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KEAP1 - Wiki-MPM

Search Results for: KEAP1

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
  • Ethanol oxidation
  • NADH
  • Lauric acid
  • 12-Hydroxydodecanoic Acid
  • S-Hydroxymethyl Glutathione
Novel ARPC1B actin related protein 2/3 complex subunit 1B
  • Regulation of actin dynamics for phagocytic cup formation
  • Regulation of actin dynamics for phagocytic cup formation
  • EPHB-mediated forward signaling
  • RHO GTPases Activate WASPs and WAVEs
  • RHO GTPases Activate WASPs and WAVEs
  • FCGR3A-mediated phagocytosis
  • FCGR3A-mediated phagocytosis
  • N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide
  • (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Novel BNIP3L BCL2 interacting protein 3 like
  • TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
Novel CARM1 coactivator associated arginine methyltransferase 1
  • RORA activates gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • PPARA activates gene expression
  • Transcriptional activation of mitochondrial biogenesis
  • Activation of gene expression by SREBF (SREBP)
  • RMTs methylate histone arginines
  • Transcriptional regulation of white adipocyte differentiation
  • Regulation of lipid metabolism by PPARalpha
  • Circadian Clock
  • TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
  • Estrogen-dependent gene expression
Novel ERBIN erbb2 interacting protein
  • Signaling by ERBB2
  • Downregulation of ERBB2 signaling
  • Constitutive Signaling by Overexpressed ERBB2
  • Drug-mediated inhibition of ERBB2 signaling
  • Signaling by ERBB2 KD Mutants
  • Resistance of ERBB2 KD mutants to trastuzumab
  • Resistance of ERBB2 KD mutants to sapitinib
  • Resistance of ERBB2 KD mutants to tesevatinib
  • Resistance of ERBB2 KD mutants to neratinib
  • Resistance of ERBB2 KD mutants to osimertinib
  • Resistance of ERBB2 KD mutants to afatinib
  • Resistance of ERBB2 KD mutants to AEE788
  • Resistance of ERBB2 KD mutants to lapatinib
  • Signaling by ERBB2 ECD mutants
  • Signaling by ERBB2 TMD/JMD mutants
  • Drug resistance in ERBB2 TMD/JMD mutants
Novel LONP1 lon peptidase 1, mitochondrial
Novel PANX1 pannexin 1
  • Electric Transmission Across Gap Junctions
  • The NLRP3 inflammasome
  • Probenecid
Novel RTN4R reticulon 4 receptor
  • Axonal growth inhibition (RHOA activation)
Novel S1PR2 sphingosine-1-phosphate receptor 2
  • G alpha (i) signalling events
  • Lysosphingolipid and LPA receptors
Novel SDC1 syndecan 1
  • A tetrasaccharide linker sequence is required for GAG synthesis
  • HS-GAG biosynthesis
  • HS-GAG biosynthesis
  • HS-GAG degradation
  • Cell surface interactions at the vascular wall
  • Syndecan interactions
  • Syndecan interactions
  • Defective B4GALT7 causes EDS, progeroid type
  • Defective B3GAT3 causes JDSSDHD
  • Defective EXT2 causes exostoses 2
  • Defective EXT1 causes exostoses 1, TRPS2 and CHDS
  • Defective B3GALT6 causes EDSP2 and SEMDJL1
  • Other interleukin signaling
  • Retinoid metabolism and transport
Novel SENP1 SUMO specific peptidase 1
  • SUMO is proteolytically processed
Novel SLC5A5 solute carrier family 5 member 5
  • Thyroxine biosynthesis
  • Organic anion transporters
  • Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1)
  • Iodine
  • Potassium perchlorate
  • Thyroid dyshormonogenesis; Dyshormogenetic goiter
Novel VAC14 VAC14 component of PIKFYVE complex
  • Synthesis of PIPs at the Golgi membrane
  • Synthesis of PIPs at the Golgi membrane
  • Synthesis of PIPs at the early endosome membrane
  • Synthesis of PIPs at the early endosome membrane
  • Synthesis of PIPs at the late endosome membrane
  • Synthesis of PIPs at the late endosome membrane
Novel ZNF177 zinc finger protein 177
Novel ZNF266 zinc finger protein 266
  • Generic Transcription Pathway
AK4 adenylate kinase 4
  • Interconversion of nucleotide di- and triphosphates
AMER1 APC membrane recruitment protein 1
  • Degradation of beta-catenin by the destruction complex
  • Beta-catenin phosphorylation cascade
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Signaling by GSK3beta mutants
  • S33 mutants of beta-catenin aren't phosphorylated
  • S37 mutants of beta-catenin aren't phosphorylated
  • S45 mutants of beta-catenin aren't phosphorylated
  • T41 mutants of beta-catenin aren't phosphorylated
  • APC truncation mutants have impaired AXIN binding
  • AXIN missense mutants destabilize the destruction complex
  • Truncations of AMER1 destabilize the destruction complex
  • Osteopathia striata with cranial sclerosis
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ATG5 autophagy related 5
  • Macroautophagy
  • Macroautophagy
  • PINK1-PRKN Mediated Mitophagy
  • Receptor Mediated Mitophagy
  • Negative regulators of DDX58/IFIH1 signaling
BAD BCL2 associated agonist of cell death
  • Activation of BAD and translocation to mitochondria
  • Activation of BAD and translocation to mitochondria
  • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
  • NRAGE signals death through JNK
  • AKT phosphorylates targets in the cytosol
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Navitoclax

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