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KMT2A - Wiki-MPM

Search Results for: KMT2A

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel CKMT1A creatine kinase, mitochondrial 1A
  • Creatine metabolism
  • Creatine
  • Phosphocreatine
Novel DCTN1 dynactin subunit 1
  • MHC class II antigen presentation
  • HSP90 chaperone cycle for steroid hormone receptors (SHR)
  • XBP1(S) activates chaperone genes
  • COPI-mediated anterograde transport
  • COPI-independent Golgi-to-ER retrograde traffic
  • Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
  • Perry syndrome
  • Distal hereditary motor neuropathies (dHMN)
Novel EXOSC5 exosome component 5
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol
Novel IL10RA interleukin 10 receptor subunit alpha
  • Interleukin-10 signaling
Novel INPPL1 inositol polyphosphate phosphatase like 1
  • Synthesis of PIPs at the plasma membrane
  • Synthesis of IP3 and IP4 in the cytosol
  • Interleukin receptor SHC signaling
Novel LAYN layilin
  • Hyaluronic acid
Novel MCTS1 MCTS1 re-initiation and release factor
Novel PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2
  • Neutrophil degranulation
  • COPI-independent Golgi-to-ER retrograde traffic
Novel PLAAT4 phospholipase A and acyltransferase 4
  • Acyl chain remodelling of PE
Novel PLPP2 phospholipid phosphatase 2
  • Sphingolipid de novo biosynthesis
Novel RDX radixin
  • Recycling pathway of L1
  • Recycling pathway of L1
  • 1D-myo-inositol 1,4,5-trisphosphate
Novel TGFB2 transforming growth factor beta 2
  • Platelet degranulation
  • Molecules associated with elastic fibres
  • ECM proteoglycans
  • Graft-versus-host disease
  • Allograft rejection
Novel VWA5A von Willebrand factor A domain containing 5A
ASH2L ASH2 like, histone lysine methyltransferase complex subunit
  • Formation of the beta-catenin:TCF transactivating complex
  • PKMTs methylate histone lysines
  • Deactivation of the beta-catenin transactivating complex
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
AVP arginine vasopressin
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • Vasopressin-like receptors
  • G alpha (q) signalling events
  • G alpha (s) signalling events
  • Vasopressin regulates renal water homeostasis via Aquaporins
  • Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)
  • Transport of organic anions
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI)
  • ADORA2B mediated anti-inflammatory cytokines production
  • Neurohypophyseal diabetes insipidus (NPDI); Central Diabetes Insipidus
BMI1 BMI1 proto-oncogene, polycomb ring finger
  • Oxidative Stress Induced Senescence
  • SUMOylation of DNA damage response and repair proteins
  • SUMOylation of transcription cofactors
  • SUMOylation of chromatin organization proteins
  • SUMOylation of RNA binding proteins
  • SUMOylation of DNA methylation proteins
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • Regulation of PTEN gene transcription
  • Regulation of PTEN gene transcription
  • Transcriptional Regulation by E2F6
  • Penile cancer
CBX4 chromobox 4
  • Oxidative Stress Induced Senescence
  • SUMOylation of DNA damage response and repair proteins
  • SUMOylation of transcription cofactors
  • SUMOylation of chromatin organization proteins
  • SUMOylation of RNA binding proteins
  • SUMOylation of DNA methylation proteins
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • Regulation of PTEN gene transcription
  • Regulation of PTEN gene transcription
CREBBP CREB binding protein
  • Regulation of gene expression by Hypoxia-inducible Factor
  • RORA activates gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • Pre-NOTCH Transcription and Translation
  • Pre-NOTCH Transcription and Translation
  • PPARA activates gene expression
  • PPARA activates gene expression
  • Formation of the beta-catenin:TCF transactivating complex
  • Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
  • NOTCH1 Intracellular Domain Regulates Transcription
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Transcriptional activation of mitochondrial biogenesis
  • Activation of gene expression by SREBF (SREBP)
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
  • HATs acetylate histones
  • Attenuation phase
  • Notch-HLH transcription pathway
  • Transcriptional regulation of white adipocyte differentiation
  • Transcriptional regulation of white adipocyte differentiation
  • SUMOylation of transcription cofactors
  • Regulation of lipid metabolism by PPARalpha
  • Circadian Clock
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • CD209 (DC-SIGN) signaling
  • TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
  • Activation of the TFAP2 (AP-2) family of transcription factors
  • RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
  • RUNX3 regulates NOTCH signaling
  • RUNX3 regulates NOTCH signaling
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH4 Intracellular Domain Regulates Transcription
  • Estrogen-dependent gene expression
  • TRAF3-dependent IRF activation pathway
  • TRAF6 mediated IRF7 activation
  • FOXO-mediated transcription of cell death genes
  • Regulation of FOXO transcriptional activity by acetylation
  • Regulation of FOXO transcriptional activity by acetylation
  • 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
  • Rubinstein-Taybi syndrome
CTNNB1 catenin beta 1
  • Degradation of beta-catenin by the destruction complex
  • Beta-catenin phosphorylation cascade
  • TCF dependent signaling in response to WNT
  • Formation of the beta-catenin:TCF transactivating complex
  • Formation of the beta-catenin:TCF transactivating complex
  • LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
  • Apoptotic cleavage of cell adhesion proteins
  • Deactivation of the beta-catenin transactivating complex
  • Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
  • Ca2+ pathway
  • Adherens junctions interactions
  • Binding of TCF/LEF:CTNNB1 to target gene promoters
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • VEGFR2 mediated vascular permeability
  • Myogenesis
  • Myogenesis
  • Signaling by GSK3beta mutants
  • S33 mutants of beta-catenin aren't phosphorylated
  • S37 mutants of beta-catenin aren't phosphorylated
  • S45 mutants of beta-catenin aren't phosphorylated
  • T41 mutants of beta-catenin aren't phosphorylated
  • RHO GTPases activate IQGAPs
  • Transcriptional Regulation by VENTX
  • InlA-mediated entry of Listeria monocytogenes into host cells
  • RUNX3 regulates WNT signaling
  • Urea
  • Gastric cancer
  • Colorectal cancer
  • Endometrial Cancer
  • Pilomatricoma; Epithelioma calcificans of Malherbe
  • Thyroid cancer
  • Hepatocellular carcinoma
FASLG Fas ligand
  • Caspase activation via Death Receptors in the presence of ligand
  • Regulation by c-FLIP
  • RIPK1-mediated regulated necrosis
  • CASP8 activity is inhibited
  • Interleukin-4 and Interleukin-13 signaling
  • Dimerization of procaspase-8
  • FasL/ CD95L signaling
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • FOXO-mediated transcription of cell death genes
  • TNFs bind their physiological receptors
  • Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS

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