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PRDM1 - Wiki-MPM

Search Results for: PRDM1

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel EXOSC3 exosome component 3
  • ATF4 activates genes in response to endoplasmic reticulum stress
  • mRNA decay by 3' to 5' exoribonuclease
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Major pathway of rRNA processing in the nucleolus and cytosol
Novel FRK fyn related Src family tyrosine kinase
  • Neutrophil degranulation
  • Regulation of PTEN stability and activity
  • Dasatinib
  • Regorafenib
  • Fostamatinib
  • Zanubrutinib
Novel HPGD 15-hydroxyprostaglandin dehydrogenase
  • Synthesis of Lipoxins (LX)
  • Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
  • Biosynthesis of D-series resolvins
  • Biosynthesis of E-series 18(S)-resolvins
  • NADH
  • Primary hypertrophic osteoarthropathy (PHO)
Novel MAD2L1BP MAD2L1 binding protein
Novel MAN1A1 mannosidase alpha class 1A member 1
  • Intra-Golgi traffic
  • Progressive trimming of alpha-1,2-linked mannose residues from Man9/8/7GlcNAc2 to produce Man5GlcNAc2
Novel UTP18 UTP18 small subunit processome component
  • rRNA modification in the nucleus and cytosol
  • Major pathway of rRNA processing in the nucleolus and cytosol
ATXN1 ataxin 1
  • Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
H1-1 H1.1 linker histone, cluster member
  • Apoptosis induced DNA fragmentation
  • Formation of Senescence-Associated Heterochromatin Foci (SAHF)
H3C15 H3 clustered histone 15
  • Interleukin-7 signaling
  • Interleukin-7 signaling
  • Pre-NOTCH Transcription and Translation
  • Formation of the beta-catenin:TCF transactivating complex
  • PRC2 methylates histones and DNA
  • Condensation of Prophase Chromosomes
  • Oxidative Stress Induced Senescence
  • Senescence-Associated Secretory Phenotype (SASP)
  • HDACs deacetylate histones
  • PKMTs methylate histone lysines
  • HDMs demethylate histones
  • HATs acetylate histones
  • HATs acetylate histones
  • RMTs methylate histone arginines
  • Chromatin modifying enzymes
  • SIRT1 negatively regulates rRNA expression
  • ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
  • NoRC negatively regulates rRNA expression
  • NoRC negatively regulates rRNA expression
  • B-WICH complex positively regulates rRNA expression
  • DNA methylation
  • Transcriptional regulation by small RNAs
  • Activation of anterior HOX genes in hindbrain development during early embryogenesis
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  • RNA Polymerase I Promoter Opening
  • RNA Polymerase I Promoter Escape
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Estrogen-dependent gene expression
  • Meiotic recombination
  • HCMV Early Events
  • HCMV Late Events
  • Transcriptional regulation of granulopoiesis
  • Amyloid fiber formation
  • Factors involved in megakaryocyte development and platelet production
IKZF3 IKAROS family zinc finger 3
IRF4 interferon regulatory factor 4
  • Interleukin-4 and Interleukin-13 signaling
  • Interferon gamma signaling
  • Interferon alpha/beta signaling
KDM1A lysine demethylase 1A
  • HDACs deacetylate histones
  • HDMs demethylate histones
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  • Regulation of PTEN gene transcription
  • Estrogen-dependent gene expression
  • NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
  • Potential therapeutics for SARS
  • Factors involved in megakaryocyte development and platelet production
PIAS1 protein inhibitor of activated STAT 1
  • SUMOylation of DNA damage response and repair proteins
  • SUMOylation of transcription factors
  • SUMOylation of ubiquitinylation proteins
  • SUMOylation of transcription cofactors
  • SUMOylation of intracellular receptors
  • SUMOylation of intracellular receptors
  • SUMOylation of chromatin organization proteins
  • Formation of Incision Complex in GG-NER
  • Regulation of IFNG signaling
TLE1 TLE family member 1, transcriptional corepressor
  • Formation of the beta-catenin:TCF transactivating complex
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Deactivation of the beta-catenin transactivating complex
  • Repression of WNT target genes
  • Repression of WNT target genes
TLE2 TLE family member 2, transcriptional corepressor
  • Formation of the beta-catenin:TCF transactivating complex
  • NOTCH1 Intracellular Domain Regulates Transcription
  • Deactivation of the beta-catenin transactivating complex
  • Repression of WNT target genes
  • Repression of WNT target genes
TLE5 TLE family member 5, transcriptional modulator
  • Repression of WNT target genes

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