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TRIO - Wiki-MPM

Search Results for: TRIO

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel DAP death associated protein
Novel DNAH5 dynein axonemal heavy chain 5
  • Primary ciliary dyskinesia, including: Primary ciliary dyskinesia; Kartagener syndrome
Novel MARCHF6 membrane associated ring-CH-type finger 6
  • ER Quality Control Compartment (ERQC)
Novel NIPBL NIPBL cohesin loading factor
  • Cohesin Loading onto Chromatin
  • Cornelia de Lange syndrome (CdLS)
Novel PRMT7 protein arginine methyltransferase 7
  • RMTs methylate histone arginines
BLMH bleomycin hydrolase
  • Antigen processing: Ubiquitination & Proteasome degradation
CDC42 cell division cycle 42
  • GPVI-mediated activation cascade
  • EGFR downregulation
  • Rho GTPase cycle
  • Regulation of actin dynamics for phagocytic cup formation
  • Regulation of actin dynamics for phagocytic cup formation
  • CD28 dependent Vav1 pathway
  • EPHB-mediated forward signaling
  • EPHB-mediated forward signaling
  • DCC mediated attractive signaling
  • Inactivation of CDC42 and RAC1
  • VEGFA-VEGFR2 Pathway
  • Myogenesis
  • Myogenesis
  • RHO GTPases activate KTN1
  • RHO GTPases activate IQGAPs
  • RHO GTPases activate PAKs
  • RHO GTPases Activate WASPs and WAVEs
  • RHO GTPases Activate WASPs and WAVEs
  • RHO GTPases Activate Formins
  • RHO GTPases Activate Formins
  • MAPK6/MAPK4 signaling
  • Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
  • G beta:gamma signalling through CDC42
  • FCGR3A-mediated phagocytosis
  • FCGR3A-mediated phagocytosis
  • Factors involved in megakaryocyte development and platelet production
  • Aminophosphonic acid-guanylate ester
  • Guanosine-5'-Diphosphate
CDC5L cell division cycle 5 like
  • mRNA Splicing - Major Pathway
DISC1 DISC1 scaffold protein
EXOC1 exocyst complex component 1
  • Translocation of SLC2A4 (GLUT4) to the plasma membrane
  • Insulin processing
  • VxPx cargo-targeting to cilium
FLNA filamin A
  • Platelet degranulation
  • GP1b-IX-V activation signalling
  • Cell-extracellular matrix interactions
  • RHO GTPases activate PAKs
  • OAS antiviral response
  • Artenimol
  • Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
  • Fronto-Otopalatodigital Osteodysplasia, including: Otopalatodigital syndrome, type I; Otopalatodigital syndrome, type II; Melnick-Needles syndrome; Frontometaphyseal dysplasia
  • Periventricular nodular heterotopia (PVNH)
  • FG syndrome (FGS); Opitz-Kaveggia syndrome
ITSN2 intersectin 2
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
LIMS1 LIM zinc finger domain containing 1
  • Cell-extracellular matrix interactions
  • Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
MAPRE1 microtubule associated protein RP/EB family member 1
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • Regulation of PLK1 Activity at G2/M Transition
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Anchoring of the basal body to the plasma membrane
  • RHO GTPases Activate Formins
  • Mitotic Prometaphase
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • AURKA Activation by TPX2
  • EML4 and NUDC in mitotic spindle formation
PTK2 protein tyrosine kinase 2
  • Apoptotic cleavage of cellular proteins
  • Regulation of actin dynamics for phagocytic cup formation
  • Integrin signaling
  • GRB2:SOS provides linkage to MAPK signaling for Integrins
  • p130Cas linkage to MAPK signaling for integrins
  • NCAM signaling for neurite out-growth
  • NCAM signaling for neurite out-growth
  • Signal regulatory protein family interactions
  • EPHB-mediated forward signaling
  • EPHB-mediated forward signaling
  • DCC mediated attractive signaling
  • DCC mediated attractive signaling
  • VEGFA-VEGFR2 Pathway
  • VEGFA-VEGFR2 Pathway
  • RHO GTPases Activate WASPs and WAVEs
  • RAF/MAP kinase cascade
  • MET activates PTK2 signaling
  • Extra-nuclear estrogen signaling
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
  • FCGR3A-mediated phagocytosis
  • Endostatin
  • 7-PYRIDIN-2-YL-N-(3,4,5-TRIMETHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE
  • 2-({5-CHLORO-2-[(2-METHOXY-4-MORPHOLIN-4-YLPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)-N-METHYLBENZAMIDE
  • Fostamatinib
PTPRF protein tyrosine phosphatase receptor type F
  • Receptor-type tyrosine-protein phosphatases
  • Synaptic adhesion-like molecules
RAC1 Rac family small GTPase 1
  • GPVI-mediated activation cascade
  • PIP3 activates AKT signaling
  • Signaling by SCF-KIT
  • Translocation of SLC2A4 (GLUT4) to the plasma membrane
  • Nef and signal transduction
  • NRAGE signals death through JNK
  • Rho GTPase cycle
  • Regulation of actin dynamics for phagocytic cup formation
  • Regulation of actin dynamics for phagocytic cup formation
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • DAP12 signaling
  • FCERI mediated MAPK activation
  • DSCAM interactions
  • CD28 dependent Vav1 pathway
  • EPHB-mediated forward signaling
  • Ephrin signaling
  • EPH-ephrin mediated repulsion of cells
  • Sema3A PAK dependent Axon repulsion
  • SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
  • PCP/CE pathway
  • Sema4D mediated inhibition of cell attachment and migration
  • DCC mediated attractive signaling
  • DCC mediated attractive signaling
  • Activation of RAC1
  • Inactivation of CDC42 and RAC1
  • VEGFA-VEGFR2 Pathway
  • Signal transduction by L1
  • VEGFR2 mediated vascular permeability
  • RHO GTPases activate PKNs
  • RHO GTPases activate CIT
  • RHO GTPases activate CIT
  • RHO GTPases activate KTN1
  • RHO GTPases activate IQGAPs
  • RHO GTPases activate PAKs
  • RHO GTPases Activate WASPs and WAVEs
  • RHO GTPases Activate WASPs and WAVEs
  • RHO GTPases Activate Formins
  • RHO GTPases Activate Formins
  • RHO GTPases Activate NADPH Oxidases
  • MAPK6/MAPK4 signaling
  • Neutrophil degranulation
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
  • MET activates RAP1 and RAC1
  • NTRK2 activates RAC1
  • Activated NTRK2 signals through CDK5
  • Activation of RAC1 downstream of NMDARs
  • FCGR3A-mediated phagocytosis
  • FCGR3A-mediated phagocytosis
  • WNT5:FZD7-mediated leishmania damping
  • Factors involved in megakaryocyte development and platelet production
  • Dextromethorphan
  • Azathioprine
  • Guanosine-5'-Diphosphate
RHOA ras homolog family member A
  • GPVI-mediated activation cascade
  • Axonal growth inhibition (RHOA activation)
  • Rho GTPase cycle
  • PI3K/AKT activation
  • Axonal growth stimulation
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
  • G beta:gamma signalling through PI3Kgamma
  • EPHB-mediated forward signaling
  • EPHB-mediated forward signaling
  • EPHA-mediated growth cone collapse
  • EPHA-mediated growth cone collapse
  • PCP/CE pathway
  • G alpha (12/13) signalling events
  • Sema4D mediated inhibition of cell attachment and migration
  • Sema4D induced cell migration and growth-cone collapse
  • Sema4D induced cell migration and growth-cone collapse
  • VEGFA-VEGFR2 Pathway
  • RHO GTPases activate PKNs
  • RHO GTPases activate CIT
  • RHO GTPases activate CIT
  • RHO GTPases activate KTN1
  • RHO GTPases Activate ROCKs
  • RHO GTPases Activate ROCKs
  • RHO GTPases Activate Formins
  • RHO GTPases Activate Rhotekin and Rhophilins
  • RHO GTPases Activate Rhotekin and Rhophilins
  • Ovarian tumor domain proteases
  • ERBB2 Regulates Cell Motility
  • Neutrophil degranulation
  • PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
  • SLIT2:ROBO1 increases RHOA activity
  • Guanosine-5'-Diphosphate

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