A2M and TGFBI

Data Source:
HPRD (in vitro)

		A2M	TGFBI
Description		alpha-2-macroglobulin	transforming growth factor beta induced
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Basement Membrane Extracellular Space Trans-Golgi Network Plasma Membrane Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding	Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Identical Protein Binding Cell Adhesion Molecule Binding Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Blood Coagulation, Intrinsic Pathway Negative Regulation Of Endopeptidase Activity Extracellular Matrix Disassembly Stem Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction	Angiogenesis Chondrocyte Differentiation Cell Adhesion Negative Regulation Of Cell Adhesion Visual Perception Cell Population Proliferation Extracellular Matrix Organization Cellular Protein Metabolic Process Response To Stimulus
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix Rho GTPase cycle HDL assembly	Amyloid fiber formation
Drugs		Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Granular corneal dystrophies (GCD), including: Corneal dystrophy Groenouw type I; Avellino corneal dystrophy; Granular-lattice dystrophy Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Reis-Bucklers corneal dystrophy (RBCD); Corneal dystrophy of Bowman's type I; Granular corneal dystrophy type III Thiel-Behnke dystrophies (TBCD); Corneal dystrophy of Bowman layer type II; Honeycomb corneal dystrophy; Anterior limiting membrane dystrophy type II; Curly fibers corneal dystrophy; Waardenburg-Jonker corneal dystrophy
GWAS		Refractive error ( 32231278)	Blood protein levels ( 30072576 29875488 28240269) Insomnia ( 27992416) Response to cytidine analogues (gemcitabine) ( 24483146) Stroke ( 26089329)
Interacting Genes		96 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS	13 interacting genes: A2M COL1A1 COL1A2 COL2A1 COL4A1 COL4A2 COL4A3 COL4A4 FAM9B FBXL17 FN1 LINC01554 S100P
Entrez ID		2	7045
HPRD ID		00072	03409
Ensembl ID		ENSG00000175899	ENSG00000120708
Uniprot IDs		P01023	A0A0S2Z4Q2 Q15582
PDB IDs		1BV8 2P9R 4ACQ	1X3B 2LTB 2LTC 2VXP 5NV6
Enriched GO Terms of Interacting Partners?
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