HMOX2 and AQP6

Data Source:
BioGRID (two hybrid)

		HMOX2	AQP6
Description		heme oxygenase 2	aquaporin 6
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GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Cytoplasmic Vesicle Membrane
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding	Protein Binding Nitrate Transmembrane Transporter Activity Water Channel Activity
	Biological Process	Response To Hypoxia Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Heme Catabolic Process Neutrophil Degranulation Iron Ion Homeostasis	Water Transport Excretion Carbon Dioxide Transport Nitrate Transport Odontogenesis Transmembrane Transport
Pathways		Heme degradation Neutrophil degranulation Iron uptake and transport	Passive transport by Aquaporins
Drugs		NADH Stannsoporfin
Diseases
GWAS		Erectile dysfunction ( 30583798)
Interacting Genes		67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ELOVL5 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LMNA LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746	304 interacting genes: ABCG1 ABHD16A ACSL5 ADGRE2 ADIPOQ AGMO AGPAT3 AGPAT4 AGTRAP AIG1 ALOX5AP ANKRD46 AOC2 APOA2 AQP1 ARL6IP1 ARL6IP6 ARV1 ATP13A1 ATP6V0C BET1 BMP10 BRICD5 BSG BTN2A2 C14orf180 C2CD2L C3orf52 C4orf3 C5 C5orf46 CCDC167 CCL22 CCL4L2 CD52 CD68 CD81 CDIPT CGREF1 CLDN19 CLDN4 CLDND2 CMTM3 CMTM5 CMTM7 CNIH1 CNIH3 CORIN COX20 CTSA CTXN3 CXCL16 CXCL9 CXorf66 CYB561 CYB561A3 CYB561D1 CYB5B CYB5R3 CYBC1 CYP4F2 CYP4F22 DEFB103A DEFB103B DEFB108B DEFB127 DERL1 DGAT2L6 DHRSX DNAJC30 EBP EFNA5 EMC6 EMP1 EMP3 ERG28 ERMP1 FA2H FAM177A1 FAXDC2 FDFT1 FUNDC2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GKN1 GOLT1A GOSR2 GPR151 GPR152 GPR25 GRM2 GYPC HMOX1 HMOX2 HSD3B1 HTATIP2 ICMT IFITM3 IFNGR1 IGFBP5 INSIG1 INSIG2 ITGAM JAGN1 JPH1 KCNK1 LEMD1 LEPROT LHFPL5 LNPEP LPAR3 LSS LY6D MAL MAL2 MALL MARCHF2 MARCHF5 MFF MFSD3 MFSD5 MGAM MGLL MMP14 MS4A1 MS4A13 MYADML2 NEU1 NINJ1 NINJ2 NKG7 NRM ORMDL1 ORMDL2 ORMDL3 OTULINL PAEP PDZK1IP1 PEDS1-UBE2V1 PEMT PEX11G PEX16 PIGF PLLP PLP1 PLPP6 PRAF2 PRB1 PRH1 PRRT2 PTPN1 PTPN9 RAB18 RFT1 RHD RPRM RTP2 RUSF1 SACM1L SCAMP4 SCAMP5 SCD SCGB1A1 SEC22A SEC22B SEC61G SELENOK SERF1A SERF1B SERP1 SERP2 SFRP4 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SFXN5 SLC16A12 SLC16A13 SLC25A46 SLC30A2 SLC30A8 SLC35A1 SLC35B1 SLC35B2 SLC35B4 SLC35E4 SLC35F1 SLC35F6 SLC35G2 SLC38A1 SLC39A2 SLC39A7 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC66A1 SLC66A2 SLC7A1 SLC7A8 SLCO3A1 SMAGP SMCO4 SMIM1 SNORC ST6GAL2 STARD3 STATH STRIT1 STX12 STX1B STX3 STX5 STX6 STX7 SYNDIG1 SYNGR1 SYNJ2BP TAP1 TBC1D20 TFRC THBD THSD7A THSD7B TIMM23 TLCD1 TMEM100 TMEM107 TMEM115 TMEM119 TMEM120A TMEM120B TMEM128 TMEM140 TMEM143 TMEM144 TMEM14A TMEM167B TMEM19 TMEM199 TMEM203 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM242 TMEM243 TMEM254 TMEM262 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM69 TMEM74 TMEM86B TMEM97 TMIE TMUB2 TMX2 TNFRSF10C TOMM22 TOMM6 TPRG1 TREX1 TSPO2 UBE2J2 UBTD2 UBXN8 UNC50 UNC93A USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB VEZT VKORC1L1 VMA21 VRK2 VSTM1 VTI1B WFS1 XKR3 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC21 ZDHHC24 ZNF587
Entrez ID		3163	363
HPRD ID		00783	03226
Ensembl ID		ENSG00000103415	ENSG00000086159
Uniprot IDs		A0A087WT44 B3KSE0 P30519	Q13520
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA	1S6E
Enriched GO Terms of Interacting Partners?
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