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ASXL1 - Wiki-MPM

Search Results for: ASXL1

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel DEFB115 defensin beta 115
  • Beta defensins
  • Defensins
Novel DEFB116 defensin beta 116
  • Beta defensins
  • Defensins
Novel FASN fatty acid synthase
  • ChREBP activates metabolic gene expression
  • Vitamin B5 (pantothenate) metabolism
  • Activation of gene expression by SREBF (SREBP)
  • Fatty acyl-CoA biosynthesis
  • Fatty acyl-CoA biosynthesis
  • NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
  • Cerulenin
  • Orlistat
Novel ID1 inhibitor of DNA binding 1, HLH protein
  • Oncogene Induced Senescence
  • NGF-stimulated transcription
Novel IRAG1 inositol 1,4,5-triphosphate receptor associated 1
  • cGMP effects
Novel MRPS7 mitochondrial ribosomal protein S7
  • Mitochondrial translation initiation
  • Mitochondrial translation elongation
  • Mitochondrial translation elongation
  • Mitochondrial translation termination
Novel NCOA6 nuclear receptor coactivator 6
  • RORA activates gene expression
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • PPARA activates gene expression
  • PPARA activates gene expression
  • Transcriptional activation of mitochondrial biogenesis
  • Activation of gene expression by SREBF (SREBP)
  • Transcriptional regulation of white adipocyte differentiation
  • Regulation of lipid metabolism by PPARalpha
  • Circadian Clock
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
Novel POLD1 DNA polymerase delta 1, catalytic subunit
  • Recognition of DNA damage by PCNA-containing replication complex
  • Polymerase switching on the C-strand of the telomere
  • Processive synthesis on the C-strand of the telomere
  • Telomere C-strand (Lagging Strand) Synthesis
  • Removal of the Flap Intermediate from the C-strand
  • Cytosolic iron-sulfur cluster assembly
  • Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
  • Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
  • PCNA-Dependent Long Patch Base Excision Repair
  • Termination of translesion DNA synthesis
  • HDR through Homologous Recombination (HRR)
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • Polymerase switching
  • Removal of the Flap Intermediate
  • Processive synthesis on the lagging strand
Novel SRM spermidine synthase
  • Metabolism of polyamines
APP amyloid beta precursor protein
  • Platelet degranulation
  • ECM proteoglycans
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • G alpha (q) signalling events
  • G alpha (i) signalling events
  • Lysosome Vesicle Biogenesis
  • Formyl peptide receptors bind formyl peptides and many other ligands
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex
  • The NLRP3 inflammasome
  • Advanced glycosylation endproduct receptor signaling
  • Advanced glycosylation endproduct receptor signaling
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Post-translational protein phosphorylation
  • TRAF6 mediated NF-kB activation
  • Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
  • Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
  • Purinergic signaling in leishmaniasis infection
  • Amyloid fiber formation
  • Deferoxamine
  • Aluminium
  • Zinc
  • L-methionine (R)-S-oxide
  • Resveratrol
  • Tromethamine
  • Phenserine
  • Tetrathiomolybdate
  • CAD106
  • Mito-4509
  • Edonerpic
  • Dimercaprol
  • Copper
  • Florbetaben (18F)
  • Florbetapir (18F)
  • Flutemetamol (18F)
  • Zinc acetate
  • Aluminium phosphate
  • Aluminum acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
  • Alzheimer's disease (AD)
GOLGA6L9 golgin A6 family like 9
H1-2 H1.2 linker histone, cluster member
  • Apoptosis induced DNA fragmentation
  • Formation of Senescence-Associated Heterochromatin Foci (SAHF)
SRPK1 SRSF protein kinase 1
STAT3 signal transducer and activator of transcription 3
  • Interleukin-6 signaling
  • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
  • Interleukin-7 signaling
  • Interleukin-7 signaling
  • Signaling by SCF-KIT
  • Signaling by cytosolic FGFR1 fusion mutants
  • Downstream signal transduction
  • Signalling to STAT3
  • Senescence-Associated Secretory Phenotype (SASP)
  • Signaling by Leptin
  • POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
  • Association of TriC/CCT with target proteins during biosynthesis
  • Transcriptional regulation of pluripotent stem cells
  • Interleukin-10 signaling
  • Interleukin-4 and Interleukin-13 signaling
  • PTK6 Activates STAT3
  • PTK6 Activates STAT3
  • Interleukin-20 family signaling
  • MET activates STAT3
  • MET activates STAT3
  • Interleukin-15 signaling
  • Interleukin-35 Signalling
  • Interleukin-9 signaling
  • Interleukin-37 signaling
  • Interleukin-23 signaling
  • Interleukin-23 signaling
  • Interleukin-27 signaling
  • Interleukin-21 signaling
  • Transcriptional regulation of granulopoiesis
  • Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
  • Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
  • Signaling by PDGFRA extracellular domain mutants
  • Growth hormone receptor signaling
  • ENMD-1198
  • Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
  • Oral cancer
UBC ubiquitin C
  • Translesion synthesis by REV1
  • Recognition of DNA damage by PCNA-containing replication complex
  • Translesion Synthesis by POLH
  • Activation of NF-kappaB in B cells
  • ISG15 antiviral mechanism
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
  • ER-Phagosome pathway
  • Downregulation of ERBB4 signaling
  • Spry regulation of FGF signaling
  • Downregulation of ERBB2:ERBB3 signaling
  • Budding and maturation of HIV virion
  • NOD1/2 Signaling Pathway
  • TICAM1, RIP1-mediated IKK complex recruitment
  • DDX58/IFIH1-mediated induction of interferon-alpha/beta
  • APC/C:Cdc20 mediated degradation of Cyclin B
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • SCF-beta-TrCP mediated degradation of Emi1
  • APC/C:Cdc20 mediated degradation of Securin
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • Membrane binding and targetting of GAG proteins
  • Assembly Of The HIV Virion
  • APC-Cdc20 mediated degradation of Nek2A
  • Vpu mediated degradation of CD4
  • Vif-mediated degradation of APOBEC3G
  • EGFR downregulation
  • SCF(Skp2)-mediated degradation of p27/p21
  • Degradation of beta-catenin by the destruction complex
  • TCF dependent signaling in response to WNT
  • Downstream TCR signaling
  • NRIF signals cell death from the nucleus
  • p75NTR recruits signalling complexes
  • NF-kB is activated and signals survival
  • Regulation of activated PAK-2p34 by proteasome mediated degradation
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Activated NOTCH1 Transmits Signal to the Nucleus
  • Activated NOTCH1 Transmits Signal to the Nucleus
  • Downregulation of TGF-beta receptor signaling
  • Downregulation of TGF-beta receptor signaling
  • TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • Separation of Sister Chromatids
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • Oncogene Induced Senescence
  • Regulation of PLK1 Activity at G2/M Transition
  • Constitutive Signaling by NOTCH1 PEST Domain Mutants
  • Stimuli-sensing channels
  • Constitutive Signaling by NOTCH1 HD Domain Mutants
  • FCERI mediated NF-kB activation
  • Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
  • NOTCH2 Activation and Transmission of Signal to the Nucleus
  • Regulation of innate immune responses to cytosolic DNA
  • Glycogen synthesis
  • Autodegradation of the E3 ubiquitin ligase COP1
  • Deactivation of the beta-catenin transactivating complex
  • Myoclonic epilepsy of Lafora
  • ABC-family proteins mediated transport
  • Circadian Clock
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex
  • activated TAK1 mediates p38 MAPK activation
  • JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
  • AUF1 (hnRNP D0) binds and destabilizes mRNA
  • Asymmetric localization of PCP proteins
  • Degradation of AXIN
  • Degradation of DVL
  • Regulation of FZD by ubiquitination
  • PINK1-PRKN Mediated Mitophagy
  • N-glycan trimming in the ER and Calnexin/Calreticulin cycle
  • Regulation of TNFR1 signaling
  • TNFR1-induced NFkappaB signaling pathway
  • Hedgehog ligand biogenesis
  • Hh mutants are degraded by ERAD
  • Dectin-1 mediated noncanonical NF-kB signaling
  • CLEC7A (Dectin-1) signaling
  • Degradation of GLI1 by the proteasome
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • Hedgehog 'on' state
  • Hedgehog 'on' state
  • Negative regulation of FGFR1 signaling
  • Negative regulation of FGFR2 signaling
  • Negative regulation of FGFR3 signaling
  • Negative regulation of FGFR4 signaling
  • Translesion synthesis by POLK
  • Translesion synthesis by POLI
  • Termination of translesion DNA synthesis
  • Regulation of RAS by GAPs
  • TNFR2 non-canonical NF-kB pathway
  • Negative regulation of MAPK pathway
  • Regulation of necroptotic cell death
  • NIK-->noncanonical NF-kB signaling
  • Defective CFTR causes cystic fibrosis
  • MAP3K8 (TPL2)-dependent MAPK1/3 activation
  • HDR through Homologous Recombination (HRR)
  • MAPK6/MAPK4 signaling
  • UCH proteinases
  • UCH proteinases
  • Josephin domain DUBs
  • Ub-specific processing proteases
  • Ovarian tumor domain proteases
  • Metalloprotease DUBs
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Processing of DNA double-strand break ends
  • DNA Damage Recognition in GG-NER
  • Formation of Incision Complex in GG-NER
  • Gap-filling DNA repair synthesis and ligation in GG-NER
  • Dual Incision in GG-NER
  • Formation of TC-NER Pre-Incision Complex
  • Transcription-Coupled Nucleotide Excision Repair (TC-NER)
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • Fanconi Anemia Pathway
  • Regulation of TP53 Activity through Phosphorylation
  • Regulation of TP53 Degradation
  • Regulation of TP53 Activity through Methylation
  • Negative regulation of MET activity
  • CDT1 association with the CDC6:ORC:origin complex
  • Orc1 removal from chromatin
  • CDK-mediated phosphorylation and removal of Cdc6
  • Cyclin D associated events in G1
  • G2/M Checkpoints
  • Stabilization of p53
  • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
  • Ubiquitin-dependent degradation of Cyclin D
  • PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • Downregulation of ERBB2 signaling
  • Synthesis of active ubiquitin: roles of E1 and E2 enzymes
  • Synthesis of active ubiquitin: roles of E1 and E2 enzymes
  • E3 ubiquitin ligases ubiquitinate target proteins
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • InlA-mediated entry of Listeria monocytogenes into host cells
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX3 expression and activity
  • Regulation of PTEN localization
  • Regulation of PTEN stability and activity
  • Neddylation
  • ER Quality Control Compartment (ERQC)
  • Regulation of expression of SLITs and ROBOs
  • Regulation of expression of SLITs and ROBOs
  • NOTCH3 Activation and Transmission of Signal to the Nucleus
  • NOTCH3 Activation and Transmission of Signal to the Nucleus
  • TICAM1-dependent activation of IRF3/IRF7
  • TICAM1,TRAF6-dependent induction of TAK1 complex
  • Interleukin-1 signaling
  • Peroxisomal protein import
  • Peroxisomal protein import
  • Regulation of signaling by CBL
  • Endosomal Sorting Complex Required For Transport (ESCRT)
  • Iron uptake and transport
  • Negative regulators of DDX58/IFIH1 signaling
  • Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
  • IRAK1 recruits IKK complex
  • IKK complex recruitment mediated by RIP1
  • IRAK2 mediated activation of TAK1 complex
  • TRAF6-mediated induction of TAK1 complex within TLR4 complex
  • Negative regulation of NOTCH4 signaling
  • Chaperone Mediated Autophagy
  • Late endosomal microautophagy
  • Prevention of phagosomal-lysosomal fusion
  • Modulation by Mtb of host immune system
  • Alpha-protein kinase 1 signaling pathway
  • Aggrephagy
  • Aggrephagy
  • RAS processing
  • Pexophagy
  • Maturation of protein E
  • Maturation of protein E
  • Negative regulation of FLT3
  • FLT3 signaling by CBL mutants
  • TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
  • IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
  • IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
  • Amyloid fiber formation
  • Antigen processing: Ubiquitination & Proteasome degradation
  • N-Formylmethionine

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