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KDR - Wiki-MPM

Search Results for: KDR

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel ALB albumin
  • Platelet degranulation
  • Recycling of bile acids and salts
  • Heme biosynthesis
  • Heme degradation
  • Scavenging of heme from plasma
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Transport of organic anions
  • Post-translational protein phosphorylation
  • HDL remodeling
  • Amsacrine
  • Cefotaxime
  • Pyridostigmine
  • Phenol
  • Norelgestromin
  • Aniline
  • Guaiacol
  • Artenimol
  • Silver
  • Patent Blue
Novel CACNA1S calcium voltage-gated channel subunit alpha1 S
  • NCAM1 interactions
  • Ergocalciferol
  • Enflurane
  • Ranolazine
  • Phenytoin
  • Isradipine
  • Topiramate
  • Nimodipine
  • Nisoldipine
  • Spironolactone
  • Cinnarizine
  • Magnesium sulfate
  • Levomenthol
  • Ethanol
  • Felodipine
  • Nitrendipine
  • Miconazole
  • Nifedipine
  • Amiodarone
  • Mibefradil
  • Dronedarone
  • Clevidipine
  • Nilvadipine
  • Trimebutine
  • Pinaverium
  • Aranidipine
  • Benidipine
  • Cilnidipine
  • Lacidipine
  • Manidipine
  • Butamben
  • Bioallethrin
  • Bioallethrin
  • Fish oil
  • Hypokalemic periodic paralysis (HypoPP)
Novel CHIC2 cysteine rich hydrophobic domain 2
Novel GSTA2 glutathione S-transferase alpha 2
  • Glutathione conjugation
  • Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
  • Glutathione
  • Chloroquine
  • Glutathione disulfide
Novel KIT KIT proto-oncogene, receptor tyrosine kinase
  • PIP3 activates AKT signaling
  • Signaling by SCF-KIT
  • Signaling by SCF-KIT
  • Regulation of KIT signaling
  • Regulation of KIT signaling
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • RAF/MAP kinase cascade
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
  • Dasatinib-resistant KIT mutants
  • Imatinib-resistant KIT mutants
  • KIT mutants bind TKIs
  • Masitinib-resistant KIT mutants
  • Nilotinib-resistant KIT mutants
  • Regorafenib-resistant KIT mutants
  • Signaling by kinase domain mutants of KIT
  • Sunitinib-resistant KIT mutants
  • Signaling by juxtamembrane domain KIT mutants
  • Sorafenib-resistant KIT mutants
  • Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
  • Signaling by extracellular domain mutants of KIT
  • Sorafenib
  • Imatinib
  • Dasatinib
  • Sunitinib
  • Phosphonotyrosine
  • Nilotinib
  • XL820
  • OSI-930
  • ABT-869
  • Pazopanib
  • Midostaurin
  • Regorafenib
  • Ponatinib
  • Lenvatinib
  • Ancestim
  • Fostamatinib
  • Erdafitinib
  • Amuvatinib
  • Pexidartinib
  • Ripretinib
  • Avapritinib
  • Piebaldism
  • Acute myeloid leukemia (AML)
Novel SHOX2 short stature homeobox 2
Novel SRP72 signal recognition particle 72
  • SRP-dependent cotranslational protein targeting to membrane
  • SRP-dependent cotranslational protein targeting to membrane
Novel UTP3 UTP3 small subunit processome component
  • rRNA modification in the nucleus and cytosol
  • Major pathway of rRNA processing in the nucleolus and cytosol
ACP1 acid phosphatase 1
  • Adenine
  • 4-Nitrophenyl Phosphate
AIMP2 aminoacyl tRNA synthetase complex interacting multifunctional protein 2
  • Selenoamino acid metabolism
  • Cytosolic tRNA aminoacylation
ANXA5 annexin A5
  • Platelet degranulation
  • Fluocinolone acetonide
  • L-Alpha-Glycerophosphorylserine
  • L-thioproline
  • K201 free base
  • sn-glycero-3-phosphoethanolamine
  • 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid
  • N,O6-Disulfo-Glucosamine
  • 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid
  • Copper
ATR ATR serine/threonine kinase
  • Meiotic synapsis
  • Activation of ATR in response to replication stress
  • Regulation of HSF1-mediated heat shock response
  • HDR through Single Strand Annealing (SSA)
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Fanconi Anemia Pathway
  • TP53 Regulates Transcription of DNA Repair Genes
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Alveolar rhabdomyosarcoma
  • Seckel syndrome
BMX BMX non-receptor tyrosine kinase
  • Apoptotic cleavage of cellular proteins
  • Synthesis of PIPs at the plasma membrane
  • Fostamatinib
  • Zanubrutinib
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
  • Activation of NF-kappaB in B cells
  • Prolactin receptor signaling
  • SCF-beta-TrCP mediated degradation of Emi1
  • Vpu mediated degradation of CD4
  • Degradation of beta-catenin by the destruction complex
  • Downstream TCR signaling
  • Regulation of PLK1 Activity at G2/M Transition
  • FCERI mediated NF-kB activation
  • Deactivation of the beta-catenin transactivating complex
  • Circadian Clock
  • Dectin-1 mediated noncanonical NF-kB signaling
  • CLEC7A (Dectin-1) signaling
  • Degradation of GLI1 by the proteasome
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • NIK-->noncanonical NF-kB signaling
  • MAP3K8 (TPL2)-dependent MAPK1/3 activation
  • Neddylation
  • Interleukin-1 signaling
  • Antigen processing: Ubiquitination & Proteasome degradation
CAV1 caveolin 1
  • Triglyceride catabolism
  • eNOS activation
  • NOSTRIN mediated eNOS trafficking
  • Basigin interactions
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • VEGFR2 mediated vascular permeability
  • Extra-nuclear estrogen signaling
  • FOXO-mediated transcription of cell cycle genes
  • Congenital generalized lipodystrophy (CGL)
CBL Cbl proto-oncogene
  • Interleukin-6 signaling
  • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
  • Spry regulation of FGF signaling
  • Regulation of KIT signaling
  • EGFR downregulation
  • TGF-beta receptor signaling activates SMADs
  • Constitutive Signaling by EGFRvIII
  • Negative regulation of FGFR1 signaling
  • Negative regulation of FGFR2 signaling
  • Negative regulation of FGFR3 signaling
  • Negative regulation of FGFR4 signaling
  • Negative regulation of MET activity
  • PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • Regulation of signaling by CBL
  • Regulation of signaling by CBL
  • Negative regulation of FLT3
  • FLT3 signaling by CBL mutants
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
CCDC88A coiled-coil domain containing 88A
CDH5 cadherin 5
  • Adherens junctions interactions
  • VEGFR2 mediated vascular permeability
  • Lenalidomide
  • FX06
COL18A1 collagen type XVIII alpha 1 chain
  • Collagen degradation
  • Activation of Matrix Metalloproteinases
  • Collagen biosynthesis and modifying enzymes
  • Assembly of collagen fibrils and other multimeric structures
  • Integrin cell surface interactions
  • Laminin interactions
  • Collagen chain trimerization
  • Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC)
  • Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
CRK CRK proto-oncogene, adaptor protein
  • ARMS-mediated activation
  • ARMS-mediated activation
  • Downstream signal transduction
  • Regulation of actin dynamics for phagocytic cup formation
  • p130Cas linkage to MAPK signaling for integrins
  • VEGFA-VEGFR2 Pathway
  • PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
  • MET activates RAP1 and RAC1
  • MET receptor recycling
  • Regulation of signaling by CBL
  • FCGR3A-mediated phagocytosis

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