This is a resource centered on protein-protein interactions (PPIs), built over Wiki-Pi, extending it to present the PPIs in Malignant Pleural Mesothelioma (MPM) Interactome. In addition to previously known PPIs of human genes, collected from BioGRID and HPRD, this resource presents novel PPIs of 62 genes linked to MPM. The novel PPIs are predicted with HiPPIP: a High-confidence Protein-Protein Interaction Prediction model that we presented previously. The website will have functionality to retrieve and discover interactions effectively, through simple queries such as associations to diseases or pathways, or complex queries conditioned on annotations of one or both proteins in the interaction. We propose to update the backend database once a month to reflect recently-assembled annotations of the proteins. Each interaction will be provided with automatically updated annotations of individual proteins from databases such as Gene Ontology, KEGG, REACTOM, Pubmed2ENSEMBL, and DrugBank. Most importantly, we will enable “wiki-style” capabilities to allow registered users to discuss the PPIs, especially the novel PPIs that hold a potential for translational impact.
Please cite the following papers when referring to each of these components:
MPM Interactome: Karunakaran KB, Yanamala N, Boyce G, Ganapathiraju MK. Mesothelioma Interactome with 367 Novel Protein-Protein Interactions. bioRxiv. 2018 Jan 1:459065.
HiPPIP: Ganapathiraju MK, et al (2016) Schizophrenia interactome with 504 novel protein–protein interactions. npj Schizophrenia 2, Article number: 16012, doi:10.1038/npjschz.2016.12.
Wiki-Pi: Orii N, Ganapathiraju MK (2012) Wiki-Pi: A Web-Server of Annotated Human Protein-Protein Interactions to Aid in Discovery of Protein Function. PLoS ONE 7(11): e49029. doi:10.1371/journal.pone.0049029.