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KDM6A - Wiki-MPM

Search Results for: KDM6A

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel AKAP4 A-kinase anchoring protein 4
Novel BMP15 bone morphogenetic protein 15
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
  • Premature ovarian failure
  • 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
Novel ELK1 ETS transcription factor ELK1
  • ERK/MAPK targets
  • NGF-stimulated transcription
  • HCMV Early Events
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Novel HSD17B10 hydroxysteroid 17-beta dehydrogenase 10
  • tRNA processing in the mitochondrion
  • tRNA modification in the mitochondrion
  • Branched-chain amino acid catabolism
  • rRNA processing in the mitochondrion
  • NADH
  • 1-Azepan-1-Yl-2-Phenyl-2-(4-Thioxo-1,4-Dihydro-Pyrazolo[3,4-D]Pyrimidin-5-Yl)Ethanone Adduct
  • Omega-3-carboxylic acids
  • 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency; HSD10 deficiency
  • Non-syndromic X-linked mental retardation
  • Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
Novel MAGED2 MAGE family member D2
  • Platelet degranulation
Novel RBM3 RNA binding motif protein 3
Novel ZNF157 zinc finger protein 157
  • Generic Transcription Pathway
GSC2 goosecoid homeobox 2
H3-4 H3.4 histone
  • Recognition and association of DNA glycosylase with site containing an affected pyrimidine
  • Cleavage of the damaged pyrimidine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Recognition and association of DNA glycosylase with site containing an affected purine
  • Cleavage of the damaged purine
  • Cleavage of the damaged purine
  • Meiotic synapsis
  • Packaging Of Telomere Ends
  • Formation of the beta-catenin:TCF transactivating complex
  • Formation of the beta-catenin:TCF transactivating complex
  • Condensation of Prophase Chromosomes
  • DNA Damage/Telomere Stress Induced Senescence
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Nonhomologous End-Joining (NHEJ)
  • Processing of DNA double-strand break ends
  • G2/M DNA damage checkpoint
  • Meiotic recombination
  • Inhibition of DNA recombination at telomere
H3C1 H3 clustered histone 1
  • Interleukin-7 signaling
  • Interleukin-7 signaling
  • Pre-NOTCH Transcription and Translation
  • Formation of the beta-catenin:TCF transactivating complex
  • PRC2 methylates histones and DNA
  • Condensation of Prophase Chromosomes
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • HDACs deacetylate histones
  • PKMTs methylate histone lysines
  • HDMs demethylate histones
  • HATs acetylate histones
  • HATs acetylate histones
  • RMTs methylate histone arginines
  • Chromatin modifying enzymes
  • SIRT1 negatively regulates rRNA expression
  • ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
  • NoRC negatively regulates rRNA expression
  • NoRC negatively regulates rRNA expression
  • B-WICH complex positively regulates rRNA expression
  • DNA methylation
  • Transcriptional regulation by small RNAs
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  • RNA Polymerase I Promoter Opening
  • RNA Polymerase I Promoter Escape
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Estrogen-dependent gene expression
  • Meiotic recombination
  • HCMV Early Events
  • HCMV Late Events
  • Transcriptional regulation of granulopoiesis
  • Amyloid fiber formation
  • Factors involved in megakaryocyte development and platelet production
H3C14 H3 clustered histone 14
  • Interleukin-7 signaling
  • Interleukin-7 signaling
  • Pre-NOTCH Transcription and Translation
  • Formation of the beta-catenin:TCF transactivating complex
  • PRC2 methylates histones and DNA
  • Condensation of Prophase Chromosomes
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • HDACs deacetylate histones
  • PKMTs methylate histone lysines
  • HDMs demethylate histones
  • HATs acetylate histones
  • HATs acetylate histones
  • RMTs methylate histone arginines
  • Chromatin modifying enzymes
  • SIRT1 negatively regulates rRNA expression
  • ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
  • NoRC negatively regulates rRNA expression
  • NoRC negatively regulates rRNA expression
  • B-WICH complex positively regulates rRNA expression
  • DNA methylation
  • Transcriptional regulation by small RNAs
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  • RNA Polymerase I Promoter Opening
  • RNA Polymerase I Promoter Escape
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Estrogen-dependent gene expression
  • Meiotic recombination
  • HCMV Early Events
  • HCMV Late Events
  • Transcriptional regulation of granulopoiesis
  • Amyloid fiber formation
  • Factors involved in megakaryocyte development and platelet production
MEOX2 mesenchyme homeobox 2
MTDH metadherin
NKX2-5 NK2 homeobox 5
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression
  • Physiological factors
  • Atrial septal defect
  • Tetralogy of Fallot
  • Congenital nongoitrous hypothyroidism (CHNG)
SMAD9 SMAD family member 9
  • Signaling by BMP
SRF serum response factor
  • RHO GTPases Activate Formins
  • NGF-stimulated transcription
  • NGF-stimulated transcription
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
TBX5 T-box transcription factor 5
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression
  • Physiological factors
  • Holt-Oram syndrome
TLE1 TLE family member 1, transcriptional corepressor
  • Formation of the beta-catenin:TCF transactivating complex
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Deactivation of the beta-catenin transactivating complex
  • Repression of WNT target genes
  • Repression of WNT target genes

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