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WT1 - Wiki-MPM

Search Results for: WT1

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
  • Keratan sulfate biosynthesis
  • O-linked glycosylation of mucins
Novel BST2 bone marrow stromal cell antigen 2
  • Neutrophil degranulation
  • Interferon alpha/beta signaling
Novel CALML5 calmodulin like 5
  • Neutrophil degranulation
Novel CAPRIN1 cell cycle associated protein 1
Novel FJX1 four-jointed box kinase 1
Novel HIPK3 homeodomain interacting protein kinase 3
  • Fostamatinib
Novel PAX6 paired box 6
  • Regulation of gene expression in beta cells
  • Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
  • Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Aniridia
  • Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
  • Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON)
Novel PEX3 peroxisomal biogenesis factor 3
  • ABC transporters in lipid homeostasis
  • Class I peroxisomal membrane protein import
  • Class I peroxisomal membrane protein import
  • Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
AREG amphiregulin
  • PIP3 activates AKT signaling
  • Signaling by EGFR
  • GRB2 events in EGFR signaling
  • GAB1 signalosome
  • SHC1 events in EGFR signaling
  • EGFR downregulation
  • COPII-mediated vesicle transport
  • EGFR interacts with phospholipase C-gamma
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • Inhibition of Signaling by Overexpressed EGFR
  • RAF/MAP kinase cascade
  • Cargo concentration in the ER
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • Extra-nuclear estrogen signaling
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
BHLHE40 basic helix-loop-helix family member e40
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
CASZ1 castor zinc finger 1
CCDC136 coiled-coil domain containing 136
CCDC33 coiled-coil domain containing 33
CCL5 C-C motif chemokine ligand 5
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events
  • Interleukin-10 signaling
  • Heparin Disaccharide I-S
  • Heparin Disaccharide Iii-S
CEP70 centrosomal protein 70
  • Regulation of PLK1 Activity at G2/M Transition
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Anchoring of the basal body to the plasma membrane
  • AURKA Activation by TPX2
CIAO1 cytosolic iron-sulfur assembly component 1
  • Cytosolic iron-sulfur cluster assembly
CREBBP CREB binding protein
  • Regulation of gene expression by Hypoxia-inducible Factor
  • RORA activates gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • Pre-NOTCH Transcription and Translation
  • Pre-NOTCH Transcription and Translation
  • PPARA activates gene expression
  • PPARA activates gene expression
  • Formation of the beta-catenin:TCF transactivating complex
  • Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
  • NOTCH1 Intracellular Domain Regulates Transcription
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Transcriptional activation of mitochondrial biogenesis
  • Activation of gene expression by SREBF (SREBP)
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
  • HATs acetylate histones
  • Attenuation phase
  • Notch-HLH transcription pathway
  • Transcriptional regulation of white adipocyte differentiation
  • Transcriptional regulation of white adipocyte differentiation
  • SUMOylation of transcription cofactors
  • Regulation of lipid metabolism by PPARalpha
  • Circadian Clock
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • CD209 (DC-SIGN) signaling
  • TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
  • Activation of the TFAP2 (AP-2) family of transcription factors
  • RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
  • RUNX3 regulates NOTCH signaling
  • RUNX3 regulates NOTCH signaling
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH3 Intracellular Domain Regulates Transcription
  • NOTCH4 Intracellular Domain Regulates Transcription
  • Estrogen-dependent gene expression
  • TRAF3-dependent IRF activation pathway
  • TRAF6 mediated IRF7 activation
  • FOXO-mediated transcription of cell death genes
  • Regulation of FOXO transcriptional activity by acetylation
  • Regulation of FOXO transcriptional activity by acetylation
  • 9-ACETYL-2,3,4,9-TETRAHYDRO-1H-CARBAZOL-1-ONE
  • Rubinstein-Taybi syndrome
CYSRT1 cysteine rich tail 1
DIRAS3 DIRAS family GTPase 3
DVL2 dishevelled segment polarity protein 2
  • TCF dependent signaling in response to WNT
  • WNT mediated activation of DVL
  • Signaling by Hippo
  • PCP/CE pathway
  • PCP/CE pathway
  • Asymmetric localization of PCP proteins
  • Degradation of DVL
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • WNT5A-dependent internalization of FZD4
  • Negative regulation of TCF-dependent signaling by DVL-interacting proteins
  • RHO GTPases Activate Formins
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • WNT5:FZD7-mediated leishmania damping
  • WNT5:FZD7-mediated leishmania damping

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