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HMOX2 and A2M
Data Source:
BioGRID
(two hybrid)
HMOX2
A2M
Description
heme oxygenase 2
alpha-2-macroglobulin
Image
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Specific Granule Membrane
Extracellular Region
Extracellular Space
Cytosol
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Molecular Function
Heme Oxygenase (decyclizing) Activity
Protein Binding
Heme Binding
Metal Ion Binding
Protease Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Growth Factor Binding
Enzyme Binding
Interleukin-8 Binding
Interleukin-1 Binding
Tumor Necrosis Factor Binding
Calcium-dependent Protein Binding
Biological Process
Response To Hypoxia
Heme Oxidation
Cellular Iron Ion Homeostasis
Response To Oxidative Stress
Heme Catabolic Process
Neutrophil Degranulation
Iron Ion Homeostasis
Negative Regulation Of Complement Activation, Lectin Pathway
Platelet Degranulation
Blood Coagulation, Intrinsic Pathway
Negative Regulation Of Endopeptidase Activity
Extracellular Matrix Disassembly
Stem Cell Differentiation
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
Heme degradation
Neutrophil degranulation
Iron uptake and transport
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Degradation of the extracellular matrix
Rho GTPase cycle
HDL assembly
Drugs
NADH
Stannsoporfin
Becaplermin
Cisplatin
Bacitracin
Zinc
Ocriplasmin
Silver
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Diseases
GWAS
Erectile dysfunction (
30583798
)
Refractive error (
32231278
)
Interacting Genes
67 interacting genes:
A2M
APP
AQP6
ARL13B
ASGR2
ATP5F1B
BCL2L13
BLOC1S2
CCR2
CD79A
CEBPZ
CEP126
COPS6
CRB3
CSNK2A1
EBP
EEF1G
EIF3C
ELOVL4
ELOVL5
ERGIC3
F2RL1
FAM209A
FAM210B
GET1
GIT1
GPR152
GPRASP1
GPX8
HAP1
IMMT
INPP5K
ITFG1
JADE1
KCNJ6
KCNMA1
LAPTM5
LMNA
LRIF1
MED31
MGST3
MTNR1A
NDUFS2
NKRF
NR3C1
PLXNB2
PTGER4
RBBP4
RETREG3
RNASEK
SAR1A
SETDB1
SGPL1
SHC1
SKA2
SLC30A8
SMO
SNX5
SNX7
SSMEM1
STOM
SYT1
TMEM14B
TMX2
VMA21
ZFP28
ZNF746
96 interacting genes:
ACTB
ADAM19
ADAMTS1
AMBP
ANXA6
ANXA7
AP1M2
APOE
APP
ATF7IP
ATP1A1
B2M
C11orf58
CDC37
CDC42
CDK2AP2
CDKN1A
CELA1
CPB2
CTSB
CTSE
CYP2C18
CYP2C8
DNAJB1
ECSIT
EGLN2
ELAVL3
ENO2
EVI5L
EXOSC1
FARSA
FBXL12
FBXW4
FIS1
GCDH
GEM
GRB2
H2AX
HMOX2
HSPA5
HSPB2
IFIT3
IFIT5
IGSF8
IL10
IL1B
IL4
KLK1
KLK13
KLK2
KLK3
LCAT
LEP
LINC02582
LONP1
LRP1
LYZ
MAST1
MLST8
MMP2
MYOC
NCDN
NGF
NOS3
NUDT21
OGA
PAEP
PAXIP1
PDGFA
PDGFB
PRAM1
PRDX2
RAB3A
RAD23A
RAP1B
RETN
RHEB
RNF32
RPP14
SEPTIN8
SHBG
SMN1
STAMBPL1
SWSAP1
TGFBI
TGIF1
TGM2
TK1
TNFRSF14
TRAPPC5
TSC22D1
TTR
TUBA1B
TYRO3
UFD1
UMPS
Entrez ID
3163
2
HPRD ID
00783
00072
Ensembl ID
ENSG00000103415
ENSG00000175899
Uniprot IDs
A0A087WT44
B3KSE0
P30519
P01023
PDB IDs
2Q32
2QPP
2RGZ
4WMH
5UC8
5UC9
5UCA
1BV8
2P9R
4ACQ
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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