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PIK3CA - Wiki-MPM

Search Results for: PIK3CA

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel ACOT8 acyl-CoA thioesterase 8
  • Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
  • alpha-linolenic acid (ALA) metabolism
  • Beta-oxidation of pristanoyl-CoA
  • Beta-oxidation of very long chain fatty acids
  • Peroxisomal protein import
  • Peroxisomal protein import
Novel ALCAM activated leukocyte cell adhesion molecule
  • L1CAM interactions
Novel CRIP1 cysteine rich protein 1
Novel LYPLA1 lysophospholipase 1
  • eNOS activation
  • RAS processing
Novel MAP3K9 mitogen-activated protein kinase kinase kinase 9
  • 12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one
  • Fostamatinib
Novel PRKCI protein kinase C iota
  • Pre-NOTCH Transcription and Translation
  • p75NTR recruits signalling complexes
  • Tight junction interactions
  • Tamoxifen
  • Bisindolylmaleimide I
  • Fostamatinib
Novel RHOC ras homolog family member C
  • Rho GTPase cycle
  • G alpha (12/13) signalling events
  • Sema4D induced cell migration and growth-cone collapse
  • Sema4D induced cell migration and growth-cone collapse
  • RHO GTPases activate PKNs
  • RHO GTPases activate CIT
  • RHO GTPases activate CIT
  • RHO GTPases Activate ROCKs
  • RHO GTPases Activate ROCKs
  • RHO GTPases Activate Formins
  • RHO GTPases Activate Rhotekin and Rhophilins
Novel TRA2B transformer 2 beta homolog
  • mRNA Splicing - Major Pathway
ADAP1 ArfGAP with dual PH domains 1
  • Nuclear signaling by ERBB4
AKT1 AKT serine/threonine kinase 1
  • Activation of BAD and translocation to mitochondria
  • PIP3 activates AKT signaling
  • PIP3 activates AKT signaling
  • Downregulation of ERBB2:ERBB3 signaling
  • Translocation of SLC2A4 (GLUT4) to the plasma membrane
  • Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
  • MTOR signalling
  • AKT phosphorylates targets in the cytosol
  • AKT phosphorylates targets in the cytosol
  • AKT phosphorylates targets in the nucleus
  • Negative regulation of the PI3K/AKT network
  • eNOS activation
  • AKT-mediated inactivation of FOXO1A
  • Integrin signaling
  • Deactivation of the beta-catenin transactivating complex
  • CD28 dependent PI3K/Akt signaling
  • CTLA4 inhibitory signaling
  • G beta:gamma signalling through PI3Kgamma
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • VEGFR2 mediated vascular permeability
  • TP53 Regulates Metabolic Genes
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Interleukin-4 and Interleukin-13 signaling
  • Regulation of TP53 Degradation
  • Regulation of TP53 Activity through Acetylation
  • Regulation of TP53 Activity through Association with Co-factors
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • Cyclin E associated events during G1/S transition
  • Cyclin A:Cdk2-associated events at S phase entry
  • PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
  • RAB GEFs exchange GTP for GDP on RABs
  • RUNX2 regulates genes involved in cell migration
  • Regulation of PTEN stability and activity
  • Extra-nuclear estrogen signaling
  • Negative regulation of NOTCH4 signaling
  • FLT3 Signaling
  • Regulation of localization of FOXO transcription factors
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
  • ATP
  • Arsenic trioxide
  • Genistein
  • Inositol 1,3,4,5-Tetrakisphosphate
  • Resveratrol
  • Archexin
  • Enzastaurin
  • Perifosine
  • N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
  • PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
AMBP alpha-1-microglobulin/bikunin precursor
  • Scavenging of heme from plasma
APLP2 amyloid beta precursor like protein 2
  • Platelet degranulation
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
  • Zinc
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
APPL1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  • Caspase activation via Dependence Receptors in the absence of ligand
ARAF A-Raf proto-oncogene, serine/threonine kinase
  • RAF activation
  • MAP2K and MAPK activation
  • Negative regulation of MAPK pathway
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by high-kinase activity BRAF mutants
  • Signaling by BRAF and RAF fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • Signaling downstream of RAS mutants
  • Signaling by RAF1 mutants
  • Signaling by MRAS-complex mutants
  • ATP
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
ATP5IF1 ATP synthase inhibitory factor subunit 1
ATR ATR serine/threonine kinase
  • Meiotic synapsis
  • Activation of ATR in response to replication stress
  • Regulation of HSF1-mediated heat shock response
  • HDR through Single Strand Annealing (SSA)
  • Processing of DNA double-strand break ends
  • Presynaptic phase of homologous DNA pairing and strand exchange
  • Fanconi Anemia Pathway
  • TP53 Regulates Transcription of DNA Repair Genes
  • Regulation of TP53 Activity through Phosphorylation
  • G2/M DNA damage checkpoint
  • Alveolar rhabdomyosarcoma
  • Seckel syndrome
BEX1 brain expressed X-linked 1
BEX2 brain expressed X-linked 2
CCND2 cyclin D2
  • Cyclin D associated events in G1
  • Regulation of RUNX1 Expression and Activity
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
  • Testicular cancer
CSF1R colony stimulating factor 1 receptor
  • Other interleukin signaling
  • Transcriptional Regulation by VENTX
  • Imatinib
  • Sunitinib
  • ABT-869
  • 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE
  • 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE
  • Fostamatinib
  • Erdafitinib
  • Pexidartinib
  • Choriocarcinoma

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