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GSN and PTK2B
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
HPRD
(two hybrid, in vitro, in vivo)
GSN
PTK2B
Description
gelsolin
protein tyrosine kinase 2 beta
Image
GO Annotations
Cellular Component
Ruffle
Podosome
Extracellular Region
Extracellular Space
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Actin Cytoskeleton
Sarcoplasm
Lamellipodium
Actin Cap
Cortical Actin Cytoskeleton
Protein-containing Complex
Secretory Granule Lumen
Myelin Sheath
Phagocytic Vesicle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Blood Microparticle
Ficolin-1-rich Granule Lumen
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Focal Adhesion
Cell Cortex
Postsynaptic Density
NMDA Selective Glutamate Receptor Complex
Lamellipodium
Dendrite
Growth Cone
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Neuronal Cell Body
Dendritic Spine
Cell Body
Membrane Raft
Perinuclear Region Of Cytoplasm
Apical Dendrite
Glutamatergic Synapse
Molecular Function
Actin Binding
Calcium Ion Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Phosphatidylinositol 3-kinase Catalytic Subunit Binding
Myosin II Binding
Actin Filament Binding
Calmodulin-dependent Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
NMDA Glutamate Receptor Activity
Signaling Receptor Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Ubiquitin Protein Ligase Binding
3-phosphoinositide-dependent Protein Kinase Binding
Protein-containing Complex Binding
Biological Process
Phagocytosis, Engulfment
Central Nervous System Development
Aging
Actin Polymerization Or Depolymerization
Positive Regulation Of Gene Expression
Oligodendrocyte Development
Striated Muscle Atrophy
Extracellular Matrix Disassembly
Cell Projection Assembly
Actin Filament Polymerization
Actin Filament Depolymerization
Regulation Of Cell Adhesion
Protein Destabilization
Response To Muscle Stretch
Wound Healing
Tissue Regeneration
Sequestering Of Actin Monomers
Neutrophil Degranulation
Cellular Protein Metabolic Process
Actin Nucleation
Response To Ethanol
Negative Regulation Of Viral Entry Into Host Cell
Phosphatidylinositol-mediated Signaling
Actin Filament Severing
Barbed-end Actin Filament Capping
Positive Regulation Of Actin Nucleation
Response To Folic Acid
Actin Filament Capping
Relaxation Of Cardiac Muscle
Cilium Assembly
Cellular Response To Cadmium Ion
Cellular Response To Interferon-gamma
Regulation Of Podosome Assembly
Cardiac Muscle Cell Contraction
Actin Filament Reorganization
Renal Protein Absorption
Hepatocyte Apoptotic Process
Positive Regulation Of Keratinocyte Apoptotic Process
Regulation Of Establishment Of T Cell Polarity
Regulation Of Plasma Membrane Raft Polarization
Regulation Of Receptor Clustering
Positive Regulation Of Protein Processing In Phagocytic Vesicle
Amyloid Fibril Formation
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
MAPK Cascade
Angiogenesis
Oocyte Maturation
Response To Hypoxia
Positive Regulation Of Cell-matrix Adhesion
Sprouting Angiogenesis
Adaptive Immune Response
Marginal Zone B Cell Differentiation
Protein Phosphorylation
Apoptotic Process
Cellular Defense Response
Response To Osmotic Stress
Signal Transduction
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Signal Complex Assembly
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Response To Mechanical Stimulus
Response To Hormone
Response To Glucose
Response To Lithium Ion
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Muscle Cell Apoptotic Process
Regulation Of CGMP-mediated Signaling
Regulation Of Macrophage Chemotaxis
Positive Regulation Of Neuron Projection Development
Glial Cell Proliferation
Peptidyl-tyrosine Phosphorylation
Cell Differentiation
Regulation Of Cell Adhesion
Positive Regulation Of Cell Growth
Positive Regulation Of Cell Migration
Negative Regulation Of Bone Mineralization
Positive Regulation Of Actin Filament Polymerization
Neuron Projection Development
Regulation Of Inositol Trisphosphate Biosynthetic Process
Tumor Necrosis Factor-mediated Signaling Pathway
Ionotropic Glutamate Receptor Signaling Pathway
Response To Immobilization Stress
Peptidyl-tyrosine Autophosphorylation
Interleukin-2-mediated Signaling Pathway
Response To Cocaine
Response To Drug
Response To Hydrogen Peroxide
Activation Of Janus Kinase Activity
Negative Regulation Of Apoptotic Process
Stress Fiber Assembly
Negative Regulation Of Potassium Ion Transport
Positive Regulation Of JUN Kinase Activity
Negative Regulation Of Neuron Apoptotic Process
Blood Vessel Endothelial Cell Migration
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Nitric Oxide Biosynthetic Process
Bone Resorption
Response To Ethanol
Negative Regulation Of Myeloid Cell Differentiation
Positive Regulation Of Translation
Positive Regulation Of Angiogenesis
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Focal Adhesion Assembly
Regulation Of Synaptic Plasticity
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Calcium-mediated Signaling
Positive Regulation Of Nitric-oxide Synthase Activity
Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Response To CAMP
Response To Calcium Ion
Positive Regulation Of Synaptic Transmission, Glutamatergic
Long-term Synaptic Potentiation
Long-term Synaptic Depression
Protein-containing Complex Assembly
Chemokine-mediated Signaling Pathway
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Fluid Shear Stress
Endothelin Receptor Signaling Pathway
Activation Of GTPase Activity
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Establishment Of Cell Polarity
Regulation Of Actin Cytoskeleton Reorganization
Regulation Of NMDA Receptor Activity
Positive Regulation Of Excitatory Postsynaptic Potential
Positive Regulation Of B Cell Chemotaxis
Positive Regulation Of DNA Biosynthetic Process
Pathways
Caspase-mediated cleavage of cytoskeletal proteins
Neutrophil degranulation
Amyloid fiber formation
Signal regulatory protein family interactions
VEGFA-VEGFR2 Pathway
Interleukin-2 signaling
Drugs
Zinc
Latrunculin A
Copper
Zinc acetate
Leflunomide
Genistein
4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Baricitinib
Fostamatinib
Diseases
Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome
Familial amyloidosis
GWAS
Blood protein levels (
30072576
)
Adult body size (
32376654
)
Alzheimer's disease (
31473137
)
Alzheimer's disease (late onset) (
30617256
24162737
)
Alzheimer's disease in APOE e4- carriers (
25778476
)
Alzheimer's disease or family history of Alzheimer's disease (
30617256
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bone mineral content (
31790847
)
Bone mineral density (
31790847
)
Crohn's disease (
26192919
)
Dental caries (
23259602
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Family history of Alzheimer's disease (
30617256
)
Inflammatory bowel disease (
26192919
)
Schizophrenia (
29483656
)
Takayasu arteritis (
25604533
30498034
)
White blood cell count (
32888494
)
Interacting Genes
24 interacting genes:
ACTA1
ACTB
ACTG1
ACTN4
APP
AR
BCAR1
CASP3
CLIC5
CSK
ERBB2
FHIT
FN1
LIMK2
PIK3CG
PLCG1
PTK2B
PXN
STK39
TNIK
TOM1L1
VASP
VCL
VDAC1
69 interacting genes:
ARHGAP21
ARHGAP5
ASAP1
ASAP2
BCAR1
CBL
CCR5
CRK
DLG3
DLG4
DLGAP3
EFS
EGFR
ERBB2
ERBB3
EWSR1
FGFR2
FGFR3
FLT1
FYN
GNA13
GRB2
GRIN2A
GSN
IL7R
ITGB2
ITGB3
JAK1
JAK2
JAK3
KCNA2
LCK
LPXN
LYN
MAP3K4
MAPT
MATK
MCAM
MYH2
NEDD9
NPHP1
PDCD6IP
PDPK1
PIK3R1
PITPNM1
PITPNM2
PITPNM3
PRKCD
PTK2
PTPN11
PTPN12
PTPN6
PXN
RASA1
RB1CC1
SH2D3C
SHC1
SKAP2
SLC2A1
SNCA
SORBS2
SRC
STAP1
STAT3
SYK
TGFB1I1
TLN1
VAV1
ZAP70
Entrez ID
2934
2185
HPRD ID
00674
03131
Ensembl ID
ENSG00000148180
ENSG00000120899
Uniprot IDs
A0A0A0MS51
A0A0A0MT01
A0A384MEF1
B7Z4U6
P06396
Q14289
PDB IDs
1C0F
1C0G
1D4X
1DEJ
1EQY
1ESV
1H1V
1KCQ
1MDU
1NLV
1NM1
1NMD
1P8X
1P8Z
1SOL
1T44
1YAG
1YVN
2FF3
2FF6
2FH1
2FH2
2FH3
2FH4
3A5L
3A5M
3A5N
3A5O
3CI5
3CIP
3CJB
3CJC
3FFK
3FFN
3TU5
4PKG
4PKH
4PKI
4S10
4Z94
5DD2
5FAE
5FAF
5H3M
5H3N
5O2Z
5UBO
5ZZ0
6H1F
6JCO
6JEG
6JEH
6LJE
6LJF
6Q9R
6Q9Z
6QBF
6QW3
2FO6
2LK4
3CC6
3ET7
3FZO
3FZP
3FZR
3FZS
3FZT
3GM1
3GM2
3GM3
3H3C
3U3F
4EKU
4H1J
4H1M
4R32
4XEF
4XEK
4XEV
5TO8
5TOB
6LF3
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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