GSN and VCL

Data Source:
HPRD (in vivo)

		GSN	VCL
Description		gelsolin	vinculin
Image
GO Annotations	Cellular Component	Ruffle Podosome Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Lamellipodium Actin Cap Cortical Actin Cytoskeleton Protein-containing Complex Secretory Granule Lumen Myelin Sheath Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Podosome Extracellular Region Cytosol Cytoskeleton Cell-cell Junction Adherens Junction Fascia Adherens Focal Adhesion Cell-substrate Junction Protein-containing Complex Secretory Granule Lumen Specific Granule Lumen Sarcolemma Costamere Cell-cell Contact Zone Extracellular Exosome Extracellular Vesicle Ficolin-1-rich Granule Lumen
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol 3-kinase Catalytic Subunit Binding Myosin II Binding Actin Filament Binding	Dystroglycan Binding Actin Binding Structural Molecule Activity Protein Binding Beta-catenin Binding Ubiquitin Protein Ligase Binding Alpha-catenin Binding Cadherin Binding
	Biological Process	Phagocytosis, Engulfment Central Nervous System Development Aging Actin Polymerization Or Depolymerization Positive Regulation Of Gene Expression Oligodendrocyte Development Striated Muscle Atrophy Extracellular Matrix Disassembly Cell Projection Assembly Actin Filament Polymerization Actin Filament Depolymerization Regulation Of Cell Adhesion Protein Destabilization Response To Muscle Stretch Wound Healing Tissue Regeneration Sequestering Of Actin Monomers Neutrophil Degranulation Cellular Protein Metabolic Process Actin Nucleation Response To Ethanol Negative Regulation Of Viral Entry Into Host Cell Phosphatidylinositol-mediated Signaling Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Response To Folic Acid Actin Filament Capping Relaxation Of Cardiac Muscle Cilium Assembly Cellular Response To Cadmium Ion Cellular Response To Interferon-gamma Regulation Of Podosome Assembly Cardiac Muscle Cell Contraction Actin Filament Reorganization Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Morphogenesis Of An Epithelium Platelet Degranulation Muscle Contraction Cell Adhesion Cell-matrix Adhesion Lamellipodium Assembly Negative Regulation Of Cell Migration Adherens Junction Assembly Protein Localization To Cell Surface Maintenance Of Blood-brain Barrier Apical Junction Assembly Neutrophil Degranulation Axon Extension Regulation Of Focal Adhesion Assembly Platelet Aggregation Epithelial Cell-cell Adhesion Regulation Of Establishment Of Endothelial Barrier Regulation Of Protein Localization To Adherens Junction
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Amyloid fiber formation	Platelet degranulation Smooth Muscle Contraction MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		Zinc Latrunculin A Copper Zinc acetate
Diseases		Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis
GWAS		Blood protein levels ( 30072576)	Cardiac troponin-I levels ( 31014085) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Left ventricular internal dimension in diastole ( 29403010) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278)
Interacting Genes		24 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK ERBB2 FHIT FN1 LIMK2 PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1	38 interacting genes: ABI2 ACTA1 ACTN1 BCAR1 BIRC6 BRME1 CDH1 CLTC CORO2B CTNNA1 ENOX2 GSN ITGA5 LINC01554 LPXN NEBL NRAP PKD1 POMP PRKCA PRPF40A PSME1 PTK2 PXN RAVER1 SAPCD2 SELE SORBS1 SORBS2 SORBS3 SRC TEKT1 TGFB1I1 TLN1 TRIM15 TRIP6 TUBA1A VASP
Entrez ID		2934	7414
HPRD ID		00674	01900
Ensembl ID		ENSG00000148180	ENSG00000035403
Uniprot IDs		A0A0A0MS51 A0A0A0MT01 A0A384MEF1 B7Z4U6 P06396	A0A024QZN4 B3KXA2 P18206 V9HWK2
PDB IDs		1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5DD2 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6LJE 6LJF 6Q9R 6Q9Z 6QBF 6QW3	1RKC 1RKE 1SYQ 1TR2 1YDI 2GWW 2HSQ 2IBF 3H2U 3H2V 3JBK 3MYI 3RF3 3S90 3TJ5 3TJ6 3VF0 4DJ9 4EHP 4LN2 4LNP 4PR9 5L0C 5L0D 5L0F 5L0G 5L0H 5L0I 5L0J 5O2Q 6FUY 6UPW
Enriched GO Terms of Interacting Partners?
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