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H2AC18 and USP21
Data Source:
BioGRID
(enzymatic study)
H2AC18
USP21
Description
H2A clustered histone 18
ubiquitin specific peptidase 21
Image
GO Annotations
Cellular Component
Nucleosome
Nucleus
Extracellular Exosome
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Molecular Function
Molecular_function
DNA Binding
Protein Binding
Protein Heterodimerization Activity
Transcription Coactivator Activity
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Cysteine-type Peptidase Activity
NEDD8-specific Protease Activity
Metal Ion Binding
Biological Process
Chromatin Silencing
Biological_process
Ubiquitin-dependent Protein Catabolic Process
Histone Deubiquitination
Protein Deubiquitination
Protein Phosphopantetheinylation
Neuron Projection Development
Positive Regulation Of Transcription, DNA-templated
Pathways
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Cleavage of the damaged purine
Meiotic synapsis
Packaging Of Telomere Ends
Pre-NOTCH Transcription and Translation
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
PRC2 methylates histones and DNA
Condensation of Prophase Chromosomes
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
HDACs deacetylate histones
HATs acetylate histones
HATs acetylate histones
RMTs methylate histone arginines
SIRT1 negatively regulates rRNA expression
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
NoRC negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
DNA methylation
Transcriptional regulation by small RNAs
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
UCH proteinases
Ub-specific processing proteases
Metalloprotease DUBs
Deposition of new CENPA-containing nucleosomes at the centromere
RNA Polymerase I Promoter Opening
RNA Polymerase I Promoter Escape
RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Estrogen-dependent gene expression
Meiotic recombination
HCMV Early Events
HCMV Late Events
Transcriptional regulation of granulopoiesis
Inhibition of DNA recombination at telomere
Amyloid fiber formation
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Drugs
Diseases
GWAS
Interacting Genes
20 interacting genes:
APP
BAP1
BMI1
DNAJC2
H2BC15
IL33
MSL2
NOC2L
PARP1
PRMT6
RCC1
RNF168
RNF169
RNF2
RNF20
TBL1X
UBC
UBE2H
USP16
USP21
59 interacting genes:
ADAMTSL4
ATXN3
AURKA
BAP1
BRCA2
CBL
CBLC
CPSF6
DTX3
EFEMP2
ESPL1
EXOSC10
FOXM1
H2AC18
HOXC10
ISG15
JOSD1
KCTD9
KRT40
LRSAM1
MAPK3
MPP1
NANOG
OTUB1
OTUB2
PCGF6
RBCK1
RNF144A
RNF185
SENP3
SENP8
SLF1
STAMBP
SYNE1
TP53
TRAF6
TRIM23
TRIM5
TRIM54
TRIM63
TRIM8
TRIM9
UBC
UBE2S
UCHL1
UCHL3
USP14
USP15
USP2
USP20
USP28
USP33
USP4
USP51
USP7
USP8
WDR47
YOD1
ZNF350
Entrez ID
8337
27005
HPRD ID
08851
05291
Ensembl ID
ENSG00000203812
ENSG00000143258
Uniprot IDs
Q6FI13
Q9UK80
PDB IDs
6SE6
6SEE
6SEF
6SEG
6Y5D
2Y5B
3I3T
3MTN
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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