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HMOX2 and LAPTM5
Data Source:
BioGRID
(two hybrid)
HMOX2
LAPTM5
Description
heme oxygenase 2
lysosomal protein transmembrane 5
Image
No pdb structure
GO Annotations
Cellular Component
Endoplasmic Reticulum Membrane
Plasma Membrane
Membrane
Specific Granule Membrane
Lysosome
Lysosomal Membrane
Cytosol
Integral Component Of Plasma Membrane
Transport Vesicle
Cytoplasmic Vesicle
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Heme Oxygenase (decyclizing) Activity
Protein Binding
Heme Binding
Metal Ion Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin-dependent Protein Binding
Protein Sequestering Activity
Biological Process
Response To Hypoxia
Heme Oxidation
Cellular Iron Ion Homeostasis
Response To Oxidative Stress
Heme Catabolic Process
Neutrophil Degranulation
Iron Ion Homeostasis
Defense Response To Tumor Cell
Positive Regulation Of Cytokine Production Involved In Immune Response
Protein Targeting To Lysosome
Intracellular Protein Transport
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Induction Of Programmed Cell Death
Positive Regulation Of Protein Ubiquitination
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-2 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of MAPK Cascade
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of T Cell Activation
Negative Regulation Of B Cell Activation
Positive Regulation Of Macrophage Cytokine Production
Golgi To Lysosome Transport
Positive Regulation Of Lysosomal Membrane Permeability
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Negative Regulation Of Autophagic Cell Death
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Receptor Catabolic Process
Pathways
Heme degradation
Neutrophil degranulation
Iron uptake and transport
Drugs
NADH
Stannsoporfin
Diseases
GWAS
Erectile dysfunction (
30583798
)
Loneliness (
27629369
)
Loneliness (linear analysis) (
27629369
)
Neutrophil count (
32888494
)
White blood cell count (
32888494
)
Interacting Genes
67 interacting genes:
A2M
APP
AQP6
ARL13B
ASGR2
ATP5F1B
BCL2L13
BLOC1S2
CCR2
CD79A
CEBPZ
CEP126
COPS6
CRB3
CSNK2A1
EBP
EEF1G
EIF3C
ELOVL4
ELOVL5
ERGIC3
F2RL1
FAM209A
FAM210B
GET1
GIT1
GPR152
GPRASP1
GPX8
HAP1
IMMT
INPP5K
ITFG1
JADE1
KCNJ6
KCNMA1
LAPTM5
LMNA
LRIF1
MED31
MGST3
MTNR1A
NDUFS2
NKRF
NR3C1
PLXNB2
PTGER4
RBBP4
RETREG3
RNASEK
SAR1A
SETDB1
SGPL1
SHC1
SKA2
SLC30A8
SMO
SNX5
SNX7
SSMEM1
STOM
SYT1
TMEM14B
TMX2
VMA21
ZFP28
ZNF746
39 interacting genes:
AIG1
ANKRD13A
C4orf3
CLDN19
CYB5R3
DCUN1D1
DISP1
EPN1
EPN2
EPN3
EPS15
GYPA
HERC1
HEY1
HEYL
HMOX2
HUWE1
INSIG2
ITCH
KIR3DL3
KRT7
LDLRAD1
MRPL18
NEDD4
NEDD4L
RNF168
RPRM
RTP2
SLC22A2
SMURF2
TNFAIP3
TOM1L2
UBA52
UBAC1
UBC
UBE2J1
USP13
VAMP1
WWP1
Entrez ID
3163
7805
HPRD ID
00783
03280
Ensembl ID
ENSG00000103415
ENSG00000162511
Uniprot IDs
A0A087WT44
B3KSE0
P30519
Q13571
Q5TBB8
PDB IDs
2Q32
2QPP
2RGZ
4WMH
5UC8
5UC9
5UCA
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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