GSN and VDAC1

Data Source:
HPRD (in vivo, in vitro)

		GSN	VDAC1
Description		gelsolin	voltage dependent anion channel 1
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GO Annotations	Cellular Component	Ruffle Podosome Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Lamellipodium Actin Cap Cortical Actin Cytoskeleton Protein-containing Complex Secretory Granule Lumen Myelin Sheath Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Nucleus Mitochondrion Mitochondrial Outer Membrane Mitochondrial Permeability Transition Pore Complex Plasma Membrane Synaptic Vesicle Membrane Mitochondrial Membrane Mitochondrial Nucleoid Membrane Raft Pore Complex Extracellular Exosome
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol 3-kinase Catalytic Subunit Binding Myosin II Binding Actin Filament Binding	Protein Binding Voltage-gated Anion Channel Activity Porin Activity Cholesterol Binding Protein Kinase Binding Phosphatidylcholine Binding Identical Protein Binding Ion Channel Binding Protein-containing Complex Binding Ceramide Binding
	Biological Process	Phagocytosis, Engulfment Central Nervous System Development Aging Actin Polymerization Or Depolymerization Positive Regulation Of Gene Expression Oligodendrocyte Development Striated Muscle Atrophy Extracellular Matrix Disassembly Cell Projection Assembly Actin Filament Polymerization Actin Filament Depolymerization Regulation Of Cell Adhesion Protein Destabilization Response To Muscle Stretch Wound Healing Tissue Regeneration Sequestering Of Actin Monomers Neutrophil Degranulation Cellular Protein Metabolic Process Actin Nucleation Response To Ethanol Negative Regulation Of Viral Entry Into Host Cell Phosphatidylinositol-mediated Signaling Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Response To Folic Acid Actin Filament Capping Relaxation Of Cardiac Muscle Cilium Assembly Cellular Response To Cadmium Ion Cellular Response To Interferon-gamma Regulation Of Podosome Assembly Cardiac Muscle Cell Contraction Actin Filament Reorganization Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Behavioral Fear Response Pyruvate Metabolic Process Anion Transport Mitochondrial Calcium Ion Transmembrane Transport Apoptotic Process Neuron-neuron Synaptic Transmission Learning Inorganic Anion Transport Viral Process Macroautophagy Epithelial Cell Differentiation Negative Regulation Of Apoptotic Process Anion Transmembrane Transport Negative Regulation Of Calcium Import Into The Mitochondrion Positive Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Amyloid fiber formation	Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases Pyruvate metabolism Mitochondrial calcium ion transport
Drugs		Zinc Latrunculin A Copper Zinc acetate	Aluminium monostearate Cannabidiol Medical Cannabis Nabiximols
Diseases		Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis
GWAS		Blood protein levels ( 30072576)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Systemic lupus erythematosus ( 28714469) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		24 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK ERBB2 FHIT FN1 LIMK2 PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1	24 interacting genes: ADRB2 BAK1 BAX BCL2L1 BCL2L11 CKMT1A CKMT1B CSNK2B DUX4 DYNLT1 DYNLT3 GSN HK1 KLHL40 MCL1 PLAT PPIF PRKCE PRKN RAF1 RNF31 SUMO4 TOMM20 TUBA4A
Entrez ID		2934	7416
HPRD ID		00674	05137
Ensembl ID		ENSG00000148180	ENSG00000213585
Uniprot IDs		A0A0A0MS51 A0A0A0MT01 A0A384MEF1 B7Z4U6 P06396	A0A1L1UHR1 B3KTS5 P21796
PDB IDs		1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5DD2 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6LJE 6LJF 6Q9R 6Q9Z 6QBF 6QW3	2JK4 2K4T 5JDP 5XDN 5XDO 6G6U 6G73 6TIQ 6TIR
Enriched GO Terms of Interacting Partners?
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