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A2M and IL4
Data Source:
BioGRID
(pull down)
A2M
IL4
Description
alpha-2-macroglobulin
interleukin 4
Image
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cytosol
Platelet Alpha Granule Lumen
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Extracellular Region
Extracellular Space
Molecular Function
Protease Binding
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Signaling Receptor Binding
Protein Binding
Growth Factor Binding
Enzyme Binding
Interleukin-8 Binding
Interleukin-1 Binding
Tumor Necrosis Factor Binding
Calcium-dependent Protein Binding
Cytokine Activity
Interleukin-4 Receptor Binding
Protein Binding
Growth Factor Activity
Biological Process
Negative Regulation Of Complement Activation, Lectin Pathway
Platelet Degranulation
Blood Coagulation, Intrinsic Pathway
Negative Regulation Of Endopeptidase Activity
Extracellular Matrix Disassembly
Stem Cell Differentiation
Regulation Of Small GTPase Mediated Signal Transduction
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Innate Immune Response In Mucosa
Positive Regulation Of Defense Response To Virus By Host
Negative Regulation Of Acute Inflammatory Response
Negative Regulation Of Chronic Inflammatory Response
Immune Response
Cholesterol Metabolic Process
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial Cell Migration
Positive Regulation Of Macroautophagy
Cytokine-mediated Signaling Pathway
B Cell Differentiation
Positive Regulation Of Cell Migration
Positive Regulation Of B Cell Proliferation
B Cell Costimulation
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-13 Production
T-helper 2 Cell Cytokine Production
Type 2 Immune Response
Positive Regulation Of T Cell Proliferation
T Cell Activation
Macrophage Activation
Regulation Of Phosphorylation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Activation Of Janus Kinase Activity
Myeloid Dendritic Cell Differentiation
Negative Regulation Of Macrophage Activation
Negative Regulation Of Apoptotic Process
Positive Regulation Of Mast Cell Degranulation
T-helper 2 Cell Differentiation
Regulation Of Isotype Switching
Positive Regulation Of MHC Class II Biosynthetic Process
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Osteoclast Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Receptor-mediated Endocytosis
Positive Regulation Of Isotype Switching To IgE Isotypes
Positive Regulation Of Isotype Switching To IgG Isotypes
Negative Regulation Of Inflammatory Response
Regulation Of Immune Response
Positive Regulation Of Mononuclear Cell Migration
Dendritic Cell Differentiation
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Positive Regulation Of Cold-induced Thermogenesis
Neuroinflammatory Response
Negative Regulation Of Neuroinflammatory Response
Positive Regulation Of Amyloid-beta Clearance
Positive Regulation Of Myoblast Fusion
Positive Regulation Of Cellular Respiration
Negative Regulation Of Complement-dependent Cytotoxicity
Negative Regulation Of Cellular Response To Transforming Growth Factor Beta Stimulus
Negative Regulation Of T-helper 17 Cell Differentiation
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Eosinophil Chemotaxis
Positive Regulation Of ATP Biosynthetic Process
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Degradation of the extracellular matrix
Rho GTPase cycle
HDL assembly
Interleukin-4 and Interleukin-13 signaling
Interleukin-18 signaling
Drugs
Becaplermin
Cisplatin
Bacitracin
Zinc
Ocriplasmin
Silver
Zinc acetate
Zinc chloride
Zinc sulfate, unspecified form
Pascolizumab
Diseases
Asthma
GWAS
Refractive error (
32231278
)
Asthma (
31959851
31619474
29273806
)
Asthma (childhood onset) (
31036433
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Atopic dermatitis (
25574825
)
Atopic march (
26542096
)
Inflammatory bowel disease (
23128233
)
Psoriasis (
25574825
23143594
)
Psoriasis vulgaris (
26626624
)
Refractive error (
32231278
)
Interacting Genes
96 interacting genes:
ACTB
ADAM19
ADAMTS1
AMBP
ANXA6
ANXA7
AP1M2
APOE
APP
ATF7IP
ATP1A1
B2M
C11orf58
CDC37
CDC42
CDK2AP2
CDKN1A
CELA1
CPB2
CTSB
CTSE
CYP2C18
CYP2C8
DNAJB1
ECSIT
EGLN2
ELAVL3
ENO2
EVI5L
EXOSC1
FARSA
FBXL12
FBXW4
FIS1
GCDH
GEM
GRB2
H2AX
HMOX2
HSPA5
HSPB2
IFIT3
IFIT5
IGSF8
IL10
IL1B
IL4
KLK1
KLK13
KLK2
KLK3
LCAT
LEP
LINC02582
LONP1
LRP1
LYZ
MAST1
MLST8
MMP2
MYOC
NCDN
NGF
NOS3
NUDT21
OGA
PAEP
PAXIP1
PDGFA
PDGFB
PRAM1
PRDX2
RAB3A
RAD23A
RAP1B
RETN
RHEB
RNF32
RPP14
SEPTIN8
SHBG
SMN1
STAMBPL1
SWSAP1
TGFBI
TGIF1
TGM2
TK1
TNFRSF14
TRAPPC5
TSC22D1
TTR
TUBA1B
TYRO3
UFD1
UMPS
7 interacting genes:
A2M
CD53
FBXO7
IL13RA2
IL2RG
IL4R
PIK3CD
Entrez ID
2
3565
HPRD ID
00072
00989
Ensembl ID
ENSG00000175899
ENSG00000113520
Uniprot IDs
P01023
D4HNR6
P05112
Q5FC01
PDB IDs
1BV8
2P9R
4ACQ
1BBN
1BCN
1CYL
1HIJ
1HIK
1HZI
1IAR
1ILL
1ITE
1ITI
1ITL
1ITM
1RCB
2B8U
2B8X
2B8Y
2B8Z
2B90
2B91
2CYK
2D48
2INT
3BPL
3BPN
3QB7
4YDY
5FHX
6OEL
Enriched GO Terms of Interacting Partners
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