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GSN and PXN
Data Source:
HPRD
(in vivo)
GSN
PXN
Description
gelsolin
paxillin
Image
GO Annotations
Cellular Component
Ruffle
Podosome
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Sarcoplasm
Lamellipodium
Actin Cap
Cortical Actin Cytoskeleton
Protein-containing Complex
Secretory Granule Lumen
Myelin Sheath
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Stress Fiber
Cytosol
Microtubule Associated Complex
Plasma Membrane
Cell-cell Junction
Focal Adhesion
Cell Cortex
Lamellipodium
Molecular Function
Actin Binding
Calcium Ion Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Phosphatidylinositol 3-kinase Catalytic Subunit Binding
Myosin II Binding
Actin Filament Binding
Transcription Coregulator Activity
Protein Binding
Beta-catenin Binding
Vinculin Binding
Protein Phosphatase Binding
Neuropilin Binding
Metal Ion Binding
Biological Process
Phagocytosis, Engulfment
Central Nervous System Development
Aging
Actin Polymerization Or Depolymerization
Positive Regulation Of Gene Expression
Oligodendrocyte Development
Striated Muscle Atrophy
Extracellular Matrix Disassembly
Cell Projection Assembly
Actin Filament Polymerization
Actin Filament Depolymerization
Regulation Of Cell Adhesion
Protein Destabilization
Response To Muscle Stretch
Wound Healing
Tissue Regeneration
Sequestering Of Actin Monomers
Neutrophil Degranulation
Cellular Protein Metabolic Process
Actin Nucleation
Response To Ethanol
Negative Regulation Of Viral Entry Into Host Cell
Phosphatidylinositol-mediated Signaling
Actin Filament Severing
Barbed-end Actin Filament Capping
Positive Regulation Of Actin Nucleation
Response To Folic Acid
Actin Filament Capping
Relaxation Of Cardiac Muscle
Cilium Assembly
Cellular Response To Cadmium Ion
Cellular Response To Interferon-gamma
Regulation Of Podosome Assembly
Cardiac Muscle Cell Contraction
Actin Filament Reorganization
Renal Protein Absorption
Hepatocyte Apoptotic Process
Positive Regulation Of Keratinocyte Apoptotic Process
Regulation Of Establishment Of T Cell Polarity
Regulation Of Plasma Membrane Raft Polarization
Regulation Of Receptor Clustering
Positive Regulation Of Protein Processing In Phagocytic Vesicle
Amyloid Fibril Formation
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Regulation Of Transcription, DNA-templated
Muscle Contraction
Cell Adhesion
Cell-matrix Adhesion
Signal Transduction
Signal Complex Assembly
Transforming Growth Factor Beta Receptor Signaling Pathway
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Reactive Oxygen Species
Endothelial Cell Migration
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Stress Fiber Assembly
Growth Hormone Receptor Signaling Pathway
Pathways
Caspase-mediated cleavage of cytoskeletal proteins
Neutrophil degranulation
Amyloid fiber formation
GAB1 signalosome
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Zinc
Latrunculin A
Copper
Zinc acetate
Diseases
Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome
Familial amyloidosis
GWAS
Blood protein levels (
30072576
)
Bipolar disorder (
31043756
)
Mean spheric corpuscular volume (
32888494
)
Platelet count (
29403010
)
Interacting Genes
24 interacting genes:
ACTA1
ACTB
ACTG1
ACTN4
APP
AR
BCAR1
CASP3
CLIC5
CSK
ERBB2
FHIT
FN1
LIMK2
PIK3CG
PLCG1
PTK2B
PXN
STK39
TNIK
TOM1L1
VASP
VCL
VDAC1
87 interacting genes:
ABL1
ACO1
AHCY
AR
ARHGEF7
ASAP1
ASAP2
BCAR1
BCL2
BLK
CASP3
CEACAM1
CLTC
CREB3L2
CRK
CRKL
CSK
DGUOK
DPY30
EPHB1
FYN
GART
GIT1
GIT2
GRB2
GSK3A
GSK3B
GSN
HDAC6
ILK
ITGA4
ITGA6
ITGA9
ITGAV
ITGB1
ITGB3
LCK
LIMK1
LMO1
LMO3
MAPK1
MAPK3
MAPK8
MATK
NCK1
NEDD9
NF2
PABPC1
PAK1
PAK3
PARVA
PDPK1
PKD1
PLEKHH2
PLEKHN1
POLR1D
PPP2CA
PPP2R5C
PTEN
PTK2
PTK2B
PTPN11
PTPN12
PTPRH
RASA1
REPS2
RHOU
RNF5
SDC4
SELE
SH3RF1
SORBS1
SRC
SYK
TCEANC
TGM2
TLN1
TRIM15
TRIP6
TUBA1B
TUBA3C
TUBA8
TUBG1
TUBG2
VCL
WHRN
YES1
Entrez ID
2934
5829
HPRD ID
00674
03937
Ensembl ID
ENSG00000148180
ENSG00000089159
Uniprot IDs
A0A0A0MS51
A0A0A0MT01
A0A384MEF1
B7Z4U6
P06396
A0A140VJQ8
P49023
PDB IDs
1C0F
1C0G
1D4X
1DEJ
1EQY
1ESV
1H1V
1KCQ
1MDU
1NLV
1NM1
1NMD
1P8X
1P8Z
1SOL
1T44
1YAG
1YVN
2FF3
2FF6
2FH1
2FH2
2FH3
2FH4
3A5L
3A5M
3A5N
3A5O
3CI5
3CIP
3CJB
3CJC
3FFK
3FFN
3TU5
4PKG
4PKH
4PKI
4S10
4Z94
5DD2
5FAE
5FAF
5H3M
5H3N
5O2Z
5UBO
5ZZ0
6H1F
6JCO
6JEG
6JEH
6LJE
6LJF
6Q9R
6Q9Z
6QBF
6QW3
1KKY
1KL0
1OW6
1OW7
1OW8
2K2R
2O9V
2VZD
2VZG
2VZI
3GM1
3PY7
3RQE
3RQF
3RQG
3U3F
4EDN
4R32
4XGZ
4XH2
5UWH
6IUI
6PW8
6U4M
6U4N
Enriched GO Terms of Interacting Partners
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