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ACTA1 and HCLS1
Data Source:
HPRD
(in vitro)
ACTA1
HCLS1
Description
actin alpha 1, skeletal muscle
hematopoietic cell-specific Lyn substrate 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Stress Fiber
Extracellular Space
Cytosol
Striated Muscle Thin Filament
Dynactin Complex
Actin Filament
Actin Cytoskeleton
Sarcomere
Lamellipodium
Filopodium
Cell Body
Extracellular Exosome
Blood Microparticle
Nucleus
Transcription Regulator Complex
Cytoplasm
Mitochondrion
Cytosol
Actin Filament
Plasma Membrane
Site Of Polarized Growth
Cortical Actin Cytoskeleton
Molecular Function
Structural Constituent Of Cytoskeleton
Protein Binding
ATP Binding
Myosin Binding
ADP Binding
RNA Polymerase II Transcription Factor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Actin Filament Binding
Biological Process
Muscle Contraction
Response To Mechanical Stimulus
Response To Extracellular Stimulus
Response To Lithium Ion
Positive Regulation Of Gene Expression
Muscle Filament Sliding
Skeletal Muscle Thin Filament Assembly
Skeletal Muscle Fiber Adaptation
Response To Steroid Hormone
Skeletal Muscle Fiber Development
Cellular Response To Organonitrogen Compound
Mesenchyme Migration
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription, DNA-templated
Positive Regulation Of Cell Population Proliferation
Response To Hormone
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Actin Filament Polymerization
Erythrocyte Differentiation
Regulation Of Actin Filament Polymerization
Positive Regulation Of Granulocyte Differentiation
Positive Regulation Of Peptidyl-serine Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Protein Import Into Nucleus
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Positive Regulation Of Macrophage Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Cellular Response To Cytokine Stimulus
Negative Regulation Of Leukocyte Apoptotic Process
Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways
Striated Muscle Contraction
Drugs
Latrunculin A
Sucrose
Ulapualide A
Kabiramide C
Jaspisamide A
Tmr
1-Methylhistidine
Phosphoaminophosphonic Acid-Adenylate Ester
Aplyronine A
Reidispongiolide A
Reidispongiolide C
Sphinxolide B
Latrunculin B
Diseases
Congenital fiber type disproportion (CFTD)
Cap myopathy
Nemaline myopathy
GWAS
Interacting Genes
114 interacting genes:
ABL1
ABRA
ACTR10
ACTR1B
ADSS2
AFAP1
AIF1
AJUBA
AMOT
ANXA2
BIN1
CCIN
CCT2
CCT4
CCT5
CFL1
CLIC5
CNN1
CORO2B
COTL1
CTNND1
CTTN
CYFIP1
CYTH1
DHX9
DLG1
DMD
DNASE1
DNMBP
DTNA
DUX4L9
EGFR
EPB41
EPB41L2
EPS8
FGD4
FHOD1
FSCN1
GAS2
GAS7
GC
GSN
HCLS1
HDAC4
HIP1R
HSPB2
HTRA2
IQGAP1
ITGA2
ITPKA
KIF23
KLHL20
LASP1
MACF1
MAP1A
MAPT
MIB2
MINPP1
MYL1
MYLK
MYO10
MYO6
MYO7A
MYO9B
NEXN
NR3C2
NRAP
PAK1
PARVA
PCYT1B
PFDN1
PFN1
PHACTR1
PLD1
PPP1R9B
PRKCA
PRKCD
PRKCE
RAC1
RNF167
RPS6KB1
S100A1
S100A4
SCIN
SMTN
SNCA
SORBS1
SPRR1A
SPTA1
SPTAN1
SPTBN2
TAGLN
TJP1
TLN1
TMSB4X
TMSB4Y
TNNI1
TNNI3
TNNI3K
TP53
TPM2
TPM3
TRIM55
TRIM63
TTN
UBC
USP25
USP6NL
UTRN
VASP
VAV1
VCL
VIL1
XIRP1
24 interacting genes:
ACTA1
ACTR2
ACTR3
BLZF1
CASP3
CD79A
CSNK2A1
FGR
GRB2
HAX1
HS1BP3
IKBKG
LYN
LZTR1
MAP4K1
QKI
SH2D4A
SH3BP2
SSBP3
SYK
TERF1
TRIM29
WAS
ZBTB25
Entrez ID
58
3059
HPRD ID
00030
03199
Ensembl ID
ENSG00000143632
ENSG00000180353
Uniprot IDs
P68133
P14317
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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