PLXNB2 and ARHGEF11

Data Source:
BioGRID (two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology)
HPRD (two hybrid)

		PLXNB2	ARHGEF11
Description		plexin B2	Rho guanine nucleotide exchange factor 11
Image
GO Annotations	Cellular Component	Semaphorin Receptor Complex Integral Component Of Plasma Membrane Cell Surface Extracellular Exosome	Cytoplasm Cytosol Membrane
	Molecular Function	Protein Binding Semaphorin Receptor Activity	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Neural Tube Closure Regulation Of Protein Phosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Neuroblast Proliferation Brain Development Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Translation Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Excitatory Synapse Assembly Regulation Of Neuron Migration	Regulation Of Cell Growth Striated Muscle Contraction G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Establishment Of Cell Polarity Actin Cytoskeleton Organization Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Regulation Of Small GTPase Mediated Signal Transduction
Pathways			NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576 29875488) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sensorimotor dexterity ( 31596458) Systolic blood pressure ( 30224653)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Height ( 31562340) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		7 interacting genes: ARHGEF11 ARHGEF12 CENPU HMOX2 PFDN1 PTN RND1	15 interacting genes: ABCA1 CDC42 GNA12 GNA13 LPAR1 LPAR2 MAP1A MAP1B PLXNB1 PLXNB2 PLXNB3 PTPRF RHOA RPS6KA1 SLC1A6
Entrez ID		23654	9826
HPRD ID		05050	09302
Ensembl ID		ENSG00000196576	ENSG00000132694
Uniprot IDs		O15031	O15085
PDB IDs		4E71	1HTJ 1XCG 2DLS 3KZ1 3T06 5E6P 5JHG 5JHH 5TYT
Enriched GO Terms of Interacting Partners?
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