USP21 and UCHL3

Data Source:
BioGRID (enzymatic study)

		USP21	UCHL3
Description		ubiquitin specific peptidase 21	ubiquitin C-terminal hydrolase L3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Peptidase Activity NEDD8-specific Protease Activity Metal Ion Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Ubiquitin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Histone Deubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Neuron Projection Development Positive Regulation Of Transcription, DNA-templated	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Protein Catabolic Process Post-translational Protein Modification
Pathways		TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases	UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
Drugs
Diseases
GWAS			Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)
Interacting Genes		59 interacting genes: ADAMTSL4 ATXN3 AURKA BAP1 BRCA2 CBL CBLC CPSF6 DTX3 EFEMP2 ESPL1 EXOSC10 FOXM1 H2AC18 HOXC10 ISG15 JOSD1 KCTD9 KRT40 LRSAM1 MAPK3 MPP1 NANOG OTUB1 OTUB2 PCGF6 RBCK1 RNF144A RNF185 SENP3 SENP8 SLF1 STAMBP SYNE1 TP53 TRAF6 TRIM23 TRIM5 TRIM54 TRIM63 TRIM8 TRIM9 UBC UBE2S UCHL1 UCHL3 USP14 USP15 USP2 USP20 USP28 USP33 USP4 USP51 USP7 USP8 WDR47 YOD1 ZNF350	20 interacting genes: ATM ATXN7L3 CDH1 FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5
Entrez ID		27005	7347
HPRD ID		05291	04367
Ensembl ID		ENSG00000143258	ENSG00000118939
Uniprot IDs		Q9UK80	A0A087WTB8 A0A140VJZ4 P15374
PDB IDs		2Y5B 3I3T 3MTN	1UCH 1XD3 6ISU 6QML
Enriched GO Terms of Interacting Partners?
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