HMOX2 and ZNF746

Data Source:
BioGRID (two hybrid)

		HMOX2	ZNF746
Description		heme oxygenase 2	zinc finger protein 746
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding
	Biological Process	Response To Hypoxia Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Heme Catabolic Process Neutrophil Degranulation Iron Ion Homeostasis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Death
Pathways		Heme degradation Neutrophil degranulation Iron uptake and transport	Generic Transcription Pathway
Drugs		NADH Stannsoporfin
Diseases
GWAS		Erectile dysfunction ( 30583798)	Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)
Interacting Genes		67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ELOVL5 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LMNA LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746	14 interacting genes: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K20 MAP3K7 PRKN PRKRA RPS6KA6 UBE2E3
Entrez ID		3163	155061
HPRD ID		00783	08099
Ensembl ID		ENSG00000103415	ENSG00000181220
Uniprot IDs		A0A087WT44 B3KSE0 P30519	Q6NUN9
PDB IDs		2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?
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