SRC, LYN, FGFR2, FGFR3 GNA11, ADCY6, MAPK10, PRKCQ, GNAQ, FRS2, CD4, ITPR1, PRKCH, PRKCE, PIK3R3, RAF1, PIK3C2B, PTK2, PRKCD, PIK3R2, BCAR1, JUN, AKT1, GNA12, IRS1, GAB1, PIK3R1, GNAI2, PIK3CA, PTPN11, GRB2, CRK, MAPK8, PRKCI, PRKCZ, MAPK3, PAK2, IRS2, ATM, PAK1, MYL12A, PXN, EGR1, AKT2, PIK3CG, PRKCA, MAPK1, PRKD1, PAK4, HRAS, RAC1 MYL6B, RHOQ, RND2
HIF1_ Signaling 5.01E-22 FGFR2, FGFR1, HSP90AA1, FGFR3 JUN, MMP2, AKT1, MAPK10, PGF, IRS1, GAB1, PIK3R1, TP53, MAPK15, NOS1, PIK3CA, PTPN11, FRS2, EGLN1, GRB2, CREBBP, ARNT, NOS3, MAPK8, VEGFB, VEGFC, MAPK3, PIK3R3, IRS2, VEGFA, ATM, EP300, PIK3C2B, AKT2, MAPK6, PDGFC, PIK3CG, VHL, NOS2, SLC2A4, PIK3R2, HIF1A, MAPK1, MDM2, HRAS MMP17
Th2 Pathway 7.94E-22 FGFR1, HLA-DQA1, IL4R, FGFR2, FGFR3 PRKCQ, JAK3, IL13, IL2RG, GATA3, FRS2, CD80, CD4, CD86, S1PR1, CD3E, PIK3R3, JAK2, JAK1, PIK3C2B, VAV1, BMPR2, TGFBR2, CD28, PIK3R2, STAT6, HLA-B, STAT5B, JUN, IL2RB, IRS1, GAB1, PIK3R1, CD40, CCR5, PIK3CA, PTPN11, STAT5A, GRB2, NFKB1, IRS2, NOTCH1, ATM, IL4, TYK2, PIK3CG, HLA-A, CD247 IL1RL1, HLA-DQA2, HLA-DPB1, HLA-DQB1, ACVR1B
STAT3 Pathway 7.94E-22 FGFR2, FGFR1, FLT1, NTRK2, FGFR3, PDGFRB, SRC, FLT4, KDR, PDGFRA SOCS5, MAPK10, SOCS7, STAT3, CDKN1A, PTPN6, MAPK8, TNFRSF11A, MAPK3, EGFR, JAK2, RAF1, PTPN2, INSR, TYK2, IGF2R, IGF1R, BMPR2, MYC, TGFBR2, NGFR, PIM1, MAPK1, SOCS1, SOCS6, HRAS, RAC1
UVB-Induced MAPK Signaling 7.94E-22 FGFR2, FGFR1, FGFR3 JUN, AKT1, MAPK10, PRKCQ, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, GRB2, PRKCH, MAPK8, PRKCI, PRKCZ, RPS6KB1, MAPK3, PRKCE, EGFR, PIK3R3, IRS2, RPS6KA3, ATM, PIK3C2B, PIK3CG, PRKCD, PRKCA, PIK3R2, MAPK1, PRKD1 EIF4EBP1
Melanoma Signaling 1.00E-21 FGFR2, FGFR1, CDKN2A, FGFR3 AKT1, E2F1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, CDKN1A, GRB2, CDH1, MAPK3, PIK3R3, CDK4, IRS2, ATM, RAF1, PIK3C2B, AKT2, PIK3CG, PIK3R2, CCND1, MAPK1, MDM2, RB1, HRAS MITF
Cell Cycle: G2/M DNA Damage Checkpoint Regulation 2.00E-21 CDKN2A KAT2B, YWHAQ, TRIP12, YWHAE, TP53, YWHAH, BORA, CDC25C, SKP1, ATR, CDKN1A, CKS2, PRKCZ, PRKDC, YWHAB, BRCA1, YWHAG, CDK7, ATM, EP300, BTRC, ABL1, RPS6KA1, MDM2, CKS1B, YWHAZ, CDK1, PLK1, CHEK1
CREB Signaling in Neurons 2.00E-21 FGFR1, FGFR2, FGFR3 CAMK2B, GNA11, ADCY6, PRKCQ, GNAQ, FRS2, ITPR1, PRKCH, PRKCE, PIK3R3, POLR2E, RAF1, PIK3C2B, PRKCD, GRIN2A, PIK3R2, TBP, AKT1, GNA12, IRS1, GAB1, PIK3R1, GRIA3, GNAI2, PIK3CA, PTPN11, GRB2, GRM7, CREBBP, PRKCI, PRKCZ, MAPK3, IRS2, ATM, EP300, SOS1, AKT2, PLCG2, PIK3CG, GRIN2B, PRKCA, RPS6KA1, MAPK1, PLCG1, PRKD1, POLR2G, PRKACA, HRAS, SHC1 PRKAG1, CALML5, GRIN1, PLCL1, GRIA1
PPAR_/RXR_ Activation 2.00E-21 HSP90B1, HSP90AA1, HSP90AB1 NCOR2, GNA11, ADCY6, PPARA, SMAD4, NFKBIA, IKBKG, GNAQ, NCOA6, SMAD3, RXRA, TRAF6, JAK2, IL1B, SMAD2, RAF1, INSR, IKBKB, NFKB2, BMPR2, CD36, TGFBR2, STAT5B, IKBKE, JUN, IRS1, NR2C2, GRB2, CREBBP, NCOR1, MAPK8, MAPK3, NFKB1, AIP, CHUK, EP300, MAP3K14, MEF2C, SOS1, RELA, PLCG2, PRKCA, NR2F1, MAPK1, PLCG1, PRKACA, HRAS, SHC1 IL1RL1, GPD1, ACVR1B, PRKAG1, IL6, PLCL1, MAP3K7
Endometrial Cancer Signaling 2.51E-21 FGFR2, FGFR1, FGFR3, FOXO3 GSK3B, AKT1, IRS1, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, ERBB2, GRB2, CDH1, MAPK3, PIK3R3, IRS2, CTNNB1, ATM, RAF1, CASP9, PIK3C2B, SOS1, AKT2, PIK3CG, MYC, PDPK1, PIK3R2, CCND1, MAPK1, HRAS APC2
Rac Signaling 2.51E-21 FGFR2, FGFR1, FGFR3 JUN, IQGAP1, CDC42, IRS1, GAB1, PIK3R1, PLD1, CFL1, PIK3CA, PTPN11, ITGB1, FRS2, GRB2, MAPK8, PRKCI, PRKCZ, RPS6KB1, MAPK3, PAK2, NFKB1, PIK3R3, IRS2, ATM, PAK1, RAF1, TIAM1, PIK3C2B, PTK2, CD44, PI4KA, RELA, PIK3CG, NFKB2, ARFIP2, CDK5R1, PIK3R2, PTK2B, MAPK1, PAK4, HRAS, ITGA5, RAC1 ELK4
Thrombin Signaling 2.51E-21 FGFR1, SRC, FGFR2, FGFR3 CAMK2B, GNA11, ADCY6, PRKCQ, GATA3, GNAQ, FRS2, ITPR1, PRKCH, RPS6KB1, PRKCE, EGFR, PIK3R3, RAF1, IKBKB, PIK3C2B, PTK2, NFKB2, PRKCD, PIK3R2, MYLK, TBP, AKT1, GNA12, IRS1, GAB1, PIK3R1, GNAI2, PIK3CA, PTPN11, GATA4, GRB2, PRKCI, PRKCZ, MAPK3, NFKB1, IRS2, ATM, MYL12A, GATA1, SOS1, AKT2, RELA, PLCG2, PIK3CG, PDPK1, PRKCA, MAPK1, PLCG1, PRKD1, HRAS, SHC1 MYL6B, CAMK1D, RHOQ, PLCL1, RND2
Osteoarthritis Pathway 3.16E-21 FGFR1, FOXO3, FGFR3, SP1 TNFRSF1A, SPHK1, SMAD4, TLR4, SMAD3, LRP1, VEGFC, TLR2, IL1B, CTNNB1, VEGFA, SMAD2, ANXA2, FGF2, HDAC3, PDGFC, NFKB2, PPARD, BMPR2, TGFBR2, SMAD1, HNF1A, CASP3, ITGA5, PGF, FGF18, FN1, SMAD7, TNF, ITGB1, CREBBP, VEGFB, SIRT1, CASP7, NFKB1, S100A8, CHUK, NOTCH1, EP300, ANXA5, CASP9, MEF2C, RELA, CASP6, NOS2, HIF1A, CEBPB, TIMP3, EPAS1, FGF8, RAC1, DDR2 IL1RL1, ALPP, OCRL, HMGB1, PRKAG1, SP7
Cell Cycle: G1/S Checkpoint Regulation 1.00E-20 CDKN2A GSK3B, E2F1, SMAD4, MAX, E2F3, TP53, SMAD3, E2F2, SKP1, ATR, CDKN1A, RBL1, CDK6, FOXO1, HDAC1, HDAC2, CDK4, CCND2, CDKN2C, ATM, CDK2, BTRC, HDAC3, ABL1, MYC, HDAC6, CDKN1B, CCND1, BMI1, MDM2, RB1 NRG1, CDKN2B
PEDF Signaling 1.00E-20 FGFR2, FGFR1, FGFR3 AKT1, IRS1, GAB1, PIK3R1, NFKBIA, TP53, IKBKG, PIK3CA, PTPN11, FRS2, GRB2, BDNF, CASP7, MAPK3, NFKB1, FASLG, PIK3R3, IRS2, CHUK, ATM, RAF1, IKBKB, PIK3C2B, AKT2, RELA, PIK3CG, NFKB2, SRF, PIK3R2, HNF1A, MAPK1, BCL2L1, FAS, HRAS, RAC1, IKBKE
Reelin Signaling in Neurons 1.26E-20 FGFR2, FGFR1, LCK, FGFR3, SRC, LYN GSK3B, DAB1, PAFAH1B1, AKT1, MAPK10, FGR, IRS1, GAB1, PIK3R1, FYN, PIK3CA, PTPN11, ITGB1, FRS2, GRB2, ITGB3, MAPT, MAPK8, PAFAH1B3, APBB1, PIK3R3, IRS2, CRKL, ATM, MAP4K1, PIK3C2B, APP, MAPK8IP3, CDK5, PIK3CG, CDK5R1, PIK3R2, YES1, ITGA5
GNRH Signaling 2.51E-20 SRC CAMK2B, CDC42, GNA11, MMP2, ADCY6, MAPK10, PRKCQ, DNM1, GNAQ, ITPR1, PRKCH, PRKCE, EGFR, RAF1, PTK2, NFKB2, PRKCD, DNM2, PTK2B, JUN, DNM1L, GNAI2, GRB2, CREBBP, MAPK8, PRKCI, PRKCZ, MAP3K3, MAPK3, PAK2, NFKB1, PAK1, EP300, MAP3K14, PXN, EGR1, SOS1, RELA, PRKCA, MAPK1, PRKD1, PAK4, PRKACA, HRAS, RAC1 PRKAG1, CALML5, MAP3K7
P2Y Purigenic Receptor Signaling Pathway 3.16E-20 FGFR2, FGFR1, FGFR3 JUN, AKT1, ADCY6, PRKCQ, IRS1, GAB1, PIK3R1, GNAQ, GNAI2, PIK3CA, PTPN11, FRS2, GRB2, P2RY2, CREBBP, ITGB3, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, NFKB1, PIK3R3, IRS2, ATM, RAF1, EP300, PIK3C2B, AKT2, RELA, PLCG2, PIK3CG, NFKB2, MYC, PRKCD, PRKCA, PIK3R2, MAPK1, PLCG1, PRKD1, PRKACA, HRAS PLCL1, PRKAG1
ErbB4 Signaling 3.16E-20 FGFR2, FGFR1, FGFR3 AKT1, PRKCQ, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, SOS1, PLCG2, PIK3CG, PRKCD, PDPK1, PRKCA, PIK3R2, MAPK1, PLCG1, PRKD1, HRAS, SHC1 NRG1
Sertoli Cell-Sertoli Cell Junction Signaling 3.16E-20 TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, TUBA8, TUBB2A, TUBB4A CDC42, VCL, TNFRSF1A, GUCY1B3, MAPK10, WAS, ACTG1, ACTB, NOS3, ACTN4, DLG1, CTNNB1, RAF1, JUP, ACTN1, RAB8B, SORBS1, BCAR1, TUBA1B, ITGA5, SPTAN1, JUN, GSK3B, AKT1, TJP1, EPB41, NOS1, TNF, ITGB1, CDH1, MAPK8, MAP3K3, MAPK3, TUBB, MAP3K14, AKT2, NOS2, MAPK1, PRKACA, HRAS, RAC1 PRKAG1, TUBA3E, MAP3K7
Epithelial Adherens Junction Signaling 5.01E-20 FGFR1, TUBB3, TUBG1, TUBB1, TUBA1C, TUBA1A, SRC, TUBB4B, TUBA4A, TUBA8, TUBB2A, TUBB4A IQGAP1, CDC42, VCL, ZYX, WAS, ACTG1, ACTB, ACTN4, EGFR, CTNNB1, JUP, ACTN1, WASL, BMPR2, TGFBR2, SORBS1, HNF1A, TUBA1B, YES1, FGF1, AKT1, CTNND1, APC, CLIP1, MET, CRK, CDH1, RAPGEF1, NOTCH1, TUBB, AKT2, FARP2, HRAS, RAC1 MYL6B, ACVR1B, TUBA3E
Neurotrophin/TRK Signaling 5.01E-20 FGFR2, FGFR1, NTRK2, FGFR3 JUN, CDC42, AKT1, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, CREBBP, MAPK8, NTF4, BDNF, MAPK3, PIK3R3, IRS2, ATM, RAF1, EP300, NTF3, PIK3C2B, SOS1, PIK3CG, PDPK1, NGFR, PIK3R2, RPS6KA1, MAPK1, PLCG1, HRAS, SHC1
Phospholipase C Signaling 6.31E-20 LCK, SRC, LYN ADCY6, PRKCQ, FCER1G, PLD1, LCP2, GNAQ, SYK, ITPR1, PRKCH, LAT, CD79A, HDAC1, ZAP70, PRKCE, CD3E, RAF1, HDAC3, FCGR2A, NFKB2, PRKCD, ITGA5, FYN, ARHGEF7, ITGB1, ITK, GRB2, CREBBP, PRKCI, MEF2D, PRKCZ, MAPK3, NFKB1, HDAC2, RPS6KA3, CD79B, MYL12A, BTK, EP300, NFATC1, MEF2C, SOS1, RELA, PLCG2, NFATC3, FCGR2B, HDAC6, PRKCA, PLD2, MAPK1, PLCG1, PRKD1, HRAS, CD247, RAC1, SHC1, AHNAK MYL6B, CALML5, RHOQ, RAPGEF3, RND2
AMPK Signaling 6.31E-20 FGFR1, SRC, FOXO3, FGFR2, FGFR3 ADRB2, KAT2B, PPM1A, SMARCA4, EEF2, SMARCB1, PPP2R5A, ACTB, FRS2, MLST8, NOS3, RPS6KB1, PIK3R3, CHRNA7, INSR, PIK3C2B, HLTF, SMARCE1, SMARCC2, FOXG1, PIK3R2, CCND1, HNF4A, CFTR, ACACA, ARID1A, AKT1, IRS1, GAB1, PIK3R1, SMARCC1, PIK3CA, PTPN11, CDKN1A, GRB2, CREBBP, TSC1, FOXO1, SIRT1, IRS2, ADRB3, PPAT, ATM, EP300, AKT2, PIK3CG, PDPK1, SLC2A4, MAPK1, CCNA2, PRKACA PPP2CB, PRKAG1, ULK1, EIF4EBP1, MAP3K7, CHRM3
Estrogen-Dependent Breast Cancer Signaling 7.94E-20 FGFR2, FGFR1, FGFR3, SRC, SP1 JUN, AKT1, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, STAT5A, GRB2, CREBBP, ESR1, MAPK3, NFKB1, EGFR, PIK3R3, IRS2, ATM, EP300, PIK3C2B, AKT2, TERT, RELA, PIK3CG, NFKB2, IGF1R, PIK3R2, CCND1, MAPK1, STAT5B, HRAS
Cardiac Hypertrophy Signaling 7.94E-20 FGFR1, FGFR2, FGFR3 ADRB2, GNA11, ADCY6, MAPK10, GNAQ, FRS2, RPS6KB1, PIK3R3, RAF1, PIK3C2B, IGF1R, TGFBR2, PIK3R2, JUN, GSK3B, AKT1, IL6R, GNA12, IRS1, GAB1, PIK3R1, GNAI2, PIK3CA, PTPN11, GATA4, GRB2, CREBBP, MAPK8, MEF2D, MAP3K3, CACNA1D, MAPK3, IRS2, ADRB3, ATM, MYL12A, EP300, MAP3K14, MEF2C, SOS1, PLCG2, PIK3CG, SRF, RPS6KA1, MAPK1, PLCG1, PRKACA, HRAS NKX2-5, MYL6B, PRKAG1, CALML5, CACNA1S, RHOQ, IL6, EIF2B1, EIF2B2, PLCL1, MAP3K7, RND2
Systemic Lupus Erythematosus Signaling 1.26E-19 FGFR1, LCK, LYN, FGFR2, FGFR3 CD72, HNRNPC, CD22, FCER1G, FRS2, CD80, SNRPA, LAT, CD79A, CD86, CD3E, PIK3R3, IL1B, PIK3C2B, LSM1, FCGR2A, CD28, PIK3R2, HLA-B, JUN, AKT1, IL6R, IRS1, GAB1, PIK3R1, CD40, CBL, CREM, INPP5D, PIK3CA, PTPN11, TNF, GRB2, PTPN6, MAPK3, IRS2, ATM, CD79B, PIM2, NFATC1, SOS1, AKT2, PLCG2, PIK3CG, NFATC3, FCGR2B, HLA-A, MAPK1, PLCG1, PTPRC, HNRNPA2B1, HRAS, CD247, SNRPB C7, IL6, SNRPA1
Melanocyte Development and Pigmentation Signaling 2.00E-19 FGFR2, FGFR1, FGFR3, SRC ADCY6, IRS1, GAB1, PIK3R1, PIK3CA, PTPN11, FRS2, GRB2, CREBBP, PTPN6, CRK, SH2B2, RPS6KB1, MAPK3, RPS6KB2, PIK3R3, IRS2, RPS6KA3, ATM, RAF1, EP300, KIT, PIK3C2B, SOS1, PLCG2, PIK3CG, SOX10, PIK3R2, RPS6KA1, MAPK1, PLCG1, PRKACA, HRAS, SHC1 MITF, PRKAG1
Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes 2.51E-19 JUN, MAPK10, SMAD4, NFKBIA, IKBKG, FYN, SMAD3, GRB2, CD80, MAPK8, LAT, ZAP70, MAPK3, CD3E, NFKB1, CHUK, SMAD2, RAF1, IKBKB, NFATC1, VAV1, SOS1, RELA, PLCG2, NFKB2, NFATC3, TGFBR2, CD28, MAPK1, PLCG1, HRAS, CD247, RAC1, IKBKE CALML5
Apoptosis Signaling 3.98E-19 BIRC2, APAF1, TNFRSF1A, PRKCQ, NFKBIA, TP53, IKBKG, TNF, MAPK8, CASP7, MAPK3, PRKCE, NFKB1, FASLG, CHUK, HTRA2, RAF1, MAP3K14, CASP9, IKBKB, RELA, PLCG2, CASP6, NFKB2, PARP1, PRKCA, RPS6KA1, MAPK1, PLCG1, CASP3, BCL2L1, FAS, HRAS, CDK1, IKBKE, SPTAN1 MCL1, CAPN2
Neuropathic Pain Signaling In Dorsal Horn Neurons 5.01E-19 FGFR2, FGFR1, NTRK2, FGFR3, SRC CAMK2B, PRKCQ, IRS1, GAB1, PIK3R1, GRIA3, PIK3CA, PTPN11, FRS2, GRB2, GRM7, ITPR1, PRKCH, PRKCI, PRKCZ, BDNF, MAPK3, PRKCE, PIK3R3, IRS2, ATM, PIK3C2B, PLCG2, PIK3CG, GRIN2B, PRKCD, GRIN2A, PRKCA, PIK3R2, MAPK1, PLCG1, PRKD1, PRKACA GRIN1, PLCL1, GRIA1, CAMK1D, PRKAG1
IL-9 Signaling 5.01E-19 FGFR2, FGFR1, FGFR3 JAK3, IRS1, GAB1, PIK3R1, IL2RG, STAT3, PIK3CA, STAT1, PTPN11, TNF, FRS2, STAT5A, GRB2, NFKB1, PIK3R3, IRS2, ATM, JAK1, PIK3C2B, RELA, PIK3CG, NFKB2, PIK3R2, STAT5B
Hepatic Cholestasis 7.94E-19 ADCY6, TNFRSF1A, MAPK10, PRKCQ, PPARA, IL13, NR5A2, NFKBIA, TLR4, IKBKG, RXRA, PRKCH, ESR1, TRAF6, PRKCE, IL1B, INSR, IKBKB, NFKB2, PRKCD, HNF1A, HNF4A, IKBKE, JUN, TRAF2, RARA, TNF, NR1H3, MAPK8, PRKCI, PRKCZ, SLC4A2, IRAK1, NFKB1, CHUK, SREBF1, NR1H4, LTA, MAP3K14, IL4, RELA, PRKCA, NGFR, PRKD1, PRKACA, NR1I2 IL1RL1, PRKAG1, IL6, MAP3K7, GCG
Human Embryonic Stem Cell Pluripotency 7.94E-19 FGFR2, FGFR1, NTRK2, FGFR3, PDGFRB, PDGFRA GSK3B, PDGFD, AKT1, FGF4, IRS1, PDGFB, SPHK1, GAB1, SMAD4, PIK3R1, APC, SMAD7, PIK3CA, PTPN11, FRS2, SMAD3, GRB2, NTF4, BDNF, FOXO1, S1PR1, PIK3R3, IRS2, CTNNB1, SMAD2, ATM, NTF3, PIK3C2B, FGF2, AKT2, PDGFC, PIK3CG, BMPR2, TGFBR2, PDPK1, PIK3R2, SMAD1, HNF1A, PDGFA WNT6, WNT3, WNT7B
Remodeling of Epithelial Adherens Junctions 7.94E-19 TUBA8, TUBB3, TUBG1, TUBB1, TUBA1C, TUBB2A, TUBA1A, SRC, TUBB4B, TUBB4A, TUBA4A IQGAP1, VCL, MAPRE1, HGS, DNM1, CTNND1, APC, ZYX, DNM1L, CLIP1, ACTG1, ACTB, MET, CDH1, ACTN4, CTNNB1, TUBB, ACTN1, DNM2, TUBA1B TUBA3E
G Beta Gamma Signaling 1.26E-18 SRC CDC42, GNA11, AKT1, PRKCQ, GNA12, GNAQ, GNAI2, GRB2, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, CAV3, EGFR, PAK1, RAF1, BTK, SOS1, AKT2, PLCG2, PIK3CG, PRKCD, CAV1, PDPK1, CAV2, PRKCA, DNM2, MAPK1, PLCG1, PRKD1, PRKACA, HRAS, SHC1 PRKAG1
GP6 Signaling Pathway 1.58E-18 FGFR2, FGFR1, FGFR3, LYN GSK3B, AKT1, PRKCQ, IRS1, FCER1G, GAB1, PIK3R1, LCP2, SYK, FYN, PIK3CA, PTPN11, FRS2, GRB2, ITPR1, ITGB3, PRKCH, LAT, PRKCI, PRKCZ, LAMA4, PRKCE, PIK3R3, IRS2, TLN1, ATM, BTK, PIK3C2B, PTK2, AKT2, COL18A1, PLCG2, PIK3CG, PRKCD, PDPK1, GP6, PRKCA, PIK3R2, PRKD1, RAC1 CALML5
Acute Phase Response Signaling 2.51E-18 SOCS5, TNFRSF1A, NFKBIA, IKBKG, STAT3, RIPK1, TRAF6, PIK3R3, JAK2, IL1B, HNRNPK, RAF1, IKBKB, NFKB2, PIK3R2, NR3C1, HNF1A, SOCS6, TTR, IKBKE, JUN, TRAF2, TF, AKT1, IL6R, PIK3R1, SOCS7, FN1, PIK3CA, PTPN11, TNF, GRB2, MAPK8, MAPK3, IRAK1, NFKB1, CHUK, MAP3K14, SOS1, AKT2, RELA, PIK3CG, PDPK1, NGFR, CEBPB, MAPK1, SOCS1, HRAS, SHC1 IL6, ALB, MAP3K7
Sphingosine-1-phosphate Signaling 2.51E-18 FGFR2, FGFR1, FGFR3, PDGFRB, PDGFRA PDGFD, AKT1, ADCY6, GNA12, IRS1, PDGFB, SPHK1, GAB1, PIK3R1, GNAQ, GNAI2, PIK3CA, PTPN11, FRS2, GRB2, CASP7, MAPK3, S1PR1, PIK3R3, IRS2, ATM, CASP9, PIK3C2B, PTK2, AKT2, PDGFC, PLCG2, CASP6, PIK3CG, PIK3R2, PTK2B, MAPK1, PLCG1, CASP3, PDGFA, RAC1 RHOQ, PLCL1, RND2
Sirtuin Signaling Pathway 2.51E-18 TUBA1C, TUBA1A, TUBA4A, FOXO3, TUBA8, SP1 MYCN, PPARA, ESRRA, STAT3, TOMM20, NOS3, APP, MAP1LC3A, MAPK6, BECN1, NFKB2, MYC, TUBA1B, TP73, NDUFS6, JUN, GSK3B, VDAC1, AKT1, TIMM17A, NDRG1, E2F1, SMARCA5, SF3A1, TP53, GABPA, MAPK15, ARNTL, TNF, XRCC5, NR1H3, PPID, CDH1, PRKDC, FOXO1, SIRT1, MAPK3, NFKB1, SREBF1, NR1H4, TOMM34, GABARAP, NR1H2, SIRT2, WRN, RELA, SLC25A6, PARP1, TRIM28, NEDD4, NOS2, HIF1A, ACLY, MAPK1, EPAS1, RARB, TOMM40 HSF1, TOMM7, CPS1, TUBA3E, NDUFV2
SAPK/JNK Signaling 2.51E-18 FGFR2, FGFR1, LCK, FGFR3 JUN, TRAF2, CDC42, MAPK10, GNA12, IRS1, FCER1G, GAB1, PIK3R1, TP53, PIK3CA, PTPN11, FRS2, GRB2, CRK, MAPK8, RIPK1, MAP3K3, PIK3R3, IRS2, CRKL, HNRNPK, ATM, MAP4K1, PIK3C2B, MAPK8IP3, NFATC1, SOS1, SH2D2A, PIK3CG, NFATC3, PIK3R2, HRAS, RAC1, SHC1 MAP3K7
CNTF Signaling 3.16E-18 FGFR2, FGFR1, FGFR3 AKT1, IRS1, GAB1, PIK3R1, STAT3, PIK3CA, STAT1, PTPN11, FRS2, GRB2, RPS6KB1, MAPK3, RPS6KB2, PIK3R3, IRS2, JAK2, RPS6KA3, ATM, RAF1, JAK1, PIK3C2B, TYK2, SOS1, PIK3CG, PIK3R2, RPS6KA1, MAPK1, HRAS
Role of JAK2 in Hormone-like Cytokine Signaling 3.98E-18 IRS2, SOCS5, JAK2, JAK1, IRS1, HLTF, TYK2, SH2B1, EPOR, PTPN1, SOCS7, SH2B3, STAT3, STAT1, PTPN11, STAT5A, SOCS1, PTPN6, SOCS6, STAT5B, SH2B2, SHC1 SIRPA
Mouse Embryonic Stem Cell Pluripotency 5.01E-18 FGFR2, FGFR1, FGFR3 GSK3B, AKT1, JAK3, IRS1, GAB1, SMAD4, PIK3R1, TP53, APC, STAT3, PIK3CA, PTPN11, FRS2, GRB2, CREBBP, DVL3, MAPK3, PIK3R3, IRS2, JAK2, CTNNB1, ATM, RAF1, JAK1, PIK3C2B, TYK2, SOS1, AKT2, PIK3CG, BMPR2, MYC, PIK3R2, SMAD1, HNF1A, MAPK1, HRAS MAP3K7
Sumoylation Pathway 5.01E-18 SP1 JUN, RNF4, PML, MAPK10, SMAD4, PIAS1, NFKBIA, SUMO1, TP53, PCNA, SUMO4, SNCA, CREBBP, STUB1, CDH1, MAPK8, SUMO2, HDAC1, SIRT1, NFKB1, HDAC2, FASLG, RCC1, EP300, SENP6, NFKB2, AR, UBE2I, NR3C1, CTBP2, SP3, MDM2, ETS1, FAS RHOQ, RAN, RND2
Amyotrophic Lateral Sclerosis Signaling 5.01E-18 FGFR2, FGFR1, FGFR3 BIRC2, RNF19A, APAF1, PGF, IRS1, GAB1, PIK3R1, TP53, GRIA3, NOS1, PIK3CA, PTPN11, FRS2, GRB2, VEGFB, VEGFC, CACNA1D, CASP7, PIK3R3, IRS2, VEGFA, ATM, PAK1, CASP9, PIK3C2B, PDGFC, PIK3CG, GRIN2B, GRIN2A, PIK3R2, CASP3, BCL2L1, RAC1 CACNA1S, GRIN1, CAPN2, GRIA1
G-Protein Coupled Receptor Signaling 7.94E-18 FGFR1, SRC, FGFR2, FGFR3 CAMK2B, ADRB2, GNA11, ADCY6, PDE6G, NFKBIA, IKBKG, GNAQ, STAT3, FRS2, S1PR1, PRKCE, PIK3R3, RAF1, IKBKB, PIK3C2B, SYNGAP1, NFKB2, PIK3R2, PTK2B, IKBKE, TDP2, AKT1, PDE4A, IRS1, GAB1, PIK3R1, RGS16, GNAI2, FYN, PIK3CA, PTPN11, PDE4D, GRB2, GRM7, CREBBP, MAPK3, NFKB1, IRS2, CHUK, RAPGEF4, ADRB3, ATM, EP300, SOS1, AKT2, RELA, PIK3CG, PDPK1, PRKCA, RPS6KA1, MAPK1, RASA1, PRKACA, HRAS, SHC1 GLP1R, DRD3, PRKAG1, RAPGEF3, GRK4, CHRM3, RGS4
fMLP Signaling in Neutrophils 1.00E-17 FGFR2, FGFR1, FGFR3 CDC42, PRKCQ, IRS1, GAB1, PIK3R1, NFKBIA, IKBKG, WAS, GNAI2, PIK3CA, PTPN11, FRS2, GRB2, ITPR1, PRKCH, PRKCI, PRKCZ, MAPK3, PRKCE, NFKB1, PIK3R3, IRS2, ATM, RAF1, PIK3C2B, NFATC1, RELA, PIK3CG, NFKB2, NFATC3, PRKCD, PRKCA, PIK3R2, MAPK1, PRKD1, HRAS, RAC1 CALML5
3-phosphoinositide Biosynthesis 1.26E-17 FGFR1, LCK, PDGFRA, FGFR2, FGFR3, PDGFRB, PDCD1 PPP1R8, PPP2R5A, FRS2, ERBB2, CD80, PTPRF, CD86, EGFR, PIK3R3, KIT, PIK3C2B, PAWR, VAV1, PI4KA, PTPN1, CD28, ACP1, PTPN12, PIK3R2, TRAT1, ERBB3, PPP1CC, NUDT3, PTPN22, IRS1, GAB1, PIK3R1, CDC25C, TPTE, PTPRH, WBP11, FYN, DUSP23, PIK3CA, PTPN11, GRB2, CD19, MET, PTPN6, IRS2, ATM, PTPN2, PTPRJ, PIK3CG, CA3, RASA1, PTPRC OCRL, SIRPA
Protein Kinase A Signaling 1.26E-17 CAMK2B, ADCY6, PRKCQ, PDE6G, SMAD4, YWHAE, NFKBIA, IKBKG, PTPN18, GNAQ, SMAD3, PTPN21, ITPR1, PTPRF, PTPRA, NOS3, PRKCH, PTPRS, PRKCE, YWHAG, CTNNB1, FLNA, RAF1, PTK2, ADD3, PTPN1, NFKB2, TGFBR2, PRKCD, ACP1, PTPN12, PTK2B, MYLK, HNF1A, YWHAZ, GSK3B, PPP1CC, TDP2, YWHAQ, PDE4A, PTPN22, YWHAH, CDC25C, PTPRH, GNAI2, CREM, PTPN11, PDE4D, CREBBP, PTPN6, PRKCI, PRKCZ, YWHAB, MAPK3, NFKB1, CHUK, MYL12A, EP300, PTPN2, PXN, NFATC1, PTPRJ, RELA, PLCG2, NFATC3, PRKCA, NGFR, PTPRE, MAPK1, PLCG1, PRKD1, PTPRC, PRKACA ADD1, PTPRT, MYL6B, CDC26, PRKAG1, CALML5, SIRPA, PLCL1, PYGL, PLN
ERK5 Signaling 1.58E-17 SRC, FOXO3 YWHAQ, AKT1, GNA12, GAB1, YWHAE, YWHAH, GNAQ, PTPN11, CREBBP, MEF2D, PRKCZ, YWHAB, MAP3K3, RPS6KB1, RPS6KB2, EGFR, YWHAG, RPS6KA3, EP300, WNK1, MEF2C, SH2D2A, MYC, SGK1, RPS6KA1, YWHAZ, HRAS, FOSL1 ELK4
Phagosome Formation 1.58E-17 FGFR2, FGFR1, FGFR3 TLR1, PRKCQ, IRS1, INPPL1, FCER1G, GAB1, PIK3R1, TLR4, SYK, FN1, INPP5D, PIK3CA, PTPN11, ITGB1, FRS2, GRB2, PRKCH, PRKCI, PRKCZ, TLR2, PRKCE, PIK3R3, IRS2, ATM, PIK3C2B, FCGR2A, PLCG2, PIK3CG, FCAR, PRKCD, FCGR2B, PRKCA, PIK3R2, PLCG1, PRKD1, ITGA5 ITGAM, RHOQ, PLCL1, RND2
Role of p14/p19ARF in Tumor Suppression 2.51E-17 FGFR2, FGFR1, CDKN2A, TTF1, FGFR3 E2F1, IRS1, GAB1,