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TP53 - Wiki-MPM

Search Results for: TP53

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel CARD14 caspase recruitment domain family member 14
Novel CFHR3 complement factor H related 3
  • Regulation of Complement cascade
Novel MMP10 matrix metallopeptidase 10
  • Collagen degradation
  • Collagen degradation
  • Degradation of the extracellular matrix
  • Degradation of the extracellular matrix
  • Activation of Matrix Metalloproteinases
  • Marimastat
  • N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID
Novel POLR2A RNA polymerase II subunit A
  • Formation of RNA Pol II elongation complex
  • Formation of the Early Elongation Complex
  • Formation of HIV elongation complex in the absence of HIV Tat
  • Formation of the HIV-1 Early Elongation Complex
  • RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
  • HIV Transcription Initiation
  • RNA Polymerase II HIV Promoter Escape
  • Transcription of the HIV genome
  • Formation of HIV-1 elongation complex containing HIV-1 Tat
  • Formation of HIV-1 elongation complex containing HIV-1 Tat
  • Pausing and recovery of Tat-mediated HIV elongation
  • Abortive elongation of HIV-1 transcript in the absence of Tat
  • Tat-mediated HIV elongation arrest and recovery
  • Tat-mediated elongation of the HIV-1 transcript
  • HIV elongation arrest and recovery
  • Pausing and recovery of HIV elongation
  • Viral Messenger RNA Synthesis
  • MicroRNA (miRNA) biogenesis
  • Transcriptional regulation by small RNAs
  • PIWI-interacting RNA (piRNA) biogenesis
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • RNA Polymerase II Pre-transcription Events
  • Formation of TC-NER Pre-Incision Complex
  • Transcription-Coupled Nucleotide Excision Repair (TC-NER)
  • Dual incision in TC-NER
  • Gap-filling DNA repair synthesis and ligation in TC-NER
  • TP53 Regulates Transcription of DNA Repair Genes
  • FGFR2 alternative splicing
  • RNA polymerase II transcribes snRNA genes
  • RNA polymerase II transcribes snRNA genes
  • mRNA Capping
  • mRNA Splicing - Major Pathway
  • mRNA Splicing - Minor Pathway
  • Processing of Capped Intron-Containing Pre-mRNA
  • RNA Polymerase II Promoter Escape
  • RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
  • RNA Polymerase II Transcription Initiation
  • RNA Polymerase II Transcription Elongation
  • RNA Polymerase II Transcription Initiation And Promoter Clearance
  • RNA Pol II CTD phosphorylation and interaction with CE
  • Signaling by FGFR2 IIIa TM
  • Estrogen-dependent gene expression
  • Inhibition of DNA recombination at telomere
Novel RCVRN recoverin
  • Inactivation, recovery and regulation of the phototransduction cascade
  • Inactivation, recovery and regulation of the phototransduction cascade
  • Myristic acid
Novel ZNF367 zinc finger protein 367
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
  • Regulation of actin dynamics for phagocytic cup formation
  • Role of ABL in ROBO-SLIT signaling
  • Role of ABL in ROBO-SLIT signaling
  • Myogenesis
  • Myogenesis
  • RHO GTPases Activate WASPs and WAVEs
  • HDR through Single Strand Annealing (SSA)
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  • Cyclin D associated events in G1
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • RUNX2 regulates osteoblast differentiation
  • FCGR3A-mediated phagocytosis
  • Factors involved in megakaryocyte development and platelet production
  • ATP
  • Imatinib
  • Dasatinib
  • N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
  • Nilotinib
  • XL228
  • Bosutinib
  • 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
  • 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
  • Myristic acid
  • PD-166326
  • 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
  • 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
  • Regorafenib
  • Ponatinib
  • Fostamatinib
  • Brigatinib
  • Radotinib
  • Chronic myeloid leukemia (CML)
  • Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
ACKR3 atypical chemokine receptor 3
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events
ACTA1 actin alpha 1, skeletal muscle
  • Striated Muscle Contraction
  • Latrunculin A
  • Sucrose
  • Ulapualide A
  • Kabiramide C
  • Jaspisamide A
  • Tmr
  • 1-Methylhistidine
  • Phosphoaminophosphonic Acid-Adenylate Ester
  • Aplyronine A
  • Reidispongiolide A
  • Reidispongiolide C
  • Sphinxolide B
  • Latrunculin B
  • Congenital fiber type disproportion (CFTD)
  • Cap myopathy
  • Nemaline myopathy
AGT angiotensinogen
  • PPARA activates gene expression
  • Metabolism of Angiotensinogen to Angiotensins
  • Metabolism of Angiotensinogen to Angiotensins
  • Peptide ligand-binding receptors
  • G alpha (q) signalling events
  • G alpha (i) signalling events
  • Zinc
  • Copper
  • Sparsentan
  • Zinc acetate
  • Renal tubular dysgenesis
AKAP5 A-kinase anchoring protein 5
  • Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
  • Trafficking of AMPA receptors
  • ROBO receptors bind AKAP5
  • ROBO receptors bind AKAP5
AKT1 AKT serine/threonine kinase 1
  • Activation of BAD and translocation to mitochondria
  • PIP3 activates AKT signaling
  • PIP3 activates AKT signaling
  • Downregulation of ERBB2:ERBB3 signaling
  • Translocation of SLC2A4 (GLUT4) to the plasma membrane
  • Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
  • MTOR signalling
  • AKT phosphorylates targets in the cytosol
  • AKT phosphorylates targets in the cytosol
  • AKT phosphorylates targets in the nucleus
  • Negative regulation of the PI3K/AKT network
  • eNOS activation
  • AKT-mediated inactivation of FOXO1A
  • Integrin signaling
  • Deactivation of the beta-catenin transactivating complex
  • CD28 dependent PI3K/Akt signaling
  • CTLA4 inhibitory signaling
  • G beta:gamma signalling through PI3Kgamma
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • VEGFR2 mediated vascular permeability
  • TP53 Regulates Metabolic Genes
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Interleukin-4 and Interleukin-13 signaling
  • Regulation of TP53 Degradation
  • Regulation of TP53 Activity through Acetylation
  • Regulation of TP53 Activity through Association with Co-factors
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • Cyclin E associated events during G1/S transition
  • Cyclin A:Cdk2-associated events at S phase entry
  • PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
  • RAB GEFs exchange GTP for GDP on RABs
  • RUNX2 regulates genes involved in cell migration
  • Regulation of PTEN stability and activity
  • Extra-nuclear estrogen signaling
  • Negative regulation of NOTCH4 signaling
  • FLT3 Signaling
  • Regulation of localization of FOXO transcription factors
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
  • ATP
  • Arsenic trioxide
  • Genistein
  • Inositol 1,3,4,5-Tetrakisphosphate
  • Resveratrol
  • Archexin
  • Enzastaurin
  • Perifosine
  • N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
  • PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
ANK2 ankyrin 2
  • Interaction between L1 and Ankyrins
  • Interaction between L1 and Ankyrins
  • COPI-mediated anterograde transport
  • Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
ANKRD2 ankyrin repeat domain 2
ANTKMT adenine nucleotide translocase lysine methyltransferase
ANXA2 annexin A2
  • Smooth Muscle Contraction
  • Neutrophil degranulation
  • Dissolution of Fibrin Clot
  • Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
  • Tenecteplase
  • Fluocinolone acetonide
  • Lanoteplase
  • Artenimol
ANXA3 annexin A3
  • Fluocinolone acetonide
  • Ethanolamine
  • Difluocortolone
APBB2 amyloid beta precursor protein binding family B member 2
APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1
  • Displacement of DNA glycosylase by APEX1
  • POLB-Dependent Long Patch Base Excision Repair
  • Resolution of AP sites via the multiple-nucleotide patch replacement pathway
  • PCNA-Dependent Long Patch Base Excision Repair
  • Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
  • Resolution of Abasic Sites (AP sites)
  • Lucanthone
APOH apolipoprotein H
  • Platelet degranulation
  • LJP 1082
  • Copper

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