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SETD2 - Wiki-MPM

Search Results for: SETD2

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel EXOSC7 exosome component 7
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol
Novel GMPPB GDP-mannose pyrophosphorylase B
  • Synthesis of GDP-mannose
Novel KLHL18 kelch like family member 18
Novel NDUFAF3 NADH:ubiquinone oxidoreductase complex assembly factor 3
  • Complex I biogenesis
  • Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
Novel TEX264 testis expressed 264, ER-phagy receptor
  • Platelet degranulation
Novel TMA7 translation machinery associated 7 homolog
ATXN1 ataxin 1
  • Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
CIC capicua transcriptional repressor
H3-4 H3.4 histone
  • Recognition and association of DNA glycosylase with site containing an affected pyrimidine
  • Cleavage of the damaged pyrimidine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Cleavage of the damaged purine
  • Cleavage of the damaged purine
  • Meiotic synapsis
  • Packaging Of Telomere Ends
  • Formation of the beta-catenin:TCF transactivating complex
  • Formation of the beta-catenin:TCF transactivating complex
  • Condensation of Prophase Chromosomes
  • DNA Damage/Telomere Stress Induced Senescence
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Nonhomologous End-Joining (NHEJ)
  • Processing of DNA double-strand break ends
  • G2/M DNA damage checkpoint
  • Meiotic recombination
  • Inhibition of DNA recombination at telomere
H3C1 H3 clustered histone 1
  • Interleukin-7 signaling
  • Interleukin-7 signaling
  • Pre-NOTCH Transcription and Translation
  • Formation of the beta-catenin:TCF transactivating complex
  • PRC2 methylates histones and DNA
  • Condensation of Prophase Chromosomes
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • HDACs deacetylate histones
  • PKMTs methylate histone lysines
  • HDMs demethylate histones
  • HATs acetylate histones
  • HATs acetylate histones
  • RMTs methylate histone arginines
  • Chromatin modifying enzymes
  • SIRT1 negatively regulates rRNA expression
  • ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
  • NoRC negatively regulates rRNA expression
  • NoRC negatively regulates rRNA expression
  • B-WICH complex positively regulates rRNA expression
  • DNA methylation
  • Transcriptional regulation by small RNAs
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  • RNA Polymerase I Promoter Opening
  • RNA Polymerase I Promoter Escape
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Estrogen-dependent gene expression
  • Meiotic recombination
  • HCMV Early Events
  • HCMV Late Events
  • Transcriptional regulation of granulopoiesis
  • Amyloid fiber formation
  • Factors involved in megakaryocyte development and platelet production
HTT huntingtin
  • Regulation of MECP2 expression and activity
  • Copper
  • Huntington's disease (HD)
SIAH2 siah E3 ubiquitin protein ligase 2
  • Netrin-1 signaling
  • Ub-specific processing proteases
  • Amyloid fiber formation
  • Antigen processing: Ubiquitination & Proteasome degradation
SMAD3 SMAD family member 3
  • Signaling by NODAL
  • Signaling by NODAL
  • Signaling by Activin
  • Downregulation of TGF-beta receptor signaling
  • TGF-beta receptor signaling activates SMADs
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • SMAD2/3 Phosphorylation Motif Mutants in Cancer
  • SMAD4 MH2 Domain Mutants in Cancer
  • SMAD2/3 MH2 Domain Mutants in Cancer
  • TGFBR1 KD Mutants in Cancer
  • Ub-specific processing proteases
  • RUNX3 regulates CDKN1A transcription
  • RUNX3 regulates BCL2L11 (BIM) transcription
  • Interleukin-37 signaling
  • NOTCH4 Intracellular Domain Regulates Transcription
  • FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
  • FOXO-mediated transcription of cell cycle genes
  • FOXO-mediated transcription of cell cycle genes
SPOP speckle type BTB/POZ protein
  • Hedgehog 'on' state

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