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GSN and ACTA1
Data Source:
HPRD
(in vitro)
GSN
ACTA1
Description
gelsolin
actin alpha 1, skeletal muscle
Image
No pdb structure
GO Annotations
Cellular Component
Ruffle
Podosome
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Sarcoplasm
Lamellipodium
Actin Cap
Cortical Actin Cytoskeleton
Protein-containing Complex
Secretory Granule Lumen
Myelin Sheath
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Stress Fiber
Extracellular Space
Cytosol
Striated Muscle Thin Filament
Dynactin Complex
Actin Filament
Actin Cytoskeleton
Sarcomere
Lamellipodium
Filopodium
Cell Body
Extracellular Exosome
Blood Microparticle
Molecular Function
Actin Binding
Calcium Ion Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Phosphatidylinositol 3-kinase Catalytic Subunit Binding
Myosin II Binding
Actin Filament Binding
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Myosin Binding
ADP Binding
Biological Process
Phagocytosis, Engulfment
Central Nervous System Development
Aging
Actin Polymerization Or Depolymerization
Positive Regulation Of Gene Expression
Oligodendrocyte Development
Striated Muscle Atrophy
Extracellular Matrix Disassembly
Cell Projection Assembly
Actin Filament Polymerization
Actin Filament Depolymerization
Regulation Of Cell Adhesion
Protein Destabilization
Response To Muscle Stretch
Wound Healing
Tissue Regeneration
Sequestering Of Actin Monomers
Neutrophil Degranulation
Cellular Protein Metabolic Process
Actin Nucleation
Response To Ethanol
Negative Regulation Of Viral Entry Into Host Cell
Phosphatidylinositol-mediated Signaling
Actin Filament Severing
Barbed-end Actin Filament Capping
Positive Regulation Of Actin Nucleation
Response To Folic Acid
Actin Filament Capping
Relaxation Of Cardiac Muscle
Cilium Assembly
Cellular Response To Cadmium Ion
Cellular Response To Interferon-gamma
Regulation Of Podosome Assembly
Cardiac Muscle Cell Contraction
Actin Filament Reorganization
Renal Protein Absorption
Hepatocyte Apoptotic Process
Positive Regulation Of Keratinocyte Apoptotic Process
Regulation Of Establishment Of T Cell Polarity
Regulation Of Plasma Membrane Raft Polarization
Regulation Of Receptor Clustering
Positive Regulation Of Protein Processing In Phagocytic Vesicle
Amyloid Fibril Formation
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Muscle Contraction
Response To Mechanical Stimulus
Response To Extracellular Stimulus
Response To Lithium Ion
Positive Regulation Of Gene Expression
Muscle Filament Sliding
Skeletal Muscle Thin Filament Assembly
Skeletal Muscle Fiber Adaptation
Response To Steroid Hormone
Skeletal Muscle Fiber Development
Cellular Response To Organonitrogen Compound
Mesenchyme Migration
Pathways
Caspase-mediated cleavage of cytoskeletal proteins
Neutrophil degranulation
Amyloid fiber formation
Striated Muscle Contraction
Drugs
Zinc
Latrunculin A
Copper
Zinc acetate
Latrunculin A
Sucrose
Ulapualide A
Kabiramide C
Jaspisamide A
Tmr
1-Methylhistidine
Phosphoaminophosphonic Acid-Adenylate Ester
Aplyronine A
Reidispongiolide A
Reidispongiolide C
Sphinxolide B
Latrunculin B
Diseases
Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome
Familial amyloidosis
Congenital fiber type disproportion (CFTD)
Cap myopathy
Nemaline myopathy
GWAS
Blood protein levels (
30072576
)
Interacting Genes
24 interacting genes:
ACTA1
ACTB
ACTG1
ACTN4
APP
AR
BCAR1
CASP3
CLIC5
CSK
ERBB2
FHIT
FN1
LIMK2
PIK3CG
PLCG1
PTK2B
PXN
STK39
TNIK
TOM1L1
VASP
VCL
VDAC1
114 interacting genes:
ABL1
ABRA
ACTR10
ACTR1B
ADSS2
AFAP1
AIF1
AJUBA
AMOT
ANXA2
BIN1
CCIN
CCT2
CCT4
CCT5
CFL1
CLIC5
CNN1
CORO2B
COTL1
CTNND1
CTTN
CYFIP1
CYTH1
DHX9
DLG1
DMD
DNASE1
DNMBP
DTNA
DUX4L9
EGFR
EPB41
EPB41L2
EPS8
FGD4
FHOD1
FSCN1
GAS2
GAS7
GC
GSN
HCLS1
HDAC4
HIP1R
HSPB2
HTRA2
IQGAP1
ITGA2
ITPKA
KIF23
KLHL20
LASP1
MACF1
MAP1A
MAPT
MIB2
MINPP1
MYL1
MYLK
MYO10
MYO6
MYO7A
MYO9B
NEXN
NR3C2
NRAP
PAK1
PARVA
PCYT1B
PFDN1
PFN1
PHACTR1
PLD1
PPP1R9B
PRKCA
PRKCD
PRKCE
RAC1
RNF167
RPS6KB1
S100A1
S100A4
SCIN
SMTN
SNCA
SORBS1
SPRR1A
SPTA1
SPTAN1
SPTBN2
TAGLN
TJP1
TLN1
TMSB4X
TMSB4Y
TNNI1
TNNI3
TNNI3K
TP53
TPM2
TPM3
TRIM55
TRIM63
TTN
UBC
USP25
USP6NL
UTRN
VASP
VAV1
VCL
VIL1
XIRP1
Entrez ID
2934
58
HPRD ID
00674
00030
Ensembl ID
ENSG00000148180
ENSG00000143632
Uniprot IDs
A0A0A0MS51
A0A0A0MT01
A0A384MEF1
B7Z4U6
P06396
P68133
PDB IDs
1C0F
1C0G
1D4X
1DEJ
1EQY
1ESV
1H1V
1KCQ
1MDU
1NLV
1NM1
1NMD
1P8X
1P8Z
1SOL
1T44
1YAG
1YVN
2FF3
2FF6
2FH1
2FH2
2FH3
2FH4
3A5L
3A5M
3A5N
3A5O
3CI5
3CIP
3CJB
3CJC
3FFK
3FFN
3TU5
4PKG
4PKH
4PKI
4S10
4Z94
5DD2
5FAE
5FAF
5H3M
5H3N
5O2Z
5UBO
5ZZ0
6H1F
6JCO
6JEG
6JEH
6LJE
6LJF
6Q9R
6Q9Z
6QBF
6QW3
Enriched GO Terms of Interacting Partners
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