PLXNB2 and HMOX2

Data Source:
BioGRID (two hybrid)

		PLXNB2	HMOX2
Description		plexin B2	heme oxygenase 2
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Integral Component Of Plasma Membrane Cell Surface Extracellular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Specific Granule Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Activity	Heme Oxygenase (decyclizing) Activity Protein Binding Heme Binding Metal Ion Binding
	Biological Process	Neural Tube Closure Regulation Of Protein Phosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Neuroblast Proliferation Brain Development Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Translation Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Excitatory Synapse Assembly Regulation Of Neuron Migration	Response To Hypoxia Heme Oxidation Cellular Iron Ion Homeostasis Response To Oxidative Stress Heme Catabolic Process Neutrophil Degranulation Iron Ion Homeostasis
Pathways			Heme degradation Neutrophil degranulation Iron uptake and transport
Drugs			NADH Stannsoporfin
Diseases
GWAS		Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576 29875488) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sensorimotor dexterity ( 31596458) Systolic blood pressure ( 30224653)	Erectile dysfunction ( 30583798)
Interacting Genes		7 interacting genes: ARHGEF11 ARHGEF12 CENPU HMOX2 PFDN1 PTN RND1	67 interacting genes: A2M APP AQP6 ARL13B ASGR2 ATP5F1B BCL2L13 BLOC1S2 CCR2 CD79A CEBPZ CEP126 COPS6 CRB3 CSNK2A1 EBP EEF1G EIF3C ELOVL4 ELOVL5 ERGIC3 F2RL1 FAM209A FAM210B GET1 GIT1 GPR152 GPRASP1 GPX8 HAP1 IMMT INPP5K ITFG1 JADE1 KCNJ6 KCNMA1 LAPTM5 LMNA LRIF1 MED31 MGST3 MTNR1A NDUFS2 NKRF NR3C1 PLXNB2 PTGER4 RBBP4 RETREG3 RNASEK SAR1A SETDB1 SGPL1 SHC1 SKA2 SLC30A8 SMO SNX5 SNX7 SSMEM1 STOM SYT1 TMEM14B TMX2 VMA21 ZFP28 ZNF746
Entrez ID		23654	3163
HPRD ID		05050	00783
Ensembl ID		ENSG00000196576	ENSG00000103415
Uniprot IDs		O15031	A0A087WT44 B3KSE0 P30519
PDB IDs		4E71	2Q32 2QPP 2RGZ 4WMH 5UC8 5UC9 5UCA
Enriched GO Terms of Interacting Partners?
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