ACTA1 and SCIN

Data Source:
BioGRID (pull down)

		ACTA1	SCIN
Description		actin alpha 1, skeletal muscle	scinderin
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Space Cytosol Striated Muscle Thin Filament Dynactin Complex Actin Filament Actin Cytoskeleton Sarcomere Lamellipodium Filopodium Cell Body Extracellular Exosome Blood Microparticle	Podosome Cytoplasm Plasma Membrane Cell Cortex Actin Cytoskeleton Cell Junction Protein-containing Complex Cell Projection Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding ATP Binding Myosin Binding ADP Binding	Phosphatidylserine Binding Actin Binding Calcium Ion Binding 1-phosphatidylinositol Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Muscle Contraction Response To Mechanical Stimulus Response To Extracellular Stimulus Response To Lithium Ion Positive Regulation Of Gene Expression Muscle Filament Sliding Skeletal Muscle Thin Filament Assembly Skeletal Muscle Fiber Adaptation Response To Steroid Hormone Skeletal Muscle Fiber Development Cellular Response To Organonitrogen Compound Mesenchyme Migration	Central Nervous System Development Actin Polymerization Or Depolymerization Negative Regulation Of Cell Population Proliferation Calcium-ion Regulated Exocytosis Cell Projection Assembly Regulation Of Chondrocyte Differentiation Sequestering Of Actin Monomers Positive Regulation Of Apoptotic Process Actin Nucleation Positive Regulation Of Megakaryocyte Differentiation Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Secretion Positive Regulation Of Actin Nucleation Actin Filament Capping
Pathways		Striated Muscle Contraction
Drugs		Latrunculin A Sucrose Ulapualide A Kabiramide C Jaspisamide A Tmr 1-Methylhistidine Phosphoaminophosphonic Acid-Adenylate Ester Aplyronine A Reidispongiolide A Reidispongiolide C Sphinxolide B Latrunculin B
Diseases		Congenital fiber type disproportion (CFTD) Cap myopathy Nemaline myopathy
GWAS			Height ( 31562340) Metabolite levels ( 23823483) Small cell lung carcinoma ( 28604730)
Interacting Genes		114 interacting genes: ABL1 ABRA ACTR10 ACTR1B ADSS2 AFAP1 AIF1 AJUBA AMOT ANXA2 BIN1 CCIN CCT2 CCT4 CCT5 CFL1 CLIC5 CNN1 CORO2B COTL1 CTNND1 CTTN CYFIP1 CYTH1 DHX9 DLG1 DMD DNASE1 DNMBP DTNA DUX4L9 EGFR EPB41 EPB41L2 EPS8 FGD4 FHOD1 FSCN1 GAS2 GAS7 GC GSN HCLS1 HDAC4 HIP1R HSPB2 HTRA2 IQGAP1 ITGA2 ITPKA KIF23 KLHL20 LASP1 MACF1 MAP1A MAPT MIB2 MINPP1 MYL1 MYLK MYO10 MYO6 MYO7A MYO9B NEXN NR3C2 NRAP PAK1 PARVA PCYT1B PFDN1 PFN1 PHACTR1 PLD1 PPP1R9B PRKCA PRKCD PRKCE RAC1 RNF167 RPS6KB1 S100A1 S100A4 SCIN SMTN SNCA SORBS1 SPRR1A SPTA1 SPTAN1 SPTBN2 TAGLN TJP1 TLN1 TMSB4X TMSB4Y TNNI1 TNNI3 TNNI3K TP53 TPM2 TPM3 TRIM55 TRIM63 TTN UBC USP25 USP6NL UTRN VASP VAV1 VCL VIL1 XIRP1	3 interacting genes: ACTA1 ACTC1 ACTG1
Entrez ID		58	85477
HPRD ID		00030	11539
Ensembl ID		ENSG00000143632	ENSG00000006747
Uniprot IDs		P68133	Q9Y6U3
PDB IDs			3FG6 5A1K 5A1M
Enriched GO Terms of Interacting Partners?
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