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GSN and ERBB2
Data Source:
BioGRID
(two hybrid)
GSN
ERBB2
Description
gelsolin
erb-b2 receptor tyrosine kinase 2
Image
GO Annotations
Cellular Component
Ruffle
Podosome
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Sarcoplasm
Lamellipodium
Actin Cap
Cortical Actin Cytoskeleton
Protein-containing Complex
Secretory Granule Lumen
Myelin Sheath
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Nucleus
Early Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
ERBB3:ERBB2 Complex
Myelin Sheath
Receptor Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Actin Binding
Calcium Ion Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Phosphatidylinositol 3-kinase Catalytic Subunit Binding
Myosin II Binding
Actin Filament Binding
RNA Polymerase I Core Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Growth Factor Binding
Protein Phosphatase Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Biological Process
Phagocytosis, Engulfment
Central Nervous System Development
Aging
Actin Polymerization Or Depolymerization
Positive Regulation Of Gene Expression
Oligodendrocyte Development
Striated Muscle Atrophy
Extracellular Matrix Disassembly
Cell Projection Assembly
Actin Filament Polymerization
Actin Filament Depolymerization
Regulation Of Cell Adhesion
Protein Destabilization
Response To Muscle Stretch
Wound Healing
Tissue Regeneration
Sequestering Of Actin Monomers
Neutrophil Degranulation
Cellular Protein Metabolic Process
Actin Nucleation
Response To Ethanol
Negative Regulation Of Viral Entry Into Host Cell
Phosphatidylinositol-mediated Signaling
Actin Filament Severing
Barbed-end Actin Filament Capping
Positive Regulation Of Actin Nucleation
Response To Folic Acid
Actin Filament Capping
Relaxation Of Cardiac Muscle
Cilium Assembly
Cellular Response To Cadmium Ion
Cellular Response To Interferon-gamma
Regulation Of Podosome Assembly
Cardiac Muscle Cell Contraction
Actin Filament Reorganization
Renal Protein Absorption
Hepatocyte Apoptotic Process
Positive Regulation Of Keratinocyte Apoptotic Process
Regulation Of Establishment Of T Cell Polarity
Regulation Of Plasma Membrane Raft Polarization
Regulation Of Receptor Clustering
Positive Regulation Of Protein Processing In Phagocytic Vesicle
Amyloid Fibril Formation
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Peripheral Nervous System Development
Heart Development
Neuromuscular Junction Development
Motor Neuron Axon Guidance
Positive Regulation Of Cell Population Proliferation
Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Positive Regulation Of Cell Growth
Regulation Of Microtubule-based Process
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Kinase Activity
Intracellular Signal Transduction
ERBB2 Signaling Pathway
Wound Healing
Myelination
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of GTPase Activity
Positive Regulation Of Translation
Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase I
Protein Autophosphorylation
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Kinase B Signaling
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Protein Targeting To Membrane
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Cell Motility
Pathways
Caspase-mediated cleavage of cytoskeletal proteins
Neutrophil degranulation
Amyloid fiber formation
Signaling by ERBB2
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Drugs
Zinc
Latrunculin A
Copper
Zinc acetate
Trastuzumab
Lapatinib
IGN311
Trastuzumab emtansine
Varlitinib
AV-412
Pertuzumab
Afatinib
Tucatinib
Tesevatinib
Fostamatinib
Brigatinib
Margetuximab
Zanubrutinib
Diseases
Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome
Familial amyloidosis
Choriocarcinoma
Pancreatic cancer
Gastric cancer
Bladder cancer
Endometrial Cancer
Ovarian cancer
Cholangiocarcinoma
Breast cancer
Cervical cancer
GWAS
Blood protein levels (
30072576
)
Adult asthma (
30787307
)
Asthma (
31619474
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
27329760
)
Estimated glomerular filtration rate (
31451708
)
Pancreatic ductal adenocarcinoma (
30541042
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
26502338
28714469
)
Ulcerative colitis (
20228799
)
Interacting Genes
24 interacting genes:
ACTA1
ACTB
ACTG1
ACTN4
APP
AR
BCAR1
CASP3
CLIC5
CSK
ERBB2
FHIT
FN1
LIMK2
PIK3CG
PLCG1
PTK2B
PXN
STK39
TNIK
TOM1L1
VASP
VCL
VDAC1
350 interacting genes:
AATK
ABCB5
ABL1
ABL2
ACP1
ACP3
ADGRB1
AIP
AKAP12
AKT1
ALDOA
ALDOC
ALK
ANKS1A
ANKS1B
ANXA6
AP3B2
APBB1
APBB3
APLP1
ARF1
ARF5
ARNT
ASRGL1
ATP6AP1
ATP6V0C
AURKA
BAAT
BCAR3
BECN1
BLK
BLNK
BMX
BNIP1
BTC
CACYBP
CALM1
CAV1
CBLC
CBR1
CCDC180
CCND2
CCT3
CD44
CD82
CDK4
CDK6
CDK8
CDKN2B
CDKN2C
CEND1
CFAP298
CFL1
CHN1
CISH
CKB
CLASP2
CLCN6
CLNK
COL9A2
COL9A3
CRIP2
CRK
CRKL
CSDE1
CTNNB1
CXCL8
CYLC2
CYP17A1
DAB1
DDR1
DLG4
DOK1
DOK4
DOK6
DST
DUSP14
DUSP18
DUSP19
EGF
EGFR
EPHA1
EPHA2
EPHA3
EPHA4
EPHA5
EPHB1
EPHB2
EPHB3
EPHB6
ERBB3
ERBB4
ERBIN
ERG28
ERRFI1
ESR1
FAM241B
FBP1
FBXO7
FER
FES
FGFR1
FGFR2
FGFR3
FGFR4
FGR
FKBP1A
FKBP3
FKBP8
FLNB
FLT3
FLT4
FRAT2
FZR1
GAB1
GABARAPL1
GABARAPL2
GAPDH
GLCE
GLIS2
GLRX3
GMPR2
GPM6B
GRAP2
GRB10
GRB14
GRB2
GRB7
GRK2
GRM1
GSN
HCK
HDAC6
HDLBP
HGF
HLA-A
HRAS
HSD17B3
HSH2D
HSP90AA1
HSP90B1
HSPA1A
HSPA5
HSPA9
HSPD1
IARS1
IGF1R
IL13RA2
IL6ST
ILF3
ILKAP
INPPL1
INSR
INSRR
IRF2BP2
IRS1
IRS4
ITGA5
ITGB4
ITK
ITPKA
ITPR1
JAK1
JAK2
JMJD4
JUP
KCTD6
KDELR2
KLC1
KLK5
LATS2
LCK
LCP2
LGALS8
LPCAT4
LRRC7
LYN
LYPD3
MAP2K1
MAP2K3
MAP2K5
MAPK8IP1
MAPK8IP2
MATK
MDH1
MEPCE
MERTK
MET
MSN
MST1R
MTCH1
MUC1
MUC4
MUCL1
MYC
MYO9A
NAT2
NCK1
NCK2
NEFH
NF2
NINL
NRG1
NTRK1
NTRK2
NTRK3
NUDT16L1
ODF2L
PABPC1
PAK1
PDCD11
PDGFRA
PDGFRB
PEBP1
PGAM1
PHF23
PICK1
PIK3C2A
PIK3C2B
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
POLD2
POU6F1
PPA1
PPM1A
PPM1F
PRDM14
PRDX5
PSAP
PSMA1
PSMC3
PSMC3IP
PSMD3
PTGES3L-AARSD1
PTK2
PTK2B
PTK6
PTK7
PTPN11
PTPN18
PTPN6
PTPRR
PTPRT
PTPRU
RAB5C
RAF1
RASA1
RASSF1
RBM15B
RET
RHBDD2
RHOBTB2
RIN1
RIN2
ROR2
RPRML
RTN4
S100A11
SAFB2
SELENOK
SERPINA3
SFRP4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH2D5
SH3BGRL3
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SLC7A4
SMAD1
SMIM20
SMPD4
SNAP91
SOCS1
SOCS3
SOCS5
SOCS6
SOS1
SPP1
SRC
SRPK1
STAP1
STAT3
STIP1
STK11
STK24
STMN1
STMN2
STUB1
STYK1
STYX
SUPT6H
SYK
SYNM
TCEAL2
TEC
TGFA
TGFB1
THRSP
TLN1
TMA7
TMEM134
TMEM230
TNS1
TNS2
TNS3
TOB1
TP53
TRIP6
TRMO
TSEN15
TTC9B
TTYH2
TVP23B
TXK
TXN
TYMP
TYRO3
UBB
USP2
UTP18
VAPA
VAV1
VAV2
VAV3
YES1
YWHAZ
ZAP70
ZFAND1
ZMAT2
ZMYND8
ZNF189
ZNF532
Entrez ID
2934
2064
HPRD ID
00674
01281
Ensembl ID
ENSG00000148180
ENSG00000141736
Uniprot IDs
A0A0A0MS51
A0A0A0MT01
A0A384MEF1
B7Z4U6
P06396
F5H1T4
J3QLU9
P04626
X5DNK3
PDB IDs
1C0F
1C0G
1D4X
1DEJ
1EQY
1ESV
1H1V
1KCQ
1MDU
1NLV
1NM1
1NMD
1P8X
1P8Z
1SOL
1T44
1YAG
1YVN
2FF3
2FF6
2FH1
2FH2
2FH3
2FH4
3A5L
3A5M
3A5N
3A5O
3CI5
3CIP
3CJB
3CJC
3FFK
3FFN
3TU5
4PKG
4PKH
4PKI
4S10
4Z94
5DD2
5FAE
5FAF
5H3M
5H3N
5O2Z
5UBO
5ZZ0
6H1F
6JCO
6JEG
6JEH
6LJE
6LJF
6Q9R
6Q9Z
6QBF
6QW3
1MFG
1MFL
1MW4
1N8Z
1OVC
1QR1
1S78
2A91
2JWA
2KS1
2L4K
2N2A
3BE1
3H3B
3MZW
3N85
3PP0
3RCD
3WLW
3WSQ
4GFU
4HRL
4HRM
4HRN
5K33
5KWG
5MY6
5O4G
5OB4
5TQS
6ATT
6BGT
6J71
6OGE
Enriched GO Terms of Interacting Partners
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