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A2M and HSPA5
Data Source:
HPRD
(in vivo)
A2M
HSPA5
Description
alpha-2-macroglobulin
heat shock protein family A (Hsp70) member 5
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Nucleus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Endoplasmic Reticulum-Golgi Intermediate Compartment
Cytosol
Plasma Membrane
Focal Adhesion
COP9 Signalosome
Cell Surface
Membrane
Integral Component Of Endoplasmic Reticulum Membrane
Midbody
Protein-containing Complex
Endoplasmic Reticulum Chaperone Complex
Melanosome
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Molecular Function
Protease Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Growth Factor Binding
Enzyme Binding
Interleukin-8 Binding
Interleukin-1 Binding
Tumor Necrosis Factor Binding
Calcium-dependent Protein Binding
Calcium Ion Binding
Protein Binding
ATP Binding
ATPase Activity
Enzyme Binding
Protein Domain Specific Binding
Heat Shock Protein Binding
Ubiquitin Protein Ligase Binding
Ribosome Binding
Protein Folding Chaperone
Cadherin Binding
Unfolded Protein Binding
Chaperone Binding
Misfolded Protein Binding
Biological Process
Negative Regulation Of Complement Activation, Lectin Pathway
Platelet Degranulation
Blood Coagulation, Intrinsic Pathway
Negative Regulation Of Endopeptidase Activity
Extracellular Matrix Disassembly
Stem Cell Differentiation
Regulation Of Small GTPase Mediated Signal Transduction
Luteolysis
ER Overload Response
Positive Regulation Of Neuron Projection Development
Cerebellum Structural Organization
Cerebellar Purkinje Cell Layer Development
Substantia Nigra Development
Neuron Differentiation
Positive Regulation Of Cell Migration
Ubiquitin-dependent ERAD Pathway
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Endoplasmic Reticulum Unfolded Protein Response
Posttranslational Protein Targeting To Membrane, Translocation
Negative Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Protein Ubiquitination
Cellular Response To Unfolded Protein
Protein Folding In Endoplasmic Reticulum
Maintenance Of Protein Localization In Endoplasmic Reticulum
Cellular Response To Drug
IRE1-mediated Unfolded Protein Response
PERK-mediated Unfolded Protein Response
ATF6-mediated Unfolded Protein Response
Protein Refolding
Cellular Response To Glucose Starvation
Response To Cocaine
Negative Regulation Of Apoptotic Process
Chaperone Cofactor-dependent Protein Refolding
Neuron Apoptotic Process
Regulation Of Protein Folding In Endoplasmic Reticulum
Cellular Response To Antibiotic
Cellular Response To Calcium Ion
Cellular Response To Manganese Ion
Cellular Response To CAMP
Cellular Response To Interleukin-4
Cellular Response To Gamma Radiation
Stress Response To Metal Ion
Toxin Transport
Regulation Of ATF6-mediated Unfolded Protein Response
Regulation Of IRE1-mediated Unfolded Protein Response
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Regulation Of PERK-mediated Unfolded Protein Response
Response To Methamphetamine Hydrochloride
Cellular Response To Nerve Growth Factor Stimulus
Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Degradation of the extracellular matrix
Rho GTPase cycle
HDL assembly
Platelet degranulation
Regulation of HSF1-mediated heat shock response
ATF6 (ATF6-alpha) activates chaperones
PERK regulates gene expression
IRE1alpha activates chaperones
ATF6 (ATF6-alpha) activates chaperone genes
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Becaplermin
Cisplatin
Bacitracin
Zinc
Ocriplasmin
Silver
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Antihemophilic factor, human recombinant
Acetylsalicylic acid
Copper
Lonoctocog alfa
Moroctocog alfa
Diseases
GWAS
Refractive error (
32231278
)
Refractive error (
32231278
)
Interacting Genes
96 interacting genes:
ACTB
ADAM19
ADAMTS1
AMBP
ANXA6
ANXA7
AP1M2
APOE
APP
ATF7IP
ATP1A1
B2M
C11orf58
CDC37
CDC42
CDK2AP2
CDKN1A
CELA1
CPB2
CTSB
CTSE
CYP2C18
CYP2C8
DNAJB1
ECSIT
EGLN2
ELAVL3
ENO2
EVI5L
EXOSC1
FARSA
FBXL12
FBXW4
FIS1
GCDH
GEM
GRB2
H2AX
HMOX2
HSPA5
HSPB2
IFIT3
IFIT5
IGSF8
IL10
IL1B
IL4
KLK1
KLK13
KLK2
KLK3
LCAT
LEP
LINC02582
LONP1
LRP1
LYZ
MAST1
MLST8
MMP2
MYOC
NCDN
NGF
NOS3
NUDT21
OGA
PAEP
PAXIP1
PDGFA
PDGFB
PRAM1
PRDX2
RAB3A
RAD23A
RAP1B
RETN
RHEB
RNF32
RPP14
SEPTIN8
SHBG
SMN1
STAMBPL1
SWSAP1
TGFBI
TGIF1
TGM2
TK1
TNFRSF14
TRAPPC5
TSC22D1
TTR
TUBA1B
TYRO3
UFD1
UMPS
70 interacting genes:
A2M
APC
APOB
BAG3
BCAR1
CASP7
CPT1A
DDX24
DNAJC1
DNAJC10
DNAJC3
DPH1
DPYSL5
EIF2AK3
ERBB2
ERCC6
ERN1
ERP29
F8
FCHSD2
GRB2
GRIA1
HLA-C
HMGB1
HSPB1
HSPBP1
HTR3A
IGHM
KRT14
KRT18
KRT8
LCT
LDLR
LINC01554
MATK
METTL21A
MTNR1A
MTNR1B
NDRG1
OTUD3
PARK7
PAWR
PCSK7
PRNP
PSME3
PTPN11
PTPRF
RPN1
SEC61A1
SEC63
SERPINB5
SH3BP4
SIL1
SIRPA
SQSTM1
SREBF2
STMN1
SUMO2
SUMO4
TCERG1
TG
TMEM132A
TMEM62
TRA
TSHR
UBE3A
UBQLN4
VHL
VWF
YWHAB
Entrez ID
2
3309
HPRD ID
00072
00682
Ensembl ID
ENSG00000175899
ENSG00000044574
Uniprot IDs
P01023
P11021
V9HWB4
PDB IDs
1BV8
2P9R
4ACQ
3IUC
3LDL
3LDN
3LDO
3LDP
5E84
5E85
5E86
5EVZ
5EX5
5EXW
5EY4
5F0X
5F1X
5F2R
6ASY
6CZ1
6DFM
6DFO
6DO2
6DWS
Enriched GO Terms of Interacting Partners
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