GSN and VASP

Data Source:
HPRD (in vitro)

		GSN	VASP
Description		gelsolin	vasodilator stimulated phosphoprotein
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GO Annotations	Cellular Component	Ruffle Podosome Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Lamellipodium Actin Cap Cortical Actin Cytoskeleton Protein-containing Complex Secretory Granule Lumen Myelin Sheath Phagocytic Vesicle Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen	Cytosol Plasma Membrane Bicellular Tight Junction Focal Adhesion Actin Cytoskeleton Lamellipodium Membrane Filopodium Membrane Extracellular Exosome
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol 3-kinase Catalytic Subunit Binding Myosin II Binding Actin Filament Binding	Actin Binding Protein Binding Profilin Binding SH3 Domain Binding Cadherin Binding
	Biological Process	Phagocytosis, Engulfment Central Nervous System Development Aging Actin Polymerization Or Depolymerization Positive Regulation Of Gene Expression Oligodendrocyte Development Striated Muscle Atrophy Extracellular Matrix Disassembly Cell Projection Assembly Actin Filament Polymerization Actin Filament Depolymerization Regulation Of Cell Adhesion Protein Destabilization Response To Muscle Stretch Wound Healing Tissue Regeneration Sequestering Of Actin Monomers Neutrophil Degranulation Cellular Protein Metabolic Process Actin Nucleation Response To Ethanol Negative Regulation Of Viral Entry Into Host Cell Phosphatidylinositol-mediated Signaling Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Response To Folic Acid Actin Filament Capping Relaxation Of Cardiac Muscle Cilium Assembly Cellular Response To Cadmium Ion Cellular Response To Interferon-gamma Regulation Of Podosome Assembly Cardiac Muscle Cell Contraction Actin Filament Reorganization Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Neural Tube Closure Axon Guidance Actin Polymerization Or Depolymerization Actin Cytoskeleton Organization Positive Regulation Of Actin Filament Polymerization Cell Junction Assembly Protein Homotetramerization
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Amyloid fiber formation	Generation of second messenger molecules Signaling by ROBO receptors Signaling by ROBO receptors Cell-extracellular matrix interactions
Drugs		Zinc Latrunculin A Copper Zinc acetate
Diseases		Lattice corneal dystrophies (LCD), including: Biber-Haab-Dimmer dystrophy; Familial amyloid polyneuropathy type IV; Meretoja syndrome Familial amyloidosis
GWAS		Blood protein levels ( 30072576)	Alzheimer's disease or HDL levels (pleiotropy) ( 30805717)
Interacting Genes		24 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK ERBB2 FHIT FN1 LIMK2 PIK3CG PLCG1 PTK2B PXN STK39 TNIK TOM1L1 VASP VCL VDAC1	44 interacting genes: ABI1 ABI2 ABI3 ACTA1 ACTG1 APBB1 APBB1IP CDC42 CEP43 DMRTB1 DNMBP ENAH ERMAP EVL FAT1 FRS3 FYB1 GSN IQGAP1 LPP NOL3 NR4A1 PFN1 PFN2 PLSCR1 PRKACA PRKG1 PRPF40A PSORS1C2 RAD51 RAPH1 SAT1 SCGB2A2 SPTA1 TES TRIM15 TRIM9 VCL WAS WASL WWP2 XIRP1 XPO6 ZYX
Entrez ID		2934	7408
HPRD ID		00674	03415
Ensembl ID		ENSG00000148180	ENSG00000125753
Uniprot IDs		A0A0A0MS51 A0A0A0MT01 A0A384MEF1 B7Z4U6 P06396	A0A024R0V4 P50552
PDB IDs		1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5DD2 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6LJE 6LJF 6Q9R 6Q9Z 6QBF 6QW3	1EGX 1JNG 1USD 1USE 2PAV 2PBD 3CHW
Enriched GO Terms of Interacting Partners?
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