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Novel |
CELA2A |
chymotrypsin like elastase 2A |
- Formation of the cornified envelope
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- 2-(2-HYDROXY-CYCLOPENTYL)-PENT-4-ENAL
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Novel |
CELA2B |
chymotrypsin like elastase 2B |
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Novel |
CTRC |
chymotrypsin C |
- Cobalamin (Cbl, vitamin B12) transport and metabolism
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- Tropical calcific pancreatitis
- Hereditary pancreatitis; Hereditary chronic pancreatitis
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Novel |
FBLIM1 |
filamin binding LIM protein 1 |
- Cell-extracellular matrix interactions
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Novel |
KIF1B |
kinesin family member 1B |
- COPI-dependent Golgi-to-ER retrograde traffic
- Kinesins
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- Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
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Novel |
NPPA |
natriuretic peptide A |
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- Physiological factors
- Amyloid fiber formation
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ARID5A |
AT-rich interaction domain 5A |
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CLVS2 |
clavesin 2 |
- Lysosome Vesicle Biogenesis
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COIL |
coilin |
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DVL3 |
dishevelled segment polarity protein 3 |
- TCF dependent signaling in response to WNT
- WNT mediated activation of DVL
- PCP/CE pathway
- PCP/CE pathway
- Degradation of DVL
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- Negative regulation of TCF-dependent signaling by DVL-interacting proteins
- RHO GTPases Activate Formins
- WNT5:FZD7-mediated leishmania damping
- WNT5:FZD7-mediated leishmania damping
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LMO2 |
LIM domain only 2 |
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
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- Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
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LZTS1 |
leucine zipper tumor suppressor 1 |
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LZTS2 |
leucine zipper tumor suppressor 2 |
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PPL |
periplakin |
- Formation of the cornified envelope
- Butyrophilin (BTN) family interactions
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PSMA1 |
proteasome 20S subunit alpha 1 |
- Activation of NF-kappaB in B cells
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- ER-Phagosome pathway
- Cross-presentation of soluble exogenous antigens (endosomes)
- Autodegradation of Cdh1 by Cdh1:APC/C
- SCF-beta-TrCP mediated degradation of Emi1
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Vpu mediated degradation of CD4
- Vif-mediated degradation of APOBEC3G
- SCF(Skp2)-mediated degradation of p27/p21
- Degradation of beta-catenin by the destruction complex
- Downstream TCR signaling
- Regulation of activated PAK-2p34 by proteasome mediated degradation
- Separation of Sister Chromatids
- FCERI mediated NF-kB activation
- Autodegradation of the E3 ubiquitin ligase COP1
- Regulation of ornithine decarboxylase (ODC)
- ABC-family proteins mediated transport
- AUF1 (hnRNP D0) binds and destabilizes mRNA
- Asymmetric localization of PCP proteins
- Degradation of AXIN
- Degradation of DVL
- Hedgehog ligand biogenesis
- Hh mutants are degraded by ERAD
- Dectin-1 mediated noncanonical NF-kB signaling
- CLEC7A (Dectin-1) signaling
- Degradation of GLI1 by the proteasome
- Degradation of GLI2 by the proteasome
- GLI3 is processed to GLI3R by the proteasome
- Hedgehog 'on' state
- Regulation of RAS by GAPs
- TNFR2 non-canonical NF-kB pathway
- NIK-->noncanonical NF-kB signaling
- Defective CFTR causes cystic fibrosis
- MAPK6/MAPK4 signaling
- UCH proteinases
- Ub-specific processing proteases
- CDT1 association with the CDC6:ORC:origin complex
- Orc1 removal from chromatin
- CDK-mediated phosphorylation and removal of Cdc6
- G2/M Checkpoints
- Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
- Ubiquitin-dependent degradation of Cyclin D
- The role of GTSE1 in G2/M progression after G2 checkpoint
- FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- Regulation of RUNX2 expression and activity
- Regulation of RUNX2 expression and activity
- Regulation of RUNX3 expression and activity
- Regulation of PTEN stability and activity
- Neddylation
- Regulation of expression of SLITs and ROBOs
- Interleukin-1 signaling
- Negative regulation of NOTCH4 signaling
- Antigen processing: Ubiquitination & Proteasome degradation
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- (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
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TNS4 |
tensin 4 |
- MET interacts with TNS proteins
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TXN2 |
thioredoxin 2 |
- Degradation of cysteine and homocysteine
- Detoxification of Reactive Oxygen Species
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USP2 |
ubiquitin specific peptidase 2 |
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Ub-specific processing proteases
- Regulation of TP53 Degradation
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