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RHEB - Wiki-MPM

Search Results for: RHEB

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel CENPE centromere protein E
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • MHC class II antigen presentation
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • RHO GTPases Activate Formins
  • COPI-dependent Golgi-to-ER retrograde traffic
  • Mitotic Prometaphase
  • EML4 and NUDC in mitotic spindle formation
  • Kinesins
  • GSK-923295
Novel MAPK15 mitogen-activated protein kinase 15
  • Acetylsalicylic acid
  • Minocycline
  • Fostamatinib
Novel NOS3 nitric oxide synthase 3
  • ROS and RNS production in phagocytes
  • Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
  • eNOS activation
  • NOSTRIN mediated eNOS trafficking
  • NOSIP mediated eNOS trafficking
  • Nitric oxide stimulates guanylate cyclase
  • VEGFR2 mediated vascular permeability
  • Extra-nuclear estrogen signaling
  • Arginine
  • Citrulline
  • Sapropterin
  • Miconazole
  • N,N-dimethylarginine
  • L-N(omega)-Nitroarginine-2,4-L-diaminobutyric amide
  • Canavanine
  • 3-Bromo-7-Nitroindazole
  • N-{(4S)-4-Amino-5-[(2-aminoethyl)amino]pentyl}-N'-nitroguanidine
  • N-[3-(aminomethyl)benzyl]acetamidine
  • 1,2,4-Triazole-Carboxamidine
  • L-N(omega)-nitroarginine-(4R)-amino-L-proline amide
  • S,S'-(1,4-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
  • 7-Nitroindazole
  • S-Ethylisothiourea
  • 2-Aminothiazoline
  • Se-Ethyl-Isoselenourea
  • 2,4-Diamino-6-Phenyl-5,6,7,8,-Tetrahydropteridine
  • N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane
  • Cacodylic acid
  • 7-Nitroindazole-2-Carboxamidine
  • 6-Nitroindazole
  • N(5)-[(hydroxyamino)(imino)methyl]-L-ornithine
  • N(G)-Iminoethylornithine
  • 5,6-Cyclic-Tetrahydropteridine
  • S-Ethyl-N-Phenyl-Isothiourea
  • S,S'-(1,3-Phenylene-Bis(1,2-Ethanediyl))Bis-Isothiourea
  • 6S-5,6,7,8-Tetrahydrobiopterin
  • S-(Dimethylarsenic)Cysteine
  • L-homoarginine
  • S-Isopropyl-Isothiourea
  • Nitroarginine
  • 5-Nitroindazole
  • N-(Chlorophenyl)-N'-hydroxyguanidine
  • (3S,5E)-3-propyl-3,4-dihydrothieno[2,3-f][1,4]oxazepin-5(2H)-imine
  • 5-{4-[(3,5-DIFLUOROBENZYL)AMINO]PHENYL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE
  • ETHYL 4-[(4-METHYLPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE
  • N-{(3S,4S)-4-[(6-AMINO-4-METHYLPYRIDIN-2-YL)METHYL]PYRROLIDIN-3-YL}-N'-(4-CHLOROBENZYL)ETHANE-1,2-DIAMINE
  • N-{(3R,4S)-4-[(6-amino-4-methylpyridin-2-yl)methyl]pyrrolidin-3-yl}-N'-(3-chlorobenzyl)ethane-1,2-diamine
  • Levamlodipine
Novel PIGB phosphatidylinositol glycan anchor biosynthesis class B
  • Synthesis of glycosylphosphatidylinositol (GPI)
Novel PPP1R3C protein phosphatase 1 regulatory subunit 3C
  • Glycogen synthesis
  • Myoclonic epilepsy of Lafora
Novel PTPRN2 protein tyrosine phosphatase receptor type N2
  • Neutrophil degranulation
A2M alpha-2-macroglobulin
  • Platelet degranulation
  • Intrinsic Pathway of Fibrin Clot Formation
  • Degradation of the extracellular matrix
  • Rho GTPase cycle
  • HDL assembly
  • Becaplermin
  • Cisplatin
  • Bacitracin
  • Zinc
  • Ocriplasmin
  • Silver
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
APOE apolipoprotein E
  • Nuclear signaling by ERBB4
  • Scavenging by Class A Receptors
  • Scavenging by Class A Receptors
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
  • Post-translational protein phosphorylation
  • Chylomicron assembly
  • Chylomicron remodeling
  • Chylomicron clearance
  • Chylomicron clearance
  • HDL remodeling
  • NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
  • Retinoid metabolism and transport
  • Retinoid metabolism and transport
  • Zinc
  • Copper
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
  • Lipoprotein glomerulopathy
  • Hyperlipoproteinemia, type III; Dysbetalipoproteinemia
  • Alzheimer's disease (AD)
APPBP2 amyloid beta precursor protein binding protein 2
ARIH2 ariadne RBR E3 ubiquitin protein ligase 2
  • Antigen processing: Ubiquitination & Proteasome degradation
ATM ATM serine/threonine kinase
  • DNA Damage/Telomere Stress Induced Senescence
  • Regulation of HSF1-mediated heat shock response
  • Autodegradation of the E3 ubiquitin ligase COP1
  • HDR through Single Strand Annealing (SSA)
  • HDR through Homologous Recombination (HRR)
  • Sensing of DNA Double Strand Breaks
  • Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Resolution of D-loop Structures through Holliday Junction Intermediates
  • Nonhomologous End-Joining (NHEJ)
  • Homologous DNA Pairing and Strand Exchange
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • TP53 Regulates Transcription of DNA Repair Genes
  • TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
  • TP53 Regulates Transcription of Caspase Activators and Caspases
  • Regulation of TP53 Activity through Phosphorylation
  • Regulation of TP53 Degradation
  • Regulation of TP53 Activity through Methylation
  • G2/M DNA damage checkpoint
  • Stabilization of p53
  • Meiotic recombination
  • Pexophagy
  • Caffeine
  • Ataxia telangiectasia (AT); Louis-Bar syndrome; Boder-Sedgwick syndrome
  • DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
  • Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)
  • Chronic lymphocytic leukemia (CLL)
ATR ATR serine/threonine kinase
  • Meiotic synapsis
  • Activation of ATR in response to replication stress
  • Regulation of HSF1-mediated heat shock response
  • HDR through Single Strand Annealing (SSA)
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Fanconi Anemia Pathway
  • TP53 Regulates Transcription of DNA Repair Genes
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Alveolar rhabdomyosarcoma
  • Seckel syndrome
BNIP3 BCL2 interacting protein 3
BNIP3L BCL2 interacting protein 3 like
  • TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
BRAF B-Raf proto-oncogene, serine/threonine kinase
  • Spry regulation of FGF signaling
  • Frs2-mediated activation
  • Frs2-mediated activation
  • ARMS-mediated activation
  • Signalling to p38 via RIT and RIN
  • RAF activation
  • MAP2K and MAPK activation
  • Negative feedback regulation of MAPK pathway
  • Negative regulation of MAPK pathway
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by high-kinase activity BRAF mutants
  • Signaling by BRAF and RAF fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • Signaling downstream of RAS mutants
  • Signaling by RAF1 mutants
  • Signaling by MRAS-complex mutants
  • Sorafenib
  • XL281
  • RAF-265
  • PLX-4720
  • N-{2,4-difluoro-3-[(5-pyridin-3-yl-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]phenyl}ethanesulfonamide
  • (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime
  • Vemurafenib
  • Regorafenib
  • Dabrafenib
  • Encorafenib
  • Fostamatinib
  • Ripretinib
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
  • Thyroid cancer
  • Malignant melanoma
CREB3 cAMP responsive element binding protein 3
  • CREB3 factors activate genes
  • CREB3 factors activate genes
ECSIT ECSIT signaling integrator
  • MyD88:MAL(TIRAP) cascade initiated on plasma membrane
  • Complex I biogenesis
  • TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
  • MyD88 cascade initiated on plasma membrane
FKBP8 FKBP prolyl isomerase 8
  • Ub-specific processing proteases
HTT huntingtin
  • Regulation of MECP2 expression and activity
  • Copper
  • Huntington's disease (HD)
MTOR mechanistic target of rapamycin kinase
  • PIP3 activates AKT signaling
  • Macroautophagy
  • MTOR signalling
  • mTORC1-mediated signalling
  • HSF1-dependent transactivation
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • CD28 dependent PI3K/Akt signaling
  • VEGFR2 mediated vascular permeability
  • TP53 Regulates Metabolic Genes
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Regulation of TP53 Degradation
  • Regulation of PTEN gene transcription
  • Amino acids regulate mTORC1
  • Pimecrolimus
  • Sirolimus
  • Everolimus
  • Rimiducid
  • SF1126
  • XL765
  • Ridaforolimus
  • Temsirolimus
  • Fostamatinib

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